High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma

Sirtuin-1 Regulates Acinar-to-Ductal Metaplasia and Supports Cancer Cell Viability in Pancreatic Cancer

(2013) E. Wauters et al.   CANCER RESEARCH

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis

(2011) Hsieh-Cheng Chen et al.   ANNALS OF SURGICAL ONCOLOGY

p53 Modulates Acquired Resistance to EGFR Inhibitors and Radiation

(2011) S. Huang et al.   CANCER RESEARCH

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells

(2011) G Zhao et al.   GENE THERAPY

Nicotinamide Phosphoribosyltransferase Is Essential for Interleukin-1β-mediated Dedifferentiation of Articular Chondrocytes via SIRT1 and Extracellular Signal-regulated Kinase (ERK) Complex Signaling

(2011) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic cancer

(2011) Audrey Vincent et al.   LANCET

Restitution of Tumor Suppressor MicroRNAs Using a Systemic Nanovector Inhibits Pancreatic Cancer Growth in Mice

(2011) D. Pramanik et al.   MOLECULAR CANCER THERAPEUTICS

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Major Molecular Markers in Pancreatic Ductal Adenocarcinoma and Their Roles in Screening, Diagnosis, Prognosis, and Treatment

(2011) Puneet Singh et al.   PANCREAS

Genomics and pharmacogenomics of pancreatic adenocarcinoma

(2011) M A Lowery et al.   PHARMACOGENOMICS JOURNAL

Targeting Epigenetic Regulation of miR-34a for Treatment of Pancreatic Cancer by Inhibition of Pancreatic Cancer Stem Cells

(2011) Dara Nalls et al.   PLoS One

SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability

(2011) Glenn M. Marshall et al.   PLoS Genetics

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Pancreatic Cancer

(2010) Manuel Hidalgo   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Hypoxia-Inducible Factor 2  Signaling by the Stress-Responsive Deacetylase Sirtuin 1

(2009) E. M. Dioum et al.   SCIENCE

PTEN Acetylation Modulates Its Interaction with PDZ Domain

(2008) T. Ikenoue et al.   CANCER RESEARCH

Deacetylation of cortactin by SIRT1 promotes cell migration

(2008) Y Zhang et al.   ONCOGENE

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One