How to treat VAP due to MDR pathogens in ICU patients

Effectiveness of tigecycline-based versus colistin- based therapy for treatment of pneumonia caused by multidrug-resistant Acinetobacter baumanniiin a critical setting: a matched cohort analysis

(2014) Yu-Chung Chuang et al.   BMC INFECTIOUS DISEASES

Late Onset Ventilator-Associated Pneumonia Due to Multidrug-Resistant Acinetobacter spp.: Experience with Tigecycline

(2014) D. Curcio et al.   JOURNAL OF CHEMOTHERAPY

Imipenem, Meropenem, or Doripenem To Treat Patients with Pseudomonas aeruginosa Ventilator-Associated Pneumonia

(2013) Charles-Edouard Luyt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Successful Ertapenem-Doripenem Combination Treatment of Bacteremic Ventilator-Associated Pneumonia Due to Colistin-Resistant KPC-Producing Klebsiella pneumoniae

(2013) Giancarlo Ceccarelli et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergistic Activity of Colistin plus Rifampin against Colistin-Resistant KPC-Producing Klebsiella pneumoniae

(2013) Carlo Tascini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Experience of Colistin-Glycopeptide Combination in Critically Ill Patients Infected with Gram-Negative Bacteria

(2013) Nicola Petrosillo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Randomized Phase 2 Trial To Evaluate the Clinical Efficacy of Two High-Dosage Tigecycline Regimens versus Imipenem-Cilastatin for Treatment of Hospital-Acquired Pneumonia

(2013) Julio Ramirez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical Efficacy and Safety of the Combination of Colistin plus Vancomycin for the Treatment of Severe Infections Caused by Carbapenem-Resistant Acinetobacter baumannii

(2013) José Garnacho-Montero et al.   CHEMOTHERAPY

Short- vs Long-Duration Antibiotic Regimens for Ventilator-Associated Pneumonia

(2013) George Dimopoulos et al.   CHEST

Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial

(2013) Emanuele Durante-Mangoni et al.   CLINICAL INFECTIOUS DISEASES

Potentially resistant microorganisms in intubated patients with hospital-acquired pneumonia: the interaction of ecology, shock and risk factors

(2013) Ignacio Martin-Loeches et al.   INTENSIVE CARE MEDICINE

Outcomes of critically ill intensive care unit patients treated with fosfomycin for infections due to pandrug-resistant and extensively drug-resistant carbapenemase-producing Gram-negative bacteria

(2013) Konstantinos Pontikis et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Application of a Loading Dose of Colistin Methanesulfonate in Critically Ill Patients: Population Pharmacokinetics, Protein Binding, and Prediction of Bacterial Kill

(2012) Ami F. Mohamed et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

High-Dose, Extended-Interval Colistin Administration in Critically Ill Patients: Is This the Right Dosing Strategy? A Preliminary Study

(2012) L. Dalfino et al.   CLINICAL INFECTIOUS DISEASES

Linezolid in Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia: A Randomized, Controlled Study

(2012) R. G. Wunderink et al.   CLINICAL INFECTIOUS DISEASES

Colistin vs. the combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia

(2012) H. AYDEMIR et al.   EPIDEMIOLOGY AND INFECTION

Penetration of Vancomycin into Epithelial Lining Fluid in Healthy Volunteers

(2011) Thomas P. Lodise et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Double-Carbapenem Therapy for Carbapenemase-Producing Klebsiella pneumoniae

(2011) Catharine C. Bulik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Carbapenems: Past, Present, and Future

(2011) Krisztina M. Papp-Wallace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Relationship between the MIC of vancomycin and clinical outcome in patients with MRSA nosocomial pneumonia

(2011) Eun Young Choi et al.   INTENSIVE CARE MEDICINE

BAY41-6551 achieves bactericidal tracheal aspirate amikacin concentrations in mechanically ventilated patients with Gram-negative pneumonia

(2011) Michael S. Niederman et al.   INTENSIVE CARE MEDICINE

In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumannii

(2011) D. W. Wareham et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Site of infection rather than vancomycin MIC predicts vancomycin treatment failure in methicillin-resistant Staphylococcus aureus bacteraemia

(2011) C. J. Walraven et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Efficacy of Rifampin and Its Combinations with Imipenem, Sulbactam, and Colistin in Experimental Models of Infection Caused by Imipenem-Resistant Acinetobacter baumannii

(2010) M. E. Pachon-Ibanez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Potent Synergy and Sustained Bactericidal Activity of a Vancomycin-Colistin Combination versus Multidrug-Resistant Strains of Acinetobacter baumannii

(2010) N. C. Gordon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Relationship of Vancomycin Minimum Inhibitory Concentration to Mortality in Patients With Methicillin-Resistant Staphylococcus aureus Hospital-Acquired, Ventilator-Associated, or Health-care-Associated Pneumonia

(2010) Nadia Z. Haque et al.   CHEST

Steady-State Pharmacokinetics and BAL Concentration of Colistin in Critically Ill Patients After IV Colistin Methanesulfonate Administration

(2010) Roberto Imberti et al.   CHEST

Aerosolized plus Intravenous Colistin versus Intravenous Colistin Alone for the Treatment of Ventilator‐Associated Pneumonia: A Matched Case‐Control Study

(2010) Diamantis P. Kofteridis et al.   CLINICAL INFECTIOUS DISEASES

Spectrum of practice in the diagnosis of nosocomial pneumonia in patients requiring mechanical ventilation in European intensive care units

(2010) Despoina Koulenti et al.   CRITICAL CARE MEDICINE

Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia

(2010) Antonio T. Freire et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Off-label prescription of tigecycline: clinical and microbiological characteristics and outcomes

(2010) David Conde-Estévez et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Randomized controlled trial of nebulized colistimethate sodium as adjunctive therapy of ventilator-associated pneumonia caused by Gram-negative bacteria

(2010) P. Rattanaumpawan et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Population Pharmacokinetic Analysis of Colistin Methanesulfonate and Colistin after Intravenous Administration in Critically Ill Patients with Infections Caused by Gram-Negative Bacteria

(2009) D. Plachouras et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhaled colistin as adjunctive therapy to intravenous colistin for the treatment of microbiologically documented ventilator-associated pneumonia: a comparative cohort study

(2009) I.P. Korbila et al.   CLINICAL MICROBIOLOGY AND INFECTION

Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: A multicenter, randomized study*

(2009) Jean Chastre et al.   CRITICAL CARE MEDICINE

Aerosolized antibiotics in critically ill ventilated patients

(2009) Lucy B Palmer   Current Opinion in Critical Care

Procalcitonin for reduced antibiotic exposure in ventilator-associated pneumonia: a randomised study

(2009) D. Stolz et al.   EUROPEAN RESPIRATORY JOURNAL

Tigecycline possibly underdosed for the treatment of pneumonia: a pharmacokinetic viewpoint

(2009) Olaf Burkhardt et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution

(2009) Jason A. Roberts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum β-lactamase producing, Enterobacteriaceae infections: a systematic review

(2009) Matthew E Falagas et al.   LANCET INFECTIOUS DISEASES

Therapeutic monitoring of vancomycin in adult patients: A consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists

(2008) M. Rybak et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

In Vitro Activities of Tigecycline, Minocycline, and Colistin-Tigecycline Combination against Multi- and Pandrug-Resistant Clinical Isolates of Acinetobacter baumannii Group

(2008) L. A. Arroyo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aerosolized colistin as adjunctive treatment of ventilator-associated pneumonia due to multidrug-resistant Gram-negative bacteria: A prospective study

(2008) Argyris Michalopoulos et al.   RESPIRATORY MEDICINE