Article
Multidisciplinary Sciences
Chunxiao Xu, Xiaofu Du, Le Fang, Jieming Zhong, Feng Lu
Summary: A cross-sectional study was conducted in China in 2017 to assess the relationship between sodium, potassium, and the sodium to potassium ratio (Na/K) with albuminuria. The study examined sodium, potassium, and albumin excretions in a 24-h urine sample collected from 1486 participants. The results showed that sodium concentration increased significantly with 24-h urinary albumin, while potassium and the Na/K ratio were not associated with outcome indicators.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Soshiro Ogata, Yuumi Akashi, Takaya Sakusabe, Shigehito Yoshizaki, Yuko Maeda, Kunihiro Nishimura, Kenji Maeda, Shigeru Nakai
Summary: This study found that there is an association between kidney function decline in patients with chronic kidney disease and sodium and potassium intake. Higher sodium intake was positively correlated, while higher potassium intake was negatively correlated with kidney function decline. Higher sodium intake but lower potassium intake was associated with more severe decline in kidney function.
KIDNEY INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Fang Fan, Yinghua Li, Li Li, Xueqiong Nie, Puhong Zhang, Yuan Li, Rong Luo, Gang Zhang, Lanlan Wang, Feng J. He
Summary: Salt intake in China is high and increases the risk of hypertension and cardiovascular disease. A study found that salt-related knowledge, attitudes, and behaviors are inversely associated with 24-hour urinary sodium excretion. The results suggest the need for large-scale health education, particularly targeting rural areas, individuals with low education levels, and older people, to reduce salt intake.
Article
Nutrition & Dietetics
Carlos Heriberto Garcia-Lithgow, Madeline Duran-Cabral, Alexandra Winter-Matos, Kilsaris Garcia-Estrella, Julen Garcia-Duran, Estefania Di-Sanzo, Nicole Martinez-De-La-Cruz, Julia Rodriguez-Abreu, Begona Olmedilla-Alonso
Summary: This study evaluated the 24-hour urinary sodium and potassium excretion and estimated the salt intake in normotensive and hypertensive Dominican adults. The results showed no significant correlation between urinary sodium and potassium excretion and blood pressure, except for a correlation between potassium and systolic blood pressure in the normotensive group. The sodium-to-potassium ratio was higher in younger subjects and was associated with blood pressure in the hypertensive and older groups. Age, sex, body mass index, and sodium-to-potassium ratio were determinants of blood pressure.
Article
Public, Environmental & Occupational Health
Mohamed Idrissi, Naima Saeid, Samir Mounach, Hicham El Berri, Ayoub Al Jawaldah, Fadoua Rahhaoui, Fatima-Zahra Mouzouni, Anass Rami, Kaoutar Benjeddou, Houria Lahmam, Hasnae Benkirane, Mohammed Elmzibri, Khalid El Kari, Abdallah Bagri, Hassan Aguenaou, Latifa Belakhel
Summary: This study estimated the mean sodium and potassium intake in a Moroccan population and examined their association with blood pressure. The results showed that sodium intake exceeded the WHO recommendation while potassium intake was below the recommendation.
ARCHIVES OF PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Chikako Seko, Mikoto Yamashiro, Kiyoko Odani, Sayori Wada, Kengo Yoshii, Akane Higashi
Summary: The study examined salt intake among elementary school teachers and lunch cooks, finding that most participants had salt excretion levels above the median, with female teachers exhibiting significantly lower salt intake compared to male teachers and cooks. This highlights the importance of dietary health education for teachers and cooks.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Nutrition & Dietetics
Puhong Zhang, Fang Fan, Yinghua Li, Yuan Li, Rong Luo, Li Li, Gang Zhang, Lanlan Wang, Xiaofei Jiao, Feng J. He
Summary: The use of low-sodium salt substitute (LSSS) has the potential to reduce sodium and increase potassium intake. However, its real-world use and impact on sodium/potassium intake is unclear.
Article
Peripheral Vascular Disease
Abu Mohd Naser, Feng J. He, Mahbubur Rahman, Norm R. C. Campbell
Summary: The study evaluated the relationship between estimated 24-hour urinary sodium excretion from different formulas and blood pressure, finding discrepancies between formula-estimated sodium levels and actual measurements. The formulas resulted in overestimation of sodium at lower levels and underestimation at higher levels, impacting the relationship with blood pressure.
Article
Nutrition & Dietetics
Assaf Buch, Rebecca Goldsmith, Lesley Nitsan, Miri Margaliot, Gabi Shefer, Yonit Marcus, Naftali Stern
Summary: The study indicates that higher potassium excretion is associated with a lower risk of metabolic syndrome, and individuals with higher MS scores tend to have lower potassium excretion. Potassium excretion correlates with all components of MS and can predict the syndrome independently from other variables.
Article
Medicine, General & Internal
Yuan Ma, Feng J. He, Qi Sun, Changzheng Yuan, Lyanne M. Kieneker, Gary C. Curhan, Graham A. MacGregor, Stephan J. L. Bakker, Norm R. C. Campbell, Molin Wang, Eric B. Rimm, JoAnn E. Manson, Walter C. Willett, Albert Hofman, Ron T. Gansevoort, Nancy R. Cook, Frank B. Hu
Summary: This study analyzed data from six prospective cohorts of healthy adults and found that higher sodium and lower potassium intakes, estimated from multiple 24-hour urine samples, were associated in a dose-dependent manner with a higher cardiovascular risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Dianis Wulan Sari, Maiko Noguchi-Watanabe, Satoshi Sasaki, Junaiti Sahar, Noriko Yamamoto-Mitani
Summary: The study revealed high sodium and low potassium intakes among Indonesian adults, especially pronounced in participants with higher BMI. Future intervention programs should take into account these issues when planned in the country.
BRITISH JOURNAL OF NUTRITION
(2021)
Review
Environmental Sciences
Zhao Dan, Li Hua Min, Li Chao Xiu, Zhou Bo
Summary: There is a significant non-linear relationship between sodium excretion and CV events. Studies collecting 24-hour urine samples have shown a linear association between sodium excretion and CV event risk.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xiaofu Du, Le Fang, Jing Guo, Xiangyu Chen, Shuoci Su, Jie Zhang
Summary: The study revealed significant bias and poor correlation in predicting 24-hour urinary sodium excretion among Chinese adults using eight existing methods, indicating their limited validity for individual level estimation.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Zihao Wu, Mulalibieke Heizhati, Junli Hu, Mengyue Lin, Lin Gan, Mei Li, Wenbo Yang, Ling Yao, Jing Hong, Le Sun, Jing Li, Wei Li, Nanfang Li
Summary: A study conducted in China found that lower potassium intake is associated with the presence of anxiety and depression in the general population. These findings could be used as a basis for developing programs to increase potassium intake and prevent these conditions.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, General & Internal
Ya-Guang Peng, Jing-Jing Feng, Ying Zhang, Kun Li, Si-Yu Cai, Ruo-Hua Yan, Xiao-Xia Peng
Summary: This study explored the circadian rhythm of urinary sodium, potassium, and creatinine excretion in healthy young Chinese adults. While the circadian rhythm patterns differed for each substance, urinary creatinine excretion showed significant parameters, in contrast to sodium. There was some synchronization between the circadian rhythms of sodium and creatinine excretion, with both peaking at night, while potassium peaked in the morning. Hourly urine excretion also followed a similar circadian rhythm.
CHINESE MEDICAL JOURNAL
(2021)
Article
Peripheral Vascular Disease
Thirumagal Kanagasabai, Wuxiang Xie, Li Yan, Liancheng Zhao, Ellison Carter, Dongshuang Guo, Stella S. Daskalopoulou, Queenie Chan, Paul Elliott, Majid Ezzati, Xudong Yang, Gaoqiang Xie, Frank Kelly, Yangfeng Wu, Jill Baumgartner
Summary: The study suggests that household air pollution from cooking and heating with solid fuel may contribute to higher blood pressure, thicker intima-media in arteries, and larger plaque area.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Letter
Biochemistry & Molecular Biology
Ash Routen, Lauren O'Mahoney, Daniel Ayoubkhani, Amitava Banerjee, Chris Brightling, Melanie Calvert, Nishi Chaturvedi, Ian Diamond, Rosalind Eggo, Paul Elliott, Rachael A. Evans, Shamil Haroon, Emily Herret, Margaret E. O'Hara, Roz Shafran, Julie Stanborough, Terence Stephenson, Jonathan Sterne, Helen Ward, Kamlesh Khunti
Article
Multidisciplinary Sciences
Paul Elliott, Barbara Bodinier, Oliver Eales, Haowei Wang, David Haw, Joshua Elliott, Matthew Whitaker, Jakob Jonnerby, David Tang, Caroline E. Walters, Christina Atchison, Peter J. Diggle, Andrew J. Page, Alexander J. Trotter, Deborah Ashby, Wendy Barclay, Graham Taylor, Helen Ward, Ara Darzi, Graham S. Cooke, Marc Chadeau-Hyam, Christl A. Donnelly
Summary: The unprecedented increase in SARS-CoV-2 infections, particularly due to the Omicron variant, during December 2021 has been observed in England and globally. This study analyzed the prevalence and dynamics of SARS-CoV-2 in England from late November to mid-December 2021 among nearly 100,000 participants in the REACT-1 study. The results showed a high prevalence and rapid growth of infections, particularly in London, with an increasing proportion of Omicron cases. Vaccination and booster campaigns are crucial in controlling the spread of the virus, although additional measures have been necessary to control the rapid growth of the Omicron variant.
Article
Multidisciplinary Sciences
Paul Elliott, David Haw, Haowei Wang, Oliver Eales, Caroline E. Walters, Kylie E. C. Ainslie, Christina Atchison, Claudio Fronterre, Peter J. Diggle, Andrew J. Page, Alexander J. Trotter, Sophie J. Prosolek, Deborah Ashby, Christl A. Donnelly, Wendy Barclay, Graham Taylor, Graham Cooke, Helen Ward, Ara Darzi, Steven Riley
Summary: During early summer 2021, the Real-time Assessment of Community Transmission-1 (REACT-1) study in England found that infections were rising due to the Delta variant, with unvaccinated individuals having three times the prevalence of infection compared to double-vaccinated individuals. Despite vaccination, the vaccine effectiveness for double-vaccinated individuals was estimated to be around 50% to 60% during this period. Increased social mixing in the presence of the Delta variant had the potential to generate sustained growth in infections, even with high levels of vaccination.
Article
Medicine, General & Internal
Joshua Elliott, Matthew Whitaker, Barbara Bodinier, Oliver Eales, Steven Riley, Helen Ward, Graham Cooke, Ara Darzi, Marc Chadeau-Hyam, Paul Elliott
Summary: This study identified a set of 7 symptoms that can jointly predict COVID-19, including infection with the B.1.1.7 lineage, which helps maximize the detection of potential cases in the community.
Article
Cardiac & Cardiovascular Systems
Rami Al-Jafar, Maria Zografou Themeli, Sadia Zaman, Sharmin Akbar, Victor Lhoste, Ahlam Khamliche, Paul Elliott, Konstantinos K. Tsilidis, Abbas Dehghan
Summary: Ramadan fasting has beneficial effects on blood pressure, independent of potential confounders. Lower blood pressures were observed in groups of healthy individuals or those with hypertension or diabetes, but not in patients with chronic kidney disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Paul Elliott, Oliver Eales, Nicholas Steyn, David Tang, Barbara Bodinier, Haowei Wang, Joshua Elliott, Matthew Whitaker, Christina Atchison, Peter J. Diggle, Andrew J. Page, Alexander J. Trotter, Deborah Ashby, Wendy Barclay, Graham Taylor, Helen Ward, Ara Darzi, Graham S. Cooke, Christl A. Donnelly, Marc Chadeau-Hyam
Summary: The rapid transmission of the Omicron variant of SARS-CoV-2 has caused a surge in cases worldwide, including in England. The prevalence of infection is increasing, particularly among older age groups, but hospitalizations and deaths remain lower compared to previous waves, likely due to high levels of vaccination.
Article
Multidisciplinary Sciences
Matthew Whitaker, Joshua Elliott, Marc Chadeau-Hyam, Steven Riley, Ara Darzi, Graham Cooke, Helen Ward, Paul Elliott
Summary: This study characterizes Long COVID using data from the REACT-2 community-based study in England, estimating the prevalence of persistent symptoms and identifying risk factors. It also finds evidence of symptom clustering.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Paul Elliott, Oliver Eales, Barbara Bodinier, David Tang, Haowei Wang, Jakob Jonnerby, David Haw, Joshua Elliott, Matthew Whitaker, Caroline E. Walters, Christina Atchison, Peter J. Diggle, Andrew J. Page, Alexander J. Trotter, Deborah Ashby, Wendy Barclay, Graham Taylor, Helen Ward, Ara Darzi, Graham S. Cooke, Marc Chadeau-Hyam, Christl A. Donnelly
Summary: The REACT-1 study highlighted the significant increase in SARS-CoV-2 infection prevalence, especially among children, in England in January 2022. The rapid transmission of the Omicron variant has resulted in record-breaking case incidence rates globally.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Thirumagal Kanagasabai, Ellison Carter, Li Yan, Queenie Chan, Paul Elliott, Majid Ezzati, Frank Kelly, Gaoqiang Xie, Xudong Yang, Liancheng Zhao, Dongshuang Guo, Stella S. Daskalopoulou, Yangfeng Wu, Jill Baumgartner
Summary: In this cross-sectional study of peri-urban Chinese adults, we found inconsistent evidence linking household solid fuel use and renal function.
ENVIRONMENTAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal
Summary: The SSaSS study found that potassium-enriched salt can have definitive effects on cardiovascular outcomes and death. By quantifying the amount of potassium-enriched salt used, researchers were able to estimate the impact on risk reduction and the potential for population-wide scale-up. The results showed that even a partial replacement of regular salt with potassium-enriched salt can deliver significant health gains.
Article
Multidisciplinary Sciences
Fotios Koskeridis, Evangelos Evangelou, Saredo Said, Joseph J. Boyle, Paul Elliott, Abbas Dehghan, Ioanna Tzoulaki
Summary: In this study, the authors investigated the shared genetic determinants of low-grade inflammation and lipometabolism using a multi-trait GWAS approach. They identified many genetic loci associated with C-reactive protein, which are also related to lipid and glucose metabolism, indicating common biological pathways between inflammation and metabolic traits. Additionally, the study revealed novel pleiotropic loci and unexpected discordant effects between shared traits, with implications for clinical outcomes. These findings provide insights into the shared mechanisms underlying inflammation and lipid metabolism, highlighting potential targets for prevention and therapy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Matthew Whitaker, Joshua Elliott, Barbara Bodinier, Wendy Barclay, Helen Ward, Graham Cooke, Christl A. Donnelly, Marc Chadeau-Hyam, Paul Elliott
Summary: This study assesses changing symptom profiles associated with different SARS-CoV-2 variants in England from May 2020 to March 2022. The authors find that Omicron infection is more often associated with cold and influenza-like symptoms, and less with loss of taste and smell. Contrary to the perception that recent variants have become milder, Omicron BA.2 was associated with reporting more symptoms and greater disruption to daily activities than BA.1.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Loukas Zagkos, Marie-Joe Dib, Rui Pinto, Dipender Gill, Fotios Koskeridis, Fotios Drenos, Georgios Markozannes, Paul Elliott, Verena Zuber, Kostas Tsilidis, Abbas Dehghan, Ioanna Tzoulaki
Summary: This study investigated the relationship between genetically predicted fatty acid concentrations and clinical health outcomes. The results suggest potentially protective effects of circulating docosahexaenoic acid (DHA) and omega-3 concentrations on cholelithiasis, cholecystitis, and obesity. The findings do not support the supplementation of unsaturated fatty acids for cardiovascular disease prevention. Further evaluation in clinical trials is needed to strengthen the evidence.
Article
Endocrinology & Metabolism
Yik Weng Yew, Theresia Mina, Hong Kiat Ng, Benjamin Chih Chiang Lam, Elio Riboli, Eng Sing Lee, Jimmy Lee, Joanne Ngeow, Paul Elliott, Steven Tien Guan Thng, John C. Chambers, Marie Loh
Summary: This study aims to establish the association between obesity and skin physiology measurements and investigates whether obesity may play a possible causal role on skin barrier dysfunction. The results show a strong association between BMI and TEWL and skin pH, with suggestive evidence of a possible causal relationship. It highlights the potential impact of obesity on skin barrier function and the opportunity for prevention.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
