Article
Plant Sciences
Madiha Zaynab, Jiaofeng Peng, Yasir Sharif, Mohammed Albaqami, Rashid Al-Yahyai, Mahpara Fatima, Muhammad Azhar Nadeem, Khalid Ali Khan, Saqer S. Alotaibi, Ibrahim A. Alaraidh, Hassan O. Shaikhaldein, Shuangfei Li
Summary: This study conducted a comprehensive analysis of DDP proteins in the potato genome, identifying 10 DDP genes and studying their characteristics in terms of phylogenetics, gene duplication, expression profiles, and promoter regions involved in stress response. The research revealed that StDDP genes were distributed across different clades, and exhibited various expression patterns in response to heat stress and salt stress. Real-time qPCR results indicated that StDDPs played significant roles in potato growth and development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Shibei Tan, Yanqiong Liang, Yanlei Huang, Jingen Xi, Xing Huang, Xiaohan Yang, Kexian Yi
Summary: This study identified 19 NPF genes in Agave and investigated their expression patterns in different tissues, developmental stages, and under various stresses and nutrient deficiencies. Several potential regulators in the agave NPF family were identified.
Article
Fisheries
Jose Carlos Campos-Sanchez, Javier Mayor-Lafuente, Daniel Gonzalez-Silvera, Francisco A. Guardiola, Maria Angeles Esteban
Summary: The study evaluated the expression of inflammation-related genes in fish skin injected with carrageenin, finding it to be a good stimulator for studying skin inflammation in gilthead seabream. This method could potentially be used to study the modulation of fish inflammatory processes caused by internal or external factors.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xuejiao Liu, Feiyan Yu, Guiyan Yang, Xiaoqiang Liu, Shaobing Peng
Summary: This study identified twenty-one TIFY transcription factors in the walnut genome, divided into four subfamilies by bioinformatics analysis. Chromosome location revealed tandem duplication of some genes. Phylogenetic tree analysis showed JrTIFYs were closely related to the TIFY gene family of Arabidopsis thaliana. qRT-PCR analysis revealed different expression patterns of TIFY genes in 'Qingxiang' and 'Xiangling' walnut varieties under drought, heat, and salt stress. JAZ subfamily showed higher expression in different abiotic stress conditions, with JrTIFY14 significantly higher under heat and salt stress than under drought stress.
Article
Agronomy
Binqi Li, Muhammad Moaaz Ali, Tianxin Guo, Shariq Mahmood Alam, Shaista Gull, Junaid Iftikhar, Ahmed Fathy Yousef, Walid F. A. Mosa, Faxing Chen
Summary: In this study, 21 putative SWEET genes were identified and characterized from the loquat genome. Comprehensive bioinformatics analysis revealed the physicochemical properties, gene organization, conserved motifs, and phylogenetic relationships of the EjSWEET genes. The expression patterns of EjSWEET genes in different tissues of loquat were also analyzed. The study provides a foundation for further functional analysis of the SWEET gene family in loquat.
Article
Genetics & Heredity
Jiaojiao Lu, Lianwei Qu, Guimei Xing, Zhenlei Liu, Xiaochun Lu, Xiaori Han
Summary: This study identified 32 MADS-box transcription factor family members in tulips and analyzed their structures and expression patterns. The results showed that some TgMADS genes were significantly upregulated under cold conditions, indicating their potential involvement in the cold response of tulips.
Article
Plant Sciences
Waqar Khan, Ahmed M. El-Shehawi, Fayaz Ali, Murad Ali, Mohammed Alqurashi, Mohammed M. Althaqafi, Siraj B. Alharthi
Summary: Laccase-like multi-copper oxidases (LMCOs) are enzymes that oxidize various substrates by linking four-electron reduction of O-2 to water. They have practical applications in biology. The study investigated the LMCO gene family (Br-Lac) and identified 18 members located on five chromosomes. Phylogenetic analysis classified the genes into seven groups. Certain genes in the family responded positively to abiotic stresses. The study provides important insights into the functional diversity of LMCO genes in B. rapa.
Article
Fisheries
Mika Watanabe, Yo Okamura, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: This study analyzed the functional significance of IL-22 in fish gills and found that IL-22 may be involved in immune responses through the production of inflammatory cytokines and antimicrobial peptides in fish gills.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Plant Sciences
Mingming Liu, Ke Li, Shichao Sheng, Mingyu Wang, Panpan Hua, Yanfang Wang, Ping Chen, Kangyu Wang, Mingzhu Zhao, Yi Wang, Meiping Zhang
Summary: This study investigated the MYB transcription factor family in ginseng and identified PgMYB transcripts in Jilin ginseng. The results showed that PgMYB transcripts were classified into different functional subclasses and exhibited spatiotemporally specific expression patterns. Some of these transcripts may be related to salt resistance in ginseng.
Article
Plant Sciences
Li Li, Boxin Lv, Kaiyou Zang, Yue Jiang, Chaofan Wang, Yanfang Wang, Kangyu Wang, Mingzhu Zhao, Ping Chen, Jun Lei, Yi Wang, Meiping Zhang
Summary: The PgHDZ gene family was identified and analyzed systematically in ginseng. Five potential hub genes were identified, and four of them were shown to be involved in ginseng response to environmental pH stress. These results provide new insights into the characteristics, diversity, evolution, and functionality of the PgHDZ gene family in ginseng and lay a foundation for comprehensive research of the gene family in plants.
Article
Plant Sciences
Xian Zhang, Lantian Zhang, Yuyu Chen, Siyi Wang, Yunxia Fang, Xiaoqin Zhang, Yuhuan Wu, Dawei Xue
Summary: The study conducted bioinformatics research and expression analysis of the SOD gene family in barley under drought and salt stress, identifying key genes HvCSD1, HvCSD4, and HvFSD1 for further research due to significant expression changes after stress treatment. These findings lay the foundation for studying gene function and improving drought and salt tolerance through genetic breeding in barley.
PLANT GROWTH REGULATION
(2021)
Article
Biotechnology & Applied Microbiology
Quanchao Wang, Tiangui Cao, Chunde Wang
Summary: In this study, bioinformatics methods were used to identify and analyze Dmrt genes in 15 bivalves, resulting in the retrieval of 55 Dmrt genes. The phylogenetic tree showed that these genes can be divided into 5 classes. The Ka/Ks ratios suggested that these genes underwent purifying selection pressure. Additionally, the spatiotemporal expression analysis indicated that different Dmrt genes may have different functions, and scallop-specific Dmrt genes may play a key role in sex determination/differentiation. Overall, this study provides a molecular basis for further investigation of the functions of Dmrt genes and phylogenomic analyses in bivalves.
Article
Plant Sciences
Areeqa Shamshad, Muhammad Rashid, Qamar uz Zaman
Summary: In this study, 25 randomly dispersed HSF genes with significant DNA binding domains were identified in the rice genome. Gene structural analysis revealed that all members of the OsHSF family share 10 identical amino acid sequences. Rice HSF family genes are widely distributed in vegetative organs and exhibit high levels of expression in reproductive tissues. Tandem duplication and repetition may have contributed to the development of novel genes in the rice genome. OsHSFs play a significant role in gene expression regulation, regulation in primary metabolism, and tolerance to environmental stress, according to gene networking analyses.
Article
Microbiology
Yang Yang, Frederick Leo Sossah, Zhuang Li, Kevin D. Hyde, Dan Li, Shijun Xiao, Yongping Fu, Xiaohui Yuan, Yu Li
Summary: This study conducted a comprehensive analysis of GH18 genes in Mycogone perniciosa, identifying 23 differentially expressed genes. The findings contribute to understanding M. perniciosa mycoparasitism of Agaricus bisporus and offer a foundation for further research.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Ibrahim Khan, Sikandar Khan, Yong Zhang, Jianping Zhou
Summary: Exhaustive searches of the rice genome revealed 30 potential OsDof genes, with analyses conducted on their subcellular localization, phylogenetic relationship, conserved motifs, chromosomal allocation, expression patterns, and interaction networks. The Dof proteins in rice were found to be distributed into 4 groups, showing significant variances in expression levels across tissues and developmental stages. Protein-protein correlation network analysis indicated potential overlapping functions and co-expression among some OsDofs, providing insights for further studies and development of high-quality rice varieties.
Article
Cell Biology
Hend Alnafea, Brett Vahkal, C. Kellie Zelmer, Sergey Yegorov, Jan Bogerd, Sara V. Good
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Immunology
Ronald Moses Galiwango, Sergey Yegorov, Vineet Joag, Jessica Prodger, Kamnoosh Shahabi, Sanja Huibner, Enoch Muyanja, Brian Roy Kabuubi, Annmarie Namuniina, Annet Nalutaaya, Aloysius Ssemaganda, Fredrick Lutwama, Paul Kato Kitandwe, Annet Nanvubya, Juliet Mpendo, Bernard Bagaya, Noah Kiwanuka, Rupert Kaul
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2019)
Article
Endocrinology & Metabolism
Brett Vahkal, Sergey Yegorov, Chukwunonso Onyilagha, Jacqueline Donner, Dean Reddick, Anuraag Shrivastav, Jude Uzonna, Sara V. Good
Summary: INSL5-RXFP4 may play a novel role in both central and peripheral immune cell signaling, as indicated by the expression patterns in immune organs and the immune-associated transcription factors. Systemic effects show elevated metabolic peptides and altered cytokine expression following INSL5 injection, while immune cell effects demonstrate changes in cytokine levels and cell growth. Overall, these findings suggest a potential link between INSL5-RXFP4 and immune system regulation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Nisha Ajmani, Tamanna Yasmin, Margaret F. Docker, Sara Good
Summary: Sequencing and analysis of the somatic and germline genomes of lampreys have provided insights into the genetic basis of gonadal differentiation. Differential gene expression and pathways associated with gonadal development were identified between stages and sexes, with potential implications for morphological changes and sexual maturity. This study lays the groundwork for further research on the orthology and function of genes involved in gonadal development in lamprey species.
G3-GENES GENOMES GENETICS
(2021)
Article
Biology
Tamanna Yasmin, Phil Grayson, Margaret F. Docker, Sara V. Good
Summary: RNA-sequencing of sea lamprey gonads at different life-history stages identifies germline-specific genes that are highly expressed in males during spermatogenesis, suggesting a link between male-biased germline expression and sex differentiation in the sea lamprey.
COMMUNICATIONS BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Assem Ashimova, Askhat Myngbay, Sergey Yegorov, Baurzhan Negmetzhanov, Irina Kadyrova, Angelina Yershova, Ulpan Kart, Matthew S. Miller, Gonzalo Hortelano
Summary: This study demonstrates the feasibility of using a capsule-based cell system for the delivery of intact SARS-CoV-2 mAb, with potential therapeutic applications.
Review
Microbiology
Nurlan Sandybayev, Vyacheslav Beloussov, Vitaliy Strochkov, Maxim Solomadin, Joanna Granica, Sergey Yegorov
Summary: The COVID-19 pandemic has led to increased interest in understanding the complete repertoire of viruses - the virome - in both health and disease, particularly in infectious respiratory diseases. Next-generation sequencing (NGS) is commonly used to study microorganisms, but the lack of standardization in methodological approaches and result processing formats is a challenge.
Article
Multidisciplinary Sciences
Nurlan Sandybayev, Vyacheslav Beloussov, Vitaliy Strochkov, Maxim Solomadin, Joanna Granica, Sergey Yegorov
Summary: This pilot study investigated the etiological causes of respiratory tract infections (RTI) among adults during a low COVID-19 transmission period in 2021. The results showed that COVID-19 accounted for a small proportion of symptomatic RTI, while common community respiratory viruses, such as hPIV and hRV, were more prevalent. Therefore, the clinical management and prevention of adult RTI in the post-pandemic era should consider respiratory viruses other than SARS-CoV-2.
Article
Multidisciplinary Sciences
Anar Turmukhambetova, Sergey Yegorov, Ilya Korshukov, Valentina Barkhanskaya, Svetlana Kolesnichenko, Dmitriy Klyuyev, Zhibek Zhumadilova, Aruzhan Pralieva, Laylim Absaghit, Ruslan Belyaev, Dmitriy Babenko, Gonzalo H. Hortelano, Matthew S. Miller, Dmitriy Vazenmiller, Irina Kadyrova
Summary: COVID-19 vaccines can lead to rare but severe thrombotic events. This study showed a significant increase in circulating endothelin-1 (ET-1) levels after the first dose of Gam-Covid-Vac, an adenoviral vectored COVID-19 vaccine, which was sustained after the second dose. Prior COVID-19 exposure and vaccination were associated with mild increases in plasminogen activator inhibitor (PAI) levels after the first dose. Elevated ET-1 levels persisted up to day 21 after the second dose, while other biomarkers, including platelet factor 4 IgG antibody, did not show significant changes.
Article
Cell Biology
Sergey Yegorov, Daniel B. Celeste, Kimberly Braz Gomes, Jann C. Ang, Colin Vandenhof, Joanne Wang, Ksenia Rybkina, Vanessa Tsui, Hannah D. Stacey, Mark Loeb, Matthew S. Miller
Summary: This study describes the significant boosting of a durable bNAb response through repeated seasonal influenza vaccination in a pediatric cohort. The boosting of serological bNAb titers is comparable within inactivated and live attenuated vaccinees and declines with age.
CELL REPORTS MEDICINE
(2022)
Article
Health Care Sciences & Services
Sergey Yegorov, Maiya Goremykina, Raifa Ivanova, Sara Good, Dmitriy Babenko, Alexandr Shevtsov, Kelly S. MacDonald, Yersin Zhunussov
Summary: In Kazakhstan, older age, comorbidities, elevated white blood cell count, and male sex were identified as risk factors for COVID-19 severity and mortality. The SARS-CoV-2 diversity in the region suggests multiple importations and community-level spread before travel restrictions were imposed.
LANCET REGIONAL HEALTH-EUROPE
(2021)
Article
Multidisciplinary Sciences
Nicholas P. DeAdder, Hannah J. Gillam, Brian C. Wilson
Summary: The study showed that H2 and H3 relaxin treatments have a protective effect on cell death caused by oxygen and glucose deprivation, with the effect of H3 relaxin being partially attenuated by L-NIL, and antagonism of RXFP3 affecting the action of H3 relaxin.
Review
Public, Environmental & Occupational Health
Sergey Yegorov, Vineet Joag, Ronald M. Galiwango, Sara V. Good, Brenda Okech, Rupert Kaul
TROPICAL DISEASES TRAVEL MEDICINE AND VACCINES
(2019)
Article
Nutrition & Dietetics
Sergey Yegorov, Sabri Bromage, Ninjin Boldbaatar, Davaasambuu Ganmaa
FRONTIERS IN NUTRITION
(2019)