Article
Automation & Control Systems
Fernando Soto, Emma Purcell, Mehmet Ozgun Ozen, Prima Dewi Sinawang, Jie Wang, Demir Akin, Utkan Demirci
Summary: Developing on-site biomarker enrichment platforms can improve the early diagnosis of gastrointestinal diseases. A robotic pill is designed to collect biomarkers from the GI tract over prolonged periods, utilizing a magnetic core for locomotion, a delayed gate mechanism for sampling control, and an enrichment module for trapping biomarkers while allowing biofluid to pass through. The robotic pill demonstrated the ability to sample microparticles, proteins, and bacteria, as well as directed locomotion and docking in a targeted region against fluid flow.
ADVANCED INTELLIGENT SYSTEMS
(2022)
Article
Microbiology
Yi Huang, Jinbin Chen, Qiao Jiang, Nan Huang, Xin Ding, Liang Peng, Xiaoyan Deng
Summary: This study revealed the indirect role of ModA in the anaerobic growth, motility, biofilm formation, and pathogenicity of P. mirabilis, emphasizing the importance of ModA in mediating molybdate uptake and allowing the bacterium to adapt to complex environmental conditions and cause UTIs.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Angela del Castillo-Izquierdo, Jose Maria Moreno-Navarrete, Jessica Latorre, Maria Arnoriaga-Rodriguez, Marta Ballanti, Giovanni Monteleone, Omero Alessandro Paoluzi, Geltrude Mingrone, Josep Puig, Rafael Ramos, Josep Garre-Olmo, Mariona Jove, Reinald Pamplona, Manuel Portero-Otin, Joaquim Sol, Philippe Lefebvre, Bart Staels, Massimo Federici, Jose Manuel Fernandez-Real, Jordi Mayneris-Perxachs
Summary: In this study, the potential role of DPP9 in the gastrointestinal tract was explored, and its association with oxidative stress, antiviral pathways, and metabolites was identified. Promising existing drugs targeting DPP9-associated genes were also identified for potential repositioning against viral infection.
Article
Biochemistry & Molecular Biology
Yansong Li, Yubo Wang, Haiqing Chang, Bo Cheng, Jiwen Miao, Shuang Li, Hao Hu, Liyu Huang, Qiang Wang
Summary: Propofol and dexmedetomidine are commonly used sedatives in the ICU, but their impact on gastrointestinal motility has not been well studied. This research found that dexmedetomidine had a stronger inhibitory effect on GIT motility compared to propofol, potentially due to impaired Ca2+ response in primary enteric glia.
NEUROCHEMICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Joseph Cooney, Priscilla Appiahene, Ross Findlay, Lulia Al-Hillawi, Khizar Rafique, William Laband, Benjamin Shandro, Andrew Poullis
Summary: Although COVID-19 was initially recognized as an acute respiratory illness, more non-pulmonary symptoms are now being discovered. Acute gastrointestinal side effects have been well documented, affecting approximately 17% of patients. However, there is limited understanding of chronic gastrointestinal symptoms. This study investigates both acute and chronic gastrointestinal symptoms after COVID-19 infection, finding that 43.8% of patients still experience gastrointestinal symptoms at 6 months. Further research is needed to explore the potential new post-COVID-19 IBS and its clinical progression and response to medical therapies.
Review
Virology
Yaqian Li, Qiuyu Chen, Liwei Wang, Xin Chen, Bangmao Wang, Weilong Zhong
Summary: Gastrointestinal motility disorders are closely related to viral infections of the enteric nervous system. Viruses can infect the enteric nervous system through various means and cause symptoms such as abdominal pain and diarrhea. Studies have found that viruses are a cause of some gastrointestinal motility disorders.
Review
Biochemistry & Molecular Biology
Amy Marie Holland, Ana Carina Bon-Frauches, Daniel Keszthelyi, Veerle Melotte, Werend Boesmans
Summary: The enteric nervous system (ENS) plays a crucial role in regulating gastrointestinal function, and its dysfunction is closely linked to gastrointestinal diseases. Recent research indicates that the multifaceted connections between the ENS, intestinal epithelium, immune system, and gut microbiome are essential for maintaining gastrointestinal homeostasis. Therefore, the ENS plays a significant role in the pathogenesis of enteric neuropathies, inflammatory bowel diseases, and colorectal cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Virology
Felipe Bueno, Eliseo Albert, Estela Gimenez, Jose L. Pinana, Ariadna Perez, Maria Dolores Gomez, Juan C. Hernandez-Boluda, Eva M. Gonzalez-Barbera, Juan Montoro, Javier Buesa, Manuel Guerreiro, Aitana Balaguer-Rosello, Rafael Hernani, Jaime Sanz, Carlos Solano, David Navarro
Summary: The data in this study did not support an association between gastrointestinal infection and subsequent occurrence of aGvHD-GI in an unselected cohort of allo-HSCT recipients.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Infectious Diseases
Sophie Aurich, Ellen Prenger-Berninghoff, Christa Ewers
Summary: This study analyzed urinary tract samples from dogs and cats in Germany and determined the susceptibility of uropathogenic isolates to different antimicrobials. The results showed that Escherichia coli was the most frequently isolated pathogen and females were more likely to have positive microbiological cultures. Empiric treatment of UTI with amoxicillin/clavulanic acid or trimethoprim-sulfamethoxazole is recommended.
Review
Biochemistry & Molecular Biology
Rhian Stavely, Leah C. Ott, Niloufar Rashidi, Samy Sakkal, Kulmira Nurgali
Summary: Oxidative stress plays a critical role in gastrointestinal disorders, causing injury and dysfunction in the enteric nervous system, and offers potential opportunities for targeted therapeutics.
Review
Biochemistry & Molecular Biology
Halah Winner, Ann Friesenhahn, Yihu Wang, Nicholas Stanbury, Jie Wang, Cheng He, Guangming Zhong
Summary: The mouse-adapted pathogen Chlamydia muridarum (CM) causes pathology in the mouse genital tract but not in the gastrointestinal tract. Antigen-specific CD4+ T cells that release IFN gamma clear CM from the genital tract and small intestine, while it persists in the large intestine, regulated by IFN gamma delivered by group 3 innate lymphoid cells (ILC3s). Interestingly, ILC3-delivered IFN gamma can inhibit the human pathogen Chlamydia trachomatis (CT) in the mouse endometrium. Understanding the mechanisms of chlamydial interactions with IFN gamma produced by different cells may provide insights into chlamydial pathogenicity and mucosal immunity.
TRENDS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Elissa Elia, David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: This passage discusses the similarities between the gastrointestinal and genitourinary tracts, which both consist of hollow structures that rely on muscle contractions to facilitate the flow of materials. It describes the anatomy, pathologies, and treatments of these organs, with a particular emphasis on tissue engineering strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Adriana Belas, Catia Marques, Juliana Menezes, Luis Telo da Gama, Patricia Cavaco-Silva, Constanca Pomba
Summary: This study aimed to compare ESBL/pAmpC-producing E. coli strains causing community-acquired UTI in companion animals and humans. The study found that companion animals and humans shared two multidrug-resistant high-risk clonal lineages: ST131 and ST648. The study also reported two newly discovered clonal lineages in humans with community-acquired UTI in Portugal.
Article
Public, Environmental & Occupational Health
Nguyen Van Hao, Nguyen Ngoc My Huyen, Nguyen Thi Han Ny, Vo Thi Nhu Trang, Nguyen Van Minh Hoang, Duong Bich Thuy, Nguyen Thanh Nguyen, Pham Thi Lieu, Ha Thi Hai Duong, Tran Thi Diem Thuy, Phung Tran Huy Nhat, Dong Thi Hoai Tam, Maciej F. Boni, Lam Minh Yen, Le Van Tan, Tran Tan Thanh, James Campbell, C. Louise Thwaites
Summary: The study did not find evidence of an association between gastrointestinal C. tetani and tetanus infection, but it highlights the importance of increasing vaccination coverage.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Immunology
Brandon J. Beddingfield, Lori A. Rowe, Kasi E. Russell-Lodrigue, Lara A. Doyle-Meyers, Nadia Golden, Skye Spencer, Nicole Chirichella, Robert V. Blair, Nicholas J. Maness, Chad J. Roy
Summary: Breakthrough gastrointestinal COVID-19 was observed in a rhesus macaque undergoing low-dose monoclonal antibody prophylaxis, indicating intrahost virus evolution within the gut.
JOURNAL OF INFECTIOUS DISEASES
(2022)