Journal
BMC CARDIOVASCULAR DISORDERS
Volume 14, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1471-2261-14-79
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Categories
Funding
- Commonwealth Departments of Sport, Recreation and Tourism, and Health
- National Heart Foundation
- Commonwealth Schools Commission
- Australian National Health and Medical Research Council
- Australian National Heart Foundation
- Tasmanian Community Fund
- Veolia Environmental Services
- Sanitarium Health Food Company
- ASICS Oceania
- Target Australia
- Australian National Health and Medical Research Council (NHMRC) Early Career Public Health Fellowship [1037559]
- Peninsula Collaboration for Leadership in Applied Health Research and Care (CLAHRC)
- National Institute for Health Research
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Background: We have examined the association between adiposity and cardiac structure in adulthood, using a life course approach that takes account of the contribution of adiposity in both childhood and adulthood. Methods: The Childhood Determinants of Adult Health study (CDAH) is a follow-up study of 8,498 children who participated in the 1985 Australian Schools Health and Fitness Survey (ASHFS). The CDAH follow-up study included 2,410 participants who attended a clinic examination. Of these, 181 underwent cardiac imaging and provided complete data. The measures were taken once when the children were aged 9 to 15 years, and once in adult life, aged 26 to 36 years. Results: There was a positive association between adult left ventricular mass (LVM) and childhood body mass index (BMI) in males (regression coefficient (beta) 0.41; 95% confidence interval (CI): 0.14 to 0.67; p = 0.003), and females (beta = 0.53; 95% CI: 0.34 to 0.72; p < 0.001), and with change in BMI from childhood to adulthood (males: beta = 0.27; 95% CI: 0.04 to 0.51; p < 0.001, females: beta = 0.39; 95% CI: 0.20 to 0.58; p < 0.001), after adjustment for confounding factors (age, fitness, triglyceride levels and total cholesterol in adulthood). After further adjustment for known potential mediating factors (systolic BP and fasting plasma glucose in adulthood) the relationship of LVM with childhood BMI (males: beta = 0.45; 95% CI: 0.19 to 0.71; p = 0.001, females: beta = 0.49; 95% CI: 0.29 to 0.68; p < 0.001) and change in BMI (males: beta = 0.26; 95% CI: 0.04 to 0.49; p = 0.02, females: beta = 0.40; 95% CI: 0.20 to 0.59; p < 0.001) did not change markedly. Conclusions: Adiposity and increased adiposity from childhood to adulthood appear to have a detrimental effect on cardiac structure.
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