Review
Green & Sustainable Science & Technology
Anette von Ahsen, Lars Petruschke, Nicholas Frick
Summary: This study presents a systematic literature review on sustainability-oriented Failure Mode and Effects Analysis (FMEA), revealing that FMEA is increasingly modified to align decisions in companies with ecological and social criteria. It highlights key findings and potential approaches for further development.
JOURNAL OF CLEANER PRODUCTION
(2022)
Review
Oncology
Arely Rosas-Cruz, Nohemi Salinas-Jazmin, Marco A. Velasco-Velazquez
Summary: Dopamine receptors play a crucial role in various tumors, and targeting them may be beneficial for treating neoplastic diseases. However, data on the effectiveness of targeting dopamine receptors for certain receptor/disease combinations are currently inconclusive or contradictory. Further research is needed to clarify the precise role of dopamine receptors in tumor progression and develop better therapeutic strategies.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2021)
Review
Pharmacology & Pharmacy
Qian Shen, Xue Pan, Yi Li, Junchen Li, Chuanlong Zhang, Xiaochen Jiang, Fudong Liu, Bo Pang
Summary: Curcumin, a natural active ingredient from traditional Chinese medicine (TCM), has multi-target characteristics and extensive pharmacological activities. It has been applied in the treatment of various diseases such as cancer, cardiovascular diseases, nervous system, and autoimmune disorders. Curcumin can modulate lysosomal function through different pathways, affecting tumor proliferation, invasion, metastasis, drug resistance, and immune function. This review provides a reference for the clinical application of curcumin and anti-tumor research targeting lysosomes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Afef Ladhari, Giorgia La Mura, Cinzia Di Marino, Giovanni Di Fabio, Armando Zarrelli
Summary: Sartans are a group of chemical compounds with antagonistic action towards AT1 receptors of angiotensin II, playing a role in regulating blood pressure. Their presence and fate in the environment, as well as their impact in wastewater treatment plants, are significant areas of concern.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Review
Orthopedics
Joseph J. Kavolus, Michael A. Moverman, Vasili Karas, Richard Iorio
Summary: The increasing use of smartphones has led to a growing interest and growth in mobile health applications, particularly in the area of patient engagement platforms. These platforms offer various features that can improve healthcare, and this article provides an overview of this technology sector, the potential benefits they offer to patients and surgeons, and how to evaluate different platforms.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2021)
Article
Computer Science, Information Systems
Marek Gagolewski, Maciej Bartoszuk, Anna Cena
Summary: Internal cluster validity measures are often used to determine the appropriate number of partitions for a dataset. However, treating these measures as objective functions in unsupervised learning activities may not always lead to meaningful results. Many validity indices do not align well with expert knowledge. Meanwhile, a new variant of the Dunn index, incorporating OWA operators and near-neighbour graphs, has shown promising performance in separating subspaces of higher density.
INFORMATION SCIENCES
(2021)
Editorial Material
Orthopedics
Ronald S. Paik
Summary: All-suture anchors (ASAs) show biomechanical equivalence to conventional implants, with advantages of smaller size and easier revision. Proper depth and angle of insertion, appropriate pretensioning of the suture, and correct implantation technique are essential to optimize the strength of ASAs. Larger anchors and more sutures per anchor result in higher pullout strength.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
News Item
Multidisciplinary Sciences
XiaoZhi Lim
Summary: Scientists are urgently studying the tiny plastic specks found in marine animals and in humans.
Article
Engineering, Electrical & Electronic
Jelena Ivancan, Dragutin Lisjak, Dusko Pavletic, Davor Kolar
Summary: The reliable operation of a process plant is crucial for business safety, performance, and profitability. Failure Mode and Effects Analysis (FMEA) is used to identify potential failure modes, their root causes, and consequences in systems, subsystems, and equipment. Although criticized, FMEA is widely used in process industries as part of reliability-centered maintenance, safety management, and continuous improvement. A new conceptual model is proposed in this study to enhance the traditional FMEA technique and make it a more autonomous, data-driven, and accurate method, combining ANFIS and FIS models for defect handling, risk level quantification, and prioritization of mitigation actions.
Article
Economics
Ioannis Tsouros, Athena Tsirimpa, Ioanna Pagoni, Amalia Polydoropoulou
Summary: This study explores the demand and willingness-to-pay for MaaS through an online survey in Greater Manchester, UK. Results shed light on user preferences and willingness-to-pay for different MaaS plans and services, providing useful insights for potential MaaS operators, mobility service providers, and policymakers.
TRANSPORTATION RESEARCH PART A-POLICY AND PRACTICE
(2021)
Article
Thermodynamics
Birol Kilkis
Summary: This paper quantifies the relationship between exergy destructions and carbon dioxide emissions in a case study of a net-zero energy building. By using advanced photovoltaic-heat panels and adsorption cooling machines, the carbon dioxide emission responsibility due to avoidable exergy destructions was reduced by 96%.
Review
Pharmacology & Pharmacy
Erika Riederer, Chunlei Cang, Dejian Ren
Summary: Lysosomes have important functions in various cellular processes, and their ion channels and transporters play a crucial role in maintaining lysosomal permeability and function. These channels are regulated by various factors, and genetic variations in their genes are linked to diseases. Recent studies suggest that targeting lysosomal channels may hold promise for therapeutic interventions in human diseases.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Engineering, Mechanical
Zhi-Chao Wang, Yan Ran, Xin Yang, Xinlong Li, Yifan Chen, Genbao Zhang
Summary: Failure mode and effects analysis (FMEA) is a method used to implement failure analysis, criticality analysis, and failure clearance in various systems. This study introduces a function-motion-action (FMA) hierarchy structure specifically for mechatronic systems, which includes risk factors like occurrence, detection or non-detection, and severity, along with a risk calculation model for each failure. Multiple and specific risk levels of each failure are explained based on different levels of failure effects and control methods.
ENGINEERING FAILURE ANALYSIS
(2021)
News Item
Multidisciplinary Sciences
Katharine Sanderson
Summary: Governments and companies are pledging to reduce and offset carbon emissions, but the lack of robust strategies to accomplish their goals is evident.
Article
Engineering, Electrical & Electronic
Ting Zhu, Xiaokang Yin, Chengjie Deng, Martin Mwelango, Zhaorui Zhang, Xin'An Yuan, Wei Li, Guoming Chen
Summary: In this article, a novel detection technique that combines inductive and capacitive methods is proposed for the inspection of insulator-conductor composite structures. The output signal of the sensor is analyzed using equivalent circuit analysis and finite element simulation. Experimental results show that the proposed method is sensitive to defects in both the insulating and conducting layers and can accurately reflect the size of the defects.
IEEE SENSORS JOURNAL
(2023)
Article
Nursing
Adam Black, Heather Gage, Christine Norton, Bryony Dean Franklin, Trevor Murrells, Molly Courtenay
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2020)
Article
Health Care Sciences & Services
Matthew D. Jones, Anita McGrogan, D. K. Raynor, Margaret C. Watson, Bryony Dean Franklin
Summary: This study aimed to compare the frequency of medication errors when using the current National Health Service Injectable Medicines Guide versus a user-tested version. The results demonstrated that the user-tested guidelines led to fewer errors, increased staff confidence, and reduced preparation and administration time.
BMJ QUALITY & SAFETY
(2021)
Article
Health Care Sciences & Services
Kathrin Cresswell, Aziz Sheikh, Bryony Dean Franklin, Marta Krasuska, Hung The Nguyen, Susan Hinder, Wendy Lane, Hajar Mozaffar, Kathy Mason, Sally Eason, Henry Potts, Robin Williams
Summary: The study on the GDE program revealed that formal processes initiated by the program accelerated informal knowledge networking and laid the foundation for a learning ecosystem. Formal networks were most effective when supported by informal networking, with benefits enhanced by factors like geographical proximity, shared culture, technological functionality, and professional agendas. The study emphasized the importance of sustained knowledge exchange through informal networking and the need for policy interventions to incentivize and facilitate sharing across the ecosystem.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Multidisciplinary Sciences
Susan Hinder, Kathrin Cresswell, Aziz Sheikh, Bryony Dean Franklin, Marta Krasuska, Hung The Nguyen, Wendy Lane, Hajar Mozaffar, Kathy Mason, Sally Eason, Henry W. W. Potts, Robin Williams
Summary: Inter-organisational partnerships between GDE and FF sites have promoted knowledge sharing and learning between organisations, with formal linkages being most effective when supported by informal networking driven by mutual benefits of information sharing. The initiatives have led to a two-way flow of information, enhancing the profile of shared learning within the NHS.
Editorial Material
Health Care Sciences & Services
Yogini H. Jani, Bryony Dean Franklin
BMJ QUALITY & SAFETY
(2021)
Article
Economics
Matthew D. Jones, Bryony Dean Franklin, D. K. Raynor, Howard Thom, Margaret C. Watson, Rebecca Kandiyali
Summary: The study aimed to model the cost-effectiveness of user-testing injectable medicines guidelines, showing it to be a low-cost intervention highly likely to be cost-effective especially for high-risk medicines.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2022)
Review
Pharmacology & Pharmacy
Navila Talib Chaudhry, Bryony Dean Franklin, Salmaan Mohammed, Jonathan Benn
Summary: The majority of interventions based on secondary use of data were successful in improving medication safety, but the factors contributing to this success require further exploration. The process of secondary data usage typically involves nine steps, and factors influencing this process include electronic system implementation and functionality, knowledge and skills of SUD users, etc.
Editorial Material
Health Care Sciences & Services
Bryony Dean Franklin, Eric J. Thomas
BMJ QUALITY & SAFETY
(2022)
Article
Public, Environmental & Occupational Health
Lindemberg Assuncao-Costa, Charleston Ribeiro Pinto, Juliana Ferreira Fernandes Machado, Cleidenete Gomes Valli, Luis Eugenio Portela Fernandes de Souza, Bryony Dean Franklin
Summary: This study aims to validate a method for assessing the potential severity of medication administration errors and evaluate its validity and reliability through scoring cases. The importance of this study for public health lies in its ability to assist researchers in conducting more standardized evaluations to reduce the impact of medication errors.
JOURNAL OF PUBLIC HEALTH RESEARCH
(2022)
Editorial Material
Health Care Sciences & Services
Perla J. Marang-van de Mheen, John P. Browne, Eric J. Thomas, Bryony Dean Franklin
BMJ QUALITY & SAFETY
(2023)
Review
Public, Environmental & Occupational Health
Dervla Kelly, Aaron Koay, Gabriela Mineva, Monika Volz, Aoibhin McCool, Eavan McLoughlin, Ruan O. Conluain, Manuj Sharma, Aisling Kerr, Bryony Dean Franklin, Tamasine Grimes
Summary: This study aimed to examine the impact of public health emergencies on personal medication practices, finding that this can increase the risk of medication-related harm and other negative outcomes. The study included 129 research studies conducted in 32 countries, with a majority in the USA. Findings indicate that maintaining routine medication practices during public health emergencies is a universal problem.
Editorial Material
Health Care Sciences & Services
Bryony Dean Franklin, Eric J. Thomas, Christine Soong
BMJ QUALITY & SAFETY
(2023)
Review
Health Care Sciences & Services
Calandra Feather, Nicholas Appelbaum, Ara Darzi, Bryony Dean Franklin
Summary: Despite recommendations, indication documentation on prescriptions and inpatient medication orders is not routinely practiced. This systematic review identified and analyzed the literature on interventions aimed at improving indication documentation and/or indication-based prescribing. The findings suggest that indication documentation has a positive impact on appropriate prescribing and reducing prescribing errors, but further improvements are needed in integrating indication documentation with prescriber workflows.
BMJ QUALITY & SAFETY
(2023)
Article
Health Care Sciences & Services
Mushfique Ahmed, Carly Wheeler, Bryony Dean Franklin, Rabia Begum, Sara Garfield
Summary: The resilience of medication adherence to life changes varies among individuals, with some finding their strategies effective, while others needing to make adjustments. Beliefs about medicines and motivation to take them may also shift with changing circumstances. Healthcare professionals need to continuously monitor and support medication adherence as challenges in this area are not static.
Review
Health Care Sciences & Services
Esmita Charani, Martin McKee, Raheelah Ahmad, Manica Balasegaram, Candice Bonaconsa, Gemma Buckland Merrett, Reinhard Busse, Vanessa Carter, Enrique Castro-Sanchez, Bryony D. Franklin, Pantelis Georgiou, Kerri Hill-Cawthorne, William Hope, Yuichi Imanaka, Andrew Kambugu, Andrew J. M. Leather, Oluchi Mbamalu, M. McLeod, Marc Mendelson, Mirfin Mpundu, Timothy M. Rawson, Walter Ricciardi, Jesus Rodriguez-Manzano, Sanjeev Singh, Constantinos Tsioutis, Chibuzor Uchea, Nina Zhu, Alison H. Holmes
Summary: The focus of the 2021 G7 meeting is on addressing the silent pandemic of antimicrobial resistance (AMR) and achieving antimicrobial security through a balance between new drug development and the preservation of existing agents. Research priorities for optimizing antimicrobial use in humans include policy and strategic planning, medicines management, technology optimization, and context, culture, and behaviors. Sustainable progress depends on developing appropriate interventions, better use of data, and supporting technological innovation.
LANCET REGIONAL HEALTH-EUROPE
(2021)