Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Article
Medicine, Research & Experimental
Vaishali Chandel, Saurabh Maru, Arun Kumar, Ashok Kumar, Ashok Sharma, Brijesh Rathi, Dhruv Kumar
Summary: Head and Neck tumors exhibit highly altered metabolism, with cancer cells utilizing different pathways for energy production. Monocarboxylate transporters play a crucial role in regulating lactate and maintaining pH balance, essential for cancer cell survival and growth control.
Article
Oncology
Zongtai Qi, Yating Liu, Michael Mints, Riley Mullins, Reilly Sample, Travis Law, Thomas Barrett, Angela L. Mazul, Ryan S. Jackson, Stephen Y. Kang, Patrik Pipkorn, Anuraag S. Parikh, Itay Tirosh, Joseph Dougherty, Sidharth V. Puram
Summary: Tumors are composed of diverse cells rather than a uniform ball of cells. Recent studies have shown that deconvolution algorithms can be used to computationally estimate cell-type proportions from gene expression data, although their performance in tumor tissues remains unclear.
Review
Biochemistry & Molecular Biology
Ching-Yun Hsieh, Ching-Chan Lin, Wei-Chao Chang
Summary: Taxanes, especially docetaxel, are widely used in combination therapy for head and neck squamous cell carcinoma (HNSCC) and have shown advantages in improving patient outcomes. Taxanes not only function as antimitotics, but also impair various oncogenic signaling pathways. However, the development of drug resistance remains a major obstacle to treatment response.
Article
Cell Biology
Julia Ingruber, Dragana Savic, Teresa Bernadette Steinbichler, Susanne Sprung, Felix Fleischer, Rudolf Glueckert, Gabriele Schweigl, Ira-Ida Skvortsova, Herbert Riechelmann, Jozsef Dudas
Summary: The study found that in head and neck squamous cell carcinoma, Slug gene expression was significantly higher while KLF4 gene expression was significantly lower. There was a significant negative correlation between KLF4 and Slug gene expression in the majority of HNSCC samples. TGF-β1 contributed to the downregulation of KLF4 and the upregulation of Slug.
Review
Biochemistry & Molecular Biology
Shengjian Jin, Yasusei Kudo, Taigo Horiguchi
Summary: Ubiquitination and deubiquitination are two common post-translational modifications of proteins, affecting their intracellular localization, stability, and function. Deubiquitination is involved in various cellular processes, including histone modification, cell cycle regulation, apoptosis, and cancer development. This review focuses on the understanding of the function of deubiquitinating enzymes in head and neck squamous cell carcinoma (HNSCC) and discusses potential therapeutic strategies for HNSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Chenhang Yu, Qiang Li, Yu Zhang, Zhi-Fa Wen, Heng Dong, Yongbin Mou
Summary: Head and neck squamous cell carcinoma (HNSCC) has a high incidence and mortality rate. Immunotherapy, with its potential for a broad and long-lasting antitumor response, has become an important therapeutic strategy for HNSCC. However, immune escape limits the effectiveness of immunotherapy. Various immunotherapy strategies, including immune checkpoint inhibitors, costimulatory agonists, antigenic vaccines, oncolytic virus therapy, adoptive T cell transfer, and targeted therapy, have been developed for HNSCC. Each strategy has its unique advantages, and their appropriate application has significant value for the treatment of HNSCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ruoyan Cao, Lin Cui, Jiayu Zhang, Xianyue Ren, Bin Cheng, Juan Xia
Summary: This study identifies subtypes of head and neck squamous cell carcinoma based on immune-related lncRNAs and characterizes their biological behaviors. The researchers found that certain subtypes are associated with good prognosis and sensitivity to immunotherapy, and identified a critical lncRNA TRG-AS1 involved in the tumor microenvironment. This provides new potential targets for the treatment of this subtype.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Kainan Wu, Fen Chang, Wenming Li, Tongdong Su, Dapeng Lei
Summary: IGF2BPs are RNA-bound proteins that play a crucial part in various cell functions and act as members of the m6A reader family. They are particularly important in tumor metabolism, specifically in head and neck squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pathology
Gianluca Businello, Matteo Fassan, Silvia Degasperi, Giulia Traverso, Melania Scarpa, Imerio Angriman, Andromachi Kotsafti, Ignazio Castagliuolo, Marta Sbaraglia, Romeo Bardini, Marco Scarpa
Summary: The study suggests that HPV infection is not a factor associated with esophageal squamous cell carcinoma (ESCC) after head and neck squamous cell carcinoma (HNSCC). Instead, p53 overexpression is common in HNSCC-associated ESCCs. The altered immune microenvironment, characterized by dysregulated lymphomonocytic infiltration, may play a crucial role in the development of metachronous ESCC.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Moran Amit, Chuan Liu, Jobran Mansour, Frederico O. Gleber-Netto, Samantha Tam, Erez N. Baruch, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Kenneth Tsai, Elsa R. Flores, Michael R. Migden, Deborah A. Silverman, Goujun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study showed that elective neck dissection (END) did not improve survival rates for patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck and no evidence of regional metastasis. Further research is needed to clarify the role of END in patients with advanced disease.
Review
Oncology
Xiao Han, Ruxian Tian, Cai Wang, Yumei Li, Xicheng Song
Summary: This review systematically summarizes the regulatory mechanisms of circular RNA (CircRNA) in head and neck squamous cell carcinoma (HNSCC), and explores its functions in tumor growth, cell death, angiogenesis, invasion, and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Anna Brandt, Benjamin Thiele, Christoph Schultheiss, Eveline Daetwyler, Mascha Binder
Summary: Tumors release cell-free DNA (cfDNA) into the bloodstream, and liquid biopsies have become a non-invasive diagnostic test to analyze cfDNA and monitor cancer progression. This technique is particularly useful in patients with head and neck squamous cell carcinoma (HNSCC) due to its genetic heterogeneity and limited imaging sensitivity. However, there are technical challenges that need to be addressed before widespread clinical application of liquid biopsy in HNSCC management.
Article
Otorhinolaryngology
David T. Liu, Martin Schally, Sven Schneider, Julia Eckl-Dorna, Katie M. Phillips, Christian A. Mueller, Ahmad R. Sedaghat, Gerold Besser
Summary: The study found that Google searches with rhinosinusitis-specific search terms consistently peaked during the winter around the world over a 15-year period, indicating sustained interest in rhinosinusitis. These findings indirectly support the model of viral infection or exposure as the predominant cause of acute rhinosinusitis and acute exacerbations of chronic rhinosinusitis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Gerold Besser, Stefan Grasl, Elias L. Meyer, Julia Schnoell, Tina J. Bartosik, Faris F. Brkic, Gregor Heiduschka
Summary: The study found that the novel electrosurgical temperature-controlled device significantly reduced surgical time and intraoperative blood loss in tonsillectomies, with no apparent negative effects on postoperative pain or bleeding compared to traditional cold-steel tonsillectomy. In time-restricted settings, the device could be beneficial after familiarization with its handling.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Medicine, Research & Experimental
Valerie Dahm, Justin T. Lui, Joseph M. Chen, Alex Kiss, Amr F. Hamour, Trung N. Le, Vincent Y. Lin
Summary: The study found that both prescription patterns achieved sufficient pain control, and using a combination of acetaminophen and nonsteroidal anti-inflammatory drugs is recommended. When prescribing opioids, the dosage should be reduced as low as possible.
Review
Otorhinolaryngology
Stefan Janik, Muhammad Faisal, Blazen Marijic, Stefan Grasl, Matthaeus Ch. Grasl, Gregor Heiduschka, Boban M. Erovic
Summary: Mammary analogue secretory carcinomas (MASCs) of the parotid gland are low-grade malignancies with good clinical outcomes. T4 tumors behave more aggressively and require extended treatment strategies and close follow-ups.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Clinical Neurology
Valerie Dahm, Harley H. L. Chan, Michael J. Daly, Justin T. Lui, Vincent Y. Lin, Jonathan Irish, Joseph M. Chen, Trung N. Le
Summary: This study compared the performance and usability of a less expensive endovascular balloon to an approved device for eustachian tube dilation. The results showed that the less costly balloon achieved similar results to the approved device without any tissue damages or safety concerns in a cadaver study.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Allergy
Tamara Quint, Valerie Dahm, Dariga Ramazanova, Michael A. Arnoldner, Harald Kurz, Stefan Janik, Patrick M. Brunner, Birgit Knerer-Schally, Wolfgang Weninger, Johannes Griss, Robin Ristl, Sven Schneider, Christine Bangert
Summary: This study investigated the effect of omalizumab treatment on aspirin tolerance in atopic and nonatopic N-ERD patients. The results showed that omalizumab can improve aspirin tolerance in the majority of patients, regardless of atopic sensitization, and has a positive impact on chronic rhinosinusitis with nasal polyps, asthma, and biomarkers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Otorhinolaryngology
Muhammad Faisal, Rudolf Seemann, Gregor Fischer, Claudia Lill, Sasan Hamzavi, Arno Wutzl, Boban M. Erovic
Summary: Parapharyngeal space tumors with complex anatomy and diverse histology are challenging for treating physicians. Neurologic complications are significantly associated with neurogenic benign tumors.
INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Anselm Joseph Gadenstaetter, Alice Barbara Auinger, Matthias Gerlitz, Dominik Riss, Valerie Dahm, Erdem Yildiz, Karl Roessler, Christian Matula, Christoph Arnoldner
Summary: This study analyzed the functional outcome and implant usage of patients with preserved auditory nerve responses after simultaneous translabyrinthine schwannoma resection and cochlear implantation. The results showed that some patients had positive cochlear nerve responses after tumor removal and successfully underwent cochlear implantation, leading to improved hearing and word recognition. Therefore, intraoperative assessment of cochlear nerve function using electrically evoked auditory brainstem response audiometry can help identify individuals eligible for simultaneous vestibular schwannoma resection and cochlear implantation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Valerie Dahm, Ursula Schwarz-Nemec, Michael A. Arnoldner, Rudolfs Liepins, Alice B. Auinger, Christian Matula, Christoph Arnoldner
Summary: It is increasingly important and interesting to assess cochlear implantation in patients with vestibular schwannomas. The visibility of the internal auditory canal after vestibular schwannoma resection and cochlear implantation can be determined with magnetic resonance imaging. The study shows that surveillance with a 1.5T MRI device using metal artifact reduction sequences is feasible and safe.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Valerie Dahm, Justin T. T. Lui, Soyeon Jung, Vincent Y. Y. Lin, Joseph M. M. Chen, Trung N. N. Le
Summary: This study assessed the feasibility of transnasal balloon dilatation of the eustachian tube with an endovascular balloon and found it to be a safe and cost-effective alternative.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Pharmacology & Pharmacy
Julia Clara Gausterer, Michael Schlager, Navid Ahmadi, Michael Nieratschker, Valerie Dahm, Michael Wirth, Christoph Arnoldner, Clemens Honeder, Franz Gabor
Summary: A reliable method of preparing human nasal mucosa samples and a tool for investigating the carbohydrate building blocks of the respiratory epithelium’s glycocalyx are necessary to study glycotargeting as a potential strategy for nasal drug delivery. By using a simple experimental setup in a 96-well plate format and a panel of six fluorescein-labeled lectins with varying carbohydrate specificities, accessible carbohydrates in the mucosa could be detected and quantified. The experimental setup also allowed for the observation of the uptake of carbohydrate-bound lectin into the cells, and provided hints about the influence of mucus renewal on bioadhesive drug delivery.
Article
Immunology
Markus Haas, Alexander Lein, Thorsten Fuereder, Julia Schnoell, Faris F. Brkic, Nicholas J. Campion, David T. Liu, Lorenz Kadletz-Wanke, Gregor Heiduschka, Bernhard J. Jank
Summary: Thyroid dysfunction is common in patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) treated with pembrolizumab. Low fT3 is associated with worse overall survival (OS), while immune-related hyperthyroidism is correlated with longer progression-free survival (PFS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Rudolfs Liepins, Alexandra Kaider, Alice Barbara Auinger, Valerie Dahm, Clemens Honeder, Dominik Riss, Christoph Arnoldner
Summary: Stimulation with triphasic pulses can reduce unwanted facial nerve stimulation in cochlear implant patients. This study evaluated the effects of different stimulation pulse shapes on speech perception, loudness perception, and subjective sound quality. The results showed that triphasic stimulation does not affect speech perception in noise and can be considered as a valuable option in cochlear implant fitting.
Review
Otorhinolaryngology
Munir Demir Bajin, Valerie Dahm, Vincent Y. W. Lin
Summary: The purpose of this review is to summarize the current knowledge on hidden hearing loss (HHL) and its development mechanisms. It is characterized by impairment of afferent synapses of inner hair cells, particularly those with slow spontaneous firing rate. Recent research suggests that HHL may also be related to demyelination of cochlear nerve. Diagnostic tests such as auditory brainstem response, envelope-following response, and middle-ear muscle reflex show promise but still need validation in humans.
CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY
(2022)
Article
Medicine, General & Internal
Erdem Yildiz, Valerie Dahm, Christian Matula, Christoph Arnoldner
Summary: Vestibular schwannomas can severely impact patients' quality of life, with facial palsy being particularly disturbing. The varying growth rates of these benign tumors complicate the prediction of cranial nerve impairment. Regular updates on therapeutic strategies and alternative treatment options are important for both physicians and patients.
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2022)
