Article
Medicine, General & Internal
Laura Sophie Tribian, Maximilian Lennartz, Doris Hoeflmayer, Noemi de Wispelaere, Sebastian Dwertmann Rico, Clara von Bargen, Simon Kind, Viktor Reiswich, Florian Viehweger, Florian Lutz, Veit Bertram, Christoph Fraune, Natalia Gorbokon, Soeren Weidemann, Claudia Hube-Magg, Anne Menz, Ria Uhlig, Till Krech, Andrea Hinsch, Eike Burandt, Guido Sauter, Ronald Simon, Martina Kluth, Stefan Steurer, Andreas H. Marx, Patrick Lebok, David Dum, Sarah Minner, Frank Jacobsen, Till S. Clauditz, Christian Bernreuther
Summary: Prostate-specific acid phosphatase (PSAP) is a marker for prostate cancer and its expression is limited in normal tissues but higher in prostate cancers. The expression level of PSAP is associated with clinical characteristics and prognosis of prostate cancer, making it a potential marker for prognostic evaluation.
Article
Biochemistry & Molecular Biology
Mourad Assidi, Fatimah M. Yahya, Maryam H. Al-Zahrani, Razan Elkhatib, Ali Zari, Aisha Elaimi, Jaudah Al-Maghrabi, Ashraf Dallol, Abdelbaset Buhmeida, Muhammad Abu-Elmagd
Summary: This study investigated the expression pattern and methylation profiles of leptin (LEP) in ovarian cancer (OC), and found that high LEP protein expression is associated with better survival outcomes. The results suggest that LEP expression in OC may be regulated by promoter hypermethylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Alexandros Lalos, Ornella Neri, Caner Ercan, Alexander Wilhelm, Sebastian Staubli, Alberto Posabella, Benjamin Weixler, Luigi Terracciano, Salvatore Piscuoglio, Sylvia Stadlmann, Giulio C. Spagnoli, Raoul A. Droeser, Gad Singer
Summary: Ovarian cancer is the most aggressive and fatal malignancy of the female reproductive system. The tumor microenvironment plays a critical role in tumorigenesis, progression, prognosis, and response to chemotherapy. High density of CD16-expressing tumor-infiltrating immune cells in recurrent ovarian cancer is associated with better recurrence-free survival and overall survival, indicating a potential interaction between standard chemotherapy and immune cell infiltration.
Article
Oncology
Mourad Assidi
Summary: This study investigates the expression patterns of N-CAD protein in ovarian cancer (OC) patients and its correlations with clinicopathological features. The study finds that N-CAD protein is often overexpressed in OC and its cytoplasmic overexpression is significantly correlated with tumor grade, subtype, necrosis, and age at menarche. Patients with cytoplasmic N-CAD overexpression have a shorter disease-free survival and higher recurrence rate. These findings highlight the poor prognostic role of N-CAD in OC and its involvement in EMT and distant metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao, Zhenqing Feng
Summary: Immunohistochemical testing revealed lower DSG2 expression in colon cancer tissues compared to pericarcinomatous tissues, and this low expression is associated with poor survival in colon cancer patients. Bioinformatics analysis indicated that low DSG2 expression affects protein activation, regulates the P53-related pathway in colon cancer, and activates the EGFR pathway.
BMC GASTROENTEROLOGY
(2021)
Article
Cell Biology
Jinxuan Hou, Chen Chen, Yingying Hu, Qing Gong, Lijuan Gan, Yu Xu
Summary: This study clarified the clinical relevance of WASP like actin nucleation promoting factor (WASL) in patients with cervical cancer and identified a correlation between WASL expression and clinical characteristics. Differential gene expression analysis and enrichment analysis revealed potential mechanisms related to the prognostic value of WASL expression in cervical cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Mina Sharbatoghli, Parisa Shamshiripour, Fahimeh Fattahi, Elham Kalantari, Zohre Habibi Shams, Mahshid Panahi, Mehdi Totonchi, Zeynab Asadi-Lari, Zahra Madjd, Leili Saeednejad Zanjani
Summary: The co-expression of SALL4/ALDH1A1 is significantly associated with clinicopathological parameters and prognosis in serous ovarian carcinoma patients, suggesting its potential as a prognostic biomarker for cancer progression.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jan Meiners, Kristina Jansen, Natalia Gorbokon, Franziska Buescheck, Andreas M. Luebke, Martina Kluth, Claudia Hube-Magg, Doris Hoeflmayer, Soeren Weidemann, Christoph Fraune, Katharina Moeller, Christian Bernreuther, Patrick Lebok, Anne Menz, Frank Jacobsen, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Jakob Izbicki, Daniel Perez, Sarah Minner, Eike Burandt, Till Krech, Andreas Marx, Ronald Simon, Stefan Steurer
Summary: ACE2 expression is detected in tumor cells and tumor-associated capillaries of various tumor types, with particularly high frequencies in certain cancers such as renal cell carcinoma and colorectal adenocarcinoma.
Article
Medicine, Research & Experimental
Juan Gu, Shu Zhang, Xin He, Sufang Chen, Yan Wang
Summary: High expression of PIG11 is associated with unfavorable prognosis in patients with gastric cancer, serving as a potential diagnostic and prognostic biomarker for gastric cancer.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Su-Wen Zhu, Shuo Wang, Zhi-Zhong Wu, Qi-Chao Yang, De-Run Chen, Shu-Cheng Wan, Zhi-Jun Sun
Summary: This study revealed the overexpression of CD168 in oral squamous cell carcinoma (OSCC) tissues, which was associated with worse patient survival and pathological grade. Additionally, CD168 expression was positively correlated with other marker expression in OSCC.
Article
Oncology
Philipp Kohn, Alexandros Lalos, Alberto Posabella, Alexander Wilhelm, Athanasios Tampakis, Ercan Caner, Uwe Guth, Sylvia Stadlmann, Giulio C. Spagnoli, Salvatore Piscuoglio, Sabine Richarz, Tarik Delko, Raoul A. Droeser, Gad Singer
Summary: High expression of CXCL12 in immune cells is associated with better chemosensitivity, overall survival, and longer recurrence-free survival in patients with high-grade serous ovarian carcinoma. Additionally, combined high density of CXCL12 and CD66b immune cells is an independent favorable predictor of recurrence-free survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Cristian Carrasco, Andres Tittarelli, Natalia Paillaleve, Maeva Del Pozo, Daniel Rojas-Sepulveda, Omar Barria, Paula Fluxa, Melissa Hott, Carolina Martin, Claudia Quezada, Flavio Salazar-Onfray
Summary: Gallbladder cancer is a highly lethal disease with low global incidence, but a significant health problem in certain regions. New tumor-associated markers, such as MUC6, CK17, and CD10, show potential as prognosis markers for gallbladder cancer, with different expressions associated with different patient prognosis.strconv
Article
Oncology
E. Sun Paik, Chi-Son Chang, Ye Lin Chae, So Young Oh, Sun-Ju Byeon, Chul Jung Kim, Yoo-Young Lee, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Chel Hun Choi
Summary: BRCA1 expression in cervical cancer tissue is associated with better survival outcomes in patients. Gene expression analysis identified specific gene alterations associated with BRCA1 expression, which could aid in individualized prediction for these patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Katharina Moller, Martina Kluth, Malik Ahmed, Lia Burkhardt, Christina Moller-Koop, Franziska Buscheck, Soren Weidemann, Maria-Christina Tsourlakis, Sarah Minner, Hans Heinzer, Hartwig Huland, Markus Graefen, Guido Sauter, Thorsten Schlomm, David Dum, Ronald Simon
Summary: Deletion of chromosome 5q is common in prostate cancer, with separate deletions at 5q13 and 5q21 leading to aggressive disease. Cancers with co-deletion of 5q13 and 5q21 have worse prognosis compared to those with isolated deletions at either locus. 5q21 deletions are associated with ERG negativity, while 5q13 deletions are not related to ERG status.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Zheng Fang, Hong-yu Shen, Qi Xu, Hong-lei Zhou, Lei Li, Si-Yuan Yang, Zhen Zhu, Jin-hai Tang
Summary: Breast cancer patients with high expression of PUS1 have poor prognosis and shorter survival time. Knockdown of PUS1 suppresses the proliferation, colony formation, and invasion abilities of breast cancer cells. PUS1 may serve as a promising biomarker and treatment target for breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Kyungeun Kim, Kris Ylaya, Candice Perry, Mi-Yeon Lee, Jeong Won Kim, Joon-Yong Chung, Stephen M. Hewitt
Summary: Water is a crucial factor for protein and RNA degradation in stored tissue sections, and storage conditions can affect the expression of certain key proteins and RNA integrity in breast tissue.
BIOPRESERVATION AND BIOBANKING
(2023)
Article
Surgery
Kapil K. Saharia, Sabrina C. Ramelli, Sydney R. Stein, Allison E. Roder, Allie Kreitman, Stephanie Banakis, Joon-Yong Chung, Peter D. Burbelo, Manmeet Singh, Robert M. Reed, Vipul Patel, Joseph Rabin, Alexander S. Krupnick, Jeffrey I. Cohen, Emmie de Wit, Elodie Ghedin, Stephen M. Hewitt, Kevin M. Vannella, Daniel S. Chertow, Alison Grazioli
Summary: Although the risk of SARS-CoV-2 transmission through lung transplantation from acutely infected donors is high, using lungs from COVID-19-recovered donors does not significantly increase the risks of virus transmission and long-term lung allograft outcomes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Jung-A Choi, Elizabeth Hyeji Lee, Hanbyoul Cho, Jae-Hoon Kim
Summary: This study found that high-dose sodium selenite (SS) can inhibit the proliferation and induce cell death of ovarian cancer cells through increased reactive oxygen species (ROS) generation. High-dose SS also reduced the levels of glutathione peroxidase (GPx) and triggered lipid peroxidation and ferroptosis via dysregulated GPx4 pathways. In mouse models, high-dose SS significantly reduced tumor growth and weight, and decreased GPx4 expression in tumors. Therefore, high-dose SS is considered a potential chemotherapeutic agent for ovarian cancer, utilizing ferroptotic therapy by depleting glutathione and increasing ROS generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Joon-Yong Chung, Kyungeun Kim, Kris Ylaya, Katharine E. Walker-Bawa, Candice Perry, Robert A. Star, Stephen M. Hewitt
Summary: Neutral buffered formalin (NBF) is commonly used as a fixative in clinical applications, but it damages proteins and nucleic acids, limiting the quality of molecular analysis. Previous studies have shown that BE70, a fixative of buffered 70% ethanol, has advantages over NBF, but protein and nucleic acid degradation in archival paraffin blocks is still a challenge. With the addition of guanidinium salts, BE70G fixative improves the quality of molecular analysis, provides better protein and RNA quality at shorter fixation times, and reduces protein degradation in archival tissue blocks.
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2023)
Article
Oncology
Gwan Hee Han, Hee Yun, Joon-Yong Chung, Jae-Hoon Kim, Hanbyoul Cho
Summary: The study aimed to investigate the function, molecular mechanisms, and clinical significance of ATP6V1B1 in epithelial ovarian cancer (EOC). It was found that ATP6V1B1 was highly expressed in EOC tissues and was associated with clinicopathological features and prognosis. Knockdown of ATP6V1B1 inhibited cancer cell proliferation and colony-forming abilities. Therefore, ATP6V1B1 could serve as a biomarker for prognostic evaluation and chemotherapy resistance, as well as a potential therapeutic target in EOC.
Article
Multidisciplinary Sciences
Se Jin Oh, Ji Yeon Lim, Min Kyu Son, Jun Hyeok Ahn, Kwon-Ho Song, Hyo-Jung Lee, Suyeon Kim, Eun Ho Cho, Joon-Yong Chung, Hanbyoul Cho, Hyosun Kim, Jae-Hoon Kim, Jooyoung Park, Jungmin Choi, Sun Wook Hwang, Tae Woo Kim
Summary: The emergence of cisplatin resistance and side-effects are important factors in cancer treatment failure. The authors identify autophagy-mediated EGFR hyperactivation by TRPV1 promotion as a mechanism of cisplatin resistance and demonstrate the efficacy of a TRPV1 inhibitor to sensitize lung cancer to cisplatin. Future studies should provide evidence regarding the mechanisms of potential targets that can overcome the resistance as well as alleviate pain.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Soseul Sung, Youjin Hong, Byoung-Gie Kim, Ji-Yeob Choi, Jae Weon Kim, Sang-Yoon Park, Jae-Hoon Kim, Yong-man Kim, Jong-Min Lee, Tae Jin Kim, Sue K. K. Park
Summary: This study aimed to verify the association between ovarian cancer (OC) and reproductive- and lifestyle-related risk factors stratified by the subtype of OC. The results showed that smoking was positively associated with high-grade serous (HGS) OC, alcohol consumption was positively associated with mucinous type (MUC), and obesity was associated with clear cell type (CLC). Further, spontaneous abortion was negatively associated with CLC, while tubal ligation, hysterectomy, and oophorectomy were associated with decreased risk of HGS. Early menarche was strongly associated with increased risk of CLC. Additionally, childbirth, oral contraceptives, and hormone replacement therapy were negatively associated with OC.
Article
Oncology
Ha Kyun Chang, Young Hoon Park, Jung-A Choi, Jeong Won Kim, Jisup Kim, Hyo Sun Kim, Hae Nam Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: The expression of Nectin-4 is significantly increased in endometrial cancer and can be used as a diagnostic marker. High Nectin-4 expression is associated with DNA mismatch repair protein deficiency and may predict short progression-free survival. This study provides clues for selecting patients for adjuvant therapy.
Article
Oncology
Ji-Won Ryu, Ha-Yeon Shin, Hyo-Sun Kim, Gwan Hee Han, Jeong Won Kim, Hae-Nam Lee, Hanbyoul Cho, Joon-Yong Chung, Jae-Hoon Kim
Summary: Hormonal factors, particularly steroid hormones, are believed to play a significant role in ovarian cancer development. The expression of glucocorticoid receptor (GR) has been associated with poor prognosis in epithelial ovarian cancer. This study investigates the clinical significance of beta-arrestin expression in ovarian cancer and the potential synergistic effect with GR as prognostic factors. The findings demonstrate a moderate correlation between beta-arrestin 1 and GR expression, suggesting a possible role in prognostication.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Razaul Haque, Jaebon Lee, Joon-Yong Chung, Ha-Yeon Shin, Hyosun Kim, Jae-Hoon Kim, Jae Won Yun, Eun-Suk Kang
Summary: This study suggests that VGLL3 is associated with tumor development and prognosis in patients with high-grade serous ovarian carcinoma, as well as with tumor-infiltrating macrophages. VGLL3 may serve as a potential prognostic marker and therapeutic target for ovarian cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Jordan M. White, Nicholas Ramos, Allen-Dexter Saliganan, Joon-Yong Chung, Meghan Bell, Jacob Lindquist, Kayla Conner, Wendy N. Wiesend, Michael Schopperle, Steve M. Patrick, Seongho Kim, Elisabeth I. Heath, Freddy E. Escorcia, Nerissa T. Viola
Summary: This study investigated the clinical implications of TRA expression in prostate cancer. It found that high PODXL copy number alterations were associated with poor prognosis. TRA-targeted PET imaging successfully located cancer stem cells (CSCs) and TRA-targeted RPT showed promising therapeutic effects. Ablation of TRA+ CSCs inhibited prostate cancer growth.
Article
Oncology
Takayuki Enomoto, Aikou Okamoto, Jae-Hoon Kim, Chyong-Huey Lai, Xiaohua Wu, Yong-Man Kim
Summary: There are racial and regional differences in gynecologic cancer, but most large-scale phase III studies have been conducted in Western countries, limiting data on Asians. To address this, four clinical trial groups in East Asia have established the East Asia Gynecologic Oncology Trial Group (EAGOT) to conduct international clinical trials and provide the best treatments for Asian women. EAGOT aims to establish standards of care and guidelines for gynecologic cancer in Asia.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Medical Laboratory Technology
Jaehyeok Jang, Yoonjung Kim, Jae-Hoon Kim, Sun-Mi Cho, Kyung-A Lee
Summary: This study comparatively evaluated the cost-effectiveness of several BRCA testing strategies in clinical practice in Korea and found that performing germline testing first, followed by somatic testing, may be a reasonable option.
ANNALS OF LABORATORY MEDICINE
(2023)