Estimating required information size by quantifying diversity in random-effects model meta-analyses

Are large trials less reliable than small trials?

(2009) Gerta Rücker et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Undue reliance on I 2 in assessing heterogeneity may mislead

(2008) Gerta Rücker et al.   BMC Medical Research Methodology

Commentary: Heterogeneity in meta-analysis should be expected and appropriately quantified

(2008) J. P T Higgins   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses

(2008) Jesper Brok et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Perioperative β blockers in patients having non-cardiac surgery: a meta-analysis

(2008) Sripal Bangalore et al.   LANCET

Perioperative oxygen fraction – effect on surgical site infection and pulmonary complications after abdominal surgery: a randomized clinical trial. Rationale and design of the PROXI-Trial

(2008) Christian S Meyhoff et al.   Trials

Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

(2008) Lesley Wood et al.   BMJ-British Medical Journal

Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis

(2007) Jørn Wetterslev et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

In the Era of Systematic Reviews, Does the Size of an Individual Trial Still Matter?

(2007) Gordon H Guyatt et al.   PLOS MEDICINE