The anxiolytic effects of a Valerian extract is based on Valerenic acid

Valerian extract characterized by high valerenic acid and low acetoxy valerenic acid contents demonstrates anxiolytic activity

(2012) F. Felgentreff et al.   PHYTOMEDICINE

Pharmacokinetics of Valerenic Acid in Rats after Intravenous and Oral Administrations

(2012) Chethan Sampath et al.   PLANTA MEDICA

The GABAA Receptor  + - Interface: A Novel Target for Subtype Selective Drugs

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Effects of GABA-transaminase inhibitor Vigabatrin on thermoregulation in rats

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Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands -in vitro and in vivo characterization

(2010) S Khom et al.   BRITISH JOURNAL OF PHARMACOLOGY

Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats

(2009) K. Murphy et al.   PHYTOMEDICINE

GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts

(2008) Dietmar Benke et al.   NEUROPHARMACOLOGY

International Union of Pharmacology. LXX. Subtypes of  -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

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Modulation of GABAA Receptors by Valerian Extracts is Related to the Content of Valerenic Acid

(2008) Gabriele Trauner et al.   PLANTA MEDICA