Article
Clinical Neurology
Martin N. Stienen, Nicolai Maldaner, Marketa Sosnova, Anna M. Zeitlberger, Michal Ziga, Astrid Weyerbrock, Oliver Bozinov, Oliver P. Gautschi
Summary: This study aimed to demonstrate the external content validity of the Timed Up and Go (TUG) test in patients with lumbar degenerative disc disease. The results showed a significant correlation between TUG test results and patient-reported outcome measures (PROMs), supporting TUG test as a quick, easy-to-use objective measure for pain and functional impairment assessment.
Article
Clinical Neurology
Victor E. Staartjes, Holger Joswig, Marco V. Corniola, Karl Schaller, Oliver P. Gautschi, Martin N. Stienen
Summary: The study found that medical comorbidities have a certain impact on the objective functional impairment of patients before surgery, but the association is weak and inconsistent. TUG testing may be valid even in patients with relatively severe comorbidities who are able to complete the test.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Michal Ziga, Marketa Sosnova, Anna M. Zeitlberger, Luca Regli, Oliver Bozinov, Astrid Weyerbrock, John K. Ratliff, Martin N. Stienen, Nicolai Maldaner
Summary: This study aimed to investigate the application of a smartphone-based 6-minute walking test in patients with degenerative lumbar disorders after surgery. The study found that this test could objectively assess patients' functional impairment and detect changes in their recovery after surgery. Additionally, a ceiling effect was observed in some patients, indicating that their patient-reported outcome measures could not further improve.
Article
Clinical Neurology
Nicolai Maldaner, Marketa Sosnova, Michal Ziga, Anna M. Zeitlberger, Oliver Bozinov, Oliver P. Gautschi, Astrid Weyerbrock, Luca Regli, Martin N. Stienen
Summary: This study aimed to validate the minimum clinically important difference (MCID) of the Timed-up-and-go (TUG) test and confirmed that a change of 2.1 seconds in TUG test time or 1.5 in TUG z score indicates a meaningful change in functional status for patients with lumbar degenerative disc disease (DDD).
Article
Clinical Neurology
Marketa Sosnova, Anna Maria Zeitlberger, Michal Ziga, Oliver P. Gautschi, Luca Regli, Astrid Weyerbrock, Oliver Bozinov, Martin N. Stienen, Nicolai Maldaner
Summary: The study found that the majority of patients preferred the smartphone-based outcome measure over conventional paper-based methods, considering it more suitable, convenient, and responsive to their symptoms. Patients also believed that the smartphone app was better at detecting changes in physical performance and differences in symptoms. Most patients indicated a preference for using a smartphone app for future assessment and monitoring of spine-related symptoms.
Article
Clinical Neurology
Nicolai Maldaner, Marketa Sosnova, Anna M. Zeitlberger, Michal Ziga, Oliver P. Gautschi, Luca Regli, Oliver Bozinov, Astrid Weyerbrock, Martin N. Stlenen
Summary: This study correlated smartphone-app-based 6WT and TUG results and found that 6WT demonstrated better internal and external responsiveness compared with the TUG test.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Pediatrics
Sabrina Gmuca, Maitry Sonagra, Rui Xiao, Elizabeth Mendoza, Kimberly S. Miller, Nina H. Thomas, Jami F. Young, Pamela F. Weiss, David D. Sherry, Jeffrey S. Gerber
Summary: Adolescents with fibromyalgia predominantly experience subjective dyscognition but more than 1/3 also experience objective dyscognition. Subjective dyscognition is independently associated with functional disability and anxiety.
FRONTIERS IN PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
M. M. Wertli, D. Rossi, J. M. Burgstaller, U. Held, N. H. Ulrich, M. Farshad, J. Steurer, F. Brunner
Summary: It is unclear whether outcome measures used in degenerative lumbar spinal stenosis (DLSS) have been validated for this condition. Out of 20 systematic reviews and meta-analyses included in the study, 95 primary studies used 242 outcome measures for pain and/or disability. Only 14 validation studies specifically validated in a DLSS population were found, with poor quality. The Zurich Claudication Questionnaire was the only tool with adequate validation for assessing treatment response in DLSS.
SCIENTIFIC REPORTS
(2023)
Article
Economics
Raj Bridgelall
Summary: This research relates the subjective ratings of roughness from regular bus passengers to objective measures of roughness using smartphones. The findings show that passengers can distinguish extreme values of roughness but not intermediate values. Ratings are less distinguishable for smoother rides than for rougher rides. The experiments also reveal a phenomenon of roughness acclimation from regular users of a road segment.
Article
Clinical Neurology
Victor E. Staartjes, Anita M. Klukowska, Vittorio Stumpo, W. Peter Vandertop, Marc L. Schroder
Summary: This study aims to identify clusters of individuals with objectively functional impairment (OFI) based on the 5R-STS test using unsupervised machine learning (ML). Three types of OFI were identified, and their characteristics and associations were analyzed.
EUROPEAN SPINE JOURNAL
(2023)
Article
Multidisciplinary Sciences
Markus Kiefer, Verena Fruehauf, Thomas Kammer
Summary: By comparing subjective and objective awareness measurements under different stimulus features and contrast levels, researchers found a similar pattern of thresholds for both objective and subjective measurements of awareness. This suggests that objective performance measures and subjective ratings can provide similar information about the content of perceptual experiences.
Article
Clinical Neurology
Matthew Scott-Young, So Mang (Simon) Lee, David Nielsen, Evelyne Rathbone, Matthew Rackham, Wayne Hing
Summary: This study aimed to compare the patient-reported outcomes of single-level total disc arthroplasty (TDA), multi-level TDA, and hybrid constructs for symptomatic degenerative disc disease. The results showed that these treatment methods achieved similar clinical and statistical results in pain and function with meticulous preoperative evaluation.
Article
Orthopedics
Adam Biczo, Ferenc Bereczki, Kristof Koch, Peter Pal Varga, Genodisc Consortium, Aron Lazary
Summary: This study investigated the associations of IL6 and IL1B gene polymorphisms with the long-term outcome of degenerative lumbar spine surgeries. The results showed that inflammatory cytokines played an important role in pain improvement, patient reported outcome, and preoperative depression levels after surgery. IL6 and IL1B gene variants were also associated with preoperative depression, somatization, and subsequent surgery. Understanding the complexity of patients' long-term well-being is crucial in treating chronic diseases and their associated mental illnesses, and further research is needed to explore the simultaneous treatment of chronic physical and mental illnesses.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Grace X. Xiong, Brian C. Goh, Nicole Agaronnik, Alexander M. Crawford, Jeremy T. Smith, Stuart H. Hershman, Andrew J. Schoenfeld, Andrew K. Simpson
Summary: This study aims to elucidate the association between insurance status and baseline patient-reported outcome measures in patients with lumbar disc herniations. The findings showed that patients with Medicaid insurance had worse physical function, mental health, and pain-related patient-reported outcomes compared to those with commercial insurance.
Article
Clinical Neurology
Robert E. Harbaugh, Clinton Devin, Michelle B. Leavy, Zoher Ghogawala, Kristin R. Archer, Mohamad Bydon, Christine Goertz, Doron Dinstein, David R. Nerenz, Guy S. Eakin, William Lavelle, William O. Shaffer, Paul M. Arnold, Charles H. Washabaugh, Richard E. Gliklich
Summary: The development of new treatment approaches for degenerative lumbar spondylolisthesis (DLS) has raised questions about comparative effectiveness and long-term outcomes. Data from patient registries could be combined to form a research data infrastructure for addressing research questions.
JOURNAL OF NEUROSURGERY-SPINE
(2021)
Article
Clinical Neurology
Victor E. Staartjes, Holger Joswig, Marco V. Corniola, Karl Schaller, Oliver P. Gautschi, Martin N. Stienen
Summary: The study found that medical comorbidities have a certain impact on the objective functional impairment of patients before surgery, but the association is weak and inconsistent. TUG testing may be valid even in patients with relatively severe comorbidities who are able to complete the test.
GLOBAL SPINE JOURNAL
(2022)
Article
Clinical Neurology
Harsh Wadhwa, Kunal Varshneya, Martin N. Stienen, Anand Veeravagu
Summary: This retrospective cohort study aimed to investigate the effect of preoperative epidural steroid injection (ESI) on quality outcomes and costs in patients undergoing surgery for cervical degenerative disease. The results showed that while ESI can offer pain relief, patients who eventually undergo surgery have greater healthcare resource utilization.
GLOBAL SPINE JOURNAL
(2023)
Editorial Material
Clinical Neurology
Martin N. Stienen, Yoon Ha
Article
Oncology
Nicolas R. Smoll, Zoe Brady, Katrina J. Scurrah, Choonsik Lee, Amy Berrington de Gonzalez, John D. Mathews
Summary: This study found that about 40% of brain tumors in children may be attributable to CT radiation rather than reverse causation. However, due to a relatively low rate of CT scanning in Australia, only 3.7% of all brain cancers are attributable to CT scans. The population-attributable fraction may be greater in countries with higher rates of pediatric scanning.
Article
Clinical Neurology
Johannes Goldberg, Werner J. Z'Graggen, Martin Hlavica, Mattia Branca, Serge Marbacher, Donato D'Alonzo, Javier Fandino, Martin N. Stienen, Marian C. Neidert, Jan-Karl Burkhardt, Luca Regli, Martin Seule, Michel Roethlisberger, Raphael Guzman, Daniel Walter Zumofen, Rodolfo Maduri, Roy Thomas Daniel, Amir El Rahal, Marco V. Corniola, Philippe Bijlenga, Karl Schaller, Roland Roelz, Christian Scheiwe, Mukesch Shah, Dieter Henrik Heiland, Oliver Schnell, Juergen Beck, Andreas Raabe, Christian Fung
Summary: This study collected prospective quality of life (QoL) data on survivors of poor-grade aneurysmal subarachnoid hemorrhage (aSAH) and found that despite high initial mortality, a reasonably large proportion of poor-grade aSAH survivors have good QoL.
Article
Clinical Neurology
Michal Ziga, Marketa Sosnova, Anna M. Zeitlberger, Luca Regli, Oliver Bozinov, Astrid Weyerbrock, John K. Ratliff, Martin N. Stienen, Nicolai Maldaner
Summary: This study aimed to investigate the application of a smartphone-based 6-minute walking test in patients with degenerative lumbar disorders after surgery. The study found that this test could objectively assess patients' functional impairment and detect changes in their recovery after surgery. Additionally, a ceiling effect was observed in some patients, indicating that their patient-reported outcome measures could not further improve.
Article
Clinical Neurology
Vaibhavi Shah, Adrian J. Rodrigues, Shreya Malhotra, Thomas Johnstone, Kunal Varshneya, Ghani Haider, Martin N. Stienen, Anand Veeravagu
Summary: We compared differences in postoperative complications, readmission rates, reoperation rates, lengths of hospital stay, and cost of treatment between patients with Medicare versus private insurance who underwent an anterior discectomy and fusion (ACDF) procedure. The study found that Medicare and privately insured patients had similar treatment outcomes after ACDF surgery.
WORLD NEUROSURGERY
(2023)
Article
Orthopedics
Adrian John Rodrigues, Kunal Varshneya, Martin Nikolaus Stienen, Ethan Schonfeld, Khoi Duc Than, Anand Veeravagu
Summary: This retrospective cohort study aimed to compare the outcomes and costs of ACDF procedures using synthetic biomechanical intervertebral cage (BC) and structural allograft (SA) implants. After adjusting for demographic characteristics and comorbidities, the clinical outcomes were found to be similar between BC and SA ACDF surgeries. However, physician's fees were higher for BC implantation procedures.
ASIAN SPINE JOURNAL
(2023)
Article
Orthopedics
Adrian John Rodrigues, Ethan Schonfeld, Kunal Varshneya, Martin Nikolaus Stienen, Anand Veeravagu
Summary: This retrospective cohort study aimed to compare the outcomes of anterior cervical discectomy and fusion (ACDF) in patients with and without myelopathy. The results showed that patients with myelopathy had a higher risk of reoperation and hospital readmission compared to those without myelopathy.
ASIAN SPINE JOURNAL
(2023)
Article
Medicine, General & Internal
Nicolas R. Smoll, Mahmudul Hassan Al Imam, Connie Shulz, Robert Booy, Gulam Khandaker
Summary: This study aimed to estimate the effectiveness of vaccination in protecting against hospitalisation with symptomatic COVID-19. The results showed that vaccination significantly reduced the hospitalisation rate among the population in Central Queensland, with vaccine effectiveness of 69.9% after the primary vaccination course and 81.8% after a booster dose.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Clinical Neurology
Tarek ElFiky, Bishoy Bessada, Martin N. Stienen, Ahmed Ezzat Siam, Ahmed Hasan
Summary: This study retrospectively evaluated the MRI results of 103 patients with cervical spondylotic myelopathy (CSM). The findings showed that 71.4% of patients aged 50 or older had Modic changes (MC), with the C3-C4 segment being the most common. In contrast, 61.5% of younger patients had no MC. Degenerative changes in the facet joints were found in the majority of patients regardless of age, with grade I degeneration being the most common. The study also revealed a significant correlation between MC and facet joint changes.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Anna L. Kalywis, Robin Samuel, Felix Scholtes, Gilles Reuter, Martin N. Stienen, Erich Seifritz, Werner Surbeck
Summary: This study compared the neuroticism levels of physicians and found that although surgeons have lower levels of neuroticism in the early stages of their career, their neuroticism increases with age. This effect is especially significant for neurosurgeons.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Stefan Motov, Felix Stengel, Florian Ringel, Oliver Bozinov, Martin N. Stienen
Summary: This study aimed to understand the decision-making process of preoperative embolization (PE) for spinal metastasis in European spine centers. The results showed that PE is not routinely performed among European spine surgeons and is mostly considered for elective cases with hypervascularized tumors scheduled in a separate anesthesia <24h before tumor resection. Most participants reported reduced intraoperative blood loss, but also noted the risk of procedure-related complications.
Article
Clinical Neurology
Gregor Fischer, Vincens Kalin, Oliver P. Gautschi, Oliver Bozinov, Martin N. Stienen
Letter
Clinical Neurology
Felix C. Stengel, Oliver Bozinov, Martin N. Stienen
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)