Article
Oncology
Rackhyun Park, Yea-In Park, Yeonjeong Park, Siyun Lee, Jaeyeon So, Junsoo Park
Summary: CTRP1 plays a critical role in tumor progression, and knockout of CTRP1 gene can inhibit cell proliferation, invasion, and tumor growth. Elevated levels of CTRP1 are associated with poor prognosis.
Article
Biochemistry & Molecular Biology
Jolanta Kulesza, Ewa Paluszkiewicz, Ewa Augustin
Summary: In this study, the researchers used multicellular tumor spheroids as a model to investigate the cellular response and impact on cancer stem cells (CSCs) of a highly active anticancer drug called unsymmetrical bisacridines (UAs). The results showed that UAs affected the viability of cancer cells and their potential to form spheroids in both two-dimensional and three-dimensional cultures. Additionally, the most promising UAs induced apoptosis in the tumor spheres and affected the population of CSC-like cells. Therefore, UAs have potential as promising candidates for future therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Jingjing Ran, Yan Li, Lei Liu, Yihan Zhu, Yinyun Ni, Hong Huang, Zhiqiang Liu, Zhiyong Miao, Li Zhang
Summary: This study revealed that apelin may enhance the proliferation and invasion ability of lung cancer cells by inhibiting miR-15a-5p encapsulated in exosomes.
Article
Biochemistry & Molecular Biology
Takeshi Furuhashi, Yuki Matsumoto, Ryuga Ishii, Takehito Sugasawa, Shigenori Ota
Summary: Cancer cells emit volatile organic compounds (VOCs), which are potentially generated from ROS-based lipid peroxidation. However, the metabolism and regulation of these VOCs are not fully understood. This study demonstrated that recombinant alcohol dehydrogenase (ADH) converted Trans 2-hexenal into Trans 2-hexenol, a known cancer VOC. Hypoxia and lactate signaling were found to positively influence Trans 2-hexenol production in A549 cancer cells, with corresponding gene expressions observed. These findings suggest that hypoxia and lactate signaling may contribute to the characteristic VOC production in cancer cells in vitro.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biology
Richard J. Lobb, Kekoolani S. Visan, Li-Ying Wu, Emma L. Norris, Marcus L. Hastie, Sarah Everitt, Ian A. Yang, Rayleen V. Bowman, Shankar Siva, Jill E. Larsen, Jeffrey J. Gorman, Michael MacManus, Antoine Leimgruber, Kwun M. Fong, Andreas Moller
Summary: Despite advancements in therapy, lung cancer remains a leading cause of cancer-related death globally. Non-small cell lung cancer (NSCLC) patients have a low five-year survival rate and current staging methods may not accurately predict outcomes. Epithelial-to-mesenchymal transition (EMT) and associated protein changes in extracellular vesicles may serve as prognostic markers in NSCLC patients, enabling personalized treatment decisions.
COMMUNICATIONS BIOLOGY
(2023)
Article
Plant Sciences
Xing Zhang, Jing Zhou, Yongping Zhu, Yin Kwan Wong, Dandan Liu, Peng Gao, Qingsong Lin, Jianbin Zhang, Xiao Chen, Jigang Wang
Summary: This study comprehensively identified the protein targets of Cel in HCT116 cells and elucidated the mechanism of Cel's anti-cancer activity. Multiple pathways were identified as potential effectors of Cel based on the specific targets.
Article
Biochemistry & Molecular Biology
Sahand Mazloum-Ravasan, Elaheh Madadi, Ali Mohammadi, Behzad Mansoori, Mohammad Amini, Ahad Mokhtarzadeh, Behzad Baradaran, Farshad Darvishi
Summary: The study found that L-asparaginase can inhibit the proliferation of lung and breast cancer cells through apoptosis induction and changes in the expression of anti-apoptotic genes. Additionally, L-asparaginase significantly induces autophagy activation and inhibits cell migration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Sun-Il Yun, Chulhwan Kwak, Song-Yi Lee, Sanghee Shin, Changsuk Oh, Jong-Seo Kim, Hyun-Woo Rhee, Kyeong Kyu Kim
Summary: This study reveals that ubiquitin-specific protease 4 (USP4) is highly expressed in colon cancer and acts as a potent protooncogenic protein by deubiquitinating beta-catenin. In addition to its well-known role, it is also found that USP4 interacts with cortactin (CTTN) to promote cell dynamics and migration. The dual role of USP4 in cancer progression, involving the stabilization of beta-catenin and the interaction with CTTN, suggests that USP4 is an important target for cancer treatment or prevention.
Article
Multidisciplinary Sciences
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, Yoshiko Hatano, Ryota Ishii, Kazuaki Sawada, Akihito Machinaga, Wataru Ikeda, Takeshi Imamura, Toshiro Sato
Summary: This study develops an experimental platform for tracking cancer stem cells in colorectal cancer and identifies dormant LGR5(+) cancer stem cells. Transcriptome analysis reveals an upregulation of cell-adhesion molecule COL17A1 in dormant cancer stem cells, and chemotherapy disrupts this dormancy through FAK-YAP activation. Inhibition of YAP signaling prevents chemoresistant cells from exiting dormancy and delays tumor regrowth.
Article
Oncology
Shengbo Han, Decai Wang, Yan Huang, Zhu Zeng, Peng Xu, Hewei Xiong, Zunxiang Ke, Ya Zhang, Yuhang Hu, Fan Wang, Jie Wang, Yong Zhao, Wenfeng Zhuo, Gang Zhao
Summary: Research has shown that the emergence of Schwann cells around premalignant lesions of colon cancer may be an early indicator promoting tumorigenesis. This study explored the communication between colon cancer cells and Schwann cells, and identified NGF and exosomal miR-21-5p as potential therapeutic targets for colon cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Nabil A. Alhakamy, Usama A. Fahmy
Summary: This study investigated the cytotoxic effects of Cordycepin (COR) on colorectal cancer cells and optimized its delivery using emulsion liposomes. The refined COR emulsion liposomes (COR-EMLs) showed increased cytotoxicity against cancer cells by inhibiting cell proliferation, promoting apoptosis, inhibiting wound healing, and reducing mitochondrial membrane potential. Loading COR into the emulsion liposomes significantly enhanced its cytotoxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Shan Li, Feng Wang, Gang Zhang, Tsui-Fen Chou
Summary: CB-5339, an ATP-competitive p97 inhibitor, shows potential as an anti-cancer therapy. Through chemical proteomics and drug-induced thermal proteome changes, the researchers identified drug targets of CB-5339, and discovered its impact on glycometabolism. Further investigations revealed that NMS-873, a non-p97 dependent inhibitor, also influences glycometabolism and identified NDUFAF5 as a potential target.
Article
Pharmacology & Pharmacy
Marina Guedes Fonseca de Souza, Fabricia Nunes de Jesus Guedes, Marli Luiza Tebaldi, Everton do Nascimento Alencar, Lucas Amaral-Machado, Eryvaldo Socrates Tabosa do Egito, Andre Luis Branco de Barros, Daniel Cristian Ferreira Soares
Summary: Stealth liposomes loaded with iron oxide were developed as a potential alternative for lung cancer treatment. These ferri-liposomes showed significant cytotoxicity against lung cancer cells but not normal cells, indicating a potential selectivity for lung tumors. Flow cytometry studies suggested that ferri-liposomes induce apoptosis/ferroptosis in A549 tumor cells by reducing mitochondrial membrane potential.
Article
Cell Biology
Mingjiao Weng, Yukuan Feng, Yan He, Weiwei Yang, Jing Li, Yuanyuan Zhu, Tianzhen Wang, Chuhan Wang, Xiao Zhang, Yu Qiao, Qi Li, Lingyu Zhao, Shuangshu Gao, Lei Zhang, Yiqi Wu, Ran Zhao, Guangyu Wang, Zhiwei Li, Xiaoming Jin, Tongsen Zheng, Xiaobo Li
Summary: Hypoxia induces the production of LIN28A mRNA but segregates it into P-bodies, inhibiting LIN28A protein expression. Non-coding LIN28A mRNA promotes colon cancer cell metastasis by up-regulating METAP2 expression, independently of LIN28A protein, indicating a distinctive role of hypoxia in manipulating metastasis and proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Wen-Hui Hsieh, Shu-Wei Liao, Shun-Ming Chan, Jin-De Hou, Szu-Yuan Wu, Bing-Ying Ho, Kung-Yen Chen, Yu-Ting Tai, Hsu-Wei Fang, Chih-Yuan Fang, Se-Yi Chen, Jui-An Lin
Summary: The effects of clinically relevant concentrations of lidocaine on epithelial-mesenchymal transition (EMT) and associated lung cancer behaviors were investigated. Lidocaine attenuated the inhibitory effect of 5-fluorouracil (5-FU) on cell migration and promoted EMT at clinically relevant concentrations. Lidocaine also induced EMT-associated anoikis resistance in lung cancer cells.