Review
Gastroenterology & Hepatology
Elton Dajti, Leonardo Frazzoni, Veronica Iascone, Matteo Secco, Amanda Vestito, Lorenzo Fuccio, Leonardo Henry Eusebi, Pietro Fusaroli, Fernando Rizzello, Carlo Calabrese, Paolo Gionchetti, Franco Bazzoli, Rocco Maurizio Zagari
Summary: Faecal calprotectin is a reliable test with high sensitivity and specificity for distinguishing patients with inflammatory bowel disease from those with irritable bowel syndrome. It seems to have a better sensitivity in Western countries and at a cut-off of <= 50 mu g/g.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Karoline Freeman, Sian Taylor-Phillips, Brian H. Willis, Ronan Ryan, Aileen Clarke
Summary: The study aimed to estimate the test accuracy of faecal calprotectin (FC) for inflammatory bowel disease (IBD) in the primary care setting using routine electronic health records. The results showed that FC testing had high sensitivity and negative predictive values for differentiating between IBD and non-IBD, as well as between IBD and irritable bowel syndrome (IBS) at the thresholds of 50 and 100 mu g/g.
Article
Medicine, General & Internal
Gonzalo Hijos-Mallada, Raul Velamazan, Raul Marti, Eduardo Chueca, Samantha Arechavaleta, Alberto Lue, Fernando Gomollon, Angel Lanas, Carlos Sostres
Summary: The study found that using a four-biomarker point-of-care test could effectively monitor the inflammatory activity in IBD patients, with fecal calprotectin showing the best sensitivity. Patients with negative results in all four biomarkers had a 100% negative predictive value, while those with all four biomarkers positive had a 100% positive predictive value of endoscopic inflammatory activity.
Review
Medicine, General & Internal
Jin-Tong Shi, Nuo Chen, Jia Xu, Hemant Goyal, Zhi-Qi Wu, Jie-Xin Zhang, Hua-Guo Xu
Summary: Fecal calprotectin (FC) levels are correlated with the disease activity of inflammatory bowel diseases (IBD), but its usefulness in predicting IBD relapse is yet to be determined. This study aimed to evaluate the efficacy of FC in predicting IBD relapse. A total of 24 prospective studies were included in the meta-analysis, and the optimal FC cut-off value was found to be 152 μg/g. The pooled sensitivity and specificity of FC were 0.720 (0.528 to 0.856) and 0.740 (0.618 to 0.834), respectively. FC is a valuable non-invasive and cost-effective biomarker for early prediction of IBD relapse, with an ideal threshold of 152 μg/g.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Dominic King, Joht Singh Chandan, Tom Thomas, Alastair K. Denniston, Tasanee Braithwaite, Krishnarajah Niranthrankumar, Raoul Reulen, Nicola Adderley, Nigel J. Trudgill
Summary: This study evaluated the risk of subsequent inflammatory bowel diseases (IBD) in patients with ocular inflammation and found that patients with ocular inflammation have a twofold increased risk of IBD diagnosis.
Article
Gastroenterology & Hepatology
Hirotaka Shimizu, Ryo Ebana, Takahiro Kudo, Takuro Sato, Tomoko Hara, Kenji Hosoi, Masaaki Usami, Masashi Yoshida, Ichiro Takeuchi, Hiroshi Nakase, Itaru Iwama, Katsuhiro Arai, Toshiaki Shimizu
Summary: Fecal calprotectin (FCP) and fecal immunochemical test (FIT) correlate well with endoscopic activity in pediatric patients with inflammatory bowel disease (IBD), and FCP is a superior marker for predicting mucosal healing (MH).
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Ying Cao, Yibei Dai, Lingyu Zhang, Danhua Wang, Wen Hu, Qiao Yu, Xuchu Wang, Pan Yu, Weiwei Liu, Ying Ping, Tao Sun, Yiwen Sang, Zhenping Liu, Yan Chen, Zhihua Tao
Summary: The study demonstrates that in addition to fecal calprotectin, fecal Oncostatin M is a novel potential biomarker, and their combined use is more beneficial for the diagnosis of inflammatory bowel disease and prediction of infliximab therapeutic response. However, further research is needed for the evaluation of disease activity.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Dickson Kofi Wiredu Ocansey, Sanhua Hang, Xinyi Yuan, Hua Qian, Mengjiao Zhou, Chinasa Valerie Olovo, Xu Zhang, Fei Mao
Summary: The gut microbiome plays a crucial role in integrating environmental inputs, genetics, and immune signals to affect the host's metabolism and immune response. Changes in gut bacteria have been shown to be linked to gastrointestinal conditions such as inflammatory bowel disease (IBD), suggesting the potential for improving IBD diagnosis, prognosis, and treatment through manipulating the gut microbiome. Advancements in sequencing techniques have allowed for a better understanding of the complexity of the gut microbial ecosystem, and current data shows promising results in predicting IBD compared to traditional biomarkers. This study reviews the differential potential of gut bacteria within IBD cohorts and between IBD and other gastrointestinal diseases.
Article
Gastroenterology & Hepatology
Andreas Zollner, Andreas Schmiderer, Simon J. Reider, Georg Oberhuber, Alexandra Pfister, Bernhard Texler, Christina Watschinger, Robert Koch, Maria Effenberger, Tim Raine, Herbert Tilg, Alexander R. Moschen
Summary: This study demonstrated the diagnostic equivalence of FLCN2 and FCAL in inflammatory bowel diseases, with both biomarkers showing comparable sensitivity and specificity. Furthermore, mucosal overexpression of LCN2 in deep remission suggests its potential as a candidate for molecular inflammation warranting further investigation.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Emergency Medicine
Benjamin G. Hassid, Julia Wei, Dana Sax, Fernando S. Velayos
Summary: This retrospective cohort study identified multiple patient characteristics associated with higher recurrent short-term use of the emergency department for inflammatory bowel disease (IBD) care. Prompt outpatient follow-up after initial emergency department visit was not found to be protective. However, targeted interventions directed at high-risk individuals based on mood disorders, opiate use, or steroid use may help optimize care and healthcare utilization.
ACADEMIC EMERGENCY MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Eun Soo Kim, Leonid Tarassishin, Caroline Eisele, Amelie Barre, Nilendra Nair, Alexa Rendon, Kelly Hawkins, Anketse Debebe, Sierra White, Anne Thjomoe, Einar Mork, Mario Bento-Miranda, Hinaben Panchal, Manasi Agrawal, Anish Patel, Ching-Lynn Chen, Asher Kornbluth, James George, Peter Legnani, Elana Maser, Holly Loudon, Maria-Teresa Mella, Joanne Stone, Marla Dubinsky, Joao Sabino, Joana Torres, Jean-Frederic Colombel, Inga Peter, Jianzhong Hu
Summary: Pregnancy is associated with reduced inflammatory activity in mothers with IBD, however, babies born to mothers with IBD show subclinical inflammation in early life. The study findings suggest a correlation between maternal FC levels and bacterial abundance.
Article
Immunology
Jagoda Pokryszka, Angelika Wagner, Ursula Wiedermann, Selma Tobudic, Harald Herkner, Stefan Winkler, Sonja Brehovsky, Walter Reinisch, Gottfried Novacek
Summary: This study assessed the mucosal inflammatory activity in IBD patients before and after vaccination with the mRNA-1273 (Moderna) vaccine. The results showed that vaccination can cause an increase in fCP levels in some patients, and vedolizumab was the only drug associated with this increase.
Article
Pediatrics
Manar Matar, Rachel Levi, Maya Zvuloni, Raanan Shamir, Amit Assa
Summary: This study aimed to assess the effect of anti-TNF alpha therapy on fecal calprotectin (FC) levels in children with inflammatory bowel disease (IBD). The results showed that the majority of patients achieved improvement in FC levels within a short period of time, but normalization of FC in responders required almost one year. The shorter the time from diagnosis to treatment, the faster the improvement in FC levels.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Jong-Mi Lee, Joo Hee Jang, Ji Hyeong Ryu, Jaeeun Yoo, Bo-In Lee, Seung-Jun Kim, Eun-Jee Oh
Summary: This study evaluated and compared the diagnostic performance of two quantitative rapid FC assays in patients with IBD. The results showed a significant correlation between the two assays, but the test results were not interchangeable. With optimized cut-off values, rapid FC tests could be helpful in diagnosing IBD and differentiating between active and inactive disease states.
Article
Gastroenterology & Hepatology
Fang Xu, Neal DeJong, Michael D. Kappelman, Kurt J. Greenlund, Susan A. Carlson
Summary: This study aimed to investigate the attitudes of primary care professionals (PCPs) in the US towards immunization practices for patients with inflammatory bowel disease (IBD). The results showed that there is room for improvement in vaccination recommendations by PCPs, and the use of clinical tools and continuing education may help enhance the certainty of vaccine recommendation for IBD patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pediatrics
Gea A. Holtman, Yvonne Lisman-van Leeuwen, Johannes B. Reitsma, Marjolein Y. Berger
Article
Primary Health Care
Gea A. Holtman, Yvonne Lisman-van Leeuwen, Boudewijn J. Kollen, Obbe F. Norbruis, Johanna C. Escher, Angelika Kindermann, Yolanda B. de Rijke, Patrick F. van Rheenen, Marjolein Y. Berger
ANNALS OF FAMILY MEDICINE
(2016)
Article
Obstetrics & Gynecology
C. M. C. R. Panman, M. Wiegersma, B. J. Kollen, M. Y. Berger, Y. Lisman-Van Leeuwen, K. M. Vermeulen, J. H. Dekker
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2017)
Editorial Material
Urology & Nephrology
Marco H. Blanker, Inge Bouwman, Maarten Voskamp, Yvonne Lisman-Van Leeuwen
Article
Primary Health Care
Gea A. Holtman, Justin J. Kranenberg, Marco H. Blanker, Alewijn Ott, Yvonne Lisman-van Leeuwen, Marjolein Y. Berger
Article
Primary Health Care
Gea A. Holtman, Yvonne Lisman-van Leeuwen, Patrick F. van Rheenen, Boudewijn J. Kollen, Johanna C. Escher, Angelika Kindermann, Yolanda B. de Rijke, Marjolein Y. Berger
Article
Gastroenterology & Hepatology
Anke Heida, Gea A. Holtman, Yvonne Lisman-van Leeuwen, Marjolein Y. Berger, Patrick F. van Rheenen
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2016)
Article
Primary Health Care
Marian J. van den Brink, Anne Linde Saaltink, Feikje Groenhof, Boudewijn J. Kollen, Marjolein Y. Berger, Yvonne Lisman-van Leeuwen, Janny H. Dekker
Article
Geriatrics & Gerontology
Marian Wiegersma, Chantal M. C. R. Panman, Boudewijn J. Kollen, Marjolein Y. Berger, Yvonne Lisman-van Leeuwen, Janny H. Dekker
Article
Pediatrics
Gea A. Holtman, Yvonne Lisman-van Leeuwen, Andrew S. Day, Ulrika L. Fagerberg, Paul Henderson, Stevan T. Leach, Gori Perminow, David Mack, Patrick F. van Rheenen, Els van de Vijver, David C. Wilson, Johannes B. Reitsma, Marjolein Y. Berger
Article
Pediatrics
Jojanneke J. G. T. van Summeren, Gea A. Holtman, Yvonne Lisman-van Leeuwen, Lisa E. A. M. Louer, Alice H. C. van Ulsen-Rust, Karin M. Vermeulen, Boudewijn J. Kollen, Janny H. Dekker, Marjolein Y. Berger
Article
Multidisciplinary Sciences
Gea A. Holtman, Yvonne Lisman-van Leeuwen, Boudewijn J. Kollen, Obbe F. Norbruis, Johanna C. Escher, Laurence C. Walhout, Angelika Kindermann, Yolanda B. de Rijke, Patrick F. van Rheenen, Marjolein Y. Berger
Review
Medicine, General & Internal
Henk van der Worp, Petra Jellema, Ilse Hordijk, Yvonne Lisman-van Leeuwen, Lisa Korteschiel, Martijn G. Steffens, Marco H. Blanker
Article
Pediatrics
Jojanneke J. G. T. van Summeren, Gea A. Holtman, Boudewijn J. Kollen, Yvonne Lisman-van Leeuwen, Alice H. C. Van Ulsen-Rust, Merit M. Tabbers, Janny H. Dekker, Marjolein Y. Berger
JOURNAL OF PEDIATRICS
(2020)
Article
Primary Health Care
Jojanneke J. G. T. van Summeren, Gea A. Holtman, Yvonne Lisman-van Leeuwen, Alice H. C. van Ulsen-Rust, Karin M. Vermeulen, Merit M. Tabbers, Boudewijn J. Kollen, Janny H. Dekker, Marjolein Y. Berger
Summary: This study evaluated the cost-effectiveness of adding physiotherapy to conventional treatment for children with functional constipation. The results showed that adding physiotherapy as first-line treatment for all children with FC is not cost-effective compared with conventional treatment alone.