Article
Pharmacology & Pharmacy
Nanang Rudianto Ariefta, Baldorj Pagmadulam, Coh-ichi Nihei, Yoshifumi Nishikawa
Summary: This study evaluated the growth-inhibitory effects of the antimalarial agent sparsomycin against drug-resistant malaria parasites. The results showed that sparsomycin had inhibitory effects on both sensitive and resistant strains of the parasites. This study suggests that sparsomycin has potential as an alternative treatment for malaria.
Article
Chemistry, Medicinal
Preeti Singh, Chiranjeev Sharma, Bhawana Sharma, Anupam Mishra, Drishti Agarwal, Deepika Kannan, Jana Held, Shailja Singh, Satish K. Awasthi
Summary: This study reports a rapid method for synthesizing N-sulfonylpiperidine dispiro-1,2,4,5-tetraoxane analogs for antimalarial research. The synthesized compounds were characterized and evaluated for their in vitro and in vivo antimalarial activities.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Sakaewan Ounjaijean, Voravuth Somsak
Summary: This study evaluated the antimalarial potential of combination dihydroartemisinin (DHA) and Gymnema inodorum leaf extract (GIE) therapy against Plasmodium berghei in a mouse model. The results showed that the 60/40 ratio of DHA and GIE demonstrated significantly higher antimalarial activity and enhanced the antimalarial effects of DHA.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Pharmacology & Pharmacy
Toshihiro Mita, Makoto Hirai, Yoshiko Maki, Saifun Nahar, Naoko Yoshida, Yoshiteru Oshima, Haruhisa Kikuchi, Yuzuru Kubohara
Summary: The study showed that DIF-1 and its derivatives have strong inhibitory effects on the growth of Plasmodium falciparum, including strains resistant to chloroquine and artemisinin. Among them, DIF-1(+2) exhibited the strongest inhibitory effect and was effective against 12 field isolates. In in vivo experiments in mice, DIF-1(+2) at certain doses effectively suppressed parasite growth without apparent adverse effects, and significantly prolonged animal survival.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Johnson Adejoh, Bassey A. Inyang, Maxwell O. Egua, Kenneth C. Nwachukwu, Lukman A. Alli, Michael P. Okoh
Summary: The study evaluated the anti-plasmodial activity of the ethanol extract of the strain against Plasmodium berghei-infected mice, demonstrating its potential as an anti-malarial agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Pedro H. S. Pereira, Celia R. S. Garcia
Summary: Malaria is a global infectious disease, affecting a large population at risk of infection. Research suggests that interference with the coordinated infection of malaria parasites in red blood cells can help the human immune system resist infection.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Plant Sciences
Clarice Noussi Djouwoug, Raceline Kamkumo Gounoue, Florence Tsofack Ngueguim, Jaures Marius NankapTsakem, Clemence Donfack Gouni, Antoine Cavaye Kandeda, Silvere Ngouela, Bruno Ndjakou Lenta, Nobert Sewald, Fabrice Boyom Fekam, Theophile Dimo
Summary: The hydroethanolic extract of Bridelia atroviridis demonstrated good antiplasmodial activity with low toxicity, preventing anemia, leukocytosis, and organ impairment. It also showed potential anti-inflammatory and antioxidant properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Emmanuel O. Adeyoju, Clement O. Ajayi, Awodayo O. Adepiti, Anthony A. Elujoba
Summary: This study compared the antimalarial activity of methanol and water extracts of MAMA Powder against Plasmodium berghei-infected mice, finding that the water extract exhibited higher efficacy and can be optimized for chloroquine-resistant malaria, aiding in the production of various dosage forms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Microbiology
Heledd Davies, Baerbel Bergmann, Philipp Walloch, Cornelius Nerlich, Christian Hansen, Sergio Wittlin, Tobias Spielmann, Moritz Treeck, Eric Beitz
Summary: Malaria parasites in the blood stage release l-lactate/H+ through a single transmembrane transport protein. This transporter belongs to the microbial formate-nitrite transporter (FNT) family and is a potential drug target.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Zekarias Zeleke Zamba, Ali Shemsedin Reshad
Summary: The study optimized the synthesis of fatty acid methyl esters from Croton macrostachyus kernel oil using response surface methodology, resulting in the conversion of 95.03% of the oil into mono FAMEs under the best conditions.
Article
Multidisciplinary Sciences
Laughing Bear Torrez Dulgeroff, Miranda S. Oakley, Michal C. Tal, Ying Ying Yiu, Joy Q. He, Maia Shoham, Victoria Majam, Winter A. Okoth, Pallavi Malla, Sanjai Kumar, Irving L. Weissman
Summary: CD47 is an antiphagocytic signal that inhibits programmed cell removal of self. Blocking CD47 can significantly improve the therapeutic effect against malaria infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Fidelia Ijeoma Uche, Xiaozhen Guo, Jude Okokon, Imran Ullah, Paul Horrocks, Joshua Boateng, Chenggang Huang, Wen-Wu Li
Summary: This study investigates the in vitro and in vivo antiplasmodial activities of BBIQ alkaloids and their analogues, showing promising results with significant anti-parasitic effects at low concentrations. Cycleanine and its semisynthetic analogues demonstrate improved potency and selectivity, with potential as leads for further drug development.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Fernanda Valerio Lopes, Pedro Henrique Fazza Stroppa, Juliane Aparecida Marinho, Roberta Reis Soares, Lara de Azevedo Alves, Priscila Vanessa Zabala Capriles Goliatt, Clarice Abramo, Adilson David da Silva
Summary: This study evaluated the antimalarial activity of triazole derivatives, with compound 5 showing promising potential for further development in antimalarial chemotherapy. In vitro and in vivo studies showed that compound 5 had significant parasitemia suppression and minimal cytotoxicity, making it a leading candidate for future research in antimalarial drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Food Science & Technology
Zeca M. Salimo, Andre L. Barros, Asenate A. X. Adriao, Aline M. Rodrigues, Marco A. Sartim, Isadora S. de Oliveira, Manuela B. Pucca, Djane C. Baia-da-Silva, Wuelton M. Monteiro, Gisely C. de Melo, Hector H. F. Koolen
Summary: Malaria is a global public health problem caused by Plasmodium spp. and transmitted by female mosquitoes. Drug therapies and vector control are commonly used methods, but drug resistance is a challenge. Animal venoms have potential as a source for new antimalarial molecules. This review summarizes antimalarial toxins from animal venoms.
Article
Pharmacology & Pharmacy
Chukwuebuka Emmanuel Umeyor, Ifunanya Okoye, Emmanuel Uronnachi, Tochukwu Okeke, Franklin Kenechukwu, Anthony Attama
Summary: The study evaluated the potential of miconazole (MNZ) as an alternative antimalarial agent by embedding MNZ in nanostructured lipid carriers (NLC). The MNZ-loaded NLC showed a controlled release effect with high encapsulation efficiency and demonstrated good in vitro and in vivo antimalarial activities. Stability testing indicated that MNZ could be repurposed as an effective alternative for the treatment of malaria.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)