Review
Biochemistry & Molecular Biology
Olaf Domaszk, Aleksandra Skwarek, Malgorzata Wojciechowska
Summary: Heart failure is a major clinical problem and the increasing incidence of heart failure with preserved ejection fraction (HFpEF) has been observed. Despite extensive research, there is currently no efficient treatment for HFpEF. However, stem cell transplantation, due to its immunomodulatory effect, shows potential as an etiology-based therapy. In this review, we explain the complex pathogenesis of HFpEF, discuss the beneficial effects of stem cells in cardiovascular therapy, and summarize the current knowledge concerning cell therapy in diastolic dysfunction. Moreover, outstanding knowledge gaps are identified, suggesting directions for future clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Fei Shao, Haibin Li, Shengkui Ma, Dou Li, Chunsheng Li
Summary: Survival rates after out-of-hospital cardiac arrest in urban areas of Beijing did not show significant improvement over 5 years, while the rate of bystander CPR increased steadily, suggesting potential for improved outcomes in patients receiving bystander CPR.
Article
Nursing
M. R. Kwan, H. J. Seo, S. J. Lee
Summary: This study examined nurses' perceptions of patient safety culture in Korean general hospitals and found a weak relationship between hospital accreditation experience and overall safety perceptions. Longitudinal research is recommended to confirm the influence of hospital accreditation on nurses' patient safety culture in general hospitals.
Article
Medical Informatics
Huiwen Luo, Guohua Liu, Jing Lu, Di Xue
Summary: Inpatient perceived shared decision making in public tertiary hospitals in Shanghai is relatively high overall, but lower regarding information about treatment alternatives. Shared decision making can be influenced by the preferences of both patients and physicians, as well as medical conditions. Improving shared decision making can lead to higher patient satisfaction, which should be a commitment at the hospital level.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2021)
Article
Nursing
Sarah Smith, Samuel Lapkin, Elizabeth Halcomb, Jenny Sim
Summary: This study aims to explore the relationships between job satisfaction, community satisfaction, practice environment, burnout, and intention to leave of nurses working in small rural hospitals in Australia. The findings show that overall job satisfaction is high, and emotional exhaustion, nurse manager ability, leadership, and support of nurses are the most significant predictors of job satisfaction.
JOURNAL OF NURSING SCHOLARSHIP
(2023)
Article
Medicine, General & Internal
Svenja Ravioli, Jolanda Oberle, Michael Haidinger, Gregor Lindner
Summary: This study analyzed gender equality in national cardiology societies affiliated with the European Society of Cardiology, as well as the American Heart Association. The findings revealed a significant gender gap in leadership positions, with men outnumbering women in all world regions.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Health Care Sciences & Services
Megan E. Gregory, Lindsey N. Sova, Timothy R. Huerta, Ann Scheck Mcalearney
Summary: This study aimed to investigate the factors influencing response rates, drop-off rates, and missing data in surveys of hospitalized patients. The results showed that shortening the survey significantly reduced drop-off rates, and adding missing item reminders greatly reduced missing data.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Medicine, General & Internal
Peter Magnusson, Gustav Mattsson, Marita Wallhagen, Jan Karlsson
Summary: Patients with ICDs have lower physical and mental HRQL compared to age-matched and sex-matched norms, but the differences are small. HRQL is similar regardless of sex, primary/secondary prevention indication, appropriate therapy, inappropriate shock, or complications, but decreases with advancing age.
Article
Medicine, General & Internal
Vicky L. Joshi, Lars H. Tang, Britt Borregaard, Line Zinckernagel, Tina Broby Mikkelsen, Rod S. Taylor, Sofie Raahauge Christiansen, Jorgen Feldbaek Nielsen, Ann Dorthe Zwisler
Summary: The DANCAS survey aims to investigate the long-term physical and psychological problems faced by out-of-hospital cardiac arrest (OHCA) survivors and their relatives, in order to make recommendations for future rehabilitation interventions. Self-report outcome data will be collected through surveys of survivors and relatives, as well as data from Danish national registries, with completion expected by February 2021.
Article
Rehabilitation
Sinyoung Park, Jing Xu, Mindi R. Manes, Allison Carrier, Raine Osborne
Summary: A study on a rehabilitation hospital found that the personal issues domain is the most important factor in determining patient satisfaction scores, overall quality of care, and willingness to recommend the hospital to others.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Health Care Sciences & Services
Nainsi Gupta, Manoj Kumar Gupta, Nitin Kumar Joshi, Neha Mantri, G. Sridevi, Mamta Patel, Akhil Dhanesh Goel, Kuldeep Singh, M. K. Garg, Pankaj Bhardwaj
Summary: This study explored doctors' perception of telemedicine consultations and patient satisfaction with teleconsultation services. The majority of doctors found telemedicine feasible and convenient for patients, but faced challenges in clinical evaluation, communication, network connectivity, and patients' e-illiteracy. Patients expressed satisfaction with ease of registration, audio quality, medication discussion, and comprehension of diagnoses.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Medicine, General & Internal
Yusha Tang, Anjiao Peng, Bo Peng, Shixu He, Xia Zhao, Yuanfeng Zhu, Wanlin Lai, Tingting Song, Lei Chen
Summary: This study found a significant association between PFO and migraine without aura in Southwest China, especially when the shunt is large.
Article
Multidisciplinary Sciences
Anwar Brhan Gidey, Taklo Simeneh Yazie, Tegegne Bogale, Tesfaye Molla Gulente
Summary: The study found that the overall satisfaction towards outpatient pharmacy service was low, indicating the need for immediate corrective measures. Factors positively associated with satisfaction included service payment insured through their workplace, while factors negatively associated with satisfaction included availability of some medications, unfair medication cost, and lack of organized pharmacy work flow.
Article
Medicine, General & Internal
Xiao Chen, Yuxia Zhang, Wei Qin, Zhenghong Yu, JingXian Yu, Ying Lin, XiaoRong Li, Zheng Zheng, Ying Wang
Summary: This study found a linear relationship between patient experience with nursing care and overall patient satisfaction, with nursing care experience significantly impacting overall satisfaction in both crude and adjusted models. Even after adjusting for sociodemographic and disease-related factors, patient experience with nursing care explained 34.9% of the variation in overall patient satisfaction.
Article
Geriatrics & Gerontology
Mojtaba Honarvar, Javad Rasouli, Jamileh Amirzadeh-Iranagh
Summary: The study found that life satisfaction and quality of life are important factors influencing retirement satisfaction. To improve retirement satisfaction in all aspects and subcomponents, it is recommended to enhance these two factors.
Article
Gastroenterology & Hepatology
Michael P. Jones, Ayesha Shah, Marjorie M. Walker, Natasha A. Koloski, Gerald Holtmann, Nicholas J. Talley
Summary: This study found that there is an overlap between irritable bowel syndrome (IBS), functional dyspepsia (FD), and heartburn (GERD), which is considered as a distinct entity with features of psychological morbidity, sleep disturbance, and elevated rates of atopy.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Medicine, Research & Experimental
Mengli Xiao, Linda L. D. Zhong, Wai Ching Lam, Yingpan Zhao, Kok-Ann Gwee, Gerald Holtmann, Jan Tack, Hidekazu Suzuki, Min-Hu Chen, Yinglian Xiao, Xiaohua Hou, Jinsong Liu, Yang Li, Xu-Dong Tang, Fang Lu
Summary: This study aims to provide further evidence on the clinical efficacy and safety of ZZKZ in treating patients with FD-PDS. By comparing the effects of ZZKZ with a placebo group over a double-blind treatment period of 8 weeks, the study aims to investigate the long-term medication effect.
Article
Gastroenterology & Hepatology
Erin R. Shanahan, Seungha Kang, Heidi Staudacher, Ayesha Shah, Anh Do, Grace Burns, Veronique S. Chachay, Natasha A. Koloski, Simon Keely, Marjorie M. Walker, Nicholas J. Talley, Mark Morrison, Gerald J. Holtmann
Summary: This study indicates a link between duodenal microbiota, gastric emptying, and FD symptoms, and this link is largely independent of long-term dietary intake.
Review
Gastroenterology & Hepatology
Kok-Ann Gwee, Yeong Yeh Lee, Hidekazu Suzuki, Uday Chand Ghoshal, Gerald Holtmann, Tao Bai, Giovanni Barbara, Min-hu Chen, Andrew Seng Boon Chua, Peter R. Gibson, Xiaohua Hou, Jinsong Liu, Atsushi Nakajima, Nitesh Pratap, Sanjeev Sachdeva, Kewin Tien Ho Siah, Alex Yu Sen Soh, Kentaro Sugano, Jan Tack, Victoria Ping Yi Tan, Xudong Tang, Marjorie Walker, Deng-Chyang Wu, Ying-Lian Xiao, Khairil Khuzaini Zulkifli, Clarissa Toh
Summary: Contemporary systems categorize patients into sub-classes based on symptoms to enable targeted treatment, but overlapping symptom categories negatively impact outcomes, lacking guidance on management. An APAGE working group developed clinical practice guidelines for management of patients with functional dyspepsia (FD) who have overlaps with other functional gastrointestinal disorders. They identified putative pathophysiology and provided a management algorithm for primary and secondary care clinicians.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Natasha A. Koloski, Michael Jones, Marjorie M. Walker, Michael Horowitz, Gerald Holtmann, Nicholas J. Talley
Summary: Diabetes is an independent risk factor for an increased frequency of gastrointestinal symptoms, adjusting for lifestyle and psychological factors.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Letter
Gastroenterology & Hepatology
Ahmad H. Ali, Cynthia W. Buness, Ryan Fischer, Gerald J. Holtmann, Ayesha Shah, Peter Lewindon, Shamita Shah, Amol S. Ragnekar, Amy E. Taylor, Aparna Goel, Kenneth L. Cox, Leina Alrabadi, Steve Wadsworth, Sakil S. Kulkarni, Keith D. Lindor
Review
Gastroenterology & Hepatology
Michael P. Jones, Gerald Holtmann
Summary: Placebo responses provide insights into mechanisms beyond the intervention and affect the potential efficacy of new interventions in clinical trials. This mini-review discusses the systematic review and meta-analysis conducted by Bosman and colleagues on placebo response in functional dyspepsia clinical trials. It also explores potential mechanisms of placebo response in the context of brain-gut interaction disorders and extra-gastrointestinal disorders.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Immunology
Grace L. Burns, Jessica K. Bruce, Kyra Minahan, Andrea Mathe, Thomas Fairlie, Raquel Cameron, Crystal Naudin, Prema M. Nair, Michael D. E. Potter, Mudar Zand Irani, Steven Bollipo, Robert Foster, Lay T. T. Gan, Ayesha Shah, Natasha A. Koloski, Paul S. Foster, Jay C. Horvat, Martin Veysey, Gerald Holtmann, Nick Powell, Marjorie M. Walker, Nicholas J. Talley, Simon Keely
Summary: This study found that patients with functional dyspepsia have increased Th2 and Th17 lymphocyte populations in the duodenal mucosa, and these cells are of effector and memory phenotype, indicating that the microinflammation in functional dyspepsia may be antigen-driven.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Uday C. Ghoshal, Gerald J. Holtmann
Summary: The aim of this review is to summarize the current and emergent approaches to characterize the small intestinal microbiota and discuss the treatment options for management of small intestinal bacterial overgrowth (SIBO). This review captures the growing body of evidence for the role of SIBO, a type of small intestinal dysbiosis in the pathophysiology various gastrointestinal and extraintestinal disorders. Although recurrence is common, targeted modulation of the gut microbiome as a therapeutic option for management of SIBO is associated with improvement in symptoms and quality of life.
CURRENT OPINION IN GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Ali Eqbal, Naomi Moy, Natasha Koloski, Helmut Messmann, Bradley J. Kendall, Prateek Sharma, Uwe Dulleck, Michael P. Jones, Gerald J. Holtmann
Summary: This study aimed to determine the prevalence of upper gastrointestinal (UGI) lesions in subjects with a positive fecal occult blood test (FOBT+). The results showed that the prevalence of UGI cancers in FOBT+ subjects was 0.8%, and the prevalence of UGI clinically significant lesions (CSLs) was 30.4%. Anemia was associated with UGI cancers and UGI CSLs, while gastrointestinal symptoms were not associated with UGI CSLs.
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Uday C. Ghoshal, Ujjala Ghoshal, Ayesha Shah, Gerald Holtmann
Summary: There is a significant interest in gut microbiota dysbiosis, specifically small intestinal bacterial overgrowth (SIBO), however, the current diagnostic methods for SIBO are not satisfactory. This review discusses the different invasive and noninvasive tests for diagnosing SIBO, their methodology, interpretation, sensitivity, specificity, and limitations. It also presents potential methods for diagnosis of SIBO that may be useful in clinical practice in the future.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ayesha Shah, Veenaa Pakeerathan, Michael P. Jones, Purna C. Kashyap, Kate Virgo, Thomas Fairlie, Mark Morrison, Uday C. Ghoshal, Gerald J. Holtmann
Summary: This systematic review and meta-analysis investigated the prevalence of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc), as well as the risk factors and the effects on gastrointestinal symptoms. The study found that SIBO prevalence in SSc patients is 39.9%, with a 10-fold increased prevalence compared to controls. It also suggested that antimicrobial therapy should be considered for SSc patients with SIBO and diarrhea.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Marguerite J. Kutyla, Jessica J. McMaster, Adam Haig, Natasha Koloski, Luke Hourigan, Vera Meeusen, Ayesha Shah, Nicholas J. Talley, Michael P. Jones, Gerald J. Holtmann
Summary: This study aimed to develop and validate a patient-reported experience measure for GI endoscopy. The Comprehensive Endoscopy Satisfaction Tool captures relevant domains that influence the patient's experience and identifies factors that shape satisfaction. The tool was tested in a large number of patients and found to be valid and responsive.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Esther Colomier, Lieselot Holvoet, Florencia Carbone, Kee-Huat Chuah, Sanjiv Mahadeva, Kewin Siah, Gerald J. Holtmann, Hidekazu Suzuki, Takashi Ueda, Magnus Simren, Kok-Ann Gwee, Jan F. Tack
Article
Rheumatology
P. R. Sternes, L. Brett, J. Phipps, F. Ciccia, T. Kenna, E. de Guzman, K. Zimmermann, M. Morrison, G. Holtmann, E. Klingberg, D. Mauro, C. McIvor, H. Forsblad-d'Elia, M. A. Brown
Summary: The gut microbiomes of AS and AS-IBD patients are different from IBD patients and healthy controls, indicating a distinct role of the gut in driving AS compared with IBD. However, the presence of potentially pathogenic genera shared between both diseases suggests a common microbial trigger of disease.
ARTHRITIS RESEARCH & THERAPY
(2022)