Article
Obstetrics & Gynecology
Alexandra C. Purdue-Smithe, Keewan Kim, Victoria C. Andriessen, Anna Z. Pollack, Lindsey A. Sjaarda, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford
Summary: This study examined whether preconception leukocyte telomere length was associated with fecundability, pregnancy loss, and live birth among women with a history of 1-2 prior pregnancy losses trying to conceive naturally. The results indicated that there was no significant association between preconception telomere length and these pregnancy outcomes.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Alexandra C. Purdue-Smithe, Keewan Kim, Carrie Nobles, Enrique F. Schisterman, Karen C. Schliep, Neil J. Perkins, Lindsey A. Sjaarda, Joshua R. Freeman, Sonia L. Robinson, Jeannie G. Radoc, James L. Mills, Robert M. Silver, Aijun Ye, Sunni L. Mumford
Summary: The study suggests that preconception vitamin D levels are positively associated with male live birth, especially among women with inflammatory markers. Vitamin D may help mitigate the detrimental effects of maternal inflammation on male embryonic implantation and survival, leading to improved pregnancy outcomes.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Xin Hui Choo, Chee Wai Ku, Yin Bun Cheung, Keith M. Godfrey, Yap-Seng Chong, Lynette Pei-Chi Shek, Kok Hian Tan, Thiam Chye Tan, Sadhana Nadarajah, Fabian Kok Peng Yap, Marjorelee T. Colega, Mary Foong-Fong Chong, Shiao-Yng Chan, See Ling Loy, Jerry Kok Yen Chan
Summary: Spontaneous miscarriage is a common complication of pregnancy, and this study recruited Asian women attempting to conceive to determine risk factors and develop a risk scoring tool through multivariable logistic regression. The study found that women with higher risk scores were more likely to experience miscarriage, allowing categorization into low, intermediate, and high-risk levels based on the score. The risk scoring tool had a receiver-operating-characteristic curve area of 0.74, indicating its effectiveness in evaluating miscarriage risk level.
SCIENTIFIC REPORTS
(2021)
Review
Obstetrics & Gynecology
Richard S. Legro
Summary: The associations between female obesity and adverse maternal and fetal outcomes have been extensively documented, including ovulatory dysfunction, delayed time to pregnancy, increased pregnancy loss, fetal anomalies, gestational diabetes, hypertensive disorders of pregnancy, preterm delivery, large for gestational age infants, and thromboembolic events. The role of preconception weight loss and its risk benefit ratio is uncertain, and the effects of obesity and preconception weight loss in males are less known.
FERTILITY AND STERILITY
(2022)
Article
Clinical Neurology
Nur K. Abdul Jafar, Elaine K. H. Tham, Derric Z. H. Eng, Sherwynn Yeo, Anne Rifkin-Graboi, Joshua J. Gooley, See Ling Loy, Johan G. Eriksson, Yap-Seng Chong, Kok Hian Tan, Jerry Kok Yen Chan, Helen Chen, Lynette Pei -Chi Shek, Peter D. Gluckman, Fabian Yap, Michael J. Meaney, Birit F. P. Broekman, Michelle Z. L. Kee, Shirong Cai
Summary: This study aimed to examine whether subjective sleep quality during preconception moderates the association between preconception hair cortisol levels and mental health. It found a significant positive correlation between preconception hair cortisol levels and depressive symptom at the second trimester among women with poor preconception sleep quality, suggesting that sleep quality moderates the relationship between hair cortisol levels and mental health.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
Carrie J. Nobles, Pauline Mendola, Sunni L. Mumford, Robert M. Silver, Keewan Kim, Neil J. Perkins, Enrique F. Schisterman
Summary: This study evaluated the role of oxidative stress biomarkers, such as isoprostanes, during the preconception period and 4 weeks gestation. It found that higher preconception isoprostane levels were associated with lower fecundability, while higher isoprostane levels at 4 weeks gestation were associated with lower risk of pregnancy loss.
Article
Obstetrics & Gynecology
Elvira Grandone, Giovanni L. Tiscia, Mario Mastroianno, Giovanni Larciprete, Mirjana Kovac, Eleonora Tamborini Permunian, Andrea Lojacono, Doris Barcellona, Victoria Bitsadze, Jamilya Khizroeva, Alexander Makatsarya, Rossella Cacciola, Ida Martinelli, Eugenio Bucherini, Valerio De Stefano, Corrado Lodigiani, Donatella Colaizzo, Antonio De Laurenzo, Gregory Piazza, Maurizio Margaglione
Summary: The evaluation and care offered to women after unexplained recurrent pregnancy loss or intra-uterine foetal death includes thrombophilia assessment and treatment with low-molecular weight heparin and/or low-dose aspirin. Reproductive outcomes were better in women treated with these medications, especially those with thrombophilia.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Endocrinology & Metabolism
Elizabeth O. Buschur, Sarit Polsky
Summary: Women with T1DM can achieve healthy and safe pregnancies through preconception planning, optimal glycemic control, and multidisciplinary care during reproductive age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Nutrition & Dietetics
Sarah A. Price, Priya Sumithran
Summary: Obesity in women of reproductive age increases the risk of adverse pregnancy outcomes and has a lasting impact on the metabolic health of the offspring. Current pre-conception weight loss therapies are sub-optimal, suggesting the need for alternative approaches.
Article
Obstetrics & Gynecology
Alex M. Kasman, Chiyuan A. Zhang, Shufeng Li, Ying Lu, Ruth B. Lathi, David K. Stevenson, Gary M. Shaw, Michael L. Eisenberg
Summary: The study showed a positive correlation between preconception paternal health and the risk of pregnancy loss, especially when fathers had metabolic syndrome and other chronic diseases. Even after adjusting for maternal factors, this association remained significant.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Annemieke Hoek, Zheng Wang, Anne M. van Oers, Henk Groen, Astrid E. P. Cantineau
Summary: Obesity can negatively impact natural fertility in both men and women, as well as pregnancy chances. Lifestyle intervention is recommended as the first-line treatment for obesity, with or without medical treatments. Investigating the effects of lifestyle intervention on reproductive outcomes is crucial.
FERTILITY AND STERILITY
(2022)
Article
Public, Environmental & Occupational Health
Elizabeth A. DeVilbiss, Alexandra C. Purdue-Smithe, Lindsey A. Sjaarda, Brandie D. Taylor, Joshua R. Freeman, Neil J. Perkins, Robert M. Silver, Enrique F. Schisterman, Sunni L. Mumford
Summary: We examined the association between preconception adiposity and offspring sex and sex ratio. Among women attempting pregnancy, higher levels of adiposity were associated with reduced sex ratio, primarily driven by a decrease in male livebirths. Obesity and higher levels of serum leptin and skinfold measurements were significantly associated with lower sex ratios. This study highlights the importance of preconception adiposity in determining offspring sex and sex ratio.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Satu-Maarit Bjorkstedt, Hannu Koponen, Hannu Kautiainen, Mika Gissler, Pirjo Pennanen, Johan G. Eriksson, Merja K. Laine
Summary: The impact of preconception severe mental disorders on pregnancy outcomes in primiparous women was evaluated in this study. The well-being of newborns was good despite the presence of severe mental disorders in the mothers. Depression and anxiety disorders were the most common severe mental health disorders.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Li Lin, Jing Huai, Boya Li, Yuchun Zhu, Juan Juan, Meihua Zhang, Shihong Cui, Xianlan Zhao, Yuyan Ma, Yangyu Zhao, Yang Mi, Hongjuan Ding, Dunjin Chen, Weishe Zhang, Hongbo Qi, Xiaotian Li, Guanlin Li, Jiahui Chen, Huijing Zhang, Mengting Yu, Xiaotong Sun, Huixia Yang
Summary: The use of 100 mg aspirin for prevention of preeclampsia in high-risk pregnant women in China did not show significant efficacy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jonathan Fix, Macarius M. Donneyong, Stephen R. Rapp, Maryam Sattari, Beverly M. Snively, Jean Wactawski-Wende, Emily W. Gower
Summary: Predictors associated with pneumococcal and seasonal influenza vaccination among older women include race, health insurance, and residential area. The study emphasizes the need to improve access, education, and provider recommendations for vaccination.
PUBLIC HEALTH REPORTS
(2023)
Article
Geriatrics & Gerontology
Bonnie C. Sachs, Sarah A. Gaussoin, Gretchen A. Brenes, Ramon Casanova, Rowan T. Chlebowski, Jiu-Chiuan Chen, Juhua Luo, Stephen R. Rapp, Aladdin H. Shadyab, Sally Shumaker, Jean Wactawski-Wende, Gretchen L. Wells, Kathleen M. Hayden
Summary: The relationship between optimism and cognitive functioning is not fully understood. This study found that less pessimism was associated with a lower risk of mild cognitive impairment (MCI) and dementia, while more optimism did not have a significant relationship with these conditions.
AGING & MENTAL HEALTH
(2023)
Article
Oncology
Kathy Pan, Aaron K. Aragaki, Yvonne Michael, Cynthia A. Thomson, Linda G. Snetselaar, Jean Wactawski-Wende, David O. Garcia, Christina M. Dieli-Conwright, Aladdin H. Shadyab, Nazmus Saquib, Rowan T. Chlebowski
Summary: This study found that women participating in the Women's Health Initiative dietary modification randomized trial had a lower rate of physical inactivity and spent more time in recreational physical activity compared to the control group.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Obstetrics & Gynecology
Edwina H. Yeung, Pauline Mendola, Rajeshwari Sundaram, Tzu-Chun Lin, Miranda M. Broadney, Diane L. Putnick, Sonia L. Robinson, Kristen J. Polinski, Jean Wactawski-Wende, Akhgar Ghassabian, Thomas G. O'Connor, Robert E. Gore -Langton, Judy E. Stern, Erin Bell
Summary: The study aimed to evaluate whether children conceived using assisted reproductive technology (ART) or ovulation induction (OI) have greater cardiometabolic risk compared to children conceived without treatment. The results showed that at 9 years of age, children conceived using ART or OI did not have greater cardiometabolic risk compared to children conceived without treatment.
FERTILITY AND STERILITY
(2022)
Article
Oncology
Tarah J. Ballinger, Zora Djuric, Sagar Sardesai, Kathleen M. Hovey, Chris A. Andrews, Theodore M. Brasky, Jian Ting Zhang, Thomas E. Rohan, Nazmus Saquib, Aladdin H. Shadyab, Michael Simon, Jean Wactawski-Wende, Robert Wallace, Ikuko Kato
Summary: This study found that the use of PPI was inversely associated with the risk of colorectal cancer, while the use of H2RA showed no such association. This relationship is consistent with the preclinical data showing the preventive effect of FASN inhibition on colon cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alexi Vasbinder, Richard K. Cheng, Susan R. Heckbert, Hilaire Thompson, Oleg Zaslavksy, Rowan T. Chlebowski, Aladdin H. Shadyab, Lisa Johnson, Jean Wactawski-Wende, Gretchen Wells, Rachel Yung, Lisa Warsinger Martin, Electra D. Paskett, Kerryn Reding
Summary: This study aimed to investigate the associations between biomarkers and long-term radiation-induced cardiovascular disease (RICVD) in breast cancer survivors. The results showed that a higher 8-OH-dG ratio was significantly associated with an elevated long-term risk of RICVD, suggesting that oxidative DNA damage may be a potential pathway for RICVD.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Lindsey J. Mattick, Jennifer W. Bea, Kathy M. Hovey, Jean Wactawski-Wende, Jane A. Cauley, Carolyn J. Crandall, Lili Tian, Heather M. Ochs-Balcom
Summary: We investigated the effects of two endogenous hormones on bone health in older women. Higher levels of follicle-stimulating hormone (FSH) were associated with bone disease, particularly in lower levels of estradiol. FSH attenuates the relationship between estradiol and bone density, which may have implications for future clinical interventions on bone loss.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Public, Environmental & Occupational Health
Sonia M. Grandi, Stefanie N. Hinkle, Sunni L. Mumford, Lindsey A. Sjaarda, Katherine L. Grantz, Pauline Mendola, James L. Mills, Anna Z. Pollack, Edwina Yeung, Cuilin Zhang, Enrique F. Schisterman
Summary: This study examined whether giving birth to male infants increases the risk of maternal mortality. The results showed that women who give birth to male infants do not have an increased risk of all-cause and cause-specific mortality, suggesting that giving birth to male infants may not influence the long-term health of women.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Aaron Holman-Vittone, Brian Monahan, Erin S. LeBlanc, Simin Liu, Rami Nassir, Nazmus Saquib, Peter F. Schnatz, Aladdin H. Shadyab, Rachel Sinkey, Jean Wactawski-Wende, Robert A. Wild, Lisa Chasan-Taber, JoAnn E. Manson, Cassandra N. Spracklen
Summary: Preterm birth is associated with increased risk of developing type 2 diabetes at an earlier age, but not with overall risk of incident type 2 diabetes. The association between preterm birth and type 2 diabetes may exist during early years but wane over time.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Sandi L. Navarro, G. A. Nagana Gowda, Lisa F. Bettcher, Robert Pepin, Natalie Nguyen, Mathew Ellenberger, Cheng Zheng, Lesley F. Tinker, Ross L. Prentice, Ying Huang, Tao Yang, Fred K. Tabung, Queenie Chan, Ruey Leng Loo, Simin Liu, Jean Wactawski-Wende, Johanna W. Lampe, Marian L. Neuhouser, Daniel Raftery
Summary: Demographic and clinical factors have an influence on the metabolome. A study on 444 post-menopausal women found correlations between serum and urine metabolites and demographic and clinical parameters.
Article
Medicine, General & Internal
Diddier Prada, Carolyn J. Crandall, Allison Kupsco, Marianthi-Anna Kioumourtzoglou, James D. Stewart, Duanping Liao, Jeff D. Yanosky, Andrea Ramirez, Jean Wactawski-Wende, Yike Shen, Gary Miller, Iuliana Ionita-Laza, Eric A. Whitsel, Andrea A. Baccarelli
Summary: Osteoporosis has a major impact on postmenopausal women, and it is influenced by environmental exposures. This study found that criteria air pollutants, such as PM10, NO, NO2, and SO2, were negatively associated with bone mineral density in postmenopausal women. Nitrogen oxides exposure was identified as the leading contributor to bone loss in this population.
Article
Oncology
Ana Babic, Qiao-Li Wang, Alice A. Lee, Chen Yuan, Nader Rifai, Juhua Luo, Fred K. Tabung, Aladdin H. Shadyab, Jean Wactawski-Wende, Nazmus Saquib, Jihye Kim, Peter Kraft, Howard D. Sesso, Julie E. Buring, Edward L. Giovannucci, JoAnn E. Manson, Meir J. Stampfer, Kimmie Ng, Charles S. Fuchs, Brian M. Wolpin
Summary: The study found that high levels of adiponectin in the prediagnostic period were associated with shorter survival among women with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR were associated with patient survival.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Surgery
Elizabeth L. Chou, Mary Pettinger, Bernhard Haring, Matthew A. Allison, Matthew W. Mell, Mark A. Hlatky, Jean Wactawski-Wende, Robert A. Wild, Aladdin H. Shadyab, Robert B. Wallace, Linda G. Snetselaar, Tracy E. Madsen, Matthew J. Eagleton, Mark F. Conrad, Simin Liu
Summary: This study finds that premature menopause may be an important risk factor for AAA in women with significant smoking history. There was no significant association between premature menopause and risk of AAA amongst women who have never smoked.
Meeting Abstract
Clinical Neurology
Galit Dunietz, Kerby Shedden, Kara Michels, Ronald Chervin, Xiru Lyu, Joshua Freeman, Ana Baylin, Louise O'Brien, Jean Wactawski-Wende, Enrique Schisterman, Sunni Mumford