Article
Geriatrics & Gerontology
Katharina Tabea Jungo, Sven Streit, Julie C. Lauffenburger
Summary: This study investigated the utilization and costs of potentially inappropriate medications (PIMs) in multimorbid older adults with polypharmacy, finding a high prevalence of PIM use (>69%) and associations with female sex, age, and Hispanic ethnicity. Gastrointestinal and central nervous system drugs were the most commonly-used PIMs, with over 10% of medication costs spent on PIMs in patients using more than one.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Article
Geriatrics & Gerontology
Katharina Tabea Jungo, Sven Streit, Julie C. Lauffenburger
Summary: This study investigated measurable patient factors associated with new outpatient prescribing of potentially inappropriate medications in older multimorbid adults. It found that factors such as gender, age, number of ambulatory visits, number of prescribing orders, and heart failure were independently associated with being newly prescribed a potentially inappropriate medication.
Article
Geriatrics & Gerontology
Shin J. Liau, Samanta Lalic, Janet K. Sluggett, Matteo Cesari, Graziano Onder, Davide L. Vetrano, Lucas Morin, Sirpa Hartikainen, Aleksi Hamina, Kristina Johnell, Edwin C. K. Tan, Renuka Visvanathan, J. Simon Bell
Summary: This report presents international consensus principles related to medication management in frail older people, covering clinical practice, research, and education. These principles highlight different considerations for optimizing medication management in frail older people and can be used in conjunction with existing best practice guidelines to help achieve optimal health outcomes for this vulnerable population.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Geriatrics & Gerontology
Katharina Tabea Jungo, Sophie Mantelli, Zsofia Rozsnyai, Aristea Missiou, Biljana Gerasimovska Kitanovska, Birgitta Weltermann, Christian Mallen, Claire Collins, Daiana Bonfim, Donata Kurpas, Ferdinando Petrazzuoli, Gindrovel Dumitra, Hans Thulesius, Heidrun Lingner, Kasper Lorenz Johansen, Katharine Wallis, Kathryn Hoffmann, Lieve Peremans, Liina Pilv, Marija Petek Ster, Markus Bleckwenn, Martin Sattler, Milly van der Ploeg, Peter Torzsa, Petra Bomberova Kanska, Shlomo Vinker, Radost Assenova, Raquel Gomez Bravo, Rita P. A. Viegas, Rosy Tsopra, Sanda Kreitmayer Pestic, Sandra Gintere, Tuomas H. Koskela, Vanja Lazic, Victoria Tkachenko, Emily Reeve, Clare Luymes, Rosalinde K. E. Poortvliet, Nicolas Rodondi, Jacobijn Gussekloo, Sven Streit
Summary: The majority of GPs in this study were willing to deprescribe one or more medications in oldest-old multimorbid patients with polypharmacy. Willingness was higher in patients with increased dependency in ADL and lower in patients with CVD.
Article
Medicine, General & Internal
Maria Teresa Chiarelli, Stefania Antoniazzi, Laura Cortesi, Luca Pasina, Alessio Novella, Francesca Venturini, Alessandro Nobili, Pier Mannuccio Mannucci
Summary: Collaboration between hospital pharmacists and clinicians in identifying and resolving medication-related problems in multimorbid older patients can effectively reduce inappropriate prescriptions and harmful drug interactions. The study highlights the feasibility and mutual acceptance of a trajectory of recognition and reconciliation in medication optimization for older patients admitted to medical wards.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Geriatrics & Gerontology
Antoinette B. Coe, Karen B. Farris, Erica Solway, Dianne C. Singer, Matthias Kirch, Jeffrey T. Kullgren, Preeti N. Malani, Julie P. W. Bynum
Summary: This study aimed to investigate the receipt of comprehensive medication review (CMR) among older adults and factors associated with it. The results showed that most older adults on multiple medications had not received a CMR, but many were interested in it. Furthermore, the study found that receiving a CMR was associated with taking multiple medications and food insecurity, while poor self-reported physical health was associated with a lower likelihood of receiving a CMR.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Health Care Sciences & Services
Caroline McCarthy, Ivana Pericin, Susan M. Smith, Bridget Kiely, Frank Moriarty, Emma Wallace, Barbara Clyne
Summary: The SPPiRE cluster randomized controlled trial found that a GP-delivered medication review incorporating screening for potentially inappropriate prescriptions resulted in a small reduction in the number of medicines but no significant reduction in PIP. The process evaluation identified variations in intervention implementation among practices, with some patients not receiving a review due to insufficient GP time. The brown bag review was the most effective in reducing the number of medications. GPs and patients responded positively to the intervention, but GPs flagged barriers such as integration into practice software and lack of resources for future implementation.
HEALTH EXPECTATIONS
(2022)
Article
Geriatrics & Gerontology
Manav V. Vyas, Jennifer A. Watt, Amy Y. X. Yu, Sharon E. Straus, Moira K. Kapral
Summary: The study found that loneliness in older adults is associated with increased daily use of opioids and benzodiazepines, but not with non-opioid analgesics. Additionally, loneliness is associated with polypharmacy.
Review
Pharmacology & Pharmacy
Joanne Reeve
Summary: Problematic polypharmacy is an increasing challenge in healthcare, where medication intended to improve patient health is now contributing to the problem. The practice of medicine itself has become a driving force behind this issue. Addressing this challenge requires a shift in thinking and the active incorporation of compromise into medication use.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Avantika Saraf Shah, Emily Kay Hollingsworth, Matthew Stephen Shotwell, Amanda S. Mixon, Sandra Faye Simmons, Eduard Eric Vasilevskis
Summary: A multipronged approach was used to obtain the best possible medication history (BPMH) for hospitalized older adults, revealing high prevalence of medication discrepancies in the study cohort. Factors such as lower age, greater prehospital medication count, and admission from assisted living or skilled nursing facility were significantly associated with greater medication discrepancies. These findings highlight the importance of addressing medication discrepancies prior to hospital discharge in order to support safe prescribing practices for multimorbid older adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Geriatrics & Gerontology
Jiaming Liu, Yongpei Yu, Suying Yan, Yan Zeng, Su Su, Tiantian He, Zimin Wang, Qian Ding, Ruixue Zhang, Wenchao Li, Xin Wang, Lan Zhang, Xiaolin Yue
Summary: Based on a multicenter cross-sectional study conducted in China, it was found that older patients with multimorbidity and polypharmacy have a high prevalence of medication nonadherence, and this is significantly associated with potentially inappropriate medication use. Targeted interventions can be implemented to improve medication adherence by addressing these factors.
Review
Geriatrics & Gerontology
Elizabeth Hickman, Mansha Seawoodharry, Clare Gillies, Kamlesh Khunti, Samuel Seidu
Summary: This systematic review investigates deprescribing practices and outcomes in older patients with end-of-life designation or residing in long-term care facilities with cardiometabolic conditions. Results suggest that controlled and regularly monitored deprescribing of preventive medications is feasible and beneficial in this patient population. However, further research is needed due to limited evidence and study heterogeneity to fully assess the benefits of deprescribing in this group.
Article
Pharmacology & Pharmacy
Caroline McCarthy, Michelle Flood, Barbara Clyne, Susan M. Smith, Emma Wallace, Fiona Boland, Frank Moriarty
Summary: This study evaluated changes in prescribing, potentially inappropriate prescriptions, and prescribing of low-value medicines in older people with multimorbidity and significant polypharmacy. The results showed reductions in the prescription of most drug groups, with the largest reduction observed in antiplatelet prescriptions. The median number of medication changes per person was five, highlighting the complexity of prescribing for patients with polypharmacy. Frequent medication changes could have important implications for patients in terms of adherence and medication safety.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Review
Health Care Sciences & Services
Gabriela Cajamarca, Valentina Proust, Valeria Herskovic, Rodrigo F. Cadiz, Nervo Verdezoto, Francisco J. Fernandez
Summary: This study reviewed and summarized the technologies used to support the management of multimorbidity for older adults. It found that mobile applications and websites are the most frequently used technologies by older adults, primarily for communication and connectivity purposes.
Article
Geriatrics & Gerontology
Emma L. M. Jennings, Denis O'Mahony, Paul F. Gallagher
Summary: The study assessed medication-related quality-of-life in ambulatory older adults with multi-morbidity and polypharmacy, finding no significant relationship between MRQoL-LS version 1 scores and number of chronic comorbid conditions, number of daily medications, number of potentially inappropriate medications taken daily or measured health-related QoL. The researchers concluded that MRQoL-LS version 1 is not suitable for most patients attending geriatric ambulatory services, highlighting the need for a new medication-related QoL assessment tool specifically targeting the impact of polypharmacy on QoL in multimorbid older people.
EUROPEAN GERIATRIC MEDICINE
(2022)
Article
Chemistry, Applied
Harwoko Harwoko, Georgios Daletos, Fabian Stuhldreier, Jungho Lee, Sebastian Wesselborg, Michael Feldbruegge, Werner E. G. Mueller, Rainer Kalscheuer, Elena Ancheeva, Peter Proksch
Summary: The study isolated several compounds with potential antifungal, antibacterial, and cytotoxic properties from endophytic fungi associated with ginger and willow, among which Pretrichodermamide A showed good activity against plant pathogenic fungi and human pathogenic bacteria, while Epicorazine A exhibited cytotoxicity against various cell lines. Further mechanistic studies revealed that Epicorazine A induces apoptotic cell death.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Julia S. Markl, Werner E. G. Mueller, Dayane Sereno, Tarek A. Elkhooly, Maria Kokkinopoulou, Johan Garderes, Frank Depoix, Matthias Wiens
BIOTECHNOLOGY AND BIOENGINEERING
(2020)
Article
Multidisciplinary Sciences
Michael Kosterhon, Meik Neufurth, Axel Neulen, Lea Schaefer, Jens Conrad, Sven R. Kantelhardt, Werner E. G. Mueller, Florian Ringel
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Biochemistry & Molecular Biology
Emad Tolba, Shunfeng Wang, Xiaohong Wang, Meik Neufurth, Maximilian Ackermann, Rafael Munoz-Espi, Bothaina M. Abd El-Hady, Heinz C. Schroeder, Werner E. G. Mueller
Article
Biochemical Research Methods
Emad Tolba, Xiaohong Wang, Shunfeng Wang, Meik Neufurth, Maximilian Ackermann, Heinz C. Schroeder, Werner E. G. Mueller
BIOTECHNOLOGY JOURNAL
(2020)
Review
Neurosciences
Gunter P. Eckert, Schamim H. Eckert, Janett Eckmann, Stephanie Hagl, Walter E. Muller, Kristina Friedland
EXPERIMENTAL NEUROLOGY
(2020)
Article
Microbiology
Qiang Li, Ang Song, Hui Yang, Werner E. G. Mueller
Summary: The study highlights the importance of natural recovery in restoring and rehabilitating degraded ecosystems, and contributes to the evaluation of interactions among soil-plant ecological networks.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Werner E. G. Mueller, Meik Neufurth, Shunfeng Wang, Heinz C. Schroder, Xiaohong Wang
Summary: Bleomycin (BLM) is a medication used to treat cancer, but its side effects, such as pulmonary fibrosis, can be reduced by co-administration with inorganic polyphosphate (polyP), potentially through upregulating the gene for BLM hydrolase. This study may also have implications for using BLM in COVID-19 patients, as polyP prevents the binding of SARS-CoV-2 to host cells.
Article
Dentistry, Oral Surgery & Medicine
L. A. R. Righesso, M. Terekhov, H. Goetz, M. Ackermann, T. Emrich, L. M. Schreiber, W. E. G. Mueller, J. Jung, J. P. Rojas, B. Al-Nawas
Summary: The study found that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can be used to monitor neovascularization, but does not predict bone regeneration. Blood perfusion showed potential value in evaluating the efficacy of osteoplastic materials in the experiment.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Medicine, Research & Experimental
S. A. Alkaabi, D. S. Natsir Kalla, G. A. Alsabri, A. Fauzi, A. Tajrin, W. E. G. Mueller, H. C. Schroeder, X. G. Wang, T. Forouzanfar, M. N. Helder, M. Ruslin
Summary: This study aims to evaluate the feasibility, safety, and osteoinductivity of Ca-polyP MPs as a bone-inducing graft material in humans. A prospective non-blinded first-in-man clinical pilot study of 8 alveolar cleft patients aged 13 years or older will be conducted to assess the safety and feasibility of Ca-PolyP MPs as a bone-inducing graft material, with clinical evaluation after 6 months.
Article
Biochemistry & Molecular Biology
Heinz C. Schroeder, Xiaohong Wang, Meik Neufurth, Shunfeng Wang, Rongwei Tan, Werner E. G. Mueller
Summary: Two biocatalytically produced inorganic biomaterials, bio-silica and bio-polyphosphate (bio-polyP), have shown great potential in regenerative medicine and other medical applications. Bio-silica is synthesized by a group of enzymes called silicateins, which form amorphous hydrated silica from monomeric precursors. Bio-polyP has morphogenetic activity and can induce cell differentiation, as well as provide metabolic energy through enzymatic cleavage of its high-energy phosphoanhydride bonds. Silicatein and alkaline phosphatase are key enzymes involved in the metabolism and biological activity of these materials.
Article
Biochemistry & Molecular Biology
Mousa AlTarabeen, Qosay Al-Balas, Amgad Albohy, Werner Ernst Georg Mueller, Peter Proksch
Summary: Manzamines are a group of compounds extracted from Acanthostrongylophora ingens species. We have identified and characterized seven compounds. Based on previous screening work by Mayer et al., who suggested that manzamine A could be an inhibitor of RSK1 kinase, our work focused on targeting the RSK1 N-terminal kinase domain. Docking using Autodock Vina software showed that Manzamine A N-oxide (5) exhibited the highest activity with an IC50 value of 3.1 μM.
Article
Pharmacology & Pharmacy
Shunfeng Wang, Meik Neufurth, Hadrian Schepler, Rongwei Tan, Zhending She, Bilal Al-Nawas, Xiaohong Wang, Heinz C. Schroeder, Werner E. G. Mueller
Summary: Amorphous calcium carbonate (ACC) precipitated in the presence of inorganic polyphosphate (polyP) has shown potential as a material for bone regeneration. ACC center dot PP particles, stabilized by polyP, have enzymatic activity that promotes the transformation of ACC into crystalline polymorphs. In experiments conducted in vitro and in vivo, ACC center dot PP was found to stimulate cell migration and accelerate wound healing, particularly in chronic wounds.
Article
Materials Science, Biomaterials
Werner E. G. Mueller, Meik Neufurth, Ingo Lieberwirth, Rafael Munoz-Espi, Shunfeng Wang, Heinz C. Schroeder, Xiaohong Wang
Summary: The novel mask filter mats attract, trap, and destroy viruses, with smart design capabilities.
BIOMATERIALS SCIENCE
(2021)
Review
Medicine, Research & Experimental
Hadrian Schepler, Xiaohong Wang, Meik Neufurth, Shunfeng Wang, Heinz C. Schroeder, Werner E. G. Mueller
Summary: PolyP can prevent the binding of the novel coronavirus to target cells, improve epithelial integrity and mucous barrier; in the airway system, polyP also releases metabolic energy through enzymatic hydrolysis by alkaline phosphatase.