Article
Chemistry, Medicinal
Chao Yang, Wansheng Xie, Heqian Zhang, Wenjian Xie, Tiantian Tian, Zhiwei Qin
Summary: Dengue is an acute tropical infectious disease transmitted by mosquitoes, posing a major challenge to global public health. The lack of clinically proven specific drugs for prevention and treatment is mainly due to the incomplete understanding of the pathogenesis of dengue fever.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Amalia Soares Vieira de Vasconcelos, Josenildo Silva de Lima, Rodrigo Tomas Nogueira Cardoso
Summary: Epidemiological models that consider arthropod vectors can help reduce the use of insecticides and social costs, and studying dengue is important in this context.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Shinji Kasai, Kentaro Itokawa, Nozomi Uemura, Aki Takaoka, Shogo Furutani, Yoshihide Maekawa, Daisuke Kobayashi, Nozomi Imanishi-Kobayashi, Michael Amoa-Bosompem, Katsunori Murota, Yukiko Higa, Hitoshi Kawada, Noboru Minakawa, Tran Chi Cuong, Nguyen Thi Yen, Tran Vu Phong, Sath Keo, Kroesna Kang, Kozue Miura, Lee Ching Ng, Hwa-Jen Teng, Samuel Dadzie, Sri Subekti, Kris Cahyo Mulyatno, Kyoko Sawabe, Takashi Tomita, Osamu Komagata
Summary: Aedes aegypti, the main mosquito vector for dengue and other arboviral infectious diseases, has developed high levels of pyrethroid resistance in populations collected from Vietnam and Cambodia. This resistance could pose a serious threat to the control of dengue fever and other Aedes-borne infectious diseases.
Article
Infectious Diseases
Catherine A. Lippi, Anna M. Stewart-Ibarra, Timothy P. Endy, Mark Abbott, Cinthya Cueva, Froilan Heras, Mark Polhemus, Efrain Beltran-Ayala, Sadie J. Ryan
Summary: The management of mosquito-borne diseases, particularly dengue fever, is a major challenge in southern coastal Ecuador, especially in Machala where dengue cases are historically high. This study combined mosquito survey data with human dengue infection data to identify household risk factors for dengue in Machala. Certain household characteristics were linked to increased mosquito presence or dengue infections, while the presence of female Aedes aegypti did not predict dengue infections. These findings contribute to improving mosquito control and surveillance efforts in southern Ecuador.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Gwenyth O. Lee, Luis Vasco, Sully Marquez, Julio C. Zuniga-Moya, Amanda Van Engen, Jessica Uruchima, Patricio Ponce, William Cevallos, Gabriel Trueba, James Trostle, Veronica J. Berrocal, Amy C. Morrison, Varsovia Cevallos, Carlos Mena, Josefina Coloma, Joseph N. S. Eisenberg
Summary: Dengue fever is not only a major health issue in large urban tropical areas, but is also observed in rural regions. Studies have shown that the physical landscape and sociodemographic factors can influence vector populations and dengue virus incidence rates. Research findings indicate that rural spatial organization can help explain disease risk, with Afro-Ecuadorian households being more susceptible to symptomatic dengue fever compared to Indigenous Chachi households, a relationship that can be attributed to vegetation proximity and distance to public spaces like football fields.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Multidisciplinary Sciences
Talya Shragai, Juliana Perez-Perez, Marcela del Pilar Quimbayo-Forero, Raul Rojo, Laura C. Harrington, Guillermo Rua-Uribe
Summary: Dengue is becoming an increasing global threat in rapidly growing urban areas. This study analyzes nine years of dengue case data in Medellin, Colombia and finds that changes in accessibility and usage of public transit are correlated with changes in the spread and magnitude of localized outbreaks. Locations closer to and with greater utilization of public transit have higher dengue incidence, with a stronger effect observed in lower socioeconomic status areas. These results emphasize the importance of public health services in conjunction with urban growth.
SCIENTIFIC REPORTS
(2022)
Article
Entomology
Wondemeneh Mekuriaw, Solomon Kinde, Bezabih Kindu, Yibeyin Mulualem, Girma Hailu, Araya Gebresilassie, Chalachw Sisay, Fitsum Bekele, Hiwot Amare, Mesfin Wossen, Adugna Woyessa, Chad L. Cross, Louisa A. Messenger
Summary: Dengue Fever (DF) is a viral disease transmitted by mosquitoes, and an outbreak occurred in the Afar Region, Ethiopia in 2019. The study found that Aedes aegypti mosquitoes were responsible for transmitting DF, and most cases occurred in individuals aged 15-49. The results emphasize the need for control measures targeting Aedes mosquitoes and improved entomological surveillance to prevent future outbreaks.
Article
Environmental Sciences
Cory W. Morin, Samuel Sellers, Kristie L. Ebi
Summary: This study explored the relationship between seasonal climate variability and dengue fever (DF) in Brazil using temperature-based models. The results showed that areas with higher mosquito survival probabilities and shorter extrinsic incubation periods (EIPs) were more likely to have DF case reports, but with significant intra-annual variability. The study also extrapolated the findings to the Americas, mapping the seasonal change in the range of areas suitable for dengue virus transmission and the population living in those areas using climate data from the past decade (2010-2019).
ENVIRONMENTAL RESEARCH LETTERS
(2022)
Article
Infectious Diseases
Ana Paula Razal Dalvi, Gerusa Gibson, Alberto Novaes Ramos Jr, Katia V. Bloch, Geziel dos Santos de Sousa, Thiago Luiz Nogueira da Silva, Jose Ueleres Braga, Marcia C. Castro, Guilherme Loureiro Werneck
Summary: This study aimed to identify sociodemographic and environmental risk factors for the occurrence of Zika, dengue, and chikungunya in adolescents. The study found that adolescents with better socioeconomic conditions had a lower risk of infection. Additionally, a higher risk of arboviral diseases was associated with a high mosquito infestation index in the school's region. These findings can contribute to the implementation of control measures in population groups and priority locations.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Infectious Diseases
Lauren A. Castro, Nicholas Generous, Wei Luo, Ana Pastore y Piontti, Kaitlyn Martinez, Marcelo F. C. Gomes, Dave Osthus, Geoffrey Fairchild, Amanda Ziemann, Alessandro Vespignani, Mauricio Santillana, Carrie A. Manore, Sara Y. Del Valle
Summary: Dengue virus poses a significant public health challenge in Brazil, with seasonal dynamics hindering preparation efforts. A framework was presented to characterize weekly dengue activity in Brazil from 2010-2016, with climate factors playing a key role in seasonal outbreaks. Remote sensing and movement patterns were found to be useful proxies for predicting outbreak properties.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Kyle R. Ryff, Aidsa Rivera, Dania M. Rodriguez, Gilberto A. Santiago, Freddy A. Medina, Esther M. Ellis, Jomil Torres, Ann Pobutsky, Jorge Munoz-Jordan, Gabriela Paz-Bailey, Laura E. Adams
Summary: From 2010 to 2020, approximately 30,000 cases of dengue were reported in the US territories, with the highest incidence during outbreak years. Children and adolescents aged <20 years were disproportionately affected, highlighting the need for interventions tailored for this population. Ongoing education for healthcare providers and dengue case surveillance and serotyping are important for improving patient outcomes and guiding future control measures.
MMWR SURVEILLANCE SUMMARIES
(2023)
Review
Immunology
Zhuanzhuan Liu, Qingxin Zhang, Liya Li, Junjie He, Jinyang Guo, Zichen Wang, Yige Huang, Zimeng Xi, Fei Yuan, Yiji Li, Tingting Li
Summary: This review explores the correlations between temperature and dengue epidemics, including the distribution and development of Aedes mosquitoes, the structure of DENV, and the vector competence of Aedes mosquitoes. Additionally, it discusses the immune and metabolic mechanism through which temperature affects the vector competence of Aedes mosquitoes to transmit DENV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jamie M. Caldwell, A. Desiree LaBeaud, Eric F. Lambin, Anna M. Stewart-Ibarra, Bryson A. Ndenga, Francis M. Mutuku, Amy R. Krystosik, Efrain Beltran Ayala, Assaf Anyamba, Mercy J. Borbor-Cordova, Richard Damoah, Elysse N. Grossi-Soyster, Froilan Heras Heras, Harun N. Ngugi, Sadie J. Ryan, Melisa M. Shah, Rachel Sippy, Erin A. Mordecai
Summary: Climate has complex effects on population dynamics and vector-borne diseases, with seemingly opposing effects in different contexts. Models incorporating laboratory-measured physiological traits of mosquitoes can predict outbreak characteristics in diverse settings, yet with variable accuracy. The effects of climate on disease dynamics are highly dependent on specific contexts, such as population demographics and environmental factors.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
L. L. Lima, A. P. F. Atman
Summary: In an increasingly interconnected society, preventing epidemics has become a major challenge. Using an agent-based model, the authors investigated the network morphology of a dengue endemic region considering different serotypes and a small population. The simulation results indicate that the spread of dengue is primarily driven by human-to-human and human-to-mosquito interaction, reinforcing the importance of controlling the vector to prevent episodes of epidemic outbreaks.
Article
Entomology
Maria E. Santana-Roman, Paola Maycotte, Salvador Uribe-Carvajal, Cristina Uribe-Alvarez, Nayeli Alvarado-Medina, Mohsin Khan, Aleem Siddiqui, Victoria Pando-Robles
Summary: Dengue is a growing public health concern without specific treatment, and vector control remains crucial for prevention. Studies show that DENV infection alters mitochondrial physiology in mosquito cells, affecting redox metabolism and membrane potential. The maintenance of mitochondrial function through fusion may play a vital role in the DENV-infected cells.
Article
Multidisciplinary Sciences
Colin J. Carlson, Rita Colwell, Mohammad Sharif Hossain, Mohammed Mofizur Rahman, Alan Robock, Sadie J. Ryan, Mohammad Shafiul Alam, Christopher H. Trisos
Summary: Solar geoengineering could increase malaria risk for one billion people, highlighting the need for health sector planning. The impact of geoengineering on human health is largely unknown.
NATURE COMMUNICATIONS
(2022)
Article
Meteorology & Atmospheric Sciences
Fernan Saenz, Hugo Gerardo Hidalgo, Angel Gabriel Munoz, Eric Jose Alfaro, Jorge Alberto Amador, Jorge Luis Vazquez-Aguirre
Summary: This study examines the relationships between weather types and rainfall characteristics in the Central American Isthmus. It defines six recurrent daily atmospheric patterns and investigates their control over temporal and spatial rainfall characteristics. The study finds that these weather types modulate moisture fluxes and thus control the intensity and distribution of rainfall. These findings can help improve climate predictions and model diagnostics at multiple timescales.
INTERNATIONAL JOURNAL OF CLIMATOLOGY
(2023)
Article
Development Studies
Rick Welsh, Elizabeth A. Pickard, Sadie J. Ryan, Joseph H. Bisesi, Joseph Makaure, Donald J. Stewart, David A. Larsen
Summary: This study explores the use of insecticide-treated nets (ITNs) as a means to kill mosquitoes in the 1980s. The World Health Organization later distributed these nets freely, but in regions where fishing is economically important, the nets have been repurposed for fishing, resulting in negative effects on the fisheries. Using the Normal Accident Framework and Weber's concepts of bureaucratic and traditional authority, this research examines how local actors respond to this unintended consequence.
SOCIETY & NATURAL RESOURCES
(2023)
Article
Parasitology
Johnny A. A. Uelmen Jr, Bennett Lamcyzk, Patrick Irwin, Dan Bartlett, Chris Stone, Andrew Mackay, Arielle Arsenault-Benoit, Sadie J. Ryan, John-Paul Mutebi, Gabriel L. Hamer, Megan Fritz, Rebecca L. Smith
Summary: This study compares traditional trapping methods with the less commonly used human landing catch (HLC) method for sampling potential West Nile virus vectors. The results show that the HLC method provides important insight into the species of mosquitoes biting humans in the region, but alternative approaches must be explored to incorporate this method safely into control programs due to the risk to collectors.
PARASITES & VECTORS
(2023)
Article
Public, Environmental & Occupational Health
Shreejana Bhattarai, Jason K. Blackburn, Sarah L. McKune, Sadie J. Ryan
Summary: Nepal aims to eliminate malaria by 2026. This study analyzed the spatio-temporal patterns of malaria in Nepal from 2005 to 2018 and identified spatial clusters with increasing malaria, indicating the need for targeted vector control interventions.
SPATIAL AND SPATIO-TEMPORAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Binqi Chen, Amy R. Sweeny, Velen Y. Wu, Rebecca C. Christofferson, Gregory Ebel, Anna C. Fagre, Emily Gallichotte, Rebekah C. Kading, Sadie J. Ryan, Colin J. Carlson
Summary: Arboviruses are often undercharacterized, receiving attention during outbreaks but otherwise lacking research. Global change is increasing the emergence of arboviral diseases, raising questions about virus-vector interactions. A systematic review found that most mosquito-virus combinations have not been tested experimentally, and entire regions are undersampled. These knowledge gaps hinder outbreak response and the development of predictive models.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Article
Ecology
Peter O. Dunn, Insiyaa Ahmed, Elise Armstrong, Natasha Barlow, Malcolm A. Barnard, Marc Belisle, Thomas J. Benson, Lisha L. Berzins, Chloe K. Boynton, T. Anders Brown, Melissa Cady, Kyle Cameron, Xuan Chen, Robert G. Clark, Ethan D. Clotfelter, Kara Cromwell, Russell D. Dawson, Elsie Denton, Andrew Forbes, Kendrick Fowler, Kevin C. Fraser, Kamal J. K. Gandhi, Dany Garant, Megan Hiebert, Claire Houchen, Jennifer Houtz, Tara L. Imlay, Brian D. Inouye, David W. Inouye, Michelle Jackson, Andrew P. Jacobson, Kristin Jayd, Christy Juteau, Andrea Kautz, Caroline Killian, Elliot Kinnear, Kimberly J. Komatsu, Kirk Larsen, Andrew Laughlin, Valerie Levesque-Beaudin, Ryan Leys, Elizabeth Long, Stephen C. Lougheed, Stuart Mackenzie, Jen Marangelo, Colleen Miller, Brenda Molano-Flores, Christy A. Morrissey, Emony Nicholls, Jessica M. Orlofske, Ian S. Pearse, Fanie Pelletier, Amber L. Pitt, Joseph P. Poston, Danielle M. Racke, Jeannine A. Randall, Matthew L. Richardson, Olivia Rooney, A. Rose Ruegg, Scott Rush, Sadie J. Ryan, Mitchell Sadowski, Ivana Schoepf, Lindsay Schulz, Brenna Shea, Thomas N. Sheehan, Lynn Siefferman, Derek Sikes, Mark Stanback, John D. Styrsky, Conor C. Taff, Jennifer J. Uehling, Kathleen Uvino, Thomas Wassmer, Kathryn Weglarz, Megan Weinberger, John Wenzel, Linda A. Whittingham
Summary: Climate change models often assume similar responses to temperatures across species, but this study found regional differences in the phenology and response to temperature among insect taxa in grassy habitats across North America. The study highlights the need to consider regional and taxonomic differences in predicting changes in insect populations in response to temperature.
Article
Entomology
Catherine A. Lippi, Samuel S. C. Rund, Sadie J. Ryan
Summary: Increasing research focus on vector-borne diseases has led to a growing body of information in various formats and data types. However, the scope and accessibility of this data can be unclear, leading to gaps in access and interoperability. This study provides an overview of current vector data efforts, assessing their level of accessibility and commenting on interoperability issues.
JOURNAL OF MEDICAL ENTOMOLOGY
(2023)
Article
Infectious Diseases
Sadie J. Ryan, Catherine A. Lippi, Oswaldo C. Villena, Aspen Singh, Courtney C. Murdock, Leah R. Johnson
Summary: Global maps of thermal transmission suitability and people at risk for malaria transmission by Anopheles stephensi were created, revealing the rapid increase of transmission risk in Africa. This study provides important references for future prevention, control, and monitoring.
Article
Public, Environmental & Occupational Health
Shreejana Bhattarai, Jason K. Blackburn, Sadie J. Ryan
Summary: Despite intervention efforts, stable and new high and moderate malaria risk wards persist in Nepal, particularly in the northwest and southwest regions. These areas should be prioritized for malaria surveillance and vector control, and further research is needed to understand the reasons for persistent risk areas.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Catherine A. A. Lippi, Holly D. D. Gaff, Robyn M. M. Nadolny, Sadie J. J. Ryan
Summary: This study updates the distribution models of D. variabilis and R. montanensis-infected D. variabilis in the United States, using newer surveillance and testing data. The results show consistency in the predicted habitat suitability for D. variabilis, indicating its generalist habitat requirements. However, there is a slight shift in the updated niche distribution, including more southern areas, highlighting the need for continued monitoring and surveillance.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2023)
Article
Ecology
Catherine A. Lippi, Samuel Canfield, Christina Espada, Holly D. Gaff, Sadie J. Ryan
Summary: Geographic approaches are increasingly used to assess the risk of tick-borne diseases and inform public health decision-making. This study explored the potential geographic range of a marsh rice rat species and found considerable overlap with the distribution of a tick species in the southeastern United States, highlighting the need for extended surveillance efforts and attention to the role of hosts in transmission cycles.
Article
Ecology
Robert J. Fletcher Jr, Maria E. Iezzi, Robert Guralnick, Andrew J. Marx, Sadie J. Ryan, Denis Valle
Summary: Dispersal typically consists of three components-departure, transience and settlement, each of which is influenced by the landscape. However, models of landscape connectivity often do not generate dispersal kernels nor explicitly capture the three components of dispersal.
Article
Remote Sensing
Jane Southworth, Sadie J. Ryan, Hannah V. Herrero, Reza Khatami, Erin L. Bunting, Mehedy Hassan, Carly S. Muir, Peter Waylen
Summary: The dynamics of terrestrial vegetation are shifting globally due to environmental changes, with potential repercussions for the proper functioning of the Earth system. This study uses a vegetation persistence metric to explore global vegetation responses to climatic, latitudinal, and land-use changes over three decades. Results show that vegetation persistence is higher in the Northern Hemisphere compared to the Southern Hemisphere.
FRONTIERS IN REMOTE SENSING
(2023)
Article
Environmental Sciences
Sadie J. Ryan, Catherine A. Lippi, Talia Caplan, Avriel Diaz, Willy Dunbar, Shruti Grover, Simon Johnson, Rebecca Knowles, Rachel Lowe, Bilal A. Mateen, Madeleine C. Thomson, Anna M. Stewart-Ibarra
Summary: Climate-sensitive infectious disease modelling relies on a complex network of software tools. However, only a limited number of these tools incorporate both climate inputs and epidemiological information, and are transparently described, validated, named, and accessible. There is a disproportionate representation of developers from North American and European institutions, and most tools focus on vector-borne diseases, particularly malaria. There is a lack of tools for estimating outbreaks of directly transmitted diseases. Evaluations show that slightly more than half of the tools are operationalized and freely available online.
LANCET PLANETARY HEALTH
(2023)