Article
Immunology
Carine Teles Sangaleti, Keyla Yukari Katayama, Katia De Angelis, Tercio Lemos de Moraes, Amanda Aparecida Araujo, Heno F. Lopes, Cleber Camacho, Luiz Aparecido Bortolotto, Lisete Compagno Michelini, Maria Claudia Irigoyen, Peder S. Olofsson, Douglas P. Barnaby, Kevin J. Tracey, Valentin A. Pavlov, Fernanda Marciano Consolim Colombo
Summary: The study found that low-dose galantamine treatment has positive effects on oxidative stress, inflammation, and cardiac metabolic parameters in MetS patients, alleviating inflammatory status and insulin resistance, and modulating neural autonomic regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jaqueline Pontes Batista, Julia Buiatte Tavares, Ludimila Ferreira Goncalves, Tallita Cristina Ferreira de Souza, Igor Moraes Mariano, Ana Luiza Amaral, Mateus de Lima Rodrigues, Larissa Aparecida Santos Matias, Ana Paula Magalhaes Resende, Guilherme Morais Puga
Summary: The aim of this study was to compare the effects of Mat Pilates training on well-controlled hypertensive and normotensive postmenopausal women, and it was found that both groups showed similar responses in ambulatory blood pressure, blood pressure variability, and heart rate variability.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Multidisciplinary Sciences
Andy Schumann, Karl-Juergen Baer
Summary: This study provides a database of high-resolution biological signals to describe the effect of healthy aging on cardiovascular regulation, demonstrating the decline of heart rate variability with increasing age.
Article
Psychology, Clinical
Frank Euteneuer, Marie Neuert, Stefan Salzmann, Susanne Fischer, Ulrike Ehlert, Winfried Rief
Summary: This exploratory trial examined the effects of treating Major Depression (MD) with cognitive behavioral therapy (CBT) on cardiac risk biomarkers. The study found that CBT was associated with an increase in overall heart rate variability, with more pronounced improvements in cardiovascular function seen in initially more depressed patients.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Andy Schumann, Christian Gaser, Rassoul Sabeghi, P. Christian Schulze, Sven Festag, Cord Spreckelsen, Karl-Juergen Baer
Summary: This study used machine learning to estimate participants' age based on autonomic cardiovascular indices. The Gaussian process regression model was found to be the most suitable, with a correlation of r=0.81 and a mean absolute error of MAE=5.6 years. The estimated age for obese participants was significantly higher compared to normal-weight controls, indicating advanced cardiovascular aging by 5.7 years.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Igor M. Mariano, Ana Luiza Amaral, Victor Hugo V. Carrijo, Juliene G. Costa, Mateus de L. Rodrigues, Thulio M. Cunha, Guilherme M. Puga
Summary: This study aims to verify the influence of beta-blockers or angiotensin receptor blockers on cardiovascular responses to exercise training in hypertensive post-menopausal women. The findings show that angiotensin receptor blockers have a pronounced effect on awake ambulatorial systolic blood pressure, while beta-blockers users have greater effects on blood pressure variability. Additionally, exercise can mitigate blood pressure reactivity to stress with no differences between groups. However, there were no major differences in heart rate variability.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Environmental Sciences
Peggy Hiu Ying Chan, Ka Ming Kwok, Michael Ho Ming Chan, Albert Martin Li, Iris Hiu Shuen Chan, Tai Fai Fok, Hugh Simon Lam
Summary: This study found an association between prenatal MeHg exposure and cardiac autonomic function in children, resulting in reduced parasympathetic activity. Adjustment for recent fish consumption further strengthened the negative associations of MeHg.
ENVIRONMENTAL RESEARCH
(2021)
Article
Peripheral Vascular Disease
Philippe Gosse, Antoine Cremer, Ajay J. Kirtane, Melvin D. Lobo, Manish Saxena, Joost Daemen, Yale Wang, Johannes Stegbauer, Michael A. Weber, Josephine Abraham, Kazuomi Kario, Sripal Bangalore, Lisa Claude, Yuyin Liu, Michel Azizi
Summary: The study found that baseline nighttime systolic blood pressure and its variability can predict the blood pressure response to renal denervation in patients with hypertension, which is helpful in identifying potential responders.
Article
Engineering, Biomedical
Jesse D. Parreira, Yekanth R. Chalumuri, Azin S. Mousavi, Mihir Modak, Yuanyuan Zhou, Jesus Antonio Sanchez-Perez, Asim H. Gazi, Anna B. Harrison, Omer T. Inan, Jin- Oh Hahn
Summary: In this study, we investigated how various cardiorespiratory parameters respond to acute mental stress by utilizing multi-modal physiological signals and wearable-based sensing platforms. The results showed that the cross-integration of these signals can provide effective signatures to elucidate the collective physiological changes during acute mental stress. This work demonstrates the proof-of-concept of tracking acute mental stress through physiology-inspired signatures derived from multi-modal physiological signals, paving the way for future research in quantifying stress responses in real-world settings.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Nutrition & Dietetics
Karoline T. Fenne, Matthieu Clauss, Daniela Schaefer Olstad, Egil I. Johansen, Jorgen Jensen
Summary: Caffeine impairs glucose tolerance and exercise improves glucose homeostasis. This study investigated the effects of caffeine on glucose tolerance the morning after aerobic exercise. The results showed that caffeine increased glucose AUC regardless of exercise.
Article
Neurosciences
M. C. Flux, Thomas H. Fine, Tate Poplin, Obada Al Zoubi, William A. Schoenhals, Jesse Schettler, Hazem H. Refai, Jessyca Naegele, Colleen Wohlrab, Hung-Wen Yeh, Christopher A. Lowry, Jason C. Levine, Ryan Smith, Sahib S. Khalsa, Justin S. Feinstein
Summary: Floatation-REST reduces anxiety levels and increases interoceptive awareness for cardiorespiratory sensations in anxious patients. The intervention lowers blood pressure, breathing rate, and certain metrics of heart rate variability, indicating a shift toward a more parasympathetic state of the autonomic nervous system.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Torrance L. Nevels, Michael D. Wirth, J. P. Ginsberg, Alexander C. McLain, James B. Burch
Summary: This study examined the individual and combined effects of poor sleep and reduced heart rate variability (HRV) on metabolic syndrome. The results showed that both poor sleep and low HRV were associated with metabolic syndrome, and the combined effect was even stronger.
Article
Cardiac & Cardiovascular Systems
Fosca Quarti-Trevano, Raffaella Dell ' Oro, Jennifer Vanoli, Michele Bombelli, Rita Facchetti, Giuseppe Mancia, Guido Grassi
Summary: This study found that there is no significant association between chronic coffee consumption and blood pressure changes, particularly when assessed through 24-hour ambulatory and home blood pressure monitoring. However, consuming coffee during the day can cause a slight increase in blood pressure, which disappears at night.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Multidisciplinary Sciences
Hooseok Lee, Hoon Ko, Heewon Chung, Yunyoung Nam, Sangjin Hong, Jinseok Lee
Summary: In this study, PPGI sensors were mounted on a robot for active and autonomous HR estimation. A proposed algorithm simplified the extraction of facial skin images and selected pixels based on the most frequent saturation value to achieve accurate HR assessment. The algorithm was validated on two datasets, demonstrating high accuracy and processing efficiency.
SCIENTIFIC REPORTS
(2022)
Review
Environmental Sciences
Sasan Faridi, Robert D. Brook, Fatemeh Yousefian, Mohammad Sadegh Hassanvand, Ramin Nabizadeh Nodehi, Mansour Shamsipour, Sanjay Rajagopalan, Kazem Naddafi
Summary: The cardiovascular benefits of particulate-filtering respirators (PFRs) remain unclear. A systematic review and meta-analysis of randomized studies were conducted to evaluate the effects of wearing PFRs on blood pressure and heart rate variability. The analysis showed modest or non-significant improvements in blood pressure and some heart rate variability parameters from wearing PFRs over short periods. However, these findings are limited by the small number of trials and variations in experimental designs and durations.
ENVIRONMENTAL POLLUTION
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Danielle da Silva Dias, Camila P. dos Santos, Amanda A. Araujo, Maycon J. Ferreira, Antonio V. Nascimento-Filho, Nathalia Bernardes, Maria Claudia Irigoyen, Katia De Angelis
Meeting Abstract
Biochemistry & Molecular Biology
Maycon J. Ferreira, Gabriel Do Carmo Silva, Nathalia Bernardes, Amanda A. De Araujo, Danielle Da Silva Dias, Maria C. Irigoyen, Katia De Angelis
Meeting Abstract
Biochemistry & Molecular Biology
Antonio Viana Do Nascimento Filho, Filipe F. Stoyell-Conti, Gauri Akolkar, Victor Hugo M. De Miranda, Pawan Singal, Maria Claudia Irigoyen, Katia De Angelis, Danielle Da Silva Dias
Meeting Abstract
Biochemistry & Molecular Biology
Amanda A. De Araujo, Tania P. Shecaira, Camila Paixao, Maycon J. Ferreira, Danielle Da Silva Dias, Nathalia Bernardes, Maria Claudia Irigoyen, Katia De Angelis
Article
Physiology
Gustavo S. M. Araujo, Thiago O. C. Silva, Grazia M. Guerra, Joao E. Izaias, Helena M. N. Rocha, Diego Faria, Natalia G. Rocha, Aline Lopes Dalmazo, Amanda Araujo, Fernanda Marciano Consolim-Colombo, Katia de Angelis, Maria C. C. Irigoyen, Allan R. K. Sales
Summary: The study found that the combination of PPL and DBF resulted in a significant impairment of endothelium-dependent function in healthy individuals after 110 minutes, despite a similar increase in oxidative stress and EMVs. Further research is needed to understand the mechanisms associated with the induced-endothelial dysfunction by the combination of PPL and DBF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Laura Alo Torres, Regina Silva Paradela, Luiza Menoni Martino, Danielle Irigoyen da Costa, Maria Claudia Irigoyen
Summary: High perceived stress is associated with lower use of emotion-focused coping strategies in hypertensive patients.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Cell Biology
Juliane B. Miranda, Guilherme Lunardon, Vanessa M. Lima, Tabatha de Oliveira Silva, Caroline A. Lino, Leonardo Jensen, Maria Claudia Irigoyen, Ivson Bezerra da Silva, Yao Wei Lu, Jianming Liu, Jose Donato Junior, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz
Summary: This study found that Set7 protein levels were enhanced in the heart and perigonadal adipose tissue of mice fed an obesogenic diet. Loss of Set7 prevented obesogenic diet-induced glucose intolerance and compromised myocardial functional recovery after ischemia and reperfusion injury in obese female mice.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Physiology
Tabatha de Oliveira Silva, Caroline A. Lino, Juliane B. Miranda, Camila S. Balbino-Silva, Guilherme Lunardon, Vanessa M. Lima, Leonardo Jensen, Jose Donato, Maria Claudia Irigoyen, Maria Luiza M. Barreto-Chaves, Gabriela P. Diniz
Summary: This study investigated the effect of an obesogenic diet on the expression of miRNAs involved in cardiac hypertrophy in female mice. The results showed that female mice fed an obesogenic diet displayed increased levels of several miRNAs, especially miR-143-3p. Further experiments revealed that miR-143-3p plays a role in obesity-induced cardiac hypertrophy by regulating the expression of Sox6 and Myh7 genes.
EXPERIMENTAL PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Diego Faria, Renata J. Moll-Bernardes, Laura Testa, Camila M. V. Moniz, Erika C. Rodrigues, Amanda G. Rodrigues, Amanda Araujo, Maria J. N. N. Alves, Bruna E. Ono, Joao E. Izaias, Vera M. C. Salemi, Camila P. Jordao, Graziela Amaro-Vicente, Maria U. P. B. Rondon, Katelyn R. Ludwig, Daniel H. Craighead, Matthew J. Rossman, Fernanda M. Consolim-Colombo, Katia De Angelis, Maria C. C. Irigoyen, Douglas R. Seals, Carlos E. Negrao, Allan R. K. Sales
Summary: COVID-19 survivors exhibit sympathetic overdrive, vascular dysfunction, cardiac morpho-functional changes, and reduced exercise capacity compared to controls. Further investigation is needed to determine whether these manifestations are persistent longer-term and their impact on the cardiovascular health of COVID-19 survivors.
Article
Biochemistry & Molecular Biology
Fernando Dos Santos, Joyce B. B. Li, Nathalia Juocys, Rafi Mazor, Laura Beretta, Nicole G. Coufal, Michael T. Y. Lam, Mazen F. Odish, Maria Claudia Irigoyen, Anthony J. O'Donoghue, Federico Aletti, Erik B. Kistler
Summary: This study investigates the patterns of plasma protease activity in COVID-19-induced sepsis with bacterial superinfection, as well as the implications of enhanced proteolysis on major protein systems. The results suggest that elevated proteolysis occurs in COVID-19-induced septic shock with bacterial superinfection, and provide insight into malfunctioning protease-mediated systems.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Sport Sciences
Adriano Dos-Santos, Bruno do Nascimento Carvalho, Nicolas Da Costa-Santos, Fernanda Queiroz de Mello-Silva, Abel de Assis Pereira, Ney Roberto de Jesus, Katia De Angelis, Maria Claudia Irigoyen, Nathalia Bernardes, Erico Chagas Caperuto, Katia Bilhar Scapini, Iris Callado Sanches
Summary: The aim of this study was to compare the effects of continuous-moderate vs. high-intensity interval aerobic training on cardiovascular and metabolic parameters in ovariectomized high-fat-fed mice. The results showed that moderate-intensity continuous training had better cardiovascular benefits, preventing an increase in arterial pressure and promoting a reduction in resting heart rate. On the other hand, high-intensity interval training was more effective in promoting metabolic benefits, reducing blood glucose and glucose intolerance.
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2023)
Article
Physiology
Bruno Nascimento-Carvalho, Adriano Dos-Santos, Nicolas Da Costa-Santos, Sabrina L. Carvalho, Oscar A. de Moraes, Camila P. Santos, Katia De Angelis, Erico C. Caperuto, Maria-Claudia Irigoyen, Katia B. Scapini, Iris C. Sanches
Summary: The objective of this study was to evaluate the effects of food readjustment and/or exercise training on metabolic, hemodynamic, autonomic, and inflammatory parameters in a model of loss of ovarian function with diet-induced obesity. The findings demonstrate that the combination of food readjustment and exercise training is effective in managing cardiometabolic risk.
PHYSIOLOGICAL REPORTS
(2023)
Article
Endocrinology & Metabolism
Nicolas Da Costa-Santos, Gabrielly Minguta Santos Costa, Adriano Dos-Santos, Bruno Nascimento-Carvalho, Thayna Fabiana Ribeiro, Sarah Cristina Ferreira Freitas, Erico Caperuto, Maria -Claudia Irigoyen, Katia De Angelis, Katia Bilhar Scapini, Iris Callado Sanches
Summary: Our research group has extensively demonstrated the increased cardiovascular risk after ovarian deprivation through cardiovascular autonomic analysis. Interventions involving different types of exercises have been recommended to prevent neuromuscular decline in postmenopausal women. However, there is limited research on the cardiovascular effects of different exercise modalities in ovariectomized animals. In this study, we found that the combination of aerobic and resistance training was more effective in preventing muscle mass loss and improving cardiovascular autonomic modulation and baroreflex sensitivity in ovariectomized rats compared to aerobic or resistance training alone.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Article
Endocrinology & Metabolism
Camila Paixao dos Santos, Antonio Viana do Nascimento-Filho, Amanda Aparecida Araujo, Danielle da Silva Dias, Deiwet Ribeiro Silva, Nathalia Bernardes, Tania Plens Shecaira, Maria Claudia Irigoyen, Katia De Angelis
Summary: The excessive consumption of fructose by parents is associated with early autonomic, cardiovascular, and metabolic derangement in their offspring. The offspring of fructose parents have lower birth weight, increased blood triglyceride levels, and insulin resistance. They also show higher mean arterial pressure and impaired baroreflex sensitivity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)