Article
Virology
Akeno Tsuneki-Tokunaga, Kyosuke Kanai, Asao Itagaki, Hideaki Tsuchie, Takayoshi Okada, Masaaki Kasagi, Kiyoshi Tanaka, Miho Aoki, Alfredo Jr A. Hinay, Seiji Kageyama
Summary: This study assessed the correlation between the growth capability of epidemic influenza A/H1N1, A/H3N2, and B viruses in cells and the viral load in nasopharyngeal swabs, revealing a positive correlation between growth capability and viral load. Additionally, a high positive correlation between growth capability and cell death was observed in the experiment. Therefore, the growth capability of viruses plays a significant role in disease prognosis.
ARCHIVES OF VIROLOGY
(2021)
Article
Environmental Sciences
Nobuyuki Takegawa, Anna Nagasaki, Akihiro Fushimi, Yuji Fujitani, Yoshiko Murashima, Hiromu Sakurai
Summary: We conducted field measurements and laboratory evaluations to characterize the physical and chemical properties of aircraft exhaust ultrafine particles near Narita International Airport. The results show that the volatility of aircraft exhaust UFPs is closely related to particle size and temperature.
ATMOSPHERIC ENVIRONMENT
(2023)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Environmental Sciences
Nobuyuki Takegawa, Yoshiko Murashima, Akihiro Fushimi, Kentaro Misawa, Yuji Fujitani, Katsumi Saitoh, Hiromu Sakurai
Summary: The study found that ultrafine particles emitted from aircraft exhaust in size ranges below 10 nm make significant contributions to total particle number concentrations, which is important for assessing their impacts on human health and climate.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2021)
Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Petra Mooij, Daniella Mortier, Aafke Aartse, Alexandre B. Murad, Ricardo Correia, Antonio Roldao, Paula M. Alves, Zahra Fagrouch, Dirk Eggink, Norbert Stockhofe, Othmar G. Engelhardt, Ernst J. Verschoor, Marit J. van Gils, Willy M. Bogers, Manuel J. T. Carrondo, Edmond J. Remarque, Gerrit Koopman
Summary: Influenza-naive cynomolgus macaques were immunized with virus-like particles (VLPs) displaying different hemagglutinin (HA) antigens from seasonal H1N1 strains. Subsequent infection with pandemic H1N1 (H1N1pdm09) resulted in increased immune response against intermediate antigenic variants but not against all H1N1 vaccine strains.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Peter W. Cook, Thomas Stark, Joyce Jones, Rebecca Kondor, Natosha Zanders, Jeffrey Benfer, Samantha Scott, Yunho Jang, Alicia Janas-Martindale, Stephen Lindstrom, Lenee Blanton, John Schiltz, Rachel Tell, Richard Griesser, Peter Shult, Erik Reisdorf, Tonya Danz, Alicia Fry, John Barnes, Amy Vincent, David E. Wentworth, C. Todd Davis
Summary: The study discusses the transmission of seasonal influenza viruses between humans and pigs, leading to sustained circulation of human-like viruses in the U.S. swine population. Two cases of human infections with A(H1N1)pdm09 viruses originating from swine hosts are identified and classified as swine-origin variant influenza viruses. The study underscores the importance of developing techniques for distinguishing human-origin and swine-origin viruses for continued surveillance of influenza viruses.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Transportation Science & Technology
Jie Feng, Cheng-Lung Wu, Jinfu Zhu
Summary: This study examines the effects of an incentive program initiated by Narita International Airport in Japan on attracting new services. The results show that the incentive program has successfully achieved its strategic goals, attracting new services, and generating additional revenue for the airport and tourism industry.
TRANSPORTATION PLANNING AND TECHNOLOGY
(2021)
Article
Virology
Weixu Zhang, Hefeng Xu, Shuxuan Guan, Chengmin Wang, Guoying Dong
Summary: This study analyzed the available NA protein sequences of H1N1 influenza viruses worldwide and found that 3.76% of H1N1 viruses currently harbor oseltamivir resistance, with the most common mutation being H274Y. Oseltamivir resistance is mainly found in humans, swine, and avian, and the resistance level peaked in 2007-2008 and quickly decreased in 2009. The study highlights the importance of globally monitoring oseltamivir resistance.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Nanoscience & Nanotechnology
Seong Uk Son, Eun-Kyung Lim, Soojin Jang, Jaewoo Lim, Seung Beom Seo, Taejoon Kang, Juyeon Jung, Seo Yeong Oh, Sun-Woo Yoon, Dongeun Yong, Jaejong Lee
Summary: The study developed a conductive thread-based immunosensor to easily detect airborne viruses, which is important in preventing the spread of infectious diseases.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Immunology
Satoshi Kamidani, Shikha Garg, Melissa A. Rolfes, Angela P. Campbell, Charisse N. Cummings, Julia C. Haston, Kyle P. Openo, Emily Fawcett, Shua J. Chai, Rachel Herlihy, Kimberly Yousey-Hindes, Maya L. Monroe, Sue Kim, Ruth Lynfield, Chad Smelser, Alison Muse, Christina B. Felsen, Laurie Billing, Ann Thomas, H. Keipp Talbot, William Schaffner, Ilene Risk, Evan J. Anderson
Summary: This study provides important population-based data on influenza-associated hospitalizations in US children. It highlights the higher rates of hospitalization and death among younger children, but also emphasizes the increased risk of severe outcomes among older children.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Krystal Lau, Ilaria Dorigatti, Marisa Miraldo, Katharina Hauck
Summary: This study estimated hospitalization rates, severity rates, mortality rates, and time lags between infections and hospitalizations of H1N1 pandemic patients in England during and after the pandemic period. Results showed increased severity in the post-pandemic flu season, highlighting the importance of continued vigilance by policymakers and researchers. Analysis of administrative hospital data and epidemiological modeling estimates can provide valuable insights for responding to COVID-19 and future pandemics.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biology
Michael Lutz, Jordana Schmierer, Toru Takimoto
Summary: Avian species are the main source of pandemic influenza A viruses that can infect humans. This study found that avian influenza A virus genes, including PA, PB1, and PB2, need to undergo host-adaptive mutations in order to replicate and transmit in humans. It was discovered that the PA gene from the 2009 pH1N1 strain had host-adaptive mutations that enhanced viral replication by increasing translation efficiency. This was achieved through increased cytosolic accumulation of viral mRNA, which depended on the host RNA binding protein GRSF1. Mutations to the GRSF1 binding site and knockdown of GRSF1 reduced viral mRNA accumulation and translation efficiency. These findings reveal a previously unrecognized mechanism by which host-adaptive mutations in PA regulate viral replication and host adaptation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Medicine, General & Internal
Gerardo Chowell, Fatima Abdirizak, Sunmi Lee, Jonggul Lee, Eunok Jung, Hiroshi Nishiura, Cecile Viboud
Article
Medicine, General & Internal
Kenji Mizumoto, Akira Endo, Gerardo Chowell, Yuichiro Miyamatsu, Masaya Saitoh, Hiroshi Nishiura
Article
Infectious Diseases
H. Nishiura, Y. Miyamatsu, G. Chowell, M. Saitoh
Article
Infectious Diseases
Hiroshi Nishiura, Ryo Kinoshita, Yuichiro Miyamatsu, Kenji Mizumoto
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Infectious Diseases
Kenji Mizumoto, Masaya Saitoh, Gerardo Chowell, Yuichiro Miyamatsu, Hiroshi Nishiura
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2015)
Article
Mathematics, Applied
Ryutaro Fukami, Hiroshi Nishiura
JAPAN JOURNAL OF INDUSTRIAL AND APPLIED MATHEMATICS
(2015)
Article
Biology
Akira Endo, Hiroshi Nishiura
JOURNAL OF THEORETICAL BIOLOGY
(2015)
Review
Mathematical & Computational Biology
Hiroshi Nishiura, Gerardo Chowell
THEORETICAL BIOLOGY AND MEDICAL MODELLING
(2015)
Editorial Material
Biochemistry & Molecular Biology
Gerardo Chowell, Hiroshi Nishiura
Article
Medicine, General & Internal
Ryo Kinoshita, Hiroshi Nishiura
Article
Medicine, General & Internal
Hiroshi Nishiura, Akira Endo, Masaya Saitoh, Ryo Kinoshita, Ryo Ueno, Shinji Nakaoka, Yuichiro Miyamatsu, Yueping Dong, Gerardo Chowell, Kenji Mizumoto
Article
Biology
Keisuke Ejima, Kazuyuki Aihara, Hiroshi Nishiura
JOURNAL OF THEORETICAL BIOLOGY
(2014)
Letter
Infectious Diseases
Hiroshi Nishiura, Keisuke Ejima, Kenji Mizumoto
LANCET INFECTIOUS DISEASES
(2014)
Letter
Immunology
Hiroshi Nishiura, Yuichiro Miyamatsu, Kenji Mizumoto
EMERGING INFECTIOUS DISEASES
(2016)
Article
Infectious Diseases
Kenji Mizumoto, Keisuke Ejima, Taro Yamamoto, Hiroshi Nishiura
JOURNAL OF VECTOR BORNE DISEASES
(2014)