Article
Oncology
Annemiek van Ommen-Nijhof, Tessa G. Steenbruggen, Laura Capel, Michel Vergouwen, Marie-Jeanne T. Vrancken Peeters, Terry G. Wiersma, Gabe S. Sonke
Summary: This study reports on the overall survival (OS), event-free survival (EFS), and prognostic factors in a large real-world cohort of patients with oligometastatic breast cancer (OMBC). Multimodality treatment including polychemotherapy and local ablative treatment (LAT) is propagating for OMBC to achieve disease remission or cure. Early optimal systemic therapy is associated with favorable OS and EFS, indicating the importance of early treatment in OMBC. The value of LAT in OMBC requires further study.
Article
Oncology
Lei Ji, Lei Cheng, Xiuzhi Zhu, Yu Gao, Lei Fan, Zhonghua Wang
Summary: Patients with breast cancer and a high risk of developing liver metastasis should receive more attention during follow-up. BCLM patients with HR+/HER2+ subtype have the longest median survival, attributed to the introduction of HER2-targeted therapy.
Article
Oncology
Anqi Geng, Jingjing Xiao, Bingyao Dong, Shifang Yuan
Summary: This study aimed to construct a nomogram model to predict the overall survival rate (OS) of patients with triple-positive breast cancer (TPBC) by comparing the clinicopathological characteristics and prognostic influences of patients in China and the United States. The Surveillance, Epidemiology, and End Results (SEER) database and patients from Xijing Hospital were used for the study. Cox multifactorial analysis showed that age, chemotherapy, radiotherapy, M-stage, T-stage, N-stage, and the mode of surgery were all independent risk factors. The nomogram model had a high C-index and reliable performance in both the training and validation cohorts, suggesting it can be a useful clinical decision support tool.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ke-Yun Zhu, Yao Tian, Ying-Xi Li, Qing-Xiang Meng, Jie Ge, Xu-Chen Cao, Ti Zhang, Yue Yu
Summary: KLF2 and KLF15 act as tumor suppressors in breast cancer and have potential as biomarkers for prognostic prediction in breast cancer patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Daniel Maria Lubian Lopez, Carmen Aisha Butron Hinojo, Maria Castillo Lara, Manuel Sanchez-Prieto, Rafael Sanchez-Borrego, Nicolas Mendoza Ladron de Guevara, Ernesto Gonzalez Mesa
Summary: Obesity, particularly central obesity, may be associated with a more aggressive tumor phenotype. No relation between breast volume and tumoral prognostic factors was found, except for a higher proportion of ER (+) tumor in women with higher breast volume.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Xue Du, Zhe Zhou, Yun Shao, Kun Qian, Yongfang Wu, Jun Zhang, Miao Cui, Jingjing Wang, Shengqi Wang, Yanhong Tai
Summary: This study evaluated the spatial distribution of tumor-infiltrating lymphocytes (TILs) in invasive breast cancer patients and identified immune architectural patterns (IPs) associated with clinicopathological features and prognosis.
Article
Oncology
Shu-tao Ma, Ding-yuan Wang, Yi-bing Liu, Hui-jing Tan, Yue-yue Ge, Yihebali Chi, Bai-lin Zhang
Summary: This multicenter retrospective study examined prognostic factors for patients with primary neuroendocrine breast carcinomas (NEBCs) who underwent surgery in China and the United States. The study found that tumor grade and Ki-67 levels were important prognostic factors for disease-free survival (DFS) in Chinese patients, while age and estrogen receptor (ER) status were important prognostic factors for overall survival (OS) in US patients. The combined analysis showed that age and positive expression of ER were potential prognostic factors for OS.
Article
Oncology
Mustapha Abubakar, Changyuan Guo, Hela Koka, Bin Zhu, Joseph Deng, Nan Hu, Bin Zhou, Montserrat Garcia-Closas, Ning Lu, Xiaohong R. Yang
Summary: The study found that factors such as age, parity, family history, and body mass index may impact clinically relevant prognostic biomarkers in breast cancer, with implications for surveillance, prognostication, and counseling.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Endocrinology & Metabolism
Yu Min, Xiaoman Liu, Daixing Hu, Hang Chen, Jialin Chen, Ke Xiang, Guobing Yin, Yuling Han, Yang Feng, Haojun Luo
Summary: Breast cancer patients with no lymph node metastasis but distant metastasis present specific clinicopathological characteristics that are associated with the risk of distant metastasis and prognosis, including factors such as age, tumor size, race, tumor location, grade, and histology. A novel nomogram for predicting 1-, 3-, and 5- year CSS in T1-3N0M1 patients has been established and validated, which could assist clinicians in better stratifying patients and implementing relatively aggressive management.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claudio Ventura, Silvia Baldassarre, Federico Cerimele, Laura Pepi, Elisabetta Marconi, Paola Ercolani, Chiara Floridi, Giulio Argalia, Gaia Goteri, Andrea Giovagnoni
Summary: This study evaluated the reproducibility of the 2D shear wave elastography (2D-SWE) method and identified prognostic factors of breast lesions. Results showed good reproducibility of 2D-SWE among operators with different experience, making it a promising tool for evaluating prognostic factors in ultrasound visible breast cancer.
Article
Health Care Sciences & Services
Zhijun Li, Yiqun Han, Jiayu Wang, Binghe Xu
Summary: This study aimed to identify prognostic factors for TNBC patients with residual disease after neoadjuvant chemotherapy. The genomic analysis revealed that TP53, PIK3CA, MET, and PTEN alterations occurred commonly. The clinical TNM stage and PIK3CA status were identified as independent prognostic factors for disease-free survival.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Cell Biology
Hongxi Chen, Lei Zhou, Juanni Li, Kuan Hu
Summary: This study discovered abnormal expression of ALKBH gene family in breast cancer, which is associated with tumor stage and subclasses. ALKBH family is closely related to several cancer-related signaling pathways and infiltration of immune cells. Additionally, ALKBH7 is strongly correlated with clinical characteristics and prognosis of breast cancer patients.
Article
Cell Biology
Hongxi Chen, Lei Zhou, Juanni Li, Kuan Hu
Summary: This study found abnormal expression of ALKBH members in breast cancer and their association with tumor stage and subclasses. Higher alteration rates of ALKBH family were observed in breast cancer and several cancer-associated signal pathways were related to ALKBH family. Infiltration of immune cells was strongly related to ALKBHs. Furthermore, ALKBH7 was correlated with worse prognosis in breast cancer patients.
Article
Oncology
Guo Sang, Hong Pan, Chen Lu, Rongneng Sun, Xiaoming Zha, Shui Wang, Dongya Zhu
Summary: Compared with female breast cancer, male breast cancer tends to occur at an older age with more comorbidities and lower survival rates. Male patients are less likely to receive aggressive treatments such as adjuvant therapy and endocrine therapy. Increasing endocrine therapy may help improve the survival rate of male breast cancer patients due to the higher proportion of luminal type tumors.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
Di Zhang, Jingtong Zhai, Lixi Li, Yun Wu, Fei Ma, Binghe Xu
Summary: Occult breast cancer (OBC), a type of breast cancer with unknown primary origin, lacks predictive models for survival outcomes. This study identified the positive lymph node ratio (PLNR) as an independent prognostic factor for OBC and developed a PLNR-based prognostic nomogram, which showed higher accuracy in predicting breast-cancer-specific survival (BCSS) compared to the TNM staging system.
JOURNAL OF CLINICAL MEDICINE
(2022)