Article
Biochemistry & Molecular Biology
Yanping Zhao, Nana Tian, Hongjun Wang, Hong Yan
Summary: Sulfated modifications of Agaricus blazei Murill (AbM) polysaccharides have shown strong anti-HIV properties, making them promising candidates for biomedical applications in HIV/AIDS treatment.
CHEMISTRY & BIODIVERSITY
(2021)
Article
Chemistry, Applied
Zhongqiu Hu, Yuanxi Yao, Meng Lv, Yiqian Zhang, Lin Zhang, Yahong Yuan, Tianli Yue
Summary: Selenoproteins PR-Se-1, PR-Se-2, and PR-Se-3 were isolated from Agaricus blazei Murrill (ABM) and identified as isoenzymes of isocitrate dehydrogenase, dihydrolipoyl dehydrogenase, and n-proline reductase, respectively. ABM is a promising source of selenium in selenium-poor regions, with organic selenium comprising about 81% of its total selenium content.
Article
Biochemistry & Molecular Biology
Matheus Morais Saraiva, Matheus da Silva Campelo, Joao Francisco Camara Neto, Maria Leonia da Costa Gonzaga, Maria do Socorro Rocha Bastos, Sandra de Aguiar Soares, Nagila Maria Pontes Silva Ricardo, Gilberto Santos Cerqueira, Renata Ferreira de Carvalho Leita, Maria Elenir Nobre Pinho Ribeiro
Summary: This study investigated the potential of polysaccharides from Agaricus blazei Murill mushroom (PAbs) as wound dressings. The results showed that PAbs had no significant impact on the viability of human neutrophils in a concentration range of 1-100 μg mL-1. Moreover, PAbs improved the mechanical properties, thickness, and water vapor permeation of the films, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Matheus da Silva Campelo, Cecilia Brilhante Araga, Izabell Maria Martins Teixeira, Erlania Alves de Siqueira, Carlos Jose Alves da Silva-Filho, Nagila Maria Pontes Silva Ricardo, Sandra de Aguiar Soares, Cristiani Lopes Capistrano Goncalves de Oliveira, Celli Rodrigues Muniz, Francisco Geraldo Barbosa, Jair Mafezoli, Tiago Lima Sampaio, Maria Elenir Nobre Pinho Ribeiro
Summary: Pentacyclic triterpene-loaded emulsions were stabilized using polysaccharides from Agaricus blazei Murill mushroom (PAb). Compatibility tests showed no physicochemical incompatibilities between the drug and excipient. The addition of PAb at 0.75% resulted in stable emulsions with small droplet size, moderate polydispersity, and high zeta-potential. Encapsulation of the drug in PAb-stabilized emulsions improved its cytocompatibility against PC12 and murine astrocyte cells, reducing cytotoxicity and maintaining mitochondrial function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Hatem Salama Ali, Ahmed Noah Badr, Tawfiq Alsulami, Mohamed Gamal Shehata, Mohamed Mahmoud Youssef
Summary: This study aimed to improve the quality and safety of tahini products by combating microbial hazards and mycotoxins. The results showed that fortifying tahini with Agaricus blazei can increase protein, fiber, and bioactive content, as well as exhibit antimicrobial and antioxidant properties. The fortified samples also demonstrated better emulsion and oxidative stability. Moreover, the fortification process effectively eliminated bacteria and degraded mycotoxins during storage.
Article
Food Science & Technology
Wenshuai Wang, Min Liu, Mengyu Zhang, Wenxue Sun, Jianjun Zhang, Le Jia
Summary: The study evaluated the protective effects of Agaricus blazei Murill polysaccharides (ABMP) on liver and lung in MODS mice induced by zymosan. Results showed that ABMP improved the survival rate, alleviated abnormal physiological behavior, and reduced tissue oxidative stress in MODS mice. Additionally, ABMP inhibited the activation of NF-kappa B signaling pathway and decreased the expressions of inflammatory cytokines.
Article
Food Science & Technology
Yukun Zhang, Feng Lu, Hang Zhang, Yuwei Ye, Penghu Liu, Dongmei Lin, Hong Zhou, Min Li, Baoxue Yang
Summary: This study investigated the therapeutic effect of Agaricus blazei Murrill polysaccharides (ABP) and selenium-enriched Agaricus blazei Murrill polysaccharides (ABP-Se) on ulcerative colitis (UC) using a mouse model. The results showed that both ABP and ABP-Se alleviated UC symptoms and improved colonic barrier functions, while reducing inflammation and oxidative stress.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Plant Sciences
Joao Francisco Camara Neto, Matheus da Silva Campelo, Gilberto Santos Cerqueira, Joao Antonio Leal de Miranda, Jhonyson Arruda Carvalho Guedes, Raimundo Rafael de Almeida, Sandra de Aguiar Soares, Nilce Viana Gramosa, Guilherme Juliao Zocolo, Icaro Gusmao Pinto Vieira, Nagila Maria Pontes Silva Ricardo, Maria Elenir Nobre Pinho Ribeiro
Summary: This study aimed to characterize the chemical profile of Agaricus blazei Murill extract and evaluate its gastroprotective effect. The results showed that the extract had antioxidant activity and could protect the gastric mucosa.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Zhong-Hao Ji, Song He, Wen-Yin Xie, Pei-Sen Zhao, Wen-Zhi Ren, Wei Gao, Bao Yuan
Summary: The study found that Agaricus blazei Murrill polysaccharide (ABP) has protective effects against DSS-induced acute colitis. ABP significantly reduces colitis symptoms, inflammatory responses, and oxidative stress, while maintaining intestinal barrier integrity and improving gut microbiota disruption and metabolic abnormalities.
Article
Entomology
Uros Glavinic, Jevrosima Stevanovic, Marko Ristanic, Milan Rajkovic, Dajana Davitkov, Nada Lakic, Zoran Stanimirovic
Summary: Nosemosis is a disease in bees that severely affects their vitality, reproduction, and productivity. Treatment traditionally involves the use of the antibiotic fumagillin, but recent issues with its production and registration have led to a search for alternative non-antibiotic treatments. Scientists globally are seeking medication or supplements to control Nosema, with a focus on natural extracts such as from the Agaricus blazei mushroom.
Article
Food Science & Technology
Wenxiu Yuan, Maotuan Huang, Yange Wu, Jiaqi Liu, Xueman Zhou, Jun Wang, Jin Liu
Summary: This study demonstrates the role of Agaricus blazei Murrill polysaccharide (ABMP) in regulating autophagy and attenuating periodontitis. ABMP enhances autophagy and reduces inflammation, leading to improved symptoms of periodontitis. These findings suggest the potential application of ABMP in the treatment of periodontitis and other autophagy-related diseases.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Food Science & Technology
Kaiyuan Huang, Hesham R. El-Seedi, Baojun Xu
Summary: This study comprehensively summarizes the chemical composition of Agaricus blazei Murrill (AbM) and thoroughly characterizes its health promotion effects such as antitumor and antidiabetic impacts. AbM is composed of abundant bioactive substances including polysaccharides, lipids, proteins, and vitamins. Research has shown that AbM polysaccharides have immunoregulation, anti-inflammatory, hepato-protective, and antitumor functions. Furthermore, AbM extracts are believed to have potential in treating diabetes and bacterial infections, as well as exhibiting anticarcinogenic and antimutagenic functions. However, some of the mechanisms behind these health promotion effects remain unclear, and there is a need for further clinical trials.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Chemistry, Applied
Dusanka A. Popovic Minic, Danijel D. Milincic, Stefan Kolasinac, Vladislav Rac, Jovana Petrovic, Marina Sokovic, Nebojsa Banjac, Jelena Ladarevic, Bojana B. Vidovic, Aleksandar Z. . Kostic, Vladimir B. Pavlovic, Mirjana B. Pesic
Summary: This study aimed to investigate mixtures of goat milk proteins and Agaricus blazei Murrill (ABM) extracts (aqueous, AE and polysaccharides, PE). The mixtures exhibited stable particles with a highly negative zeta-potential (-41.1 mV). The addition of ABM extracts to heated goat milk resulted in a significant increase in mean particle size, while no significant change was observed with non-heated milk. Fourier Transform Infrared Spectroscopy (FTIR) revealed changes in the secondary structure of milk proteins and interactions between ABM extracts and milk proteins via hydrogen and/or glycoside bonds and hydrophobic interactions. The presence of ABM extracts also led to the formation of new polypeptides in the milk protein profiles.
Article
Biochemistry & Molecular Biology
Ruirui Yu, Xiaojian Li, Peng Yi, Ping Wen, Shuhong Wang, Chenghui Liao, Xun Song, Haiqiang Wu, Zhendan He, Chenyang Li
Summary: This study explores the antifungal properties of Agaricus blazei Murrill and identifies six compounds that show significant inhibition against different pathogenic fungi.
Article
Engineering, Marine
Po-Tsang Lee, Yu-Sheng Wu, Chung-Chih Tseng, Jia-Yu Lu, Meng-Chou Lee
Summary: This study evaluated the effects of feeding Nile tilapia with spent mushroom substrate from Agaricus blazei. The results showed that the substrate enhanced the immune activity of the fish and protected them against Streptococcus agalactiae infection. This study provides a new direction for the development of more effective feed additives.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)