From microbial gene essentiality to novel antimicrobial drug targets

Identification of a two-component fatty acid kinase responsible for host fatty acid incorporation by Staphylococcus aureus

(2014) J. B. Parsons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting the vitamin biosynthesis pathways for the treatment of malaria

(2013) Thales Kronenberger et al.   Future Medicinal Chemistry

In silico analyses for the discovery of tuberculosis drug targets

(2013) B. K.-S. Chung et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Streptococcus pneumoniae Folate Biosynthesis Responds to Environmental CO2 Levels

(2013) P. Burghout et al.   JOURNAL OF BACTERIOLOGY

Nontypeable Haemophilus influenzae Carbonic Anhydrase Is Important for Environmental and Intracellular Survival

(2013) J. D. Langereis et al.   JOURNAL OF BACTERIOLOGY

Transposon insertion sequencing: a new tool for systems-level analysis of microorganisms

(2013) Tim van Opijnen et al.   NATURE REVIEWS MICROBIOLOGY

Characterization of the Molecular Interplay between Moraxella catarrhalis and Human Respiratory Tract Epithelial Cells

(2013) Stefan P. W. de Vries et al.   PLoS One

Approaches to querying bacterial genomes with transposon-insertion sequencing

(2013) Lars Barquist et al.   RNA Biology

Co-infection subverts mucosal immunity in the upper respiratory tract

(2012) Rebeccah S Lijek et al.   CURRENT OPINION IN IMMUNOLOGY

Discovery of Selective Menaquinone Biosynthesis Inhibitors against Mycobacterium tuberculosis

(2012) Joy Debnath et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genetic requirements forMoraxella catarrhalisgrowth under iron-limiting conditions

(2012) Stefan P. W. de Vries et al.   MOLECULAR MICROBIOLOGY

Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development

(2012) Manoj K. Dhar et al.   New Biotechnology

ESSENTIALS: Software for Rapid Analysis of High Throughput Transposon Insertion Sequencing Data

(2012) Aldert Zomer et al.   PLoS One

PneumocystisS-Adenosylmethionine Transport

(2011) Oscar Perez-Leal et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

KEGG for integration and interpretation of large-scale molecular data sets

(2011) M. Kanehisa et al.   NUCLEIC ACIDS RESEARCH

Five Questions about Non-Mevalonate Isoprenoid Biosynthesis

(2011) Audrey R. Odom   PLoS Pathogens

Genome-Wide Identification ofStreptococcus pneumoniaeGenes Essential for Bacterial Replication during Experimental Meningitis

(2010) T. E. Molzen et al.   INFECTION AND IMMUNITY

Carbonic Anhydrase Is Essential for Streptococcus pneumoniae Growth in Environmental Ambient Air

(2010) P. Burghout et al.   JOURNAL OF BACTERIOLOGY

Gneg-mPLoc: A top-down strategy to enhance the quality of predicting subcellular localization of Gram-negative bacterial proteins

(2010) Hong-Bin Shen et al.   JOURNAL OF THEORETICAL BIOLOGY

Lipoic Acid Metabolism in Microbial Pathogens

(2010) M. D. Spalding et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Predicting conserved essential genes in bacteria: in silico identification of putative drug targets

(2010) Melanie Duffield et al.   Molecular BioSystems

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Hospital-Acquired Infections Due to Gram-Negative Bacteria

(2010) Anton Y. Peleg et al.   NEW ENGLAND JOURNAL OF MEDICINE

PSORTdb--an expanded, auto-updated, user-friendly protein subcellular localization database for Bacteria and Archaea

(2010) N. Y. Yu et al.   NUCLEIC ACIDS RESEARCH

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

(2010) C. Knox et al.   NUCLEIC ACIDS RESEARCH

Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

(2009) Sophie Brinster et al.   NATURE

Tn-seq: high-throughput parallel sequencing for fitness and genetic interaction studies in microorganisms

(2009) Tim van Opijnen et al.   NATURE METHODS

Tracking insertion mutants within libraries by deep sequencing and a genome-wide screen for Haemophilus genes required in the lung

(2009) J. D. Gawronski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LocateP: Genome-scale subcellular-location predictor for bacterial proteins

(2008) Miaomiao Zhou et al.   BMC BIOINFORMATICS

The RAST Server: Rapid Annotations using Subsystems Technology

(2008) Ramy K Aziz et al.   BMC GENOMICS

Platensimycin: A Promising Antimicrobial Targeting Fatty Acid Synthesis

(2008) D. Manallack et al.   CURRENT MEDICINAL CHEMISTRY

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

(2008) Ian Chopra et al.   LANCET INFECTIOUS DISEASES

Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances

(2008) Irith Wiegand et al.   Nature Protocols