Current and recent clinical trials for perioperative systemic therapy for muscle invasive bladder cancer: a systematic review

Phase II trial of neoadjuvant cisplatin, gemcitabine, and bevacizumab followed by radical cystectomy (RC) in patients with muscle-invasive transitional cell carcinoma (TCC) of the bladder.

(2017) U. B. Chaudhary et al.   JOURNAL OF CLINICAL ONCOLOGY

Alterations in the PI3K/Akt signaling pathway and association with outcome in invasive high-grade urothelial cancer (UC).

(2017) Arjun Vasant Balar et al.   JOURNAL OF CLINICAL ONCOLOGY

NeuACT, a phase II, randomized, open-label trial of DN24-02: Updated analysis of HER2 expression, immune responses, product parameters, and safety in patients with surgically resected HER2+ urothelial cancer.

(2017) Dean F. Bajorin et al.   JOURNAL OF CLINICAL ONCOLOGY

Biologic activity of dasatinib administered as neoadjuvant therapy preceding radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC).

(2017) Beatrice Knudsen et al.   JOURNAL OF CLINICAL ONCOLOGY

The PTEN pathway in Tregs functions as a critical driver of the immunosuppressive tumor microenvironment and tolerance to apoptotic cells

(2015) Madhav Sharma et al.   Journal for ImmunoTherapy of Cancer

DO MIXED HISTOLOGICAL FEATURES AFFECT SURVIVAL BENEFIT FROM NEOADJUVANT PLATINUM-BASED COMBINATION CHEMOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED BLADDER CANCER?

(2015) Emil Scosyrev et al.   BJU INTERNATIONAL

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy

(2014) Woonyoung Choi et al.   CANCER CELL

Comprehensive molecular characterization of urothelial bladder carcinoma

(2014)   NATURE

Phase II study of everolimus in metastatic urothelial cancer

(2013) Matthew I. Milowsky et al.   BJU INTERNATIONAL

mTOR in aging, metabolism, and cancer

(2013) Marion Cornu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

EAU Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2013 Guidelines

(2013) J. Alfred Witjes et al.   EUROPEAN UROLOGY

Neoadjuvant chemotherapy with gemcitabine plus carboplatin followed by immediate radical cystectomy for muscle-invasive bladder cancer

(2013) Chikara Ohyama et al.   INTERNATIONAL JOURNAL OF UROLOGY

Clinicopathologic Characteristics of Malignant Mesotheliomas Arising in Patients With a History of Radiation for Hodgkin and Non-Hodgkin Lymphoma

(2013) Lucian R. Chirieac et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Trial of Intravesical Recombinant Adenovirus Mediated Interferon-α2b Formulated in Syn3 for Bacillus Calmette-Guérin Failures in Nonmuscle Invasive Bladder Cancer

(2013) Colin P.N. Dinney et al.   JOURNAL OF UROLOGY

A Phase II Trial of Neoadjuvant nab-paclitaxel, Carboplatin, and Gemcitabine (ACaG) in Patients With Locally Advanced Carcinoma of the Bladder

(2013) Petros D. Grivas et al.   UROLOGY

Trends in the Utilization of Neoadjuvant Chemotherapy in Muscle-invasive Bladder Cancer: Results From the National Cancer Database

(2013) Harras B. Zaid et al.   UROLOGY

Everolimus combined with cisplatin has a potential role in treatment of urothelial bladder cancer

(2012) Rosário Pinto-Leite et al.   BIOMEDICINE & PHARMACOTHERAPY

Gemcitabine, Cisplatin, and Sunitinib for Metastatic Urothelial Carcinoma and as Preoperative Therapy for Muscle-Invasive Bladder Cancer

(2012) Matthew D. Galsky et al.   Clinical Genitourinary Cancer

A Systematic Review of Neoadjuvant and Adjuvant Chemotherapy for Muscle-invasive Bladder Cancer

(2012) Joshua J. Meeks et al.   EUROPEAN UROLOGY

ICUD-EAU International Consultation on Bladder Cancer 2012: Chemotherapy for Urothelial Carcinoma—Neoadjuvant and Adjuvant Settings

(2012) Cora N. Sternberg et al.   EUROPEAN UROLOGY

Efficacies and safety of neoadjuvant gemcitabine plus carboplatin followed by immediate cystectomy in patients with muscle-invasive bladder cancer, including those unfit for cisplatin: a prospective single-arm study

(2012) Takuya Koie et al.   International Journal of Clinical Oncology

Randomized Controlled Trials and Comparative Effectiveness Research

(2012) Olwen M. Hahn et al.   JOURNAL OF CLINICAL ONCOLOGY

Severe Pazopanib-Induced Hepatotoxicity: Clinical and Histologic Course in Two Patients

(2012) Samuel J. Klempner et al.   JOURNAL OF CLINICAL ONCOLOGY

A phase II trial of temsirolimus in second-line metastatic urothelial cancer

(2012) H. Gerullis et al.   MEDICAL ONCOLOGY

Practical use of perioperative chemotherapy for muscle-invasive bladder cancer: Summary of session at the Society of Urologic Oncology annual meeting

(2012) Andrea B. Apolo et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Adjuvant chemotherapy with cisplatin and gemcitabine versus chemotherapy at relapse in patients with muscle-invasive bladder cancer submitted to radical cystectomy: an Italian, multicenter, randomized phase III trial

(2011) F. Cognetti et al.   ANNALS OF ONCOLOGY

Effects of mTOR Inhibitor Everolimus (RAD001) on Bladder Cancer Cells

(2011) E. Chiong et al.   CLINICAL CANCER RESEARCH

Phase I Study Utilizing a Novel Antigen-Presenting Cell-Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

(2011) M. A. Morse et al.   CLINICAL CANCER RESEARCH

Pathologic Downstaging Is a Surrogate Marker for Efficacy and Increased Survival Following Neoadjuvant Chemotherapy and Radical Cystectomy for Muscle-Invasive Urothelial Bladder Cancer

(2011) Robert Rosenblatt et al.   EUROPEAN UROLOGY

CDX-1307: a novel vaccine under study as treatment for muscle-invasive bladder cancer

(2011) Michael A Morse et al.   Expert Review of Vaccines

Neoadjuvant Gemcitabine Plus Cisplatin for Muscle-invasive Bladder Cancer

(2011) G. Kaneko et al.   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Phase III Study of Molecularly Targeted Adjuvant Therapy in Locally Advanced Urothelial Cancer of the Bladder Based on p53 Status

(2011) Walter M. Stadler et al.   JOURNAL OF CLINICAL ONCOLOGY

International Phase III Trial Assessing Neoadjuvant Cisplatin, Methotrexate, and Vinblastine Chemotherapy for Muscle-Invasive Bladder Cancer: Long-Term Results of the BA06 30894 Trial

(2011)   JOURNAL OF CLINICAL ONCOLOGY

A phase II trial of neoadjuvant erlotinib in patients with muscle-invasive bladder cancer undergoing radical cystectomy: clinical and pathological results

(2010) Raj S. Pruthi et al.   BJU INTERNATIONAL

AdCD40L Immunogene Therapy for Bladder Carcinoma--The First Phase I/IIa Trial

(2010) P.-U. Malmstrom et al.   CLINICAL CANCER RESEARCH

NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells

(2009) S. Gnjatic et al.   CLINICAL CANCER RESEARCH

Immune Responses Detected in Urothelial Carcinoma Patients After Vaccination With NY-ESO-1 Protein Plus BCG and GM-CSF

(2008) Padmanee Sharma et al.   JOURNAL OF IMMUNOTHERAPY

Phase II Trial of Paclitaxel, Carboplatin and Gemcitabine in Patients With Locally Advanced Carcinoma of the Bladder

(2008) David C. Smith et al.   JOURNAL OF UROLOGY

Adjuvant chemotherapy in lymph node positive bladder cancer

(2008) Ofer N. Gofrit et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS