Review
Clinical Neurology
Xuan Liu, Jun-Chao Fang, Xin-Yue Zhi, Qiu-Yu Yan, Hong Zhu, Juan Xie
Summary: Carrier of Val66Met AA genotype may have worse rehabilitation outcomes compared to GA+GG carriers. In general, Asian patients may have a higher proportion of the A allele. Further research is needed to determine the impact of Val66Met polymorphism on stroke recovery.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Emilio Portaccio, Angelo Bellinvia, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Mattia Fonderico, Giovanni Bosco Zimatore, Nunzia Alessandra Losignore, Sandro Sorbi, Maria Pia Amato
Summary: The study suggests a potential protective effect of BDNF Val66Met polymorphism against cognitive impairment in MS patients, possibly due to the detrimental effect of increased BDNF concentration in a neuroinflammatory environment. Higher EDSS score is associated with a progressive disease course, with a marginal association with the presence of the BDNF Val66Met polymorphism.
FRONTIERS IN NEUROLOGY
(2021)
Review
Psychiatry
Yanan Shang, Na Wang, En Zhang, Qian Liu, Hengfen Li, Xiaofeng Zhao
Summary: Our meta-analysis suggests that there is no significant association between the rs6265 polymorphism and OCD overall. However, in gender-specific analysis, female carriers of the Val66Met BDNF polymorphism might be more susceptible to developing OCD.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Behavioral Sciences
Xi-Yi Hu, Yu-Long Wu, Chao-Hui Cheng, Xiao-Xi Liu, Lan Zhou
Summary: The meta-analysis suggests that the BDNF rs6265 G > A polymorphism is associated with PTSD susceptibility, with an increased risk of A allele mutations. Subgroup analysis showed similar situations in Asian populations and other groups.
BRAIN AND BEHAVIOR
(2021)
Review
Cell Biology
Van Thuan Nguyen, Braxton Hill, Naiya Sims, Aaron Heck, Marcus Negron, Claire Lusk, Cristi L. Galindo
Summary: This article introduces the significance of brain-derived neurotrophic factor, which plays a crucial role in neurological disorders and various other biological functions.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Marcus Negron, Jeffrey Kristensen, Van Thuan Nguyen, Lauren E. Gansereit, Frank J. Raucci, Julia L. Chariker, Aaron Heck, Imamulhaq Brula, Gabrielle Kitchen, Cassandra P. Awgulewitsch, Lin Zhong, Eric C. Rouchka, Simran Banga, Cristi L. Galindo
Summary: The study found that mice with the BDNF rs6265 polymorphism exhibited altered cardiac function, with gender-specific differences. Female mice showed cardiac hypertrophy in response to stress, while male mice displayed an inflammatory immune response. These results reveal sex-based differences in how the BDNF polymorphism modifies cardiac physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Sarah K. Ashcroft, Daniel D. Ironside, Liam Johnson, Suzanne S. Kuys, Angelica G. Thompson-Butel
Summary: This systematic review and meta-analysis of 17 studies found that high intensity aerobic exercise can increase circulating BDNF concentrations, which may contribute to increased neuroplasticity in individuals poststroke.
Review
Clinical Neurology
Andrea Ballesio, Andrea Zagaria, Davide Gusmeo Curti, Rosalyn Moran, Peter J. Goadsby, Ivana Rosenzweig, Caterina Lombardo
Summary: The brain-derived neurotrophic factor (BDNF) is considered a transdiagnostic biomarker for mental disorders and is associated with emotional and cognitive functioning. A systematic review and meta-analysis of case-control studies were conducted to examine the levels of peripheral BDNF in individuals with insomnia. The results showed that subjects with insomnia had lower BDNF levels compared to healthy controls. However, the interpretation of the results should be cautious due to the small sample size, cross-sectional nature of the measurement, and high heterogeneity of the included data.
SLEEP MEDICINE REVIEWS
(2023)
Article
Psychiatry
Mona Buhusi, Daniel Griffin, Catalin Buhusi
Summary: This study investigates the role of Brain-Derived Neurotrophic Factor (BDNF)-Val66Met polymorphism and neural activation in regions involved in latent inhibition (LI) in mice, as well as the interaction between BDNF and SZ-associated gene CHL1. The results suggest that the BDNF-Met allele may reduce the expression of acute SZ symptoms and increase the expression of negative symptoms in individuals with chronic SZ.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Behavioral Sciences
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han
Summary: According to a meta-analysis, peripheral levels of brain-derived neurotrophic factor (BDNF) significantly decrease in depression compared to nondepressed healthy controls. However, the study reveals significant heterogeneity among the included studies. Factors such as history of depression and alcohol consumption affect the level of BDNF, while age and gender do not impact the heterogeneity. Although decreased BDNF expression is a risk factor for depression, it cannot be used as a reliable biomarker to assess depression in clinical practice.
BRAIN AND BEHAVIOR
(2022)
Review
Behavioral Sciences
Ya-Hai Wang, Huan-Huan Zhou, Qiang Luo, Sidong Cui
Summary: This study investigated the effects of physical exercise on brain-derived neurotrophic factor (BDNF) in healthy individuals. The findings showed that both acute and long-term exercise had significant positive effects on circulating BDNF levels. Subgroup analysis revealed that long-term aerobic exercise, female participants, participants older than 60 years, and aerobic exercise contributed to a more pronounced improvement in BDNF levels.
BRAIN AND BEHAVIOR
(2022)
Review
Clinical Neurology
Bernat de las Heras, Lynden Rodrigues, Jacopo Cristini, Maxana Weiss, Anna Prats-Puig, Marc Roig
Summary: Val66Met, a polymorphism of the BDNF gene, affects the secretion of BDNF protein, potentially influencing brain plasticity and cognition. This study reviewed 26 studies with a total of 11,417 participants, examining the role of Val66Met in moderating the cognitive response to physical activity and exercise. The findings showed inconsistent effects of Val66Met on cognitive response and no general and consistent effect was observed.
Article
Critical Care Medicine
Amery Treble-Barna, Shari L. Wade, Valentina Pilipenko, Lisa J. Martin, Keith Owen Yeates, H. Gerry Taylor, Brad G. Kurowski
Summary: The study investigated the differential effect of BDNF Val66Met polymorphism on behavioral adjustment in children with TBI compared to children with OI. Met carriers in the TBI group showed a trend of poorer behavioral adjustment relative to Val/Val homozygotes, while the opposite trend was observed in the OI group. These within-group differences did not reach statistical significance.
JOURNAL OF NEUROTRAUMA
(2022)
Review
Behavioral Sciences
Ryoki Sasaki, Shota Miyaguchi, Hideaki Onishi
Summary: Studies suggest that BDNF genotype may have a minor impact on individual motor performance and motor learning abilities.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Lin-Shuai Hao, Yang Du, Lei Chen, Yu-Guo Jiao, Yong Cheng
Summary: The present study conducted a systematic review with meta-analysis to compare peripheral blood BDNF levels between patients with OCD and healthy controls. The results showed that patients with OCD had significantly decreased peripheral blood levels of BDNF compared to the healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Clinical Neurology
Oday Atallah, Amr Badary, Yasser F. Almealawy, Vivek Sanker, Wireko Andrew Awuah, Toufik Abdul-Rahman, Sura N. Alrubaye, Bipin Chaurasia
Summary: This study investigates unexpected deaths resulting from primary brain tumors and analyzes the contributing variables. The findings reveal that unexpected deaths are a complex phenomenon, with headache being the most common initial symptom and meningiomas and astrocytomas being the most common lesions.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Alexandra E. Quimby, Mandy K. Salmon, Christopher H. Zhao, John Y. K. Lee, Douglas C. Bigelow, Michael J. Ruckenstein, Jason A. Brant
Summary: The study found that socioeconomic factors including race, health insurance, and income have an impact on the quality of life at the time of vestibular schwannoma diagnosis. Black/African American and uninsured/self-pay patients had lower quality of life, while patients with higher income had higher quality of life.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Review
Clinical Neurology
Arosha S. Dissanayake, Kwok M. Ho, Timothy J. Phillips, Stephen Honeybul, Graeme J. Hankey
Summary: This study systematically reviews models that aim to provide patient-specific predictions of pre-treatment rebleeding risk in patients with aneurysmal subarachnoid hemorrhage. The reported discriminative performance of the models varied, and no model showed consistently low bias risk and clinical applicability in all domains. Only one model was formulated using a patient cohort that underwent contemporary, evidence-based aneurysm treatment practices, but this model lacked calibration or clinical utility.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Colin Kok Ann Teo, Yilong Zheng, Jeremy Bingyuan Lin, Hock Luen Teoh, Bernard Poon Lap Chan, Vijay Kumar Sharma, Kejia Teo, Vincent Diong Weng Nga, Tseng Tsai Yeo
Summary: This study retrospectively reviewed the clinical characteristics and outcomes after surgical revascularization for adult Moyamoya disease (MMD) in a Southeast Asian cohort. The incidence of postoperative transient ischemic attack (TIA)/stroke was 25.9%, with most cases occurring within 7 days postoperatively. Risk factors for 30-day postoperative TIA/stroke included a higher number of preoperative TIAs/strokes and indirect revascularization.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Cheng-Chi Lee, Abel Po-Hao Huang, Ching-Chang Chen, Zhuo-Hao Liu, Mun-Chun Yeap, Ko-Ting Chen, Peng-Wei Hsu, Kuo-Chen Wei, Chun-Ting Chen, Yu-Chi Wang, Ting-Wei Chang, Chi-Cheng Chuang
Summary: Using a novel portable neuroendoscopic system for minimally invasive evacuation of intracerebral hemorrhage (ICH) has shown positive outcomes in reducing hematoma volume and improving neurological function without any death or rebleeding incidents.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Michael M. Haglund, Bruce M. McCormack, Daniel M. Williams, Alexander C. Lemons, Erik M. Summerside
Summary: This study evaluated the long-term radiographic outcomes of patients receiving tissue-sparing posterior cervical fusion (PCF) for the treatment of pseudarthrosis. The results showed that patients achieved rates of arthrodesis similar to open PCF, with fewer postoperative complications and long-term soft tissue pain.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Dong-Dong Meng, Zhe Ruan, Yong-Lan Tang, Zhao-Hua Ji, Yue Su, Tuo Xu, Bo-Zhou Cui, Da-Lin Ren, Ting Chang, Qian Yang
Summary: Depression symptom level, MG severity classification and family's monthly per capita income are independent factors related to the caregivers' disease family burden for MG patients. The daily activity burden of the family and the economic burden of the family were the heaviest among the six dimensions of the caregivers' family disease burdens.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Tugba Ozudogru Celik, Umit Gorgulu, Safiye Gul Kenar, Nadide Koca, Elif Yalcin, Ipek Koymen, Evren Yasar
Summary: This study investigated the forward head posture (FHP), thoracic kyphosis, and their relationship in individuals with migraine compared to healthy controls. The results showed that patients with migraine had a greater FHP and thoracic kyphosis. This suggests that a 3-dimensional objective measurement could be a reliable tool for evaluating posture analysis in clinical practice.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Jason A. Chen, Ari D. Kappel, Erickson F. Torio, David I. Bass, Abdullah Feroze, Nirav J. Patel
Summary: This report presents a case of a 63-year-old woman with a ruptured giant ICA terminus aneurysm, who underwent coil embolization followed by parent vessel sacrifice and high-flow bypass.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Sandeep Kandregula, Sneha Sai Mannam, Shahbaz Saad, Saarang Patel, Visish M. Srinivasan
Summary: A 39-year-old female with a history of smoking and a family predisposition to unruptured aneurysms presented with clinical symptoms of intermittent right-sided headaches, flashes of light, and pulsatile tinnitus. Diagnostic evaluations identified a right occipital arteriovenous malformation (AVM). Treatment involved partial embolization of primary arterial feeders followed by surgical resection, resulting in a successful outcome.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Ari D. Kappel, Jason A. Chen, Joshua I. Chalif, David I. Bass, Erickson F. Torio, Abdullah H. Feroze, Nirav J. Patel
Summary: A 48-year-old male with progressive congestive myelopathy underwent surgical clipping to treat a craniocervical DAVF. Intraoperatively, ICG was used to confirm the solitary inflow.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)
Article
Clinical Neurology
Aryeh Zolin, Cenai Zhang, Hwai Ooi, Harini Sarva, Hooman Kamel, Neal S. Parikh
Summary: In people with Parkinson's disease, comorbid liver fibrosis is associated with more rapid cognitive decline across multiple domains.
JOURNAL OF CLINICAL NEUROSCIENCE
(2024)