Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma

Whole genome DNA methylation profiling of oral cancer in ethnic population of Meghalaya, North East India reveals novel genes

(2018) Shngainlang Khongsti et al.   GENOMICS

Clinical significance of preoperative serum C-reactive protein in oral squamous cell carcinoma

(2018) S. Acharya et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Proteomic and histopathological characterization of the interface between oral squamous cell carcinoma invasion fronts and non-cancerous epithelia

(2017) Tatsuya Abé et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Hypermethylated ZNF582 and PAX1 genes in mouth rinse samples as biomarkers for oral dysplasia and oral cancer detection

(2017) Shih-Jung Cheng et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification

(2017) Rick Kamps et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A genome-wide association scan of biological processes involved in oral lichen planus and oral squamous cell carcinoma

(2017) Qiaozhen Yang et al.   MEDICINE

Improving accuracy of RNA-based diagnosis and prognosis of oral cancer by using noninvasive methods

(2017) Guy R. Adami et al.   ORAL ONCOLOGY

Investigating a case of possible field cancerization in oral squamous cell carcinoma by the use of next-generation sequencing

(2017) Siavosh Tabatabaeifar et al.   ORAL ONCOLOGY

Proteomics investigation of OSCC-specific salivary biomarkers in a Hungarian population highlights the importance of identification of population-tailored biomarkers

(2017) Éva Csősz et al.   PLoS One

Signature of genetic associations in oral cancer

(2017) Vishwas Sharma et al.   TUMOR BIOLOGY

Expression profiling of long non-coding RNA identifies linc-RoR as a prognostic biomarker in oral cancer

(2017) Ganesan Arunkumar et al.   TUMOR BIOLOGY

LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS

(2017) Yao Yuan et al.   Cell Death & Disease

Low-risk population among patients with tumor-node-metastasis stage III/IV oral squamous cell carcinoma

(2017) Tohru Ikeda et al.   Oncology Letters

The subclonal structure and genomic evolution of oral squamous cell carcinoma revealed by ultra-deep sequencing

(2017) Siavosh Tabatabaeifar et al.   Oncotarget

Genome-wide DNA methylation profile identified a unique set of differentially methylated immune genes in oral squamous cell carcinoma patients in India

(2017) Baidehi Basu et al.   Clinical Epigenetics

Head and neck cancer: improving outcomes with a multidisciplinary approach

(2017) Cristiana Lo Nigro et al.   Cancer Management and Research

CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity

(2016) Pierre-Louis Loyher et al.   CANCER RESEARCH

Salivaomics for oral diseases biomarkers detection

(2016) Jason Tasoulas et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Exome sequencing of oral squamous cell carcinoma in users of Arabian snuff reveals novel candidates for driver genes

(2016) Nezar Noor Al-hebshi et al.   INTERNATIONAL JOURNAL OF CANCER

Next generation sequencing: implications in personalized medicine and pharmacogenomics

(2016) Bahareh Rabbani et al.   Molecular BioSystems

Oral squamous cell carcinoma: microRNA expression profiling and integrative analyses for elucidation of tumourigenesis mechanism

(2016) Mayakannan Manikandan et al.   Molecular Cancer

Site-specific methylation patterns of theGALandGALR1/2genes in head and neck cancer: Potential utility as biomarkers for prognosis

(2016) Kiyoshi Misawa et al.   MOLECULAR CARCINOGENESIS

Targeting the cancer epigenome for therapy

(2016) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Hypermethylated ZNF582 and PAX1 are effective biomarkers for detection of oral dysplasia and oral cancer

(2016) Shih-Jung Cheng et al.   ORAL ONCOLOGY

Implications of cancer stem cells in developing therapeutic resistance in oral cancer

(2016) Prajna Paramita Naik et al.   ORAL ONCOLOGY

MicroRNA-31 upregulation predicts increased risk of progression of oral potentially malignant disorder

(2016) Kai-Feng Hung et al.   ORAL ONCOLOGY

Transcriptomic characterization of differential gene expression in oral squamous cell carcinoma: a meta-analysis of publicly available microarray data sets

(2016) Yang Sun et al.   TUMOR BIOLOGY

A Structural Perspective on Readout of Epigenetic Histone and DNA Methylation Marks

(2016) Dinshaw J. Patel   Cold Spring Harbor Perspectives in Biology

PDGFRβ Is a Novel Marker of Stromal Activation in Oral Squamous Cell Carcinomas

(2016) Vinay K. Kartha et al.   PLoS One

New Guideline for the Reporting of Studies Developing, Validating, or Updating a Multivariable Clinical Prediction Model

(2015) Karel G. M. Moons et al.   ADVANCES IN ANATOMIC PATHOLOGY

Poor Correlation of Histologic Parameters Between Biopsy and Resection Specimen in Early Stage Oral Squamous Cell Carcinoma

(2015) Eric A. Dik et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Microsatellite instability: an update

(2015) Hiroyuki Yamamoto et al.   ARCHIVES OF TOXICOLOGY

Comparative accuracy of different members of the dental team in detecting malignant and non-malignant oral lesions

(2015) P. Brocklehurst et al.   BRITISH DENTAL JOURNAL

Translating cancer genomes and transcriptomes for precision oncology

(2015) Sameek Roychowdhury et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Downregulation of CRNN gene and genomic instability at 1q21.3 in oral squamous cell carcinoma

(2015) Iman Salahshourifar et al.   Clinical Oral Investigations

Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers

(2015) Yoshinaga Okugawa et al.   GASTROENTEROLOGY

Comparison of Exome and Genome Sequencing Technologies for the Complete Capture of Protein-Coding Regions

(2015) Stefan H. Lelieveld et al.   HUMAN MUTATION

Heterogeneous tumor stromal microenvironments of oral squamous cell carcinoma cells in tongue and nodal metastatic lesions in a xenograft mouse model

(2015) Youichi Shirako et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Whole genome expression profiling in chewing-tobacco-associated oral cancers: a pilot study

(2015) Sanjukta Chakrabarti et al.   MEDICAL ONCOLOGY

miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets

(2015) Carolyn M. Klinge   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mapping proteins with spatial proteomics

(2015) Vivien Marx   NATURE METHODS

Associations among pretreatment tumor necrosis and the expression of HIF-1α and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof

(2015) Tseng-Cheng Chen et al.   ORAL ONCOLOGY

Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas

(2015) Anas A. Saeed et al.   ORAL ONCOLOGY

MicroRNAs as prognostic molecular signatures in human head and neck squamous cell carcinoma: A systematic review and meta-analysis

(2015) Zahra Jamali et al.   ORAL ONCOLOGY

Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas

(2015) Yuxuan Wang et al.   Science Translational Medicine

Cancer of the Oral Cavity

(2015) Pablo H. Montero et al.   Surgical Oncology Clinics of North America

Serum miR-483-5p: a novel diagnostic and prognostic biomarker for patients with oral squamous cell carcinoma

(2015) Huanxi Xu et al.   TUMOR BIOLOGY

A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

(2015) Tyler S. Alioto et al.   Nature Communications

P16 Methylation as an Early Predictor for Cancer Development From Oral Epithelial Dysplasia: A Double-blind Multicentre Prospective Study

(2015) Hongwei Liu et al.   EBioMedicine

Genome-Wide Loss of Heterozygosity and DNA Copy Number Aberration in HPV-Negative Oral Squamous Cell Carcinoma and Their Associations with Disease-Specific Survival

(2015) Chu Chen et al.   PLoS One

Statement on mouth cancer diagnosis and prevention

(2014) C. Scully et al.   BRITISH DENTAL JOURNAL

SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinoma

(2014) J Dhanda et al.   BRITISH JOURNAL OF CANCER

Promoter hypermethylation using 24-gene array in early head and neck cancer

(2014) Rob Noorlag et al.   Epigenetics

The early manifestation, tumor-specific occurrence and prognostic significance of TGFBR2 aberrant splicing in oral carcinoma

(2014) V.P. Sivadas et al.   EXPERIMENTAL CELL RESEARCH

Quantitative Proteomic Analysis of Serum Proteins from Oral Cancer Patients: Comparison of Two Analytical Methods

(2014) Yan Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genomewide Study of Salivary MicroRNAs for Detection of Oral Cancer

(2014) F. Momen-Heravi et al.   JOURNAL OF DENTAL RESEARCH

Cancer Epigenetics: Tumor Heterogeneity, Plasticity of Stem-like States, and Drug Resistance

(2014) Hariharan Easwaran et al.   MOLECULAR CELL

Small interfering RNA targeting ILK inhibits EMT in human peritoneal mesothelial cells through phosphorylation of GSK-3β

(2014) LINGRONG LUO et al.   Molecular Medicine Reports

Late stage diagnosis of oral cancer: Components and possible solutions

(2014) Pelin Güneri et al.   ORAL ONCOLOGY

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Serum and salivary levels of albumin as diagnostic tools for oral pre-malignancy and oral malignancy

(2013) R Metgud et al.   BIOTECHNIC & HISTOCHEMISTRY

The detection and implication of genome instability in cancer

(2013) Larissa Pikor et al.   CANCER AND METASTASIS REVIEWS

EDNRB and DCC Salivary Rinse Hypermethylation Has a Similar Performance as Expert Clinical Examination in Discrimination of Oral Cancer/Dysplasia versus Benign Lesions

(2013) J. Schussel et al.   CLINICAL CANCER RESEARCH

Global analysis of DNA methylation changes during progression of oral cancer

(2013) Rebecca Towle et al.   ORAL ONCOLOGY

Tumor-derived exosomes and microvesicles in head and neck cancer: Implications for tumor biology and biomarker discovery

(2013) Simona Principe et al.   PROTEOMICS

Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups

(2013)   Nature Communications

Analyzing the cancer methylome through targeted bisulfite sequencing

(2012) Eun-Joon Lee et al.   CANCER LETTERS

Gene expression changes in initiation and progression of oral squamous cell carcinomas revealed by laser microdissection and oligonucleotide microarray analysis

(2012) Jun Sumino et al.   INTERNATIONAL JOURNAL OF CANCER

Validation of a Gene Expression Signature for Assessment of Lymph Node Metastasis in Oral Squamous Cell Carcinoma

(2012) Sander R. van Hooff et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel diagnostic modalities for assessment of the clinically node-negative neck in oral squamous-cell carcinoma

(2012) Frank KJ Leusink et al.   LANCET ONCOLOGY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Safety and Activity of Anti–PD-L1 Antibody in Patients with Advanced Cancer

(2012) Julie R. Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic instability: tipping the balance

(2012) A Janssen et al.   ONCOGENE

Saliva: A potential media for disease diagnostics and monitoring

(2012) Jingyi Liu et al.   ORAL ONCOLOGY

Elevated plasma level of visfatin/pre-b cell colony-enhancing factor in male oral squamous cell carcinoma patients

(2012) T. Yu-Duan et al.   Medicina Oral Patologia Oral y Cirugia Bucal

Differential expression of miRNAs in the serum of patients with high-risk oral lesions

(2012) Sara Ann MacLellan et al.   Cancer Medicine

The Human Transcriptome: An Unfinished Story

(2012) Mihaela Pertea   Genes

Microarrays, deep sequencing and the true measure of the transcriptome

(2011) John H Malone et al.   BMC BIOLOGY

Different miRNA signatures of oral and pharyngeal squamous cell carcinomas: a prospective translational study

(2011) C B Lajer et al.   BRITISH JOURNAL OF CANCER

Gene Expression Profiling Predicts the Development of Oral Cancer

(2011) P. Saintigny et al.   Cancer Prevention Research

NID2 and HOXA9 Promoter Hypermethylation as Biomarkers for Prevention and Early Detection in Oral Cavity Squamous Cell Carcinoma Tissues and Saliva

(2011) R. Guerrero-Preston et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

(2011) Juan Sandoval et al.   Epigenetics

MALDI Imaging Mass Spectrometry (MALDI-IMS)―Application of Spatial Proteomics for Ovarian Cancer Classification and Diagnosis

(2011) Johan O. R. Gustafsson et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumour infiltrating CD25+ FoxP3+ regulatory T cells (Tregs) relate to tumour grade and stromal inflammation in oral squamous cell carcinoma

(2011) Dalal Al-Qahtani et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Differences between oral cancer and cancers of the pharynx and larynx on a molecular level

(2011) KIYOTO SHIGA et al.   Oncology Letters

Proteomic identification of salivary transferrin as a biomarker for early detection of oral cancer

(2010) Yu-Jen Jou et al.   ANALYTICA CHIMICA ACTA

Serum visfatin as a non-traditional biomarker of endothelial dysfunction in chronic kidney disease: An Egyptian study

(2010) Sahar S. Bessa et al.   European Journal of Internal Medicine

Identification of Tetranectin as a Potential Biomarker for Metastatic Oral Cancer

(2010) Martha E. Arellano-Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oral cancer over four decades: epidemiology, trends, histology, and survival by anatomical sites

(2010) Avraham Zini et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Nonsense-Mediated RNA Decay Regulation by Cellular Stress: Implications for Tumorigenesis

(2010) L. B. Gardner   MOLECULAR CANCER RESEARCH

Global regulation of alternative splicing during myogenic differentiation

(2010) Christopher S. Bland et al.   NUCLEIC ACIDS RESEARCH

Increase of microRNAmiR-31level in plasma could be a potential marker of oral cancer

(2010) C-J Liu et al.   ORAL DISEASES

Evaluation of natural killer cell defense in oral squamous cell carcinoma

(2010) Mahiye Reyhan Türkseven et al.   ORAL ONCOLOGY

Up-regulation of survivin in oral squamous cell carcinoma correlates with poor prognosis and chemoresistance

(2010) Su Liping et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Quantitative Proteomics Reveals Myosin and Actin as Promising Saliva Biomarkers for Distinguishing Pre-Malignant and Malignant Oral Lesions

(2010) Ebbing P. de Jong et al.   PLoS One

Salivary Biomarkers for the Detection of Malignant Tumors That are Remote from the Oral Cavity

(2009) Lenora R. Bigler et al.   CLINICS IN LABORATORY MEDICINE

Cancer-associated fibroblasts and tumor growth – bystanders turning into key players

(2009) Arne Östman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Clinicopathologic risk factors for distant metastases from head and neck squamous cell carcinomas

(2009) X. Li et al.   EJSO

Is diagnostic delay related to advanced-stage oral cancer? A meta-analysis

(2009) Iria Gómez et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Proteomic Approaches to Cancer Biomarkers

(2009) Kenneth E. Hung et al.   GASTROENTEROLOGY

Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma

(2009) Anthony Po-Wing Yuen et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Identification of a truncated cystatin SA-I as a saliva biomarker for oral squamous cell carcinoma using the SELDI ProteinChip platform

(2009) S. Shintani et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

Aberrant DNA methylation in skin diseases

(2009) Yaping Li et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Enhanced Interferon Signaling Pathway in Oral Cancer Revealed by Quantitative Proteome Analysis of Microdissected Specimens Using16O/18O Labeling and Integrated Two-dimensional LC-ESI-MALDI Tandem MS

(2009) Lang-Ming Chi et al.   MOLECULAR & CELLULAR PROTEOMICS

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts

(2009) Akiko Doi et al.   NATURE GENETICS

Gene Expression Profiling Identifies Genes Predictive of Oral Squamous Cell Carcinoma

(2008) C. Chen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Salivary Proteomics for Oral Cancer Biomarker Discovery

(2008) S. Hu et al.   CLINICAL CANCER RESEARCH

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

(2008) Shawn J. Cokus et al.   NATURE

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation

(2008) Kristi Kerkel et al.   NATURE GENETICS

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS

Serum biomarker profiling in cancer studies: a question of standardisation?

(2008) B. Matharoo-Ball et al.   Veterinary and Comparative Oncology