Article
Infectious Diseases
Sujun Liu, Huilin Zhi, Hong Shen, Wenwen Lv, Bo Sang, Qiuping Li, Yan Zhong, Zehu Liu, Xiujiao Xia
Summary: This study reports the clinical aspects of chromoblastomycosis (CBM) in Eastern China based on a series of 11 cases from 2018 to 2021. The majority of patients were male, and the duration of the disease varied from 3 months to 20 years. Plaque type lesions were the most common clinical manifestation, and most cases were successfully cured.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Lucas de Oliveira Las-Casas, Clara Luna Freitas Marina, Raffael Junio Araujo de Castro, Luisa Coutinho Coelho, Sonia Nair Bao, G. Sybren de Hoog, Vania Aparecida Vicente, Larissa Fernandes, Anamelia Lorenzetti Bocca
Summary: This study demonstrated for the first time that different species of Fonsecaea produce extracellular vesicles (EVs) in response to nutritional conditions, and these EVs can modulate the production of pro- and anti-inflammatory cytokines and nitric oxide by bone marrow-derived macrophages (BMDMs). The size, content, and morphology of the EVs were also affected by growth conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Microbiology
Leandro C. D. Breda, Isabela G. Menezes, Larissa N. M. Paulo, Sandro Rogerio de Almeida
Summary: Chromoblastomycosis (CBM) is a chronic and progressive subcutaneous mycosis caused by different species of fungi from the Herpotrichiellaceae family, often associated with agricultural activities. The economic challenges in treatment, lack of specific therapy, and potential for immunotherapeutic approaches make CBM a complex disease requiring further research and innovative treatment strategies.
Article
Immunology
Hongfang Liu, Jiufeng Sun, Minying Li, Wenying Cai, Yangxia Chen, Yinghui Liu, Huan Huang, Zhenmou Xie, Weiying Zeng, Liyan Xi
Summary: This study investigated the epidemiological, clinical, and laboratory characteristics of CBM in Guangdong, China. The findings revealed that CBM patients were mostly elderly with a long duration of the disease and a higher prevalence in males. The most common clinical manifestation was the verrucous form. Antifungal susceptibility tests showed low minimum inhibitory concentrations for certain drugs. Combination therapy with itraconazole and terbinafine was commonly used for treatment. Cytokine profile analysis indicated impaired immune response in CBM cases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Rowena Alves Coelho, Maria Helena Galdino Figueiredo-Carvalho, Fernando Almeida-Silva, Vanessa Brito de Souza Rabello, Gabriela Rodrigues de Souza, Leandro Stefano Sangenito, Luna Sobrino Joffe, Andre Luis Souza dos Santos, Maria Cristina da Silva Lourenco, Marcio L. Rodrigues, Rodrigo Almeida-Paes
Summary: This study discovered substances with antifungal activity against CBM agents from a collection of drugs previously approved for use in human diseases, and benzimidazoles showed the highest selectivity.
Article
Microbiology
Andrea Grassi, Matteo Gambini, Marianna Pantoli, Simona Toscano, Anna Albertetti, Deborah Maria Del Frassino, Iniobong Chukwuebuka Ikenna Ugochukwu, Orazio Romeo, Domenico Otranto, Claudia Cafarchia
Summary: This study described a case of lethal Cladosporium allicinum infection in a captive bullfrog in Europe. The infection was confirmed by histology, cytology, and molecular methods. Despite antifungal treatment, the frog died, highlighting the poor prognosis of Cladosporium infections in animals.
Article
Dermatology
Armando Guevara, Andreia Ferreira Nery, Marcia de Souza Carvalho Melhem, Lucas Bonfietti, Anderson Messias Rodrigues, Ferry Hagen, Jamile Ambrosio de Carvalho, Zoilo Pires de Camargo, Bruna Jacomel F. de Souza Lima, Vania Aparecida Vicente, Rosane Christine Hahn
Summary: Chromoblastomycosis primarily affects the poor population in Brazil, especially those involved in agricultural activities, with F. pedrosoi being the main etiological agent. Itraconazole, voriconazole, and terbinafine showed the highest antifungal activity.
Article
Immunology
Clare Logan, Manuraj Singh, Natalya Fox, Gordon Brown, Sreedhar Krishna, Kristiana Gordon, Derek Macallan, Tihana Bicanic
Summary: Chromoblastomycosis (CBM) is a chronic fungal infection of the skin and subcutaneous tissue that is difficult to treat. The lack of standardized therapeutic approach and limited evidence for treatment options contribute to its chronicity. This case study presents a successful treatment of a chronic CBM lesion of the hand using a combination of posaconazole and topical imiquimod, an immune response modifier. The clinical and histopathological improvement of the lesion was demonstrated, suggesting the potential of antifungal therapy with adjunctive immunotherapy for CBM.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Review
Infectious Diseases
Armando Guevara, Nathan Pereira Siqueira, Andreia Ferreira Nery, Leticia Rossetto da Silva Cavalcante, Ferry Hagen, Rosane Christine Hahn
Summary: Chromoblastomycosis is a chronic disease caused by melanized fungi that mainly affects individuals performing soil-related labor. The study analyzed epidemiological and clinical characteristics in Latin America and the Caribbean. Common clinical forms include verrucous and tumorous, with symptoms of itching and pain. Majority of cases were treated with itraconazole and surgery.
Article
Medicine, General & Internal
Victor A. Canela, Carley Legan
Summary: Rash is a common chief complaint in the emergency room, with infection and pathogen colonization of the skin being among the most common causes. Occupational exposure to fungal species increases the likelihood of infection, with chromoblastomycosis being a common tropical infection found in workers exposed to certain fungal species. In immunocompetent patients, dermal infections are the primary presentation and require long-term treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Infectious Diseases
Minying Li, Huan Huang, Jun Liu, Xiaohui Zhang, Qian Li, Dongmei Li, Mingfen Luo, Xiaoyue Wang, Weiying Zeng, Jiufeng Sun, Hongfang Liu, Liyan Xi
Summary: The C-terminal thioesterase (TE) in F. monophora plays a crucial role in maintaining the fully function of pks1, impacting melanin synthesis and metabolism, and consequently affecting the growth and virulence of F. monophora.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Luisa Dan Favilla, Tatiana Sobianski Herman, Camila da Silva Goersch, Rosangela Vieira de Andrade, Maria Sueli Soares Felipe, Anamelia Lorenzetti Bocca, Larissa Fernandes
Summary: This study successfully generated a novel mutant of the dematiaceous fungal genus Fonsecaea by gene deletion and homologous recombination. The mutant showed differences in nutrient supply, viability, and growth compared to the wild-type and reconstituted strains. These findings contribute to a better understanding of the biology and pathogenicity of chromoblastomycosis causative agents.
Article
Microbiology
Mengxue Zheng, Xiaoqing Zhou, Jiayin Pang, Zengjun Yang, Yongzhen Zou, Lian Zhang, Yan Xu, Rui Yin
Summary: The study evaluated the effect of new methylene blue (NMB)-induced photodynamic therapy (PDT) on multidrug-resistant chromoblastomycosis. The results showed that NMB-PDT could effectively inactivate drug-resistant chromoblastomycosis in vitro, suggesting its potential as an alternative or adjuvant treatment for refractory cases.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Mycology
Ximena Leon-Lara, Carlos Atoche, Roberto Arenas, Fernando Martinez-Hernandez, Luary C. Martinez-Chavarria, Juan Xicohtencatl-Cortes, Victor A. Vazquez-Aceituno, Rigoberto Hernandez-Castro
Summary: This article reports a 60-year-old male from southern Mexico with a 40-year history of chromoblastomycosis caused by Cyphellophora laciniata. Despite treatment with itraconazole and cryosurgery, the results were unsatisfactory.
JOURNAL DE MYCOLOGIE MEDICALE
(2022)
Review
Immunology
Luiz Felipe Domingues Passero, Italo Novais Cavallone, Walter Belda Jr
Summary: Chromoblastomycosis (CBM) is a neglected human disease caused by pigmented dematiaceous fungi, mainly affecting people working in agriculture in low-income countries. Despite some understanding of resistance and susceptibility in CBM, effective vaccines are still lacking. Limited progress has been made in treatment, with the use of immunomodulators showing promise.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Microbiology
Morgana F. Voidaleski, Flavio Queiroz-Telles, Hugo T. Itikawa, Guilherme G. Muller, Bruna J. F. S. Lima, Lucas E. Trevisoli, Regielly C. R. Cognialli, Roberta C. L. Crispim, Vania A. Vicente
Summary: This case report describes a patient with fungal keratitis caused by Roussoella neopustulans. The patient experienced visual improvement after topical natamycin treatment and regained sight after three months of therapy. This is the first reported case of keratitis associated with R. neopustulans.
Review
Infectious Diseases
Flavio Queiroz-Telles, Alexandro Bonifaz, Regielly Cognialli, Bruno P. R. Lustosa, Vania Aparecida Vicente, Hassiel Aurelio Ramirez-Marin
Summary: This review evaluates the risk and prognostic factors related to pediatric sporotrichosis. It found that Sporothrix schenckii is the major etiologic agent in Mexico, transmitted sapronotically, while Sporothrix brasiliensis is mainly transmitted by cats in Brazil. The clinical manifestations and affected anatomical sites differ between the two countries.
CURRENT FUNGAL INFECTION REPORTS
(2022)
Article
Dermatology
Armando Guevara, Andreia Ferreira Nery, Marcia de Souza Carvalho Melhem, Lucas Bonfietti, Anderson Messias Rodrigues, Ferry Hagen, Jamile Ambrosio de Carvalho, Zoilo Pires de Camargo, Bruna Jacomel F. de Souza Lima, Vania Aparecida Vicente, Rosane Christine Hahn
Summary: Chromoblastomycosis primarily affects the poor population in Brazil, especially those involved in agricultural activities, with F. pedrosoi being the main etiological agent. Itraconazole, voriconazole, and terbinafine showed the highest antifungal activity.
Article
Immunology
Lucas de Oliveira Las-Casas, Clara Luna Freitas Marina, Raffael Junio Araujo de Castro, Luisa Coutinho Coelho, Sonia Nair Bao, G. Sybren de Hoog, Vania Aparecida Vicente, Larissa Fernandes, Anamelia Lorenzetti Bocca
Summary: This study demonstrated for the first time that different species of Fonsecaea produce extracellular vesicles (EVs) in response to nutritional conditions, and these EVs can modulate the production of pro- and anti-inflammatory cytokines and nitric oxide by bone marrow-derived macrophages (BMDMs). The size, content, and morphology of the EVs were also affected by growth conditions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Materials Science, Paper & Wood
Jackeline Valendolf Nunes, Mac Wendell Barbosa da Silva, Gustavo Henrique Couto, Izadora Cervelin Flor, Vania Aparecida Vicente, Jose Daniel De Almeida, Fernanda Celinski, Claudia Regina Xavier
Summary: The microbiological diversity in an aerated facultative lagoon system treating kraft pulp industry effluent was evaluated. Bacillus cereus, Bacillus thuringiensis, and Paenibacillus glucanolyticus were found to have significant removal capabilities.
Meeting Abstract
Infectious Diseases
Regielly Cognialli, Fernanda Daros, Diesica Ferreira, Adriana Gabriel, Lili Lopuch, Francelise Cavassin, Bruno Lustosa, Vania Vicente, Giovanni Breda, Izabella Santos-Weiss, Flavio Queiroz-Telles
Meeting Abstract
Infectious Diseases
Fernanda Bastos, Marconi Farias, Fabiana Monti, Regielly Cognialli, Lili Lopuch, Adriana Gabriel, Vania Vicente, Emanuel Razzolini, Karen Wu, Flavio Queiroz-telles
Meeting Abstract
Infectious Diseases
Carolina Prado, Luciana Chiyo, Carlos Santi, Regielly Cognialli, Guilherme Reis, Marlon Geraldo, Emanuel Razzolini, Bruno Lustosa, Daniel Schroeder, Rafaella Santos, Flavia Trench, Vania Vicente, Walfrido Svoboda, Flavio Queiroz-Telles
Article
Dermatology
Morgana Ferreira Voidaleski, Flavia de Fatima Costa, G. Sybren de Hoog, Renata Rodrigues Gomes, Vania Aparecida Vicente
Summary: This study investigated the presence of black fungi in the skin microbiome and found that Exophiala and Cyphellophora europaea were the most common species. These fungi are often present on the skin without necessarily causing infections. The study provides insights into the presence and potential pathological role of black fungi in the human body.
Article
Mycology
Nickolas Menezes da Silva, Guilherme Fonseca Reis, Flavia de Fatima Costa, Maria Eduarda Grisolia, Marlon Roger Geraldo, Bruno Paulo Rodrigues Lustosa, Bruna Jacomel Favoreto de Souza Lima, Vinicius Almir Weiss, Emanuel Maltempi de Souza, Ruoyu Li, Yinggai Song, Mariana Machado Fidelis Nascimento, Diogo Robl, Renata Rodrigues Gomes, G. Sybren de Hoog, Vania Aparecida Vicente
Summary: This study focused on the sequencing, assembly, and description of the whole genome of Cladophialophora exuberans, a black yeast related fungus, with an emphasis on genes and pathways related to carbon and toxin management, tolerance and bioremediation of lead and copper, and metal homeostasis. The results showed that the strain exhibited growth inhibition at minimum inhibitory and fungicidal concentrations of copper and lead, and could grow at higher concentrations in agar tests. In addition, the strain demonstrated uptake capacities of copper and lead in heavy metal bioremediation assays. This study contributed to the annotation of genes involved in heavy metal homeostasis and provided insights into the mechanisms of tolerance and adaptation to extreme conditions.
Article
Mycology
Yu Quan, Shuwen Deng, Francesc X. Prenafeta-Boldu, Veronika E. Mayer, Lucia Muggia, Agnese Cometto, Vania A. Vicente, Nickolas Menezes da Silva, Maria Eduarda Grisolia, Yinggai Song, Sarah A. Ahmed, Xueke Niu, Bruna Jacomel Favoreto de Souza Lima, Peiying Feng, Roxana G. Vitale, Marcus Teixeira, Montarop Sudhadham, Conceicao Pedrozo e Silva de Azevedo, Anamelia Bocca, Gerhard Haase, Laura Selbmann, Dongmei Shi, Yingqian Kang, Sybren de Hoog
Summary: Fungi in the Chaetothyriales order, although not primary pathogens, have the ability to cause human infections. They exhibit extremotolerance and advanced toxin management, and their ancestral ecology involves association with metabolite-producing lichens. Ant-association and dealing with pheromones are also important aspects of this order. The Herpotrichiellaceae family, derived from phylogeny, shows dual ecology and the ability to cause disease in humans and cold-blooded vertebrates.
Article
Dermatology
Amanda Bombassaro, Bram Spruijtenburg, Fernanda Medeiros, Bruna Jacomel Favoreto de Souza Lima, Luana Beatriz Ballardin, Marconi Rodrigues de Farias, Vania Aparecida Vicente, Flavio de Queiroz-Telles, Jacques F. Meis, Theun de Groot
Summary: This study analyzed the genetic relatedness and antifungal susceptibility of 89 Sporothrix isolates from humans and cats in Curitiba, Southern Brazil. The results showed zoonotic transmission and a broad activity of seven common antifungals, including olorofim, against a large S. brasiliensis isolate collection. Only one human isolate exhibited resistance to itraconazole and posaconazole. Whole genome sequencing analysis did not reveal any unique substitutions in resistance-associated genes.
Article
Infectious Diseases
Jessica de Oliveira Bescrovaine, Jose Francisco Ghignatti Warth, Cybelle de Souza, Vanessa Wotkoski Benoni, Franciele Baja, Gabriela Xavier Schneider, Vania Aparecida Vicente, Gerrits Sybren de Hoog, Flavio Queiroz-Telles
Summary: This study aimed to evaluate the current prevalence of Nannizzia-causing canine and feline dermatophytosis in Curitiba and Metropolitan Region, Brazil, as well as perform phenotypic and phylogenetic characterizations of these isolates. The results showed that dogs were significantly more affected by Nannizzia than cats in terms of dermatophytes infection. Furthermore, molecular analysis confirmed the first report of N. incurvata as an etiological agent of canine and feline dermatophytosis in Brazil.
Article
Biology
Flavia de Fatima Costa, Renata Carolini Souza, Morgana Ferreira Voidaleski, Amanda Bombassaro, Giovanna Zuzarte Candido, Nickolas Menezes da Silva, Diogo Robl, Leandro Ferreira Moreno, Vinicius Almir Weiss, Roberto Tadeu Raittz, Mauro Antonio Castro, Renata Rodrigues Gomes, Juliana Vitoria Messias Bittencourt, Gerrit Sybren de Hoog, Mariangela Hungria, Vania Aparecida Vicente
Summary: This study analyzed the abundance of pathogenic fungi in Cerrado soils using metagenomic sequences. The results showed that the fungal abundance was lower in soils under no-tillage and conventional tillage treatments compared to native soils.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2022)
Article
Mycology
Yu Quan, Nickolas Menezes da Silva, Bruna Jacomel Favoreto de Souza Lima, Sybren de Hoog, Vania Aparecida Vicente, Veronika Mayer, Yingqian Kang, Dongmei Shi
Summary: In this study, the genomes of two newly described carton species in Chaetothyriales were sequenced and compared with the genomes of related domatia species, aiming to explore the differences between these strains.
