Review
Endocrinology & Metabolism
Emilia Grzeda, Julia Matuszewska, Kamil Ziarniak, Anna Gertig-Kolasa, Izabela Krzysko- Pieczka, Bogda Skowronska, Joanna H. Sliwowska
Summary: The prenatal period is critical for human development, and the foetus is particularly vulnerable to environmental factors. Maternal nutrition plays a significant role in the offspring's health, with imbalanced metabolic status potentially leading to metabolic disorders. Animal studies and human research have shown the influence of maternal diet on offspring development, but the mechanisms linking impaired foetal development and adult diseases are still not fully understood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Fenfen Li, Shirong Wang, Xin Cui, Jia Jing, Liqing Yu, Bingzhong Xue, Hang Shi
Summary: This study reveals that the histone demethylase Utx plays a significant role in the energy metabolism of both white adipose tissue (WAT) and brown adipose tissue (BAT). In a mouse model, Utx deficiency in adipocytes leads to obesity, impaired glucose tolerance, and disrupted brown fat thermogenesis. Furthermore, under high-fat diet challenge, mice lacking Utx in adipocytes exhibit dysfunction in adipose tissue, exacerbated inflammation and fibrosis, and increased lipid storage in the liver, resulting in disturbed whole body glucose homeostasis and hepatic steatosis.
Article
Biochemistry & Molecular Biology
Xiang Li, Chen Lyu, ZhongCheng Luo, Jing Zhao, Zhongli Wang, Chun Yang, Qi Dai, Hui Li, Yunhua Zhou, Zi Li, Fuxue Chen, Ying Gao
Summary: The study suggests that the methylation levels of IGF2 and DNMT3a genes may play a role in an ELOVL6 activity-dependent way in relation to the risk of MetS. This provides some insight into the pathogenesis of MetS in Chinese adults.
Article
Medicine, General & Internal
Teresa L. Serafim, Teresa Cunha-Oliveira, Claudia M. Deus, Vilma A. Sardao, Ines M. Cardoso, Shanshan Yang, John F. Odhiambo, Adel B. Ghnenis, Ashley M. Smith, Junfei Li, Peter W. Nathanielsz, Stephen P. Ford, Paulo J. Oliveira
Summary: Maternal obesity impacts foetal liver mitochondrial oxidative capacity and total mitochondrial phospholipid content, as well as the regulation of foetal liver redox pathways, revealing metabolic adaptations to a higher foetal lipid environment. In utero programming of foetal hepatic metabolism may persist and compromise mitochondrial bioenergetics in later life, increasing susceptibility to metabolic diseases.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Gabriela de Freitas Laiber Pascoal, Gabriela Machado Novaes, Monique de Paula Sobrinho, Andre Bubna Hirayama, Inar Alves Castro, Thomas Prates Ong
Summary: The study indicates that selenium supplementation during puberty/young adulthood could improve male physiology in the context of obesity, and potentially positively affect offspring health.
Article
Medicine, Research & Experimental
Matheus Ajackson, Brenda A. Nagagata, Ilitch A. Marcondes-de-Castro, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
Summary: The aim of this study was to investigate the effects of melatonin supplementation in the liver of adult offspring from obese mothers during pregnancy and lactation. The results showed that supplementation of melatonin reduced body weight and liver lipid levels in offspring from high-fat diet-fed mothers. Additionally, melatonin supplementation improved lipid metabolism, inflammation, oxidative stress, and endoplasmic reticulum stress in the offspring's liver.
Review
Neurosciences
Gabriela Cruz-Carrillo, Alberto Camacho-Morales
Summary: Central innate immunity plays a crucial role in neurodevelopment by integrating external signals through microglia; defects in immunity during embryonic development could lead to abnormal neural connections and psychiatric disorders in later stages.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Multidisciplinary Sciences
Alfonso D. Silva-Ochoa, Erick Velastegui, Isaac B. Falconi, Valeria I. Garcia-Solorzano, Angie Rendon-Riofrio, Gabriela A. Sanguna-Soliz, Wim Vanden Berghe, Andrea Orellana-Manzano
Summary: This article reviews important studies linking epigenetics with metabolic syndrome and discusses the significance of metabolic syndrome based on statistical data from developing countries.
Article
Developmental Biology
Evangelina Capobianco, Irune Pirrone
Summary: The alarming increase in the prevalence of metabolic pathologies has raised worldwide concerns. Recent studies have focused on the programming of metabolic diseases by paternal exposure. This review aims to explore the evidence of fetoplacental developmental alterations and metabolic pathologies in offspring, considering paternal metabolic disorders and unhealthy exposures, as well as identifying potential paternal interventions to reduce negative health outcomes in the offspring.
Article
Oncology
Whitney L. Do, Steve Nguyen, Jie Yao, Xiuqing Guo, Eric A. Whitsel, Ellen Demerath, Jerome I. Rotter, Stephen S. Rich, Leslie Lange, Jingzhong Ding, David van den Berg, Yongmei Liu, Anne E. Justice, Weihua Guan, Steve Horvath, Themistocles L. Assimes, Parveen Bhatti, Kristina Jordahl, Aladdin Shadyab, Celina I. Valencia, Aryeh D. Stein, Alicia Smith, Lisa R. Staimez, Karen Conneely, K. M. Venkat Narayan
Summary: This study identified differential associations between DNA methylation and BMI based on metabolic health status at 22 CpG sites, with one site validated and three sites predictive of incident coronary heart disease (CHD). These findings suggest a potential role for inflammation in the relationship between DNA methylation and BMI-related metabolic health.
CLINICAL EPIGENETICS
(2021)
Review
Medicine, General & Internal
Catalina Pico, Flavio Reis, Conceicao Egas, Paulo Mathias, Paulo Matafome
Summary: The concept of developmental origins of health and disease (DOHaD) focuses on the impact of nutrition restriction during fetal development and other programming windows on offspring health, as well as the harmful effects of maternal overweight during programming windows on offspring health.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Nutrition & Dietetics
Izabela Michonska, Edyta Luszczki, Magdalena Zielinska, Lukasz Oleksy, Artur Stolarczyk, Katarzyna Deren
Summary: Childhood obesity and associated diseases are major problems in modern medicine and public health. The impact of these issues extends beyond the present and immediate future, affecting long-term adult health. Nutritional programming theory explores how a child's birth weight, influenced by maternal feeding behavior, relates to diseases such as heart disease, diabetes, dyslipidemia, and hypertension. This narrative review provides an overview of the history, theory, and prenatal mechanisms of nutritional programming in relation to childhood obesity and other metabolic diseases.
Review
Veterinary Sciences
Virginie Gaillard, Sylvie Chastant, Gary England, Oliver Forman, Alexander J. German, Jan S. Suchodolski, Cecilia Villaverde, Pascale Chavatte-Palmer, Franck Peron
Summary: This article reviews the early-life risk factors for obesity, chronic enteropathy, and chronic behavioral problems in dogs and cats. It discusses the importance of understanding these risk factors in order to improve preventive veterinary care and husbandry practices. The article also explores the challenges of studying developmental origins of health and disease (DOHaD) in these species and proposes strategies to increase knowledge in this area.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Khushdeep Bandesh, Daisy Masih, Nirjhar Bhattacharyya, Dwaipayan Bharadwaj
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in human diseases, serving as both biomarkers for disease status and effective therapeutic targets. Research has shown their mechanistic role in gene expression regulation and their potential applications in human metabolic diseases.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Biochemistry & Molecular Biology
La Gil-Acevedo, Guillermo Ceballos, Yd Torres-Ramos
Summary: Preeclampsia is a pregnancy-specific syndrome with unknown causes. Lipid metabolism is altered in preeclampsia, leading to risks for both the mother and the fetus. Lipoperoxidation is the main process of lipid damage, generating toxic substances that cause reduced vasodilation and endothelial dysfunction. Neonates of mothers with preeclampsia are at increased risk of cardiovascular diseases, mental retardation, and metabolic diseases.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Nursing
Mary Carolan-Olah, Gina Kruger, Annette Garvey-Graham
Article
Obstetrics & Gynecology
Mary Carolan-Olah, Cheryl Steele, Gillian Krenzin
BMC PREGNANCY AND CHILDBIRTH
(2015)
Article
Geriatrics & Gerontology
Ladawan Panpanit, Mary Carolan-Olah, Terence V. McCann
Review
Nursing
Mary C. Carolan-Olah
Article
Nursing
Vidanka Vasilevski, Mary Carolan-Olah
JOURNAL OF CLINICAL NURSING
(2016)
Article
Education, Scientific Disciplines
Mary Carolan-Olah, Gina Kruger, Vera Brown, Felicity Lawton, Melissa Mazzarino
NURSE EDUCATION TODAY
(2016)
Article
Obstetrics & Gynecology
Padaphet Sayakhot, Mary Carolan-Olah, Cheryl Steele
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Obstetrics & Gynecology
Minerva Kyei-Nimakoh, Mary Carolan-Olah, Terence V. McCann
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Obstetrics & Gynecology
Padaphet Sayakhot, Mary Carolan-Olah
BMC PREGNANCY AND CHILDBIRTH
(2016)
Review
Obstetrics & Gynecology
Padaphet Sayakhot, Mary Carolan-Olah
BMC PREGNANCY AND CHILDBIRTH
(2016)
Article
Psychology, Clinical
Mary Carolan-Olah, Vidanka Vasilevski, Cate Nagle, Nigel Stepto
Summary: This project aimed to develop and evaluate an eHealth intervention to promote healthy lifestyle for pregnant women. The intervention was well received by most participants and achieved encouraging results prior to improvements.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2021)
Article
Nursing
Vidanka Vasilevski, Mary Carolan-Olah
Summary: This study explores the experiences of first-year midwifery students during clinical placements and their needs and expectations for peer-mentoring programs. The findings highlight the students' desire for more practical and theoretical learning opportunities during placements and the potential of peer-mentoring to address these needs and knowledge gaps.
Article
Public, Environmental & Occupational Health
Mary Carolan-Olah, Vidanka Vasilevski
Summary: This study validated the 'Knowledge of GDM' questionnaire, demonstrating its reliability and validity in measuring GDM knowledge, nutrition values, and self-management principles among pregnant women with recently diagnosed GDM.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Public, Environmental & Occupational Health
Mary Carolan-Olah, Maria Duarte-Gardea, Julia Lechuga, Silvia Salinas-Lopez
SEXUAL & REPRODUCTIVE HEALTHCARE
(2017)