Review
Clinical Neurology
Julie M. Ziobro, Krista Eschbach, Renee A. Shellhaas
Summary: Neonatal seizures have not seen significant changes in treatment for decades, but recent advances in diagnosis and pathophysiology present opportunities for precision therapies. Current treatment evidence needs further exploration and development, while new therapies have the potential to improve outcomes for patients.
Article
Pediatrics
Meredith Monaco-Brown, Upender Munshi, Michael Joseph Horgan, Jamie L. Gifford, Rubia Khalak
Summary: This study aimed to investigate whether maternal obesity increases the risk of neonatal hypoxic ischemic encephalopathy (HIE). Retrospectively reviewing data from the New York State Perinatal Data System, it was found that infants of obese mothers were more frequently diagnosed with HIE, showing a significant increase in risk.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Weixi Li, Shuiyan Wu, Huizhong Xu, Xiaoying Zhao, Yizhi Pan, Hongbiao Huang, Haitao Lv, Xueping Zhu, Ying Liu
Summary: A novel BRAT1 variant R78P was identified in this study, expanding the spectrum of BRAT1 variants. R78P led to changes in BRAT1 expression and localization, but did not affect its function in mitochondria. Additionally, R78P was associated with a range of neurological conditions.
PEDIATRIC RESEARCH
(2022)
Review
Neurosciences
Qianting Deng, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) is the leading cause of neonatal mortality and disability. Currently, hypothermia is the only approved treatment, but its therapeutic efficacy is limited. Therefore, there is a need to understand the molecular pathogenesis of HIE and develop novel therapies.
EXPERIMENTAL NEUROLOGY
(2023)
Review
Pharmacology & Pharmacy
Yue Zhou, Li Yang, Xiaoying Liu, Hao Wang
Summary: Perinatal hypoxia-ischemia is the most common cause of acute neonatal brain injury, and inflammation plays a significant role in its pathogenesis. Recent studies have discovered that lactate can regulate inflammation through histone lactylation. Understanding the interaction between histone lactylation and inflammation could lead to the development of immunomodulatory therapies for neonatal brain damage.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zuozhen Cao, Huijia Lin, Fusheng Gao, Xiaoxia Shen, Hongxi Zhang, Jiangyang Zhang, Lizhong Du, Can Lai, Xiaolu Ma, Dan Wu
Summary: This study systematically characterized the microstructural alterations in neonates with hypoxic-ischemic encephalopathy (HIE) using advanced diffusion MRI. The results showed extensive microstructural injury in severe HIE, and association fiber injury with rightward lateralization in moderate and mild HIE.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Genetics & Heredity
Eric S. Peeples, Namood-e Sahar, William Snyder, Karoly Mirnics
Summary: This study identified differentially expressed miRNAs and mRNAs in neonatal HIBI, suggesting their potential as therapeutic targets. Furthermore, the differences in miRNA expression between brain regions suggest that assessing individual brain regions is important for the development of targeted therapies.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Yu-Mi Seo, Seok Hwang-Bo, Soo-Ah Im, Myungshin Kim, Young-Ah Youn
Summary: This study aims to evaluate the significant gene expression in severe hypoxic ischemic encephalopathy (HIE) in newborns. The study found that the levels of heat-shock protein 70 and 47 were significantly elevated in the severe-HIE group, possibly playing a protective role in inhibiting exacerbated neuroinflammation and maintaining cellular homeostasis. Additionally, the >= moderate-HIE group showed significant language delay at 18-24 months.
Article
Genetics & Heredity
Liesbeth T. M. Wintjes, Maina Kava, Frans A. van den Brandt, Mariel A. M. van den Brand, Oksana Lapina, Yngve T. Bliksrud, Mari A. Kulseth, Silja S. Amundsen, Terje R. Selberg, Marion Ybema-Antoine, Omar A. Z. Tutakhel, Lawrence Greed, David R. Thorburn, Trine Tangeraas, Shanti Balasubramaniam, Richard J. T. Rodenburg
Summary: Deficiency in COX16 gene may lead to isolated complex IV deficiency and related clinical symptoms, and it acts by affecting the assembly process of complex IV.
Article
Neurosciences
Edward Beamer, Mary Isabel O'Dea, Aisling A. Garvey, Jonathon Smith, Aida Menendez-Mendez, Lynne Kelly, Andreea Pavel, Sean Quinlan, Mariana Alves, Eva M. Jimenez-Mateos, Faming Tian, Eugene Dempsey, Nicholas Dale, Deirdre M. Murray, Geraldine B. Boylan, Eleanor J. Molloy, Tobias Engel
Summary: The study demonstrates that measuring blood purine concentrations may aid in the rapid diagnosis of neonatal encephalopathy, with potential applications for identifying infants with seizures and other neurological conditions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Yuko Ogawa, Emi Tanaka, Yoshiaki Sato, Masahiro Tsuji
Summary: SCID mice can serve as an appropriate preclinical model for cell therapies for neonatal HIE, showing comparable severity of brain damage and hypothermia effects to wild-type mice.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liam M. Koehn, Kevin Nguyen, Xiaodi Chen, Andre Santoso, Richard Tucker, Yow-Pin Lim, Barbara S. Stonestreet
Summary: Targeting hypoxia-ischemia (HI)-related brain injury can effectively alleviate behavioral deficits and brain infarct volume in newborns, with no significant differences found in the efficacy of hIAIPs at different doses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Alexa C. Stone, Kyle C. Strickland, David T. Tanaka, Jennifer B. Gilner, Monica E. Lemmon, Jeffrey B. Russ
Summary: This study examines the impact of chorioamnionitis on outcomes in neonates with hypoxic-ischemic encephalopathy (HIE) and finds that chorioamnionitis is associated with an increased risk of abnormal EEG patterns and post-neonatal epilepsy, highlighting the crucial role of placental pathology in neuroprognostication for HIE patients.
PEDIATRIC RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhong Chen, Qi He, Wenxing Li, Juan Liang, Tingting Zhu, Jun Tang
Summary: This study summarized 11 randomized controlled studies to find that aEEG can effectively enhance the detection rate of neonatal severe hyperbilirubinemia patients and help them receive treatment as soon as possible to ensure the prognosis of children.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Clinical Neurology
Kristine Sarah Hedegaard Andersen, Kristina Garne Holm, Merete Nordentoft, Carsten Hjorthoj
Summary: The study aimed to determine the association between neonatal homecare and postpartum depression among mothers of preterm infants. The implementation of neonatal homecare was found to be associated with a 23% reduced incidence rate of severe postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Letter
Endocrinology & Metabolism
Macarena Ruiz-Ferrer, Raquel M. Fernandez, Elena Navarro, Guillermo Antinolo, Salud Borrego
Article
Oncology
Ana Torroglosa, Leticia Villalba-Benito, Raquel Maria Fernandez, Maria Jose Moya-Jimenez, Guillermo Antinolo, Salud Borrego
Article
Obstetrics & Gynecology
Angel Chimenea, Lutgardo Garcia-Diaz, Ana Maria Calderon, Maria Moreno-De Las Heras, Guillermo Antinolo
BMC PREGNANCY AND CHILDBIRTH
(2018)
Article
Multidisciplinary Sciences
Maria Gonzalez-del Pozo, Marta Martin-Sanchez, Nereida Bravo-Gil, Cristina Mendez-Vidal, Angel Chimenea, Enrique Rodriguez-de la Rua, Salud Borrego, Guillermo Antinolo
SCIENTIFIC REPORTS
(2018)
Article
Medicine, General & Internal
Nereida Bravo-Gil, Irene Marcos, Antonio Gonzalez-Meneses, Guillermo Antinolo, Salud Borrego
Review
Biochemistry & Molecular Biology
Ana Torroglosa, Leticia Villalba-Benito, Berta Luzon-Toro, Raquel Maria Fernandez, Guillermo Antinolo, Salud Borrego
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Genetics & Heredity
Maria Jose Morillo Sanchez, Pilar Llavero Valero, Maria Gonzalez-Del Pozo, Beatriz Ponte Zuniga, Guillermo Antinolo, Manuel Ramos Jimenez, Enrique Rodriguez De la Rua Franch
OPHTHALMIC GENETICS
(2019)
Review
Genetics & Heredity
Berta Luzon-Toro, Leticia Villalba-Benito, Ana Torroglosa, Raquel M. Fernandez, Guillermo Antinolo, Salud Borrego
Article
Obstetrics & Gynecology
Angel Chimenea, Lutgardo Garcia-Diaz, Maria Moreno-De las Heras, Felix Coserria, Guillermo Antinolo
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2020)
Article
Multidisciplinary Sciences
B. Luzon-Toro, R. M. Fernandez, J. M. Martos-Martinez, M. Rubio-Manzanares-Dorado, G. Antinolo, S. Borrego
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Clara Xiol, Silvia Vidal, Ainhoa Pascual-Alonso, Laura Blasco, Nuria Brandi, Paola Pacheco, Edgar Gerotina, Mar O'Callaghan, Merce Pineda, Judith Armstrong, Francisco Javier Aguirre, Montserrat Aleu, Xenia Alonso, Merce Alsius, Maria Inmaculada Amoros, Guillermo Antinolo, Lourdes Aquino, Carmen Arellano, Gema Arriola, Rosa Arteaga, Neus Baena, Montserrat Barcos, Nuria Belzunces, Susana Boronat, Tomas Camacho, Jaume Campistol, Miguel del Campo, Andrea Campo, Ramon Cancho, Ramon Candau, Ignacio Canos, Maria del Carmen Carrascosa, Francisco Carratala-Marco, Jovani Casano, Pedro Castro, Ana Cobo, Jaime Colomer, David Conejo, Maria Jose Corrales, Rocio Cortes, Gabriel Cruz, Gabor Csanyi, Maria Teresa de Santos, Maria de Toledo, Miguel Del Campo, Mireia Del Toro, Rosario Domingo, Anna Duat, Rosario Duque, Ana Maria Esparza, Rosa Fernandez, Maria Carme Fons, Ana Fontalba, Enrique Galan, Pia Gallano, Maria Jose Gamundi, Pedro Luis Garcia, Maria del Mar Garcia, Maria Garcia-Barcina, Maria Jesus Garcia-Catalan, Angels Garcia-Cazorla, Sixto Garcia-Minaur, Juan Jose Garcia-Penas, Maria Teresa Garcia-Silva, Rosa Gassio, Esther Gean, Belen Gil, Sarenur Gokben, Luis Gonzalez, Veronica Gonzalez, Julieta Gonzalez, Gloria Gonzalez, Encarna Guillen, Miriam Guitart, Montserrat Guitet, Juan Manuel Gutierrez, Eva Gutierrez, Jose Luis Herranz, Gemma Iglesias, Iva Karacic, Carlos H. Lahoz, Jose Ignacio Lao, Pablo Lapunzina, Maria Jesus Lautre-Ecenarro, Maria Dolores Lluch, Laura Lopez, Asuncion Lopez-Ariztegui, Alfons Macaya, Rosario Marin, Charles M. Lourenco Marquez, Elena Martin, Beatriz Martinez, Eduardo Martinez-Salcedo, Maria Jose Mas, Gonzalo Mateo, Pilar Mendez, Amparo Morant Jimenez, Sira Moreno, Fernando Mulas, Juan Narbona, Andres Nascimento, Manuel Nieto, Tania Fabiola Nunes, Nuria Nunez, Maria Obon, Ignacio Onsurbe, Carlos Ignacio Ortez, Emilio Orts, Francisco Martinez, Rafael Parrilla, Samuel Ignacio Pascual, Ana Patino, Maria Perez-Poyato, Belen Perez-Duenas, Pilar Poo, Eliodoro Puche, Feliciano Ramos, Miquel Raspall, Ana Roche, Susana Roldan, Jordi Rosell, Cesar Ruiz, Maria Luz Ruiz-Falco, Maria Eugenia Russi, Jordi Samarra, Victoria San Antonio, Ivan Sanchez, Xavier Sanmartin, Ana Sans, Alfredo Santacana, Sabine Scholl-Burgi, Nuria Serrano, Mercedes Serrano, Pilar Martin-Tamayo, Adrian Tendero, Jaime Torrents, Diego Tortosa, Emma Trivino, Ledia Troncoso, Eulalia Turon, Pilar Vazquez, Carlos Vazquez, Ramon Velazquez, Clara Ventura, Alfonso Verdu, Anna Vernet, M. Tomas Vila, Cristina Villar
SCIENTIFIC REPORTS
(2019)
Review
Genetics & Heredity
Berta Luzon-Toro, Raquel Maria Fernandez, Leticia Villalba-Benito, Ana Torroglosa, Guillermo Antinolo, Salud Borrego
Article
Medicine, Research & Experimental
Maria Gonzalez-del Pozo, Elena Fernandez-Suarez, Marta Martin-Sanchez, Nereida Bravo-Gil, Cristina Mendez-Vidal, Enrique Rodriguez-de La Rua, Salud Borrego, Guillermo Antinolo
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Ana Torroglosa, Leticia Villalba-Benito, Raquel Maria Fernandez, Berta Luzon-Toro, Maria Jose Moya-Jimenez, Guillermo Antinolo, Salud Borrego
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biotechnology & Applied Microbiology
Hongsheng Gui, Duco Schriemer, William W. Cheng, Rajendra K. Chauhan, Guillermo Antinolo, Courtney Berrios, Marta Bleda, Alice S. Brooks, Rutger W. W. Brouwer, Alan J. Burns, Stacey S. Cherny, Joaquin Dopazo, Bart J. L. Eggen, Paola Griseri, Binta Jalloh, Thuy-Linh Le, Vincent C. H. Lui, Berta Luzon-Toro, Ivana Matera, Elly S. W. Ngan, Anna Pelet, Macarena Ruiz-Ferrer, Pak C. Sham, Iain T. Shepherd, Man-Ting So, Yunia Sribudiani, Clara S. M. Tang, Mirjam C. G. N. van den Hout, Herma C. van der Linde, Tjakko J. van Ham, Wilfred F. J. van IJcken, Joke B. G. M. Verheij, Jeanne Amiel, Salud Borrego, Isabella Ceccherini, Aravinda Chakravarti, Stanislas Lyonnet, Paul K. H. Tam, Maria-Merce Garcia-Barcelo, Robert M. W. Hofstra