Article
Biotechnology & Applied Microbiology
Wei Li, Li-xiang Wu, Bai-sheng Huang, Li-jian Yang, Jun-qiang Huang, Zeng-shi Li, Jia Jiao, Tianxiang Cheng, Ding Li, Yuanyuan Xiong
Summary: This study found that hypertensive intracerebral hemorrhage (HICH) is accompanied by increased levels of inflammation markers in peripheral blood and brain, decreased gut microbiota diversity, and altered gut metabolic phenotype.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Min Yuan, Xinhua Zhou, Xiaoqing Lu, Zhilong Xiao, Huangyan Zhou, Xiaohua Wang
Summary: This study found that statin use during hospitalization may be associated with a reduced risk-adjusted mortality in patients with intracerebral hemorrhage (ICH). Further randomized controlled trials are needed to clarify this association.
Article
Medicine, General & Internal
Yusaku Morita, Toru Yoshikawa, Masaya Takahashi
Summary: This study aimed to investigate the potential mechanisms underlying overwork-related cerebrovascular and cardiovascular diseases (CCVDs) and to explore the association between extreme workload and the risk of developing hypertensive intracerebral haemorrhage (ICH) in deep brain areas. The results showed that patients with extreme workloads had a higher risk of developing hypertensive ICH compared to those without extreme workloads. There was also a dose-response relationship between the number of hours of overtime work and the risk of developing hypertensive ICH.
Article
Hematology
Ton Lisman, Virginia Hernandez-Gea, Maria Magnusson, Lara Roberts, Simon Stanworth, Jecko Thachil, Armando Tripodi
Summary: Patients with liver diseases experience complex alterations in their hemostatic system, leading to a fragile balance between bleeding and thrombotic events. Although traditionally classified as acquired bleeding disorders, laboratory observations have shown that they are also prone to developing both bleeding and thrombotic events.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Gastroenterology & Hepatology
Mohamed Attauabi, Johan Burisch, Flemming Bendtsen, Nina Kimer
Summary: A study of 2.6 million Danish citizens found that patients with liver cirrhosis have a lower risk of contracting COVID-19, but a higher risk of complications and mortality.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Suet-Ying Kwan, Jingjing Jiao, Aron Joon, Peng Wei, Lauren E. Petty, Jennifer E. Below, Carrie R. Daniel, Xiaogang Wu, Jianhua Zhang, Robert R. Jenq, P. Andrew Futreal, Ernest T. Hawk, Joseph B. McCormick, Susan P. Fisher-Hoch, Laura Beretta
Summary: This study investigated the gut microbiome characteristics and associated functional changes in Hispanics with liver fibrosis. It was found that liver fibrosis patients had high abundance of immunogenic commensals and depletion of certain bacterial species. Additionally, liver fibrosis was associated with changes in several bacterial pathways and specific gene polymorphisms.
Article
Gastroenterology & Hepatology
Thomas H. Tranah, Maria-Pilar Ballester, Juan Antonio Carbonell-Asins, Javier Ampuero, Goncalo Alexandrino, Andra Caracostea, Yolanda Sanchez-Torrijos, Karen L. Thomsen, Annarein J. C. Kerbert, Maria Capilla-Lozano, Manuel Romero-Gomez, Desamparados Escudero-Garcia, Carmina Montoliu, Rajiv Jalan, Debbie L. Shawcross
Summary: This study confirms that the severity of hyperammonaemia is an independent predictor for liver-related complications and mortality in clinically stable outpatients with cirrhosis, and performs better than traditional prognostic scores in predicting complications.
JOURNAL OF HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Dominika Jamiol-Milc, Anna Gudan, Karolina Kazmierczak-Siedlecka, Joanna Holowko-Ziolek, Dominika Maciejewska-Markiewicz, Katarzyna Janda-Milczarek, Ewa Stachowska
Summary: The liver plays a crucial role in the metabolism of nutrients and the storage of micronutrients, but chronic liver diseases can lead to nutritional deficiencies and poor prognosis. This review focuses on the dietary therapy for patients with chronic liver diseases, including those eligible for liver transplantation and in the postoperative period.
Article
Gastroenterology & Hepatology
Christian Labenz, Anita Arslanow, Marc Nguyen-Tat, Michael Nagel, Marcus-Alexander Woerns, Matthias Christian Reichert, Franz Josef Heil, Dagmar Mainz, Gundula Zimper, Barbara Roemer, Harald Binder, Erik Farin-Glattacker, Urs Fichtner, Erika Graf, Dominikus Stelzer, Reyn Van Ewijk, Julia Ortner, Louis Velthuis, Frank Lammert, Peter R. Galle
Summary: This study demonstrates that the implementation of a structured screening program using easily obtainable measures of liver function may increase the early detection rate of cirrhosis in the general population.
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hannes Hagstrom, Maja Thiele, Bjorn Roelstraete, Jonas Soderling, Jonas F. Ludvigsson
Summary: A study conducted in Sweden found that patients with biopsy-proven ALD have a nearly fivefold increased risk of death compared to the general population, and those with ALD without cirrhosis also have a higher risk of death. These results suggest the need to strengthen the management and monitoring of these patients.
Article
Gastroenterology & Hepatology
Miika Vuorinen, Ville T. Mannisto, Veikko Salomaa, Annie Britton, Antti Jula, Satu Mannisto, Annamari Lundqvist, Markus Perola, Fredrik Aberg
Summary: Diabetes is associated with a two-fold risk of liver-related outcomes and approximately 12%-14% of severe liver-related outcomes at the population level can be attributed to diabetes. Maternal diabetes and a family history of diabetes also increase the risk of liver disease, suggesting a potential mitochondrial genetic mechanism.
LIVER INTERNATIONAL
(2022)
Article
Clinical Neurology
Anna-Maija Lahti, Mirva Natynki, Juha Huhtakangas, Michaela Bode, Seppo Juvela, Pasi Ohtonen, Sami Tetri
Summary: The study revealed a high mortality rate of 81.1% among ICH patients, with cerebrovascular disease being the main cause of death. Long-term survivors had smaller ICH volume, and even 10 years after the index event, ICH patients still had a higher mortality rate compared to controls.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Gastroenterology & Hepatology
Anca Trifan, Cristina-Maria Muzica, Robert Nastasa, Sebastian Zenovia, Ermina Stratina, Remus Stafie, Adrian Rotaru, Ana-Maria Singeap, Camelia Cojocariu, Catalin Sfarti, Irina Girleanu, Stefan Chiriac, Tudor Cuciureanu, Laura Huiban, Carol Stanciu
Summary: Although liver cirrhosis is associated with high mortality, patients usually have a good quality of life in the compensated phase, and the disease may progress undiagnosed for many years. Vibration-controlled transient elastography with controlled attenuation parameter is a useful noninvasive tool to estimate the severity of fibrosis and steatosis. The study aimed to establish the prevalence of significant liver fibrosis diagnosed by vibration-controlled transient elastography in an apparently healthy population.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Food Science & Technology
Lydie Sparfel, Sandy Ratodiarivony, Elisa Boutet-Robinet, Sandrine Ellero-Simatos, Anne Jolivet-Gougeon
Summary: A. muciniphila is a bacterium that degrades mucin in the intestinal mucosa, modulating intestinal permeability and inflammation in the digestive tract, liver, and blood. Factors such as obesity, diabetes, metabolic syndromes, and inflammatory digestive diseases can decrease the relative abundance of A. muciniphila. Over-intake of ethanol can also lead to a decrease in A. muciniphila, associated with dysregulation of microbial metabolite production, impaired intestinal permeability, chronic inflammation, and cytokine production.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Immunology
Mohamed Attauabi, Jakob Benedict Seidelin, Oluf Krautwald Felding, Mads Damsgaard Wewer, Laura Kirstine Vinther Arp, Melek Zahra Sarikaya, Alexander Egeberg, Nora Vladimirova, Flemming Bendtsen, Johan Burisch
Summary: The study found a lower occurrence but a more severe disease course of COVID-19 among patients with IMIDs, associated with the use of systemic steroids and suspension of other immunosuppressants. Therefore, it emphasizes the importance of weighing risks before suspending immunosuppressants during COVID-19.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Andrology
Katrine H. Lund, Anne Sofie D. Laursen, Therese K. Gronborg, Gunnar Toft, Bjarke H. Jacobsen, Tanran R. Wang, Amelia K. Wesselink, Elizabeth E. Hatch, Greg J. Sommer, Michael L. Eisenberg, Kenneth J. Rothman, Henrik T. Sorensen, Lauren A. Wise, Ellen M. Mikkelsen
Summary: This study aimed to examine the association between perceived stress and semen quality. The analysis of data from 644 men revealed that perceived stress was not materially associated with semen volume, sperm concentration, or total sperm count.
Article
Cardiac & Cardiovascular Systems
Martin Bodtker Mortensen, Omar Dzaye, Hans Erik Botker, Jesper Moller Jensen, Michael Maeng, Jacob Fog Bentzon, Helle Kanstrup, Henrik Toft Sorensen, Jonathon Leipsic, Ron Blankstein, Khurram Nasir, Michael J. Blaha, Bjarne Linde Norgaard
Summary: Low-density lipoprotein cholesterol (LDL-C) is associated with atherosclerotic cardiovascular disease (ASCVD), but its association with ASCVD risk is modified by the presence of coronary artery calcification (CAC). This study found that LDL-C is only associated with ASCVD events in patients with CAC, and not in those without CAC. This information is valuable for individualized risk assessment among middle-aged people with or without coronary atherosclerosis.
Article
Public, Environmental & Occupational Health
Soren Viborg Vestergaard, Henrik Birn, Simon Kok Jensen, Henrik Toft Sorensen, Dorothea Nitsch, Christian Fynbo Christiansen
Summary: This study aimed to investigate the incidence, histopathology, and mortality of adult nephrotic syndrome over a 24-year period. The study found a slight increase in the incidence of adult nephrotic syndrome and a significant decrease in mortality. These findings may reflect changes in epidemiology or awareness and coding of nephrotic syndrome.
Article
Psychiatry
Meghan L. Smith, Vijaya Seegulam, Peter Szentkuti, Erzsebet Horvath-Puho, Sandro Galea, Timothy L. Lash, Anthony J. Rosellini, Paula P. Schnurr, Henrik Toft Sorensen, Jaimie L. Gradus
Summary: This study examined the differences in posttraumatic psychopathology between immigrants and native-born persons in Denmark. The findings suggest that immigrants are at a higher risk of developing posttraumatic stress disorder (PTSD) following non-interpersonal trauma, possibly due to adverse experiences during migration.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Education & Educational Research
Kala M. Mehta, Karin Lottrup Petersen, Steve Goodman, Henrik Toft Sorensen, Martin Bogsted, Jeppe Dorup Olesen, Sylvia Burks, Richard E. Shaw, Jens Dahlgaard Hove, Jakob Ousager, Carlos Milla, Vibeke Andersen, Niels Ejskjaer, Vibeke Brix-Christensen, Shomit Ghose, Andreas Kjaer, Peter V. Chin-Hong
Summary: The Danish-American Research Exchange (DARE) program provides Danish medical students with the opportunity to collaborate and conduct biomedical research with US medical institutions. This program enhances students' research skills and interdisciplinary thinking, and encourages exploration of low-cost healthcare interventions. Analysis of the research outcomes and intentions of DARE alumni suggests that this medical student-initiated research model has positive effects on promoting binational collaboration in medicine.
BMC MEDICAL EDUCATION
(2023)
Article
Gastroenterology & Hepatology
Frederikke Schonfeldt Troelsen, Henrik Toft Sorensen, Lars Pedersen, Lone Dragnes Brix, Louise Bang Grode, Evelien Dekker, Rune Erichsen
Summary: This study investigated the plausible explanations for post-colonoscopy colorectal cancer (PCCRC) in a Danish Region using the World Endoscopy Organization algorithm, finding that most PCCRCs originate from possible missed lesions and incompletely resected lesions. These findings underscore the importance of quality assurance of colonoscopy procedures and polypectomy techniques.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ola Olen, Karin E. Smedby, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Asa Hallqvist-Everhov, Johan SWIBREG Study Grp, Johan Askling, Anders Ekbom, Michael C. Sachs, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Earlier studies on lymphoma risk in patients with inflammatory bowel disease (IBD) have provided varying estimates, but have been limited by detection biases, misclassification, and small sample sizes. Our binational cohort study found that the risk of lymphoma has increased in Crohn's disease (CD) patients over the past 20 years, but not in ulcerative colitis (UC) patients. The increase in risk was mainly driven by T-cell lymphomas and aggressive B-cell lymphomas.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Joe West, Peter Jepsen, Timothy R. Card, Colin J. Crooks, Mark Bishton
Article
Gastroenterology & Hepatology
Luise Aamann, Gitte Dam, Peter Jepsen, Mette Borre, Aska Drljevic-Nielsen, Kristian Overgaard, Henning Andersen, Hendrik Vilstrup, Niels Kristian Aagaard
Summary: This study investigates whether a 12-week period of resistance training has a long-term effect on the risk of hospitalization or mortality among patients with cirrhosis. The results show that the training group has a lower risk of first hospitalization and lower all-cause mortality. This suggests that resistance training may reduce the risk of hospitalization and death in patients with cirrhosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jeffrey V. Lazarus, Henry E. Mark, Alina M. Allen, Juan Pablo Arab, Patrizia Carrieri, Mazen Noureddin, William Alazawi, Naim Alkhouri, Saleh A. Alqahtani, Marco Arrese, Ramon Bataller, Thomas Berg, Paul N. Brennan, Patrizia Burra, Graciela E. Castro-Narro, Helena Cortez-Pinto, Kenneth Cusi, Nikos Dedes, Ajay Duseja, Sven M. Francque, Hannes Hagstrom, Terry T. -K. Huang, Dana Ivancovsky Wajcman, Achim Kautz, Christopher J. Kopka, Aleksander Krag, Veronica Miller, Philip N. Newsome, Mary E. Rinella, Diana Romero, Shiv Kumar Sarin, Marcelo Silva, C. Wendy Spearman, Emmanuel A. Tsochatzis, Luca Valenti, Marcela Villota-Rivas, Shira Zelber-Sagi, Jorn M. Schattenberg, Vincent Wai-Sun Wong, Zobair M. Younossi
Summary: This study aimed to develop a research agenda for fatty liver disease, and 28 priorities were identified to address the individual and societal harms caused by this disease. Adopting this agenda can accelerate global efforts to respond to this public health threat.
JOURNAL OF HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
N. R. Gadgaard, C. Varnum, R. G. H. H. Nelissen, C. Vandenbroucke-Grauls, H. T. Sorensen, A. B. Pedersen
Summary: The impact of comorbidity on infection risk among hip fracture patients is not clear, but a high incidence of infection was found. Comorbidity was identified as an important risk factor for infection up to 1 year after surgery. The results indicate a need for increased investment and support for patients with high comorbidity in pre- and postoperative programs.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Morten Schmidt, Lars Arendt-Nielsen, Ellen-Margrethe Hauge, Henrik Toft Sorensen, Lars Pedersen
Summary: This study investigated the dose dependency of diclofenac's cardiovascular risks by using Danish health registries and a target trial emulation design. The results showed that both high-dose and low-dose diclofenac users had a similar increased risk of cardiovascular events compared to non-users. This finding challenges the assumption that low-dose diclofenac is risk-neutral.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Hematology
Maria A. de Winter, Alicia Uijl, Harry R. Buller, Marc Carrier, Alexander T. Cohen, John-Bjarne Hansen, Karin H. A. H. Kaasjager, Ajay K. Kakkar, Saskia Middeldorp, Gary E. Raskob, Henrik Toft Sorensen, Philip S. Wells, Mathilde Nijkeuter, Jannick A. N. Dorresteijn
Summary: By categorizing VTE patients without cancer, 5 distinct clinical subtypes were identified, which were associated with anticoagulant treatment and clinical outcomes. This suggests that the heterogeneity of VTE cases extends beyond the distinction between provoked and unprovoked VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Correction
Public, Environmental & Occupational Health
Dagrun Slettebo Daltveit, Kari Klungsoyr, Anders Engeland, Anders Ekbom, Mika Gissler, Ingrid Glimelius, Tom Grotmol, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Rebecca Troisi, Tone Bjorge
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Jazmine Abril, Britton Trabert, Rebecca Troisi, Tom Grotmol, Anders Ekbom, Anders Engeland, Mika Gissler, Ingrid Glimelius, Laura Madanat-Harjuoja, Anne Gulbech Ording, Henrik Toft Sorensen, Steinar Tretli, Tone Bjorge
Summary: This study examines the risk factors for uterine sarcoma and compares them with MMMTs and type I endometrial carcinomas. The results show that risk factors vary substantially between uterine sarcoma and MMMTs.
CANCER CAUSES & CONTROL
(2023)
