Review
Clinical Neurology
Grayson Beecher, Mark D. Fleming, Teerin Liewluck
Summary: The diagnostic evaluation of patients with suspected hereditary muscle disease can be challenging. Clinical history and examination features are important for diagnosis, with additional investigations assisting in definitive diagnosis. Hematological abnormalities, although rare, can provide valuable clues and assist in further investigation and interpretation of genetic variants in hereditary myopathies.
Review
Public, Environmental & Occupational Health
Asma Rahman, Roshan Niloofa, Umesh Jayarajah, Sanjay De Mel, Visula Abeysuriya, Suranjith L. Seneviratne
Summary: COVID-19 is associated with hematological abnormalities such as lymphopenia, thrombocytopenia, and elevated D-dimer levels, especially in severe cases. Close attention should be paid to coagulation abnormalities, and measures should be taken to prevent or mitigate their harmful effects.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Cardiac & Cardiovascular Systems
Rocio Enriquez, Robert Ssekubugu, Godfrey Kigozi, Dorean Nabukalu, Gaetano Marrone, Susanne Rautiainen, Bruna Gigante, Steven J. Reynolds, Fred Nalugoda, Larry W. Chang, Anna Mia Ekstrom, Nelson K. Sewankambo, David Serwadda, Helena Nordenstedt
Summary: A pilot study conducted in Uganda showed that the incorporation of ECG and arterial function measurements into a population-based cohort study was acceptable, with the proxy measures being well accepted. Left ventricular hypertrophy (LVH) and arterial stiffness were found to be common in both HIV-positive and HIV-negative participants, with arterial stiffness potentially more common among people living with HIV.
Article
Public, Environmental & Occupational Health
Liling Huang, Bo Xie, Kai Zhang, Yuanlong Xu, Lingsong Su, Yu Lv, Yangjie Lu, Jianqiu Qin, Xianwu Pang, Hong Qiu, Lanxiang Li, Xihua Wei, Kui Huang, Zhihao Meng, Yanling Hu, Jiannan Lv
Summary: A predictive model was developed using machine learning and electronic medical records to evaluate the risk of cytopenia in HIV patients during hospitalization. This model is crucial for designing a more individualized and evidence-based treatment strategy for HIV patients.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Shahid Shama, Asif Mahmood, Wen Zhang, Shahid Mehmood
Summary: The SARS-CoV-2 virus, which causes COVID-19, has led to a global pandemic resulting in millions of deaths and infections. It primarily affects the respiratory tract and can lead to complications such as cytokine storms and thrombosis. Early recognition and treatment with anticoagulants are crucial for preventing complications and improving patient outcomes.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Infectious Diseases
Christine Watera, Deogratius Ssemwanga, Grace Namayanja, Juliet Asio, Tom Lutalo, Alice Namale, Grace Sanyu, Isaac Ssewanyana, Jesus Fidel Gonzalez-Salazar, Jamirah Nazziwa, Maria Nanyonjo, Elliot Raizes, Usher Kabuga, Christina Mwangi, Wilford Kirungi, Joshua Musinguzi, Kaggwa Mugagga, Edward Katongole Mbidde, Pontiano Kaleebu
Summary: The HIVDR survey conducted in Uganda revealed a high prevalence of NNRTI drug resistance among adults, prompting a revision of the Ugandan ART guidelines to recommend dolutegravir-containing regimens as the preferred first- and second-line ART therapies.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Psychology, Multidisciplinary
Sofie Vindevogel, Emmanuel Kimera
Summary: This study explores the perceptions and representations of youths living with HIV (YLWH) and how they foster resilience in the face of HIV-related adversity. The findings reveal that participants manage tensions in material resources, sense of identity, power and control, cultural adherence, relationships, cohesion, and social justice to maintain well-being amidst HIV-related adversity.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Innocent Uzochukwu Okagu, Rita Ngozi Aguchem, Chinonso Anthony Ezema, Timothy Prince Chidike Ezeorba, Ozoemena Emmanuel Eje, Joseph Chinedum Ndefo
Summary: Malaria is a dangerous disease that causes a high number of hospital visits and deaths, particularly in children in sub-Saharan Africa. Despite existing interventions, such as vector control and treatment, the burden of the disease remains significant. Previous studies have reported the emergence of drug-resistant malaria parasites and poor access to effective antimalarial drugs as key factors contributing to the persistence of infections. Furthermore, the complex nature of malaria pathogenesis has hindered progress in combating the disease. Recent studies have identified various complex interactions and changes in blood composition induced by malaria parasites. However, there is a lack of comprehensive understanding of these alterations. This review discusses the molecular mechanisms of reported hematological and biochemical changes induced by malaria parasite infections, including anemia, thrombocytopenia, leukopenia, dyslipidemia, hypoglycemia, oxidative stress, and liver and kidney malfunctions. Additionally, the study explores strategies to limit the evasion of the immune response by malaria parasites in order to combat malaria and its complications.
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2022)
Review
Multidisciplinary Sciences
Patou Masika Musumari, Teeranee Techasrivichien, Kriengkrai Srithanaviboonchai, Rhoda K. Wanyenze, Joseph K. B. Matovu, Hemant Poudyal, S. Pilar Suguimoto, Saman Zamani, Arunrat Tangmunkongvorakul, Masako Ono-Kihara, Masahiro Kihara
Summary: The study described the status of HIV burden, prevention, and treatment in Ugandan fishing communities. It revealed a significant lack of evidence in terms of what works in HIV prevention and ART adherence, highlighting the need for intervention studies to fill the current evidence gaps.
Article
Psychiatry
Yoshihiro Matsumoto, Nobutaka Ayani, Chie Omichi, Nozomu Oya, Teruyuki Matsuoka, Tsutomu Kobayashi, Junya Kuroda, Jin Narumoto
Summary: Psychotropic drugs may lead to cytopenia, but other conditions should also be considered. When cytopenia occurs during dosage adjustment, discontinuing suspicious drugs and consulting hematologists promptly is crucial.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Immunology
Deus Lukoye, Gail Gustavson, Proscovia M. Namuwenge, Simon Muchuro, Estella Birabwa, Seyoum Dejene, Julius Ssempiira, Julius N. Kalamya, Steven Baveewo, Odile Ferroussier-Davis, Lisa A. Mills, Emilio Dirlikov, Lisa J. Nelson, Stavia Turyahabwe
Summary: Uganda significantly increased TB preventive therapy coverage among people living with HIV from 0.6% to 88.8% during the period of October 2016 to March 2022. TB notification rates among people living with HIV also increased from 881.1 to 972.5 per 100,000. Timely TB screening, diagnosis, and early treatment should be prioritized for TB/HIV prevention programming.
EMERGING INFECTIOUS DISEASES
(2023)
Article
Hematology
Chantana Polprasert, Sunisa Kongkiatkamon, Pimjai Niparuck, Thanawat Rattanathammethee, Kitsada Wudhikarn, Suporn Chuncharunee, Sirorat Kobbuaklee, Amornchai Suksusut, Theerin Lanamtieng, Panisinee Lawasut, Thiti Asawapanumas, Udomsak Bunworasate, Ponlapat Rojnuckarin
Summary: In this study, mutations in Asian MDS and MDS/MPN patients were found to be associated with more severe anemia, lower white blood cell count, or monocytosis. Patients with high-risk MDS, MDS/MPN, severe neutropenia (ANC <0.5 x 10(9)/L), and mutations in ASXL1 and SETBP1 were associated with inferior survival outcomes. These findings provide insights into the genetic basis of abnormal blood counts in myelodysplastic syndromes.
Article
Multidisciplinary Sciences
Andreas D. Knudsen, Claus Graff, Jonas Bille Nielsen, Magda Teresa Thomsen, Julie Hogh, Thomas Benfield, Jan Gerstoft, Lars Kober, Klaus F. Kofoed, Susanne D. Nielsen
Summary: The study found that in well-treated PLWH, there was a higher incidence of de novo major ECG abnormalities, which were associated with factors such as age, underweight, smoking, diabetes, and protease inhibitor use. De novo prolonged QTc was rare and did not seem to be a major issue in well-treated PLWH.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Eoghan Dunlea, Ellen Crushell, Melanie Cotter, Nenad Blau, Carlos R. Ferreira
Summary: Many classical inherited metabolic diseases have significant hematological complications. Management of these issues is important for optimal outcomes in people with IMDs. Disorders involving red cell energy metabolism have typically been cared for by hematologists. In the 16th Footprints series, 265 IMDs associated with hematological abnormalities were identified. The major hematological manifestations of IMDs are reviewed, and treatment options for specific hematological complications are discussed.
MOLECULAR GENETICS AND METABOLISM
(2023)
Article
Genetics & Heredity
Salem Alawbathani, Ana Westenberger, Natalia Ordonez-Herrera, Mariam Al-Hilali, Homoud Al Hebby, Fahad Al Abbas, Amal M. Alhashem, Ghaleb Elyamany, Andre Megarbane, Melis Kose, Nadia Alhashmi, Nashat Al Sukaiti, Mohammed Al-Raqad, Samah Al-Tawalbeh, Omar Abu Adas Blanco, Fadiah Alkhattabi, Danielle Sng, Ruslan Al-Ali, Suliman Khan, Hasan Tawamie, Kornelia Tripolszki, Vasiliki Karageorgou, Roberta Trunzo, Fuad Al Mutairi, Bruno Reversade, Peter Bauer, Aida M. Bertoli-Avella
Summary: This study confirms the role of ZNFX1 in primary genetic immunodeficiency, expands the genetic and clinical spectrum of ZNFX1-related disease, and highlights the usefulness of large, well-curated, and continually updated genotype-phenotype databases in resolving molecular diagnoses of patients with initially negative genetic testing findings.
Article
Nursing
Jennifer L. Barkin, Laura Beals, Christy C. Bridges, Amara Ezeamama, Marta Serati, Massimiliano Buoli, Amber Erickson, Megan Chapman, Joan R. Bloch
Summary: The study showed that participating in the Visiting Moms program significantly improved postpartum maternal functioning and depression symptoms, indicating that programs aimed at providing enhanced social support can effectively promote mental and emotional well-being among new mothers in the postpartum period.
JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
(2021)
Article
Public, Environmental & Occupational Health
Charles H. King, Sue Binder, Ye Shen, Christopher C. Whalen, Carl H. Campbell, Ryan E. Wiegand, Annette Olsen, William Evan Secor, Susan P. Montgomery, Rosemary Musuva, Pauline N. M. Mwinzi, Pascal Magnussen, Safari Kinung'hi, Gisele N. Andrade, Amara E. Ezeamama, Daniel G. Colley
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2020)
Review
Public, Environmental & Occupational Health
Charles H. King, David Bertsch, Gisele N. Andrade, Michael Burnim, Amara E. Ezeamama, Sue Binder, Daniel G. Colley
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2020)
Article
Public, Environmental & Occupational Health
Allan K. Nkwata, Xiao Song, Ming Zhang, Amara. E. Ezeamama
Article
Medicine, General & Internal
Amara E. Ezeamama, Alla Sikorskii, Parvathy R. Sankar, Noeline Nakasujja, Michael Ssonko, Norbert E. Kaminski, David Guwatudde, Michael J. Boivin, Bruno Giordani
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Nursing
Jennifer L. Barkin, Joan Rosen Bloch, Katherine E. R. Smith, Sarah N. Telliard, Analise McGreal, Chris Sikes, Amare Ezeamama, Massimiliano Buoli, Marta Serati, Christy C. Bridges
Summary: The study found mixed results with pregnant women showing both interest and reluctance towards home visiting programs during high-risk pregnancies. Themes of distrust and fear of judgment were present. Women varied in their preferences for home visiting services, including assistance with medical needs, functional tasks, household tasks, and child care.
JOURNAL OF MIDWIFERY & WOMENS HEALTH
(2021)
Article
Environmental Sciences
Allan K. Nkwata, Ming Zhang, Xiao Song, Bruno Giordani, Amara E. Ezeamama
Summary: The study found that discrimination, chronic stress, and low mastery were associated with worse cognition. The persistent cognitive disadvantage for African American individuals compared to White/Other races was only present among adults with high mastery, suggesting that adverse social experiences may counteract the cognitive benefits associated with mastery among African American populations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Infectious Diseases
A. E. Ezeamama, S. K. Zalwango, A. Sikorskii, R. Tuke, P. M. Musoke, B. Giordani, M. J. Boivin
Summary: The study aimed to quantify the association between in utero/peripartum antiretroviral (IPA) exposure and cognition, executive function (EF), and socioemotional adjustment (SEA) in school-aged Ugandan children. Different types of IPA exposure may have varying effects on cognitive development in children, with adjustments for caregiver sociodemographic and contextual factors based on the study findings.
Article
Clinical Neurology
Valentina Larrivey, Jennifer Neva, Katherine Finn, Alla Sikorskii, Itziar Familiar-Lopez, Valentine Ucheagwu, Amara Ezeamama, Horacio Ruisenor-Escudero, Noeline Nakasujja, Michael Boivin, Bruno Giordani
Summary: The study found that titrated computerized cognitive rehabilitation training (CCRT) showed better improvement in children's working memory, behavior, and executive functioning compared to non-titrated CCRT. The severity of malaria or other factors did not moderate CCRT performance indicators.
CHILD NEUROPSYCHOLOGY
(2022)
Article
Environmental Sciences
Allan K. Nkwata, Ming Zhang, Xiao Song, Bruno Giordani, Amara E. Ezeamama
Summary: This study investigated the relationship between toxic stress, resiliency-promoting factors, and incident dementia in American adults. The results showed that education level and race were associated with the risk of dementia. Toxic stress may override the cognitive benefits of resiliency-promoting factors, particularly in cases of discrimination or racial inequality.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Jorem Emmillian Awadu, Alla Sikorskii, Sarah Zalwango, Audrey Coventry, Bruno Giordani, Amara E. Ezeamama
Summary: This study examined the potential impact of in utero/peripartum antiretroviral (IPA) exposure on the likelihood of developmental disorders such as ADHD, ASD, and FI. The results showed that overall, IPA exposure during the peripartum period did not have a significant adverse effect on the probability of developmental disorders in children. However, exposure to SdNVP + AZT + 3TC was associated with higher probability of developmental disorders and functional impairment in children aged 6-18 years.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Jorem E. Awadu, Bruno Giordani, Alla Sikorskii, Catherine Abbo, Jenifer I. Fenton, Sarah Zalwango, Amara Esther Ezeamama
Summary: The study tested the hypothesis that vitamin D deficiency is associated with a higher probability of developmental disorders in children with perinatal HIV infection. The results showed that vitamin D deficiency was positively associated with the probability scores of autism, ADHD, emotional behavioral disorder, and functional impairment, and this relationship was dependent on developmental stage.
Article
Medicine, General & Internal
Jorem E. E. Awadu, Sarah K. K. Zalwango, Alla Sikorskii, Bruno Giordani, Michael J. J. Bovin, Philippa M. M. Musoke, Amara E. E. Ezeamama
Summary: This study investigated the growth differences between children with perinatally acquired HIV infection and children HIV exposed but uninfected, and found that children who received antiretroviral treatment showed worse growth than those who did not. This suggests that antiretroviral treatment during the peripartum period can improve the height-for-age of HIV-exposed children.
Article
Nursing
Kaitlyn Barrow, Analise McGreal, Dillon LiVecche, Susan Van Cleve, Chris Sikes, Massimiliano Buoli, Marta Serati, Christy C. Bridges, Amara Ezeamama, Jennifer L. Barkin
Summary: This study aimed to explore barriers and advantages of screening for postpartum depression in the pediatric setting, providers' knowledge of mental health supports in the community, and commonly observed mental health issues in new mothers. The results showed low compliance with screening, with main barriers including lack of time, training, and difficulties in accessing the mother's medical records.
JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
(2022)
Article
Pediatrics
Jane N. Mutanga, Simon Mutembo, Amara E. Ezeamama, Robert C. Fubisha, Derrick Sialondwe, Brenda Simuchembu, Macwani Mutukwa, Jelita Chinyonga, Philip E. Thuma, Christopher C. Whalen
JOURNAL OF TROPICAL PEDIATRICS
(2020)