Article
Infectious Diseases
Olajumoke O. Fadugba, Zaid Haddadin, Sylvie Muhimpundu, Samir Faouri, Asem Shehabi, Herdi Rahman, John Williams, E. Kathryn Miller, Najwa Khuri-Bulos, Natasha B. Halasa
Summary: A viral surveillance study in Amman, Jordan, found that respiratory syncytial virus and human metapneumovirus were associated with higher odds of acute wheezing in hospitalized children under 2 years old, while human rhinovirus was not. Future longitudinal studies are needed to further evaluate the connection between early childhood viral respiratory infections and recurrent wheezing in later childhood.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2021)
Article
Virology
Qing Ye, Dongjie Wang
Summary: This study investigated the impact of non-pharmaceutical interventions on the transmission of common respiratory viruses in children in China. The results showed a significant increase in the proportion of infants aged 0-28 days and 1-12 months in 2020 compared to 2019. There were also two noticeable peaks in the number of respiratory virus specimens among children aged 4-6 years and >7 years. Additionally, the age distribution patterns of FluA, FluB, and RSV were remarkably consistent, with the highest positive rates observed in children aged 1-12 months. The study further confirmed the effectiveness of non-pharmaceutical interventions in reducing the transmission of common childhood respiratory viruses, and suggested the implementation of different protection strategies for children of different age groups.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cell Biology
Sang Woo Park, Margarita Pons-Salort, Kevin Messacar, Camille Cook, Lindsay Meyers, Jeremy Farrar, Bryan T. Grenfell
Summary: Acute flaccid myelitis (AFM) has emerged in the United States as a rare but serious neurological condition since 2012, with Enterovirus D68 (EV-D68) considered a main causative agent. Strong spatiotemporal association between EV-D68 and AFM was demonstrated, and the impact of the ongoing COVID-19 pandemic likely reduced the sizes of EV-D68 and AFM outbreaks in 2020.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Virology
Anh N. Ly, Russell Manzanero, Adrianna Maliga, Sarah M. Gunter, Shannon E. Ronca, Emily Zielinski-Gutierrez, Francis Morey, Kim Bautista, Andres Espinosa-Bode, Beatriz Lopez, Loren Cadena, Rafael C. Fuentes, Timothy A. Erickson, Flor M. Munoz, Joy Mackey, Gerhaldine Morazan, Kristy O. Murray
Summary: This study describes the epidemiology of dengue virus infections in Belize diagnosed through AFI surveillance in 2020. Results showed that all four DENV serotypes were detected, with two cases of DENV serotype 4, the first report of this serotype in Belize since 2004. The majority of DENV cases were diagnosed in the Belize District during the dry season. Understanding the epidemiology and clinical characteristics of DENV is crucial for public health interventions to mitigate transmission.
Article
Immunology
Ville Forsstroem, Laura Toivonen, Kiara Homil, Matti Waris, Casper-Emil T. Pedersen, Klaus Bonnelykke, Tuomas Jartti, Ville Peltola
Summary: This study found that genetic predisposition to childhood asthma is associated with early respiratory tract infections, particularly in the 17q21 and CDHR3 genes. Multiple asthma risk alleles are also associated with viral respiratory infections and asthma. Therefore, non-wheezing and wheezing respiratory infections and asthma may share common genetic risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Lin Zhu, Tingting Luo, Yining Yuan, Shu Yang, Chao Niu, Ting Gong, Xueer Wang, Xiaohong Xie, Jian Luo, Enmei Liu, Zhou Fu, Daiyin Tian
Summary: The implementation of nonpharmaceutical interventions during the COVID-19 pandemic has affected the prevalence and seasonal patterns of certain respiratory viruses, such as respiratory syncytial virus (RSV), parainfluenza virus type 3 (PIV-3), and influenza viruses. Continuous surveillance of multiple respiratory pathogens, especially when nonpharmaceutical interventions are no longer necessary, is recommended.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pediatrics
Rosa-Maria Ukkonen, Marjo Renko, Ilari Kuitunen
Summary: This systematic review and meta-analysis aimed to analyze the efficacy of azithromycin in the treatment of acute bronchiolitis and wheezing. The findings suggest that azithromycin may reduce hospitalization duration, but it does not reduce the need for intensive care unit treatment or prevent wheezing recurrence.
PEDIATRIC RESEARCH
(2023)
Article
Infectious Diseases
Yuki Furuse, Raita Tamaki, Akira Suzuki, Taro Kamigaki, Michiko Okamoto, Mariko Saito-Obata, Emiko Nakagawa, Mayuko Saito, Edelwisa Segubre-Mercado, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani
Summary: This study examined the prevalence of respiratory viruses among children with acute respiratory infections in the Philippines. The research found that the prevalence of respiratory viruses in healthcare facilities was significantly higher than in households, with respiratory syncytial virus and rhinovirus being the most common.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Virology
Gregory J. Walker, Sacha Stelzer-Braid, Caroline Shorter, Claire Honeywill, Matthew Wynn, Christiana Willenborg, Phillipa Barnes, Janice Kang, Nevil Pierse, Julian Crane, Philippa Howden-Chapman, William D. Rawlinson
Summary: Acute respiratory infections are a common illness among children, with respiratory viruses being detected even in asymptomatic periods. This study aimed to define the rates of infection and community epidemiology of respiratory viruses in healthy children to help interpret molecular diagnostic assays. The results showed that respiratory viruses were more likely to be detected during symptomatic periods, and human rhinovirus was the most common virus identified.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Tengcheng Que, Jing Li, Yugan He, Panyu Chen, Wei Lin, Meihong He, Lei Yu, Aiqiong Wu, Luohao Tan, Yingjiao Li, Yanling Hu, Yigang Tong
Summary: This study investigates the virome composition of pangolins and reveals that pangolins are susceptible to human parainfluenza virus and human respiratory syncytial virus. This finding highlights the potential risk of viral transmission from pangolins to humans and emphasizes the need for public awareness.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
Varvara Probst, Andrew J. Spieker, Tess Stopczynski, Laura S. Stewart, Zaid Haddadin, Rangaraj Selvarangan, Christopher J. Harrison, Jennifer E. Schuster, Mary A. Staat, Monica McNeal, Geoffrey A. Weinberg, Peter G. Szilagyi, Julie A. Boom, Leila C. Sahni, Pedro A. Piedra, Janet A. Englund, Eileen J. Klein, Marian G. Michaels, John Williams, Angela P. Campbell, Manish Patel, Susan Gerber, Natasha B. Halasa
Summary: Co-detection of human adenovirus (HAdV) with other common respiratory viruses in children with acute respiratory illness is associated with more severe illness (e.g., hospitalization and oxygen support) compared with detection of HAdV alone.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2022)
Article
Medicine, General & Internal
Jocelyn Moyes, Stefano Tempia, Sibongile Walaza, Meredith L. McMorrow, Florette Treurnicht, Nicole Wolter, Anne von Gottberg, Kathleen Kahn, Adam L. Cohen, Halima Dawood, Ebrahim Variava, Cheryl Cohen
Summary: Based on a study in South African children, the burden of RSV-associated illness was estimated, with newborns and infants being the most affected group. Implementing maternal vaccination and monoclonal antibody products for this group can help reduce the disease burden.
Article
Virology
Qingqing Mao, Guangming Sun, Yu Qian, Yuchen Qian, Wang Li, Xiaochun Wang, Quan Shen, Shixing Yang, Chenglin Zhou, Hao Wang, Wen Zhang
Summary: This study investigated the potential reasons for unexplained acute respiratory infections in children in Xuzhou and its environs. Pharyngeal swab samples were collected from 411 children and viral metagenomic techniques were used to analyze the samples. The results identified the major virus families and observed recombination events. This study provides important information for the prevention and treatment of acute respiratory infections in children under 5 years old.
Article
Pediatrics
Marina Attanasi, Simone Sferrazza Papa, Annamaria Porreca, Giuseppe F. Sferrazza F. Papa, Paola Di Filippo, Francesca Piloni, Giulia Dodi, Francesco Sansone, Sabrina Di Pillo, Francesco Chiarelli
Summary: This study aimed to evaluate the diagnostic value of lung ultrasound (LUS) in wheezing caused by asthma, asthmatic bronchitis, and pneumonia. The results showed that LUS had high sensitivity and specificity in diagnosing pneumonia and asthmatic bronchitis, which could help clinicians determine the etiology of wheezing in school-aged children.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Yue Fan, Dongdong Li, Pu Wang, Lili Ren, Xiaowei Chen
Summary: This study found a relationship between acute otitis media (AOM) in children with viral upper respiratory infection (URI) and infection by common respiratory viruses. Among the 255 children examined, 164 (64.1%) tested positive for at least one respiratory virus, with respiratory syncytial virus (RSV) being the most common. The presence of RSV was significantly higher in children with URI + AOM compared to those with URI alone.