Article
Oncology
Debbie Anaby, David Shavin, Gali Zimmerman-Moreno, Noam Nissan, Eitan Friedman, Miri Sklair-Levy
Summary: Women with BRCA1/BRCA2 genetic mutations have a higher risk of developing breast cancer. Early detection is crucial, but the current MRI scans often overlook or misinterpret tumors, leading to delayed diagnosis. To address this issue, an artificial intelligence-based tool was developed to classify tumors with a 65% accuracy at an early stage. This AI system could serve as an aid to radiologists, improving decision-making and achieving an 'earlier than early' diagnosis of breast cancer in BRCA carriers.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey A. Tice, Charlotte C. Gard, Diana L. Miglioretti, Brian L. Sprague, Anna N. A. Tosteson, Bonnie N. Joe, Thao-Quyen H. Ho, Karla Kerlikowske
Summary: This study investigated the consistency of Breast Imaging Reporting and Data System (BI-RADS) density reporting between digital breast tomosynthesis (DBT) and digital mammography (DM). It also evaluated the effectiveness of using DM and DBT to assess breast density as a risk factor for breast cancer. The results showed that there were no significant differences in density assessment between DBT and DM, and breast density had a similar impact on breast cancer risk when assessed using either method.
Article
Oncology
Geok Hoon Lim, Veronica Siton Alcantara, Ruey Pyng Ng, Raymond Ng, John Carson Allen, Me Me Win Htein, Swee Ho Lim, Zhiyan Yan, Qing Ting Tan
Summary: This study aimed to investigate the risk factors, prevalence, and patterns of second recurrences in mastectomy patients with breast cancer. The results showed that 20.7% of patients with treated locoregional first recurrence had second recurrences, with systemic metastases as the most common pattern occurring within 2 years after the first recurrence.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Ana-Alicia Beltran-Bless, Bader Alshamsan, Mashari Jemaan Alzahrani, John Hilton, Kelly-Anne Baines, Vicky Samuel, Gregory R. Pond, Lisa Vandermeer, Mark Clemons, Gail Larocque
Summary: The study evaluated the recurrence detection rate of breast cancer patients who were transferred to a survivorship program following ASCO recommendations. The results showed that healthcare providers rarely detected recurrences during routine follow-up appointments. Therefore, reducing in-person visits may not be associated with worse breast cancer-related outcomes.
Article
Cell Biology
Bin Sheng, Zichao Wei, Xiaowei Wu, Yi Li, Zhihua Liu
Summary: This study identified USP12 as a key deubiquitinating enzyme for breast cancer metastasis, promoting angiogenesis and leading to metastasis. Overexpression of USP12 decreased DMFS, while high MDK expression predicted lower DMFS and overall survival in breast cancer patients. The USP12-MDK axis may serve as a potential therapeutic target for breast cancer metastasis.
CELL DEATH & DISEASE
(2021)
Article
Biochemical Research Methods
Angela M. Jarrett, Anum S. Kazerouni, Chengyue Wu, John Virostko, Anna G. Sorace, Julie C. DiCarlo, David A. Hormuth, David A. Ekrut, Debra Patt, Boone Goodgame, Sarah Avery, Thomas E. Yankeelov
Summary: This protocol outlines a comprehensive pipeline for using quantitative MRI data to predict the response of locally advanced breast cancer to neoadjuvant therapy, involving image acquisition, segmentation, and mathematical modeling. Successful application of the protocol results in personalized predictions for individual patients' tumor responses to therapy.
Article
Oncology
Josep Guma, Jose Adria-Cebrian, Belen Ruiz-Aguado, Cinta Albacar, Josefa Girona, Ricardo Rodriguez-Calvo, Neus Martinez-Micaelo, Eric W. F. Lam, Luis Masana, Sandra Guaita-Esteruelas
Summary: The study identified a positive association between TG-enriched particles and certain branched amino acids with breast cancer, suggesting a distinct metabolic signature in BC patients that could aid in improved stratification and treatment. This is the first time advanced NMR profiling has been used to identify relevant lipid and amino acid metabolites in BC serum samples for early and reliable diagnosis and prognosis.
Article
Clinical Neurology
Tahmina Khawajazada, Konni Kass, Karen Rudolf, Josefine Stricker Borch, Aisha Munawar Sheikh, Nanna Witting, John Vissing
Summary: The study found that men with ANO5 deficiency exhibit severe fat replacement in lower extremity muscles, while women are less affected and show more symmetric muscle involvement.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Oncology
Andrew D. James, Theresa K. Leslie, Joshua D. Kaggie, Laura Wiggins, Lewis Patten, John Murphy O'Duinn, Swen Langer, Marie-Christine Labarthe, Frank Riemer, Gabrielle Baxter, Mary A. McLean, Fiona J. Gilbert, Aneurin J. Kennerley, William J. Brackenbury
Summary: In this study, the diagnostic and treatment-monitoring potential of sodium (Na-23) MRI in breast cancer was demonstrated. The researchers found elevated sodium concentration in tumor regions compared to non-tumor regions, and combining Na-23 MRI with other imaging measurements improved the accuracy of tumor classification. This novel MRI method also showed superior sensitivity in assessing treatment response compared to traditional methods.
BRITISH JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Anna N. A. Tosteson, Karen E. Schifferdecker, Rebecca E. Smith, Karen J. Wernli, Wenyan Zhao, Celia P. Kaplan, Diana S. M. Buist, Louise M. Henderson, Brian L. Sprague, Tracy Onega, Jill Budesky, Gloria Jackson-Nefertiti, Dianne Johnson, Diana L. Miglioretti, Karla Kerlikowske
Summary: This study aimed to investigate women's confidence in breast cancer screening. The findings revealed that women with dense breasts had lower confidence in screening, while those who underwent breast magnetic resonance imaging (MRI) had higher confidence. In addition, screening choice, decision satisfaction, and worry were also associated with screening confidence.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Chemistry, Multidisciplinary
Xiujuan Zhang, Fei Luo, Shaliu Luo, Ling Li, Xinxin Ren, Jing Lin, Yingchun Liang, Chao Ma, Lihua Ding, Deyu Zhang, Tianxing Ye, Yanni Lin, Bilian Jin, Shan Gao, Qinong Ye
Summary: Aerobic glycolysis, or the Warburg effect, is a critical process in cancer cell growth and metastasis. This study demonstrates that the transcription factor OVOL2 can directly repress glycolytic gene expression to block the Warburg effect. The activation of OVOL2 by the tumor suppressor p53 through inhibiting MDM2-mediated degradation presents a potential avenue for cancer treatment, particularly in breast cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chao Cong, Xiaoguang Li, Chunlai Zhang, Jing Zhang, Kaixiang Sun, Lianluyi Liu, Bharath Ambale-Venkatesh, Xiao Chen, Yi Wang
Summary: The study implemented a deep learning method for breast cancer classification and detection by combining feature extraction and combination from multiple sequences. With optimized combinations of magnetic resonance imaging sequences, the lesion classification achieved AUC values of 0.98 and 0.91 in the internal and external cohorts, respectively. Without dynamic contrast-enhanced MRI, the deep learning-based method outperformed radiologists' readings in lesion classification.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Masa Aleckovic, Simona Cristea, Carlos R. Gil Del Alcazar, Pengze Yan, Lina Ding, Ethan D. Krop, Nicholas W. Harper, Ernesto Rojas Jimenez, Donghao Lu, Anushree C. Gulvady, Pierre Foidart, Marco Seehawer, Benedetto Diciaccio, Katherine C. Murphy, Jason Pyrdol, Jayati Anand, Kodie Garza, Kai W. Wucherpfennig, Rulla M. Tamimi, Franziska Michor, Kornelia Polyak
Summary: TGF beta signaling plays a critical role in breast cancer risk. Short-term treatment with TGFBR inhibitors prevents mammary tumors in rats and is associated with a unique epithelial subpopulation called secretory basal cells (SBCs), which are also found in human breast tissues and associated with breast cancer risk. Furthermore, SBCs are identified as the most interactive cell population and the main source of insulin-IGF signaling, and the inhibition of TGFBR and IGF1R decreases proliferation. These findings provide a proof-of-principle cancer prevention strategy.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Amy P. Early, Wong Moon
Summary: This 20-year retrospective review found an overall recurrence rate of 5.3% and a rate of 1.2% for secondary cancers in breast cancer patients who underwent autologous tissue reconstruction. The study showed that survival rates after treatment for breast carcinomas were consistent with those reported in the literature. The analysis also identified and examined secondary neoplasms, including some rare tumor types.
CLINICAL BREAST CANCER
(2021)
Article
Oncology
Abel Cordoba, Benedicte Durand, Alexandre Escande, Sophie Taieb, Mariem Ben Haj Amor, Marie Cecile Le Deley, Andree Michel, Florence Le Tinier, Delphine Hudry, Carlos Martinez, Eric Leblanc, Stephanie Becourt, Cyril Abdedaim, Lucie Bresson, Eric Lartigau, Xavier Mirabel, Fabrice Narducci
Summary: Our study confirms the prognostic impact of tumor size reduction using MRI data obtained after radiochemotherapy in patients with locally advanced cervical cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Camille Rondenet, Ingrid Millet, Lucie Corno, Wassef Khaled, Isabelle Boulay-Coletta, Patrice Taourel, Marc Zins
EUROPEAN RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Olivier Rouviere, Francois Cornelis, Serge Brunelle, Catherine Roy, Marc Andre, Marie-France Bellin, Isabelle Boulay, David Eiss, Nicolas Girouin, Nicolas Grenier, Olivier Helenon, Jean-Francois Lapray, Arnaud Lefevre, Xavier Matillon, Jean-Michel Menager, Ingrid Millet, Sebastien Ronze, Thomas Sanzalone, Jean Tourniaire, Laurence Rocher, Raphaele Renard-Penna
EUROPEAN RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Raphaele Renard-Penna, Laurence Rocher, Catherine Roy, Marc Andre, Marie-France Bellin, Isabelle Boulay, David Eiss, Nicolas Girouinn, Nicolas Grenier, Olivier Helenon, Jean-Francois Lapray, Arnaud Lefevre, Xavier Matillon, Jean-Michel Menager, Ingrid Millet, Sebastien Ronze, Thomas Sanzalone, Jean Tourniaire, Serge Brunelle, Olivier Rouviere, Michel Abihanna, Alexandre Ben Cheikh, Flavie Bratan, Laurent Brunereau, Jean Champagnac, Francois Cornelis, Malek Ezziane, Paul-Hugo Jouve De Guibert, Eric de Kerviler, Yann Lebras, Pierre Leyendecker, Laurent Milot, Paul Moldovan, Sarah Montagne, Isabelle Mollard Garassus, Sebastien Novellas, Gaele Pagnoux, Sylvain Poiree, Philippe Puech, Anne Ravel, Jean-Romain Risson, Remy Rosset, Athivada Soto Thammavong, Philippe Souteyrand
EUROPEAN RADIOLOGY
(2020)
Review
Medicine, General & Internal
Radjiv Goulabchand, Assia Hafidi, Philippe Van de Perre, Ingrid Millet, Alexandre Thibault Jacques Maria, Jacques Morel, Alain Le Quellec, Helene Perrochia, Philippe Guilpain
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Marc Zins, Ingrid Millet, Patrice Taourel
Correction
Radiology, Nuclear Medicine & Medical Imaging
Cecile Verheyden, Celine Orliac, Ingrid Millet, Patrice Taourel
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin Monsonis, Caroline Mandoul, Ingrid Millet, Patrice Taourel
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Cecile Verheyden, Celine Orliac, Ingrid Millet, Patrice Taourel
EUROPEAN JOURNAL OF RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claire Faget, Ingrid Millet, Mustapha Sebbane, Rodolphe Thuret, Cecile Verheyden, Fernanda Curros-Doyon, Nicolas Molinari, Patrice Taourel
Summary: In patients with clinical findings consistent with uncomplicated renal colic due to urolithiasis, using ultrasound as the first-line imaging modality and restricting CT to patients with negative ultrasound and a STONE score >= 10 resulted in a sensitivity and specificity above 95%, identified 84% of stones requiring urological management, and reduced the number of necessary CT scans by fourfold.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
B. Monsonis, M. Zins, C. Orliac, C. Mandoul, I Boulay-Coletta, F. Curros-Doyon, N. Molinari, P. Taourel, I Millet
Summary: CT findings were used to differentiate between appendiceal tumors and non-tumoral appendices in acute appendicitis, identifying appendicolith and fat stranding as protective factors, while mural calcifications, appendix mass, focal asymmetric wall abnormality, or diameter >= 15 mm were positive predictive factors of a tumor. A diagnostic score with a >= 1 cutoff showed high predictive accuracy in identifying underlying appendiceal neoplasms.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Thibaut Jacques, Laure Fournier, Marc Zins, Catherine Adamsbaum, Kathia Chaumoitre, Antoine Feydy, Ingrid Millet, Michel Montaudon, Jean-Paul Beregi, Jean-Michel Bartoli, Philippe Cart, Jean-Philippe Masson, Jean-Francois Meder, Louis Boyer, Anne Cotten
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jessica Delebecq, Martha Duraes, Caroline Mandoul, Gauthier Rathat, Patrice Taourel, Ingrid Millet
IMAGERIE DE LA FEMME
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jonathan Charbit, Severin Ramin, Margaux Hermida, Pierre Cavaille, Thibault Murez, Patrice Taourel, Xavier Capdevila, Ingrid Millet
EMERGENCY RADIOLOGY
(2020)
Article
Medicine, General & Internal
Isabelle Thomassin-Naggara, Edouard Poncelet, Aurelie Jalaguier-Coudray, Adalgisa Guerra, Laure S. Fournier, Sanja Stojanovic, Ingrid Millet, Nishat Bharwani, Valerie Juhan, Teresa M. Cunha, Gabriele Masselli, Corinne Balleyguier, Caroline Malhaire, Nicolas F. Perrot, Elizabeth A. Sadowski, Marc Bazot, Patrice Taourel, Raphael Porcher, Emile Darai, Caroline Reinhold, Andrea G. Rockall
Letter
Radiology, Nuclear Medicine & Medical Imaging
Nathan Banaste, Berenice Caurier, Flavie Bratan, Jean-Francois Bergerot, Vivien Thomson, Ingrid Millet