Article
Plant Sciences
Paula Schons Vieceli, Paulo Jose Lima Juiz, Pedro Santana Sales Lauria, Ricardo David Couto, Therezinha Coelho Barbosa Tomassini, Ivone Maria Ribeiro, Milena Botelho Pereira Soares, Cristiane Flora Villarreal
Summary: Physalis angulata has been widely used in folk medicine for treating inflammatory conditions, including oral inflammatory diseases. The ethanolic extract of P. angulata showed protective effects in a murine model of chronic periodontitis, potentially through modulation of cytokines and inhibition of NF-?B transcriptional activity.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hannah L. L. Smith, Juliet C. C. Gray, Stephen A. A. Beers, Janos M. M. Kanczler
Summary: Osteosarcoma, a bone cancer typically found in adolescents, is closely related to the conversion of bone marrow during adolescence. This study compared the differentiation potential of bone marrow cells from different regions with osteosarcoma cell lines. The results showed distinct differences in the differentiation abilities of hematopoietic and adipocyte-rich bone marrow, which correlated with specific characteristics of the osteosarcoma cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Romeu da Silva Leite, Marilza Neves do Nascimento, Alismario Leite da Silva, Robson de Jesus Santos
Summary: The study evaluated the use of SNP, H2O2, and Pro as potential chemical priming inducing agents in Physalis angulata plants exposed to water deficit, showing that pretreated plants exhibited significant improvements in water deficit conditions.
SCIENTIA HORTICULTURAE
(2021)
Article
Multidisciplinary Sciences
Thomas H. Ambrosi, Owen Marecic, Adrian McArdle, Rahul Sinha, Gunsagar S. Gulati, Xinming Tong, Yuting Wang, Holly M. Steininger, Malachia Y. Hoover, Lauren S. Koepke, Matthew P. Murphy, Jan Sokol, Eun Young Seo, Ruth Tevlin, Michael Lopez, Rachel E. Brewer, Shamik Mascharak, Laura Lu, Oyinkansola Ajanaku, Stephanie D. Conley, Jun Seita, Maurizio Morri, Norma F. Neff, Debashis Sahoo, Fan Yang, Irving L. Weissman, Michael T. Longaker, Charles K. F. Chan
Summary: Aging of skeletal stem cells in mice alters bone marrow signaling and differentiation of bone and blood lineages, resulting in fragile bones with poor regeneration. Aged SSCs have decreased bone-forming potential but produce more stromal lineages expressing pro-inflammatory cytokines, contributing to bone marrow niche transformation.
Article
Immunology
Rene Reitermaier, Thomas Krausgruber, Nikolaus Fortelny, Tanya Ayub, Pablo Augusto Vieyra-Garcia, Philip Kienzl, Peter Wolf, Anke Scharrer, Christian Fiala, Marita Kolz, Manuela Hiess, Martin Vierhapper, Christopher Schuster, Andreas Spittler, Christof Worda, Wolfgang Weninger, Christoph Bock, Rene Reitermaier, Adelheid Elbe-Buerger
Summary: Single-cell analyses identified a naive T cell population expressing specific T cell receptors enriched in fetal skin and intestine. These cells may contribute to early skin development and fetal immune defense, showing fundamental differences in immune surveillance between fetal and adult human skin.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Suncica Kapor, Milica Vukotic, Tijana Suboticki, Dragoslava Dikic, Olivera Mitrovic Ajtic, Milica Radojkovic, Vladan P. Cokic, Juan F. Santibanez
Summary: The study found that HU inhibits the growth of BMMSC, causing senescence-like changes and affecting cellular differentiation and immunoregulatory functions.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Michaela Ferencakova, Andrea Benova, Ivan Raska Jr, Pavel Abaffy, Radek Sindelka, Martina Dzubanova, Eliska Pospisilova, Katarina Kolostova, Tomas Cajka, Ales Paclik, Vit Zikan, Michaela Tencerova
Summary: This study investigated the impact of anticoagulants on the molecular characteristics of human BMSCs during isolation and cultivation. The results showed that the type of anticoagulant did not significantly affect the molecular characteristics and cellular composition of BMSCs, while in vitro cultivation caused significant changes in the transcriptomics of BMSCs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Jeroen van de Peppel, Gerben J. Schaaf, Adriana Arruda Matos, Yuan Guo, Tanja Strini, Wenda Verschoor, Amel Dudakovic, Andre J. van Wijnen, Johannes P. T. M. van Leeuwen
Summary: This research suggests that the cell surface glycoprotein CD24 could serve as a selective biomarker for identifying subpopulations of BMSCs with varying osteogenic potential. CD24(pos) cells have increased expression of genes related to cell adhesion, motility, and extracellular matrix, while also showing reduced proliferation compared to CD24(neg) cells.
STEM CELLS AND DEVELOPMENT
(2021)
Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Applied
Babatope Oluseun Odusina, Patricia Akpomedaye Onocha
Summary: Physalis angulata is a medicinal herb with significant antioxidant activity. Various compounds, including a new compound named Squalen-1-ol, Phytol, squalene, and alpha-tocopherol, were isolated from the plant. These compounds contribute to the pharmacological value of Physalis angulata.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
I. L. Khikmatullaev, O. Sh. Boimatov, N. K. Yuldasheva, D. Sh. Azizova, E. O. Terent'eva, R. K. Rakhmanberdyeva, S. D. Gusakova, S. F. Aripova
Summary: This study successfully isolated total alkaloids from the aerial part of Physalis angulata, and identified cuscohygrine and tropine for the first time in this plant. Additionally, the lipids of the seeds and fatty acids of the leaves were characterized, and the carbohydrate contents of the seeds and leaves were studied. These findings are of significant importance for further understanding the chemical composition of Physalis angulata.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Article
Endocrinology & Metabolism
Viktorija Avilkina, Damien Leterme, Guillaume Falgayrac, Jerome Delattre, Flore Miellot, Veronique Gauthier, Christophe Chauveau, Olfa Ghali Mhenni
Summary: This study demonstrates, for the first time, that the duration and severity of energy deficits are critical for changes in bone parameters, BMSC differentiation, and Sirt1 expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qingjie Liu, Shuang Xie, Duan Fan, Tianpeng Xie, Guilan Xue, Xue Gou, Xiaohong Li
Summary: Biomimetic piezoelectric scaffolds with gradient piezoelectric properties were fabricated to induce the integrated osteochondral differentiation of rat MSCs. The piezoelectric potential positively modulated cell adhesion, intracellular calcium transients, Ca2+ binding proteins, and differentiation-related genes. The scaffold integrated osteogenic and chondrogenic differentiation on different areas, providing a smooth transition between cartilage and bone.
Article
Biotechnology & Applied Microbiology
Lei Qi, Weiwen Ge, Cancan Pan, Weidong Jiang, Dan Lin, Lei Zhang
Summary: Stem cell senescence causes functional declines and disrupts bone environment homeostasis. Stem cell-derived exosomes are a promising therapy for aging-related osseous diseases. This study demonstrates the potential of osteoinductive exosomes in bone repair for aging individuals and highlights the importance of considering endocytic mechanisms and avoiding negative effects in future therapeutic design for aging populations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Jiao Yang, Jingyi Tian, Yuhui Yang, Yaru Zhu, Changfu Li, Yansheng Zhang
Summary: Physalis angulata is a well-known traditional Chinese medicine used for treating various conditions, with Physalin as its major bioactive constituent. The study identified the Pa24ISO gene from P. angulata, revealing its role in catalyzing an isomerization reaction in Physalin biosynthesis pathway. The down-regulation of Pa24ISO led to reduced levels of physalin B, supporting its involvement in physalin biosynthesis in plants.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Engineering, Chemical
Denise Maria Loureiro Contente, Rayanne Rocha Pereira, Antonio Manoel Cruz Rodrigues, Edilene Oliveira da Silva, Roseane Maria Ribeiro-Costa, Jose Otavio Carrera Silva-Junior
CHEMICAL ENGINEERING & TECHNOLOGY
(2020)
Review
Environmental Sciences
Leticia Santos-Sacramento, Gabriela P. Arrifano, Amanda Lopes-Araujo, Marcus Augusto-Oliveira, Raquel Albuquerque-Santos, Priscila Y. Takeda, Jose Rogerio Souza-Monteiro, Barbarella M. Macchi, Jose Luiz M. do Nascimento, Rafael R. Lima, Maria Elena Crespo-Lopez
Summary: The review identified high levels of mercury exposure in Amazonian populations, leading to neurological deficits such as cognitive, visual, motor, somatosensory, and emotional impairments. It emphasized the need for further research to understand the relationship between exposure and disease outcomes, and recommended novel approaches to studying mercury exposure and prevention strategies. Brazil, as a signatory to the Minamata Convention, has the opportunity to lead research efforts in improving human health and addressing mercury intoxication.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Maria Elena Crespo-Lopez, Marcus Augusto-Oliveira, Amanda Lopes-Araujo, Leticia Santos-Sacramento, Priscila Yuki Takeda, Barbarella de Matos Macchi, Jose Luiz Martins do Nascimento, Cristiane S. F. Maia, Rafael R. Lima, Gabriela P. Arrifano
Summary: Mercury is among the top ten most dangerous chemicals for public health worldwide, with increasing emissions particularly in South America, notably the Amazon region. Human populations in this area are highly exposed to methylmercury through contaminated fish consumption, with levels far exceeding those of other regions globally.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Virology
Priscilla dos Santos Lieuthier Freitas, Ana Victoria de Lima Lima, Karina Glazianne Barbosa Carvalho, Tatyane da Silva Cabral, Alexandre Maia de Farias, Ana Paula Drummond Rodrigues, Daniel Guerreiro Diniz, Cristovam Wanderley Picanco Diniz, Jose Antonio Picanco Diniz Junior
Summary: In this study, adult mice were infected with Cocal virus to investigate the neuroanatomical distribution of viral antigens in correlation with microglial morphological response, CNS cytokine concentration, and behavioral changes. The results indicated that environmental enrichment had a significant impact on the immune response in a mouse model of limbic encephalitis.
Article
Materials Science, Multidisciplinary
Elcio Malcher Dias Junior, Dayane dos Reis Costa Dias, Ana Paula Drummond Rodrigues, Carmen Gilda Barroso Tavares Dias, Gilmara de Nazareth Tavares Bastos, Johnatt Allan Rocha de Oliveira, Rubens Maciel Filho, Marcele Fonseca Passos
Summary: This research focuses on semi-interpenetrating polymeric scaffolds (SIPNs) based on PLLA and PHEMA for repairing cartilaginous tissue's traumatic injuries. The material was produced in the absence of solvent to address the critical limitations of hydrophilicity and the lack of biological interaction of biomaterials with surrounding tissues. Characterization of thermal properties and chemical structure was done using thermogravimetric analysis and Fourier transform infrared spectroscopy, while porosity and tissue interactions were assessed by scanning electron microscopy. In vitro and in vivo assays showed good biocompatibility of SIPNs scaffolds with absence of toxicity and excellent cell adhesion and growth.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Microbiology
Ana Patricia Cacua Gelvez, Jose Antonio Picanco Diniz Junior, Rebecca Thereza Silva Santa Brigida, Ana Paula Drummond Rodrigues
Summary: This study demonstrated the mechanism of action of the AgNP-PVP-MA nanocomposite on Leishmania amazonensis infection, showing significant alterations in parasite structure and various cytokine production levels to achieve its leishmanicidal activity.
Article
Parasitology
Rodrigo R. Furtado, Dara C. Soares, Alejandro F. Prado, Luis H. S. Farias, Bruno J. M. Da Silva, Ana P. D. Rodrigues, Edilene O. Silva
Summary: Leishmania is an intracellular parasite mainly inhabiting macrophages, with the ability to control infection through nitric oxide production. Differences between Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis lie in their levels of NO production and the presence of cNOS-like enzyme within glycosomes.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Microbiology
Jaqueline Batista de Lima, Lana Patricia da Silva Fonseca, Luciana Pereira Xavier, Barbarella de Matos Macchi, Juliana Silva Cassoli, Edilene Oliveira da Silva, Rafael Borges da Silva Valadares, Jose Luiz Martins do Nascimento, Agenor Valadares Santos, Chubert Bernardo Castro de Sena
Summary: During tuberculosis infection, Mycobacterium utilizes host macrophage cholesterol for energy, and can induce cholesterol consumption in vitro by culturing in minimal medium. This leads to changes in cell wall compound accumulation, affecting pathogenicity. Proteomics analysis revealed that after cholesterol consumption, M. smegmatis can disrupt protein expression in macrophages, potentially impacting various cellular processes such as cytoskeleton remodeling, immune response, and immunometabolism.
Article
Microbiology
Maira Turiel-Silva, Camila Wendt, Edilene O. Silva, Ana Paula Drummond Rodrigues, Wanderley de Souza, Kildare Miranda, Jose A. P. Diniz
Summary: This study utilized electron microscopy and tomography to reconstruct the three-dimensional structure of C. lignieresi-infected red blood cells, revealing the remodeling of erythrocytes induced by the parasite and providing new insights into its parasitic mechanism.
JOURNAL OF EUKARYOTIC MICROBIOLOGY
(2022)
Review
Microbiology
aurea Martins Gabriel, Adan Galue-Parra, Washington Luiz Assuncao Pereira, Ketil Winther Pedersen, Edilene Oliveira da Silva
Summary: Leishmania parasites communicate with host cells by secreting extracellular vesicles. Although many aspects of the biology of these vesicles remain unclear, new methods for isolating specific LEVs have been developed to facilitate further research.
Review
Biochemistry & Molecular Biology
Fabio Rodrigues de Oliveira, Nagila Monteiro da Silva, Moises Hamoy, Maria Elena Crespo-Lopez, Irlon Maciel Ferreira, Edilene Oliveira da Silva, Barbarella de Matos Macchi, Jose Luiz Martins do Nascimento
Summary: Seizures and epilepsy are common neurological disorders that require research into new treatment options. Studies have shown that endocannabinoids can modulate the balance between excitatory and inhibitory neurotransmitters. Plant oils from the Amazon region are a valuable source for synthesizing compounds similar to endocannabinoids, which can be used for developing new anticonvulsant therapies.
Article
Microbiology
Jorge Augusto Leao Pereira, Lienne Silveira de Moraes, Chubert Bernardo Castro de Sena, Jose Luiz Martins do Nascimento, Ana Paula D. Rodrigues, Silvia Helena Marques da Silva, Edilene O. Silva
Summary: This study found that kojic acid (KA) significantly decreased melanization of the pathogenic fungus Fonsecaea sp., which is an etiological agent of chromoblastomycosis (CBM). KA also inhibited biofilm formation and disrupted the cell wall, as well as inhibited fungal filamentation and subsequent phagocytosis. These findings suggest that KA may be a promising substance for the treatment of CBM.
