Inhibitory effects of the JAK inhibitor CP690,550 on human CD4+ T lymphocyte cytokine production

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Kinase inhibitors: a new approach to rheumatoid arthritis treatment

(2010) Stanley Cohen et al.   CURRENT OPINION IN RHEUMATOLOGY

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

What determines Th2 differentiation, in vitro and in vivo ?

(2010) William E Paul   IMMUNOLOGY AND CELL BIOLOGY

Improved pain, physical functioning and health status in patients with rheumatoid arthritis treated with CP-690,550, an orally active Janus kinase (JAK) inhibitor: results from a randomised, double-blind, placebo-controlled trial

(2009) J H Coombs et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

(2009) Joel M. Kremer et al.   ARTHRITIS AND RHEUMATISM

Plasticity of CD4+ T Cell Lineage Differentiation

(2009) Liang Zhou et al.   IMMUNITY

Janus kinases in immune cell signaling

(2009) Kamran Ghoreschi et al.   IMMUNOLOGICAL REVIEWS

Dissecting Specificity in the Janus Kinases: The Structures of JAK-Specific Inhibitors Complexed to the JAK1 and JAK2 Protein Tyrosine Kinase Domains

(2009) Neal K. Williams et al.   JOURNAL OF MOLECULAR BIOLOGY

IL-22: A critical mediator in mucosal host defense

(2009) S. J. Aujla et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Type 17 T helper cells—origins, features and possible roles in rheumatic disease

(2009) Francesco Annunziato et al.   Nature Reviews Rheumatology

Cytokines as Therapeutic Targets: Advances and Limitations

(2008) Clemens Scheinecker et al.   IMMUNITY

Janus-Kinase-3-Dependent Signals Induce Chromatin Remodeling at the Ifng Locus during T Helper 1 Cell Differentiation

(2008) Min Shi et al.   IMMUNITY

Therapeutic targeting of Janus kinases

(2008) Marko Pesu et al.   IMMUNOLOGICAL REVIEWS

Examining the Chirality, Conformation and Selective Kinase Inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550)

(2008) Jian-kang Jiang et al.   JOURNAL OF MEDICINAL CHEMISTRY