Journal
BMC CANCER
Volume 12, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/1471-2407-12-160
Keywords
Human papillomavirus genotype; Cervical screening; Cervical cancer; Prognosis
Categories
Funding
- National Nature Science Foundation of China [30973191]
- Science and Technology Program of Liaoning Province [2008225004]
- Peak Medical Construction Special Project of Liaoning Province [2010696]
- Liaoning Provincial Education Department [2007T180]
- Shengjing Hospital [200806]
Ask authors/readers for more resources
Background: Studies have shown that type-specific persistence of high-risk human papillomavirus (HPV) infection contributed significantly to cervical carcinogenesis. Methods: In this population-based study (on 24041 women), we report on the prevalent genotypes of HPVs and the prevalent genotypes of HPV persistent infection in the northeast of China. Results: Our results showed that in HPV infected women (45.6% in total), (95% CI, 44.97%-46.23%), 17.35% (95% CI, 16.87%-17.83%) suffered persistent infection. The most common high-risk HPV types in persistent positivity were HPV-16 (18.21%; 95% CI, 17.04%-19.38%), HPV-58 (13.2%; 95% CI, 12.17%-14.23%), HPV-18 (8.66%; 95% CI, 7.81%-9.51%), HPV-52 (7.06%; 95% CI, 6.28%-7.84%) and HPV-33 (6.78%; 95% CI, 6.02%-7.54%). The prevalence of persistent infections with HPV-16,-58, -18, -52 and 33 in cervicitis were lower compared to those in CIN (all P<0.05). HPV-58, -33 and multiple HPV persistent positivity were significantly associated with older age (all P<0.05). HPV-18 persistent positivity was significantly associated with adenocarcinoma and lymphatic metastasis (all P<0.05). HPV-18 persistent positivity was associated with cervical cancer prognosis (P<0.0001). Multivariate analyses showed that HPV-18 persistent positivity, (RR=1.704, 95% CI=1.095-2.654, p=0.028) and lymphatic metastasis (RR=2.304, 95% CI=1.354-3.254, P=0.015) were independent predictors for 3-year survival in cervical cancer. Conclusions: we provided extensive results of HPV genotype prevalence and distribution in the northeast of China. HPV genotyping is worthwhile to perform because of its independent prognostic value in cervical cancer
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available