Article
Oncology
John D. Murphy, Andrew F. Olshan, Feng-Chang Lin, Melissa A. Troester, Hazel B. Nichols, Julia Butt, You-Lin Qiao, Christian C. Abnet, Manami Inoue, Shoichiro Tsugane, Meira Epplein
Summary: This study developed a predictive model for noncardia gastric adenocarcinoma risk using serum data on pepsinogen, antibody response to 13 H. pylori antigens, demographic, and lifestyle factors. The model showed higher accuracy and sensitivity compared to the ABC Method, and could assist in targeting screening resources to individuals at high risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Merel J. M. van Velzen, Michelle Braemer, Grard A. P. Nieuwenhuijzen, Johanna W. van Sandick, Peter D. Siersema, Jelle P. Ruurda, Marcel Verheij, Manon C. W. Spaander, Laurens V. Beerepoot, Nadia Haj Mohammad, Hanneke W. M. van Laarhoven, Rob H. A. Verhoeven
Summary: This study aimed to analyze the trends in incidence, staging, and treatment of gastric cancer. The results showed a decrease in incidence, more accurate staging, a shift in treatment modalities, and improved patient survival.
Article
Immunology
Dongsheng Liu, Jinyun Wang, Yong Xie
Summary: Refractory Helicobacter pylori infection leads to significant alterations in gastric microbiota, inhibiting the growth of beneficial Lactobacillus. Patients with refractory H. pylori infection may be more prone to developing gastric cancer.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Dan Li, Sheng-Fang Jiang, Nan Ye Lei, Shailja C. Shah, Douglas A. Corley
Summary: This large-scale retrospective cohort study in the United States investigated the incidence of noncardia gastric adenocarcinoma (NCGA) after Helicobacter pylori eradication therapy. The findings showed a significantly reduced risk of NCGA after 8 years of treatment compared to no treatment. This study highlights the potential for substantial gastric cancer prevention through H pylori eradication. Evaluation: 8 out of 10.
Review
Biotechnology & Applied Microbiology
Linqi Zhu, Yue Huang, Hong Li, Shihe Shao
Summary: Infection with Helicobacter pylori may promote the occurrence and progression of gastric cancer by influencing the tumor microenvironment (TME).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gunter Maubach, Michael Vieth, Francesco Boccellato, Michael Naumann
Summary: NF-03 signaling pathways are crucial for immune response and gastric pathophysiology, and their alterations induced by Helicobacter pylori infection have implications for gastric diseases.
TRENDS IN MOLECULAR MEDICINE
(2022)
Article
Oncology
Fengxia Wu, Cai Chen, Fulai Peng
Summary: The prevalence of Helicobacter pylori infection is high worldwide and is associated with gastric diseases such as gastric cancer and asthma. Coptidis rhizoma has been reported to have anti-inflammatory and anti-bacterial effects and may be effective in suppressing HPI and preventing asthma.
FRONTIERS IN ONCOLOGY
(2021)
Review
Microbiology
Marina A. Senchukova
Summary: H. pylori plays a role in the development of gastric cancer through interactions with pattern-recognition receptors on immune and epithelial cells. In addition to induction, H. pylori may also affect the mechanisms of gastric cancer progression.
CURRENT MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rejina Shrestha, Naoko Murata-Kamiya, Satoshi Imai, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Masanori Hatakeyama
Summary: The initial step in bacterial infection is the adherence of the bacterium to the target cell surface. This study found that the mouse stomach has a much lower expression level of Ceacam1 compared to the human stomach, which leads to the inability of the bacteria to deliver the CagA protein due to the lack of interaction between HopQ and Ceacam1 in mouse gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Surgery
Sa-Hong Min, Yongjoon Won, Kanghaeng Lee, Sang Il Youn, Guowei Kim, Young Suk Park, Sang-Hoon Ahn, Joong Do Park, Hyung-Ho Kim
Summary: Radical gastrectomy with metastasectomy may have a potential role in stage IV gastric cancer patients. Laparoscopic gastrectomy with metastasectomy in selected stage IV gastric cancer patients is safe and feasible.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Oncology
Michelle C. C. Lim, Phatcharida Jantaree, Michael Naumann
Summary: Helicobacter pylori is a pathogenic bacterium that resides in the stomach lining and causes inflammation called type B gastritis. The chronic inflammation induced by H. pylori and other factors may lead to the development of stomach neoplasms and adenocarcinoma. Dysregulation of cellular processes in the stomach lining and microenvironment is a characteristic of H. pylori infection. In this review, we discuss the contradictory role of H. pylori in promoting or suppressing apoptosis in gastric epithelial cells and highlight the key processes in the microenvironment that contribute to apoptosis and gastric carcinogenesis.
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Oncology
Christos Kosmas, Eleftheria Kranidioti, Aikaterini Kosma, Maria Karakosta, Constantinos Miltiadous, Anastasios Grivas, Aggelos Athanasopoulos, Evangelos Lianos
LEUKEMIA & LYMPHOMA
(2019)
Article
Oncology
Evangelos Fergadis, Niki Gavrielatou, Nikos Skouteris, Aggelos Athanasopoulos, Evangelos Lianos, Christos Kosmas
Article
Oncology
Evangelos Fergadis, Abraam Assi, Eleftheria Kranidioti, Aikaterini Kosma, Maria Karakosta, Constantinos Miltiadous, George K. Dimitriadis, Anastasios Grivas, Aggelos Athanasopoulos, Evangelos Lianos, Christos Kosmas
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2020)
Article
Medicine, General & Internal
Ioannis Kalantzis, Afroditi Nonni, Kitty Pavlakis, Eumorphia-Maria Delicha, Konstantinos Miltiadou, Christos Kosmas, Nikolaos Ziras, Konstantinos Gkoumas, Harikleia Gakiopoulou
WORLD JOURNAL OF CLINICAL CASES
(2020)
Meeting Abstract
Oncology
S. Xynogalos, D. Symeonidis, G. Papageorgiou, N. Charalambakis, E. Lianos, C. Kosmas, P. Manikis, G. Vorgias, N. Ziras
ANNALS OF ONCOLOGY
(2020)
Article
Oncology
Georgios Papageorgiou, Sergios A. Tsakatikas, Rodanthi G. Fioretzaki, Christos Kosmas
Summary: Glioblastoma multiforme (GBM) is a malignant CNS disease with poor prognosis. Current treatment options have limited efficacy, prompting the need for new clinical trials. The VITb regimen has shown promising results in young patients with relapsed solid tumors and is discussed in the context of GBM treatment.
Review
Oncology
Georgios Papageorgiou, Evangelos Fergadis, Nikos Skouteris, Evridiki Christakos, Sergios A. Tsakatikas, Aikaterini Filippakou, Evangelia Papantoni, Gabriela Stanc, Efthymia Souka, Christos Valavanis, Christos Kosmas
Summary: Monoclonal antibodies against PD-1 and PD-L1 are important in immunotherapy. They have long-lasting effects but can also lead to complications. This case report describes a patient with lung adenocarcinoma who developed acute abdominal pain during treatment and was diagnosed with immune-mediated colitis. Colitis with anti-CTLA-4 drugs is more common than with anti-PD-1 drugs, and most cases of anti-PD-1 colitis have preceding symptoms.
Article
Oncology
Georgios I. Papageorgiou, David G. Symeonidis, Sergios A. Tsakatikas, Alexandros D. Liatsos, Konstantinos A. A. Douglas, Vivian P. Douglas, Marilita M. Moschos, Christos Kosmas
Summary: Trastuzumab emtansine (T-DM1) is a targeted antibody-drug conjugate approved for the treatment of Her2-positive breast cancer, with common adverse events including peripheral neuropathy and ocular events. This report presents a case of transient blurred vision and vertigo in a patient after T-DM1 infusion, which gradually resolved after discontinuation of the drug.
Article
Oncology
David Symeonidis, Georgios Papageorgiou, Alexandros Liatsos, Helen Trihia, Evangelos Lianos, Christos Kosmas
Summary: This case report describes a 55-year-old Asian female patient with metastatic high-grade neuroendocrine carcinoma of unknown origin, who showed notable response to off-label nivolumab maintenance treatment after first-line chemotherapy and radiation.
Review
Oncology
Eleni Porfyriou, Sylvia Letsa, Christos Kosmas
Summary: High-dose chemotherapy with autologous hematopoietic stem cell transplantation is crucial in managing relapsed/refractory high-risk germ cell tumors. Multiple cycles of high-dose chemotherapy can compromise HSC mobilization, necessitating alternative strategies combining novel agents with traditional mobilizing regimens.
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
David G. Symeonidis, Alexandros D. Liatsos, Evridiki K. Mazlimoglou, Eleni C. Geraki, Christos Kosmas
Summary: PRES is a reversible condition linked to hypertension that can occur after chemotherapy. MRI plays a pivotal role in diagnosing and treating PRES.
CASE REPORTS IN ONCOLOGY
(2021)
Review
Oncology
Sergios Tsakatikas, George Papageorgiou, Rodanthi Fioretzaki, Christos Kosmas
Summary: Malignant tumors in young patients pose challenges due to rarity and lack of data. Chemotherapeutic drugs can have synergistic effects when combined, and adding novel molecules may enhance efficacy in therapeutic regimens.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Georgios I. Papageorgiou, Evangelos Fergadis, Nikos Skouteris, Evridiki Christakos, Sergios A. Tsakatikas, Evangelos Lianos, Christos Kosmas
Summary: PARP inhibitors are increasingly being used in cancer treatment, especially in tumors associated with BRCA deficiency. Preclinical data support their use in tumors exhibiting BRCAness or HRD, both as monotherapy and in combination with chemotherapy. This treatment approach has shown effectiveness in patients with ATM-deficient colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Spyridon Xynogalos, David Simeonidis, George Papageorgiou, Abraham Pouliakis, Nikolaos Charalambakis, Evangelos Lianos, Evridiki Mazlimoglou, Alexandros-Nikolaos Liatsos, Christos Kosmas, Nicolaos Ziras
Summary: This study investigated the thromboprophylaxis practice patterns in active cancer patients undergoing surgical and/or chemotherapy treatment and found that thromboprophylaxis with low molecular weight heparin (LMWH) was safe and effective for patients receiving highly thrombogenic agents.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Pia Roser, Bianca M. Leca, Claudia Coelho, Klaus-Martin Schulte, Jackie Gilbert, Eftychia E. Drakou, Christos Kosmas, Ling Ling Chuah, Husam Wassati, Alexander D. Miras, James Crane, Simon J. B. Aylwin, Ashley B. Grossman, Georgios K. Dimitriadis
Summary: Parathyroid carcinoma is a rare endocrine malignancy, accounting for about 1% of primary hyperparathyroidism cases. A systematic review of literature was conducted to analyze data on parathyroid carcinoma patients, including molecular pathogenesis, clinical presentation, treatment, and overall survival. The review included 75 studies from 17 countries, covering over 3000 patients. CDC73 mutation plays a pivotal role in the molecular pathogenesis of parathyroid carcinoma. En bloc resection is the recommended surgical approach, and targeted therapy based on molecular biomarkers shows promise as a novel treatment option.
ENDOCRINE-RELATED CANCER
(2023)
