Article
Oncology
Israa T. Ismail, Ashraf Elfert, Marwa Helal, Ibrahim Salama, Hala El-Said, Oliver Fiehn
Summary: Hepatocellular carcinoma (HCC) has a poor prognosis and is a leading cause of mortality worldwide. This study analyzed lipid alterations in blood and tissues of HCC patients compared to healthy controls and those with chronic liver disease. The research identified significant changes in lipid composition, particularly in triacylglycerides and phosphatidylcholines, between healthy controls, CLD patients, and HCC patients. These findings may have implications for the prevention, early detection, and treatment of HCC.
Article
Biochemistry & Molecular Biology
Yu Zhang, Xiumei Wu, Mengyun Xu, Tong Yue, Ping Ling, Tingyu Fang, Sihui Luo, Suowen Xu, Jianping Weng
Summary: This study conducted hepatic and serum proteomic analysis in a diabetic mouse model to identify differentially expressed proteins (DEPs). The analysis revealed the involvement of these DEPs in various pathways and biological processes. Validation of mRNA expression of related genes further confirmed the results obtained from proteomic screening. These findings potentially provide sensitive non-invasive serum biomarkers for diabetes and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ming-Wei Lai, Yu-De Chu, Chao-Wei Hsu, Yi-Cheng Chen, Kung-Hao Liang, Chau-Ting Yeh
Summary: Gut dysbiosis and impaired intestinal barrier are associated with different liver diseases, affecting the systemic immune environment through the gut-liver axis. This study identified common network features in patients with liver cirrhosis or hepatocellular carcinoma (HCC), as well as disease-specific signatures. Alterations in gut microbial/viral composition may contribute to pre-HCC disorders, metabolic reprogramming, or inflammatory microenvironments for hepatocarcinogenesis.
Review
Medicine, General & Internal
Koji Fujita, Tsutomu Masaki
Summary: In recent years, non-invasive indexes of liver fibrosis based on blood examinations have been developed, partially replacing liver biopsy examinations. The concept of liver cirrhosis has been revised to compensated advanced chronic liver diseases, as serum biomarkers are unable to differentiate cirrhosis from severe fibrosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Xuan-vinh Kevin Nguyen, Jason Zhang, Ken Lee Chin, Stephen Bloom, Amanda J. Nicoll
Summary: This study compared the characteristics and survival rates of NAFLD-HCC patients to non-NAFLD-HCC patients, finding that NAFLD-HCC patients were more likely to be diagnosed based on symptoms and at an older age, with lower survival rates.
Article
Multidisciplinary Sciences
Laura M. Lilley, Steven Sanche, Shepard C. Moore, Michelle R. Salemi, Dung Vu, Srinivas Iyer, Nicolas W. Hengartner, Harshini Mukundan
Summary: The discovery of reliable signatures for the diagnosis of neurological diseases is still unrealized. This study presents a comprehensive database of signatures derived from serum and cerebrospinal fluid, as well as common pathways between them, providing a pathway for comprehensive diagnostics and therapeutics discovery for neurological injuries/disease.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Hyeyeon Cho, Ji-Yoon Jung, Hyun-Kyu Yoon, Seong-Mi Yang, Ho-Jin Lee, Won Ho Kim, Chul-Woo Jung, Kyung-Suk Suh
Summary: Early allograft dysfunction (EAD) and acute kidney injury (AKI) are common complications after liver transplantation. Researchers investigated the combination of serum lactate level and neutrophil gelatinase-associated lipocalin (NGAL) as predictors for EAD and AKI. They found that the combination of lactate-adjusted NGAL was a reliable predictor with better discriminative ability than lactate or NGAL alone.
SCIENTIFIC REPORTS
(2023)
Review
Gastroenterology & Hepatology
George Cholankeril, Hashem B. El-Serag
Summary: The burden of hepatocellular carcinoma (HCC) caused by nonalcoholic fatty liver disease (NAFLD) is increasing due to the global obesity trends. Patients with NAFLD-related cirrhosis have a higher risk of HCC, justifying surveillance based on cost-effectiveness. However, there is a lack of precise risk-stratification tools for noncirrhotic NAFLD patients. Traditional and metabolic risk factors alone are not sufficient for HCC risk stratification, and integrating molecular and genetic factors is key to personalizing HCC risk in NAFLD. This review discusses concerns regarding defining a target population, surveillance test accuracy, underuse of surveillance, and cost-effective considerations for HCC surveillance in NAFLD individuals.
SEMINARS IN LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Arun J. Sanyal, Stephen A. Williams, Joel E. Lavine, Brent A. Neuschwander-Tetri, Leigh Alexander, Rachel Ostroff, Hannah Biegel, Kris V. Kowdley, Naga Chalasani, Srinivasan Dasarathy, Anna Mae Diehl, Rohit Loomba, Bilal Hameed, Cynthia Behling, David E. Kleiner, Saul J. Karpen, Jessica Williams, Yi Jia, Katherine P. Yates, James Tonascia
Summary: Using modified-aptamer proteomics, researchers identified diagnostic signatures for key histological features of NAFLD in 636 patients. The protein models accurately diagnosed various severities of NAFLD and were able to monitor treatment effectiveness.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Abdulkadir Elmas, Amaia Lujambio, Kuan-lin Huang
Summary: In this study, proteogenomic analyses were performed on hepatocellular carcinoma (HCC) tumors, revealing overexpressed protein targets that have therapeutic potential even in the absence of clinically actionable mutations. The study demonstrates the importance of proteomics approaches in advancing precision medicine for cancer types lacking druggable mutations.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Sami Qadri, Noora Ahlholm, Ida Lonsmann, Paola Pellegrini, Anni Poikola, Panu K. Luukkonen, Kimmo Porthan, Anne Juuti, Henna Sammalkorpi, Anne K. Penttila, Roberta D'Ambrosio, Giorgio Soardo, Diana J. Leeming, Morten Karsdal, Johanna Arola, Stergios Kechagias, Serena Pelusi, Mattias Ekstedt, Luca Valenti, Hannes Hagstrom, Hannele Yki-Jarvinen
Summary: This study investigated the impact of obesity on the performance of liver fibrosis biomarkers in NAFLD and found that ADAPT and FIB-4 are the best-performing biomarkers in obese patients, unaffected by body mass index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemical Research Methods
Peipei Zhu, Xiaofeng Wu, Ruo-Yu Zhang, Chuan-Chih Hsu, Zhong-Yin Zhang, W. Andy Tao
Summary: Protein phosphatases are important in cellular processes, but studying their substrates and mechanisms is challenging. This study introduces a novel strategy to identify substrates of SHP2 using quantitative proteomics methods, and discovers new substrates.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Cristiana Bianco, Oveis Jamialahmadi, Serena Pelusi, Guido Baselli, Paola Dongiovanni, Irene Zanoni, Luigi Santoro, Silvia Maier, Antonio Liguori, Marica Meroni, Vittorio Borroni, Roberta D'Ambrosio, Rocco Spagnuolo, Anna Alisi, Alessandro Federico, Elisabetta Bugianesi, Salvatore Petta, Luca Miele, Umberto Vespasiani-Gentilucci, Quentin M. Anstee, Felix Stickel, Jochen Hampe, Janett Fischer, Thomas Berg, Anna Ludovica Fracanzani, Giorgio Soardo, Helen Reeves, Daniele Prati, Stefano Romeo, Luca Valenti
Summary: This study utilized polygenic risk scores (PRS) to investigate the causal relationship between hepatic fat and HCC, improving the accuracy of HCC detection and helping to stratify HCC risk in individuals with dysmetabolism. The PRS showed robust predictions for HCC in both high-risk individuals and the general population.
JOURNAL OF HEPATOLOGY
(2021)
Article
Physiology
Aleksandra Hliwa, Adriana Mika, Maciej Sledzinski, Dariusz Laski, Bruno Ramos-Molina, Tomasz Sledzinski
Summary: The anhepatic phase during liver transplantation produces significant changes in serum fatty acid levels, particularly very long-chain fatty acids.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Yuri Cho, Bo Hyun Kim, Joong-Won Park
Summary: The incidence of hepatocellular carcinoma (HCC) associated with nonalcoholic fatty liver disease (NAFLD) is increasing globally, including Asia. Compared to virus-related HCC, most patients with NAFLD-related HCC are diagnosed at a late stage and older age due to lack of HCC surveillance. This review provides an overview of the mechanism of hepatocarcinogenesis in NAFLD, preventive strategies for NAFLD-related HCC, and surveillance strategies for patients with NAFLD.
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Alessandro Vitale, Gianluca Svegliati-Baroni, Alessio Ortolani, Monica Cucco, Giulio Dalla Riva, Edoardo G. Giannini, Fabio Piscaglia, Gianludovico Rapaccini, Mariella Di Marco, Eugenio Caturelli, Marco Zoli, Rodolfo Sacco, Giuseppe Cabibbo, Fabio Marra, Andrea Mega, Filomena Morisco, Antonio Gasbarrini, Francesco Giuseppe Foschi, Gabriele Missale, Alberto Masotto, Gerardo Nardone, Giovanni Raimondo, Francesco Azzaroli, Gianpaolo Vidili, Filippo Oliveri, Filippo Pelizzaro, Rafael Ramirez Morales, Umberto Cillo, Franco Trevisani, Luca Miele, Giulio Marchesini, Fabio Farinati
Summary: This study compared patients with MAFLD and non-MAFLD who had hepatocellular carcinoma (HCC) in Italy. It found that the proportion of MAFLD in HCC patients was increasing over time and is expected to surpass non-MAFLD in the future. Despite a later cancer stage at diagnosis, MAFLD HCC patients had a lower risk of HCC-related death, suggesting reduced cancer aggressiveness.
Article
Oncology
Haonan Lu, Jacob George, Mohammed Eslam, Augusto Villanueva, Luigi Bolondi, Helen L. Reeves, Misti McCain, Edward Chambers, Caroline Ward, Dewi Sartika, Caroline Sands, Lynn Maslen, Matthew R. Lewis, Ramya Ramaswami, Rohini Sharma
Summary: The burden of metabolic associated fatty liver disease (MAFLD) is increasing, along with an increase in hepatocellular cancer (HCC). The characteristic features of MAFLD and its sequelae include disturbances in lipid handling, inflammation, and mitochondrial damage. This study aimed to identify a predictive model for HCC by analyzing the profile of circulating lipid and small molecule metabolites in MAFLD patients.
Article
Medicine, General & Internal
Quirino Lai, Nicoletta De Matthaeis, Michele Finotti, Giovanni Galati, Giuseppe Marrone, Fabio Melandro, Filomena Morisco, Daniele Nicolini, Riccardo Pravisani, Edoardo G. Giannini
Summary: This study evaluates the impact of antiplatelet therapy on the incidence and mortality of hepatocellular carcinoma. The results suggest that antiplatelet therapy is associated with a reduced risk of HCC incidence and post-treatment mortality.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Editorial Material
Gastroenterology & Hepatology
Lucia Cerrito, Luisa Guidi, Fabio M. Vecchio, Luca Miele
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Jenny Lee, Max Westphal, Yasaman Vali, Jerome Boursier, Salvatorre Petta, Rachel Ostroff, Leigh Alexander, Yu Chen, Celine Fournier, Andreas Geier, Sven Francque, Kristy Wonders, Dina Tiniakos, Pierre Bedossa, Mike Allison, Georgios Papatheodoridis, Helena Cortez-Pinto, Raluca Pais, Jean-Francois Dufour, Diana Julie Leeming, Stephen Harrison, Jeremy Cobbold, Adriaan G. Holleboom, Hannele Yki-Jarvinen, Javier Crespo, Mattias Ekstedt, Guruprasad P. Aithal, Elisabetta Bugianesi, Manuel Romero-Gomez, Richard Torstenson, Morten Karsdal, Carla Yunis, Joern M. Schattenberg, Detlef Schuppan, Vlad Ratziu, Clifford Brass, Kevin Duffin, Koos Zwinderman, Michael Pavlides, Quentin M. Anstee, Patrick M. Bossuyt, LITMUS Investigators
Summary: Detection of NASH and at-risk NASH can be improved by constructing independent machine learning models for each component, using only clinical predictors. Adding biomarkers only improved the accuracy of fibrosis.
Article
Gastroenterology & Hepatology
Mary E. Rinella, Jeffrey V. Lazarus, Vlad Ratziu, Sven M. Francque, Arun J. Sanyal, Fasiha Kanwal, Diana Romero, Manal F. Abdelmalek, Quentin M. Anstee, Juan Pablo Arab, Marco Arrese, Ramon Bataller, Ulrich Beuers, Jerome Boursier, Elisabetta Bugianesi, Christopher D. Byrne, Graciela E. Castro Narro, Abhijit Chowdhury, Helena Cortez-Pinto, Donna R. Cryer, Kenneth Cusi, Mohamed El-Kassas, Samuel Klein, Wayne Eskridge, Jiangao Fan, Samer Gawrieh, Cynthia D. Guy, Stephen A. Harrison, Seung Up Kim, Bart G. Koot, Marko Korenjak, Kris V. Kowdley, Florence Lacaille, Rohit Loomba, Robert Mitchell-Thain, Timothy R. Morgan, Elisabeth E. Powell, Michael Roden, Manuel Romero-Gomez, Marcelo Silva, Shivaram Prasad Singh, Silvia C. Sookoian, C. Wendy Spearman, Dina Tiniakos, Luca Valenti, Miriam B. Vos, Vincent Wai-Sun Wong, Stavra Xanthakos, Yusuf Yilmaz, Zobair Younossi, Ansley Hobbs, Marcela Villota-Rivas, Philip N. Newsome
Summary: This study aimed to determine if there was a need to change the nomenclature and definition of NAFLD and NASH. Through a Delphi process involving content experts and patient advocates, a consensus was reached to replace NAFLD with metabolic dysfunction-associated steatotic liver disease (MetALD) and modify the diagnostic criteria. The new nomenclature and criteria are widely supported, nonstigmatizing, and can improve awareness and patient identification.
Correction
Medicine, General & Internal
Maurizio Gabrielli, Giulia Pignataro, Marcello Candelli, Marta Sacco Fernandez, Martina Bizzarri, Alessandra Esperide, Francesco Franceschi
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Transplantation
Matteo Bargagli, Antonio Liguori, Cecilia Napodano, Silvia Baroni, Lidia Tomasello, Fabrizio Pizzolante, Nicoletta De Matthaeis, Grazia De Ninno, Antonio Grieco, Antonio Gasbarrini, Giovanni Gambaro, Pietro Manuel Ferraro, Luca Miele
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Gastroenterology & Hepatology
Giuseppe Marrone, Amato Serra, Luca Miele, Marco Biolato, Antonio Liguori, Antonio Grieco, Antonio Gasbarrini
Summary: Liver cirrhosis is often accompanied by nutritional alterations, affecting about 20% of patients with compensated disease and over 60% of patients with decompensated cirrhosis. Imbalance of amino acids, especially branched-chain amino acids (BCAAs), has been shown to be associated with complications and prognosis in these patients. Various studies have explored the use of BCAAs supplementation as a therapeutic option, but uncertainties persist regarding its real efficacy, optimal administration route, and dosage.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Ferenc E. Mozes, Jenny A. Lee, Yasaman Vali, Osama Alzoubi, Katharina Staufer, Michael Trauner, Rafael Paternostro, Rudolf E. Stauber, Adriaan G. Holleboom, Anne-Marieke van Dijk, Anne Linde Mak, Jerome Boursier, Marc de Saint Loup, Toshihide Shima, Elisabetta Bugianesi, Silvia Gaia, Angelo Armandi, Shalimar, Monica Lupsor-Platon, Vincent Wai-Sun Wong, Guanlin Li, Grace Lai-Hung Wong, Jeremy Cobbold, Thomas Karlas, Johannes Wiegand, Giada Sebastiani, Emmanuel Tsochatzis, Antonio Liguori, Masato Yoneda, Atsushi Nakajima, Hannes Hagstrom, Camilla Akbari, Masashi Hirooka, Wah-Kheong Chan, Sanjiv Mahadeva, Ruveena Rajaram, Ming-Hua Zheng, Jacob George, Mohammed Eslam, Salvatore Petta, Grazia Pennisi, Mauro Vigano, Sofia Ridolfo, Guruprasad Padur Aithal, Naaventhan Palaniyappan, Dae Ho Lee, Mattias Ekstedt, Patrik Nasr, Christophe Cassinotto, Victor de Ledinghen, Annalisa Berzigotti, Yuly P. Mendoza, Mazen Noureddin, Emily Truong, Celine Fournier-Poizat, Andreas Geier, Miljen Martic, Theresa Tuthill, Quentin M. Anstee, Stephen A. Harrison, Patrick M. Bossuyt, Michael Pavlides
Summary: Non-invasive tests show comparable prognostic performance to histologically assessed fibrosis in predicting clinical outcomes in NAFLD patients, suggesting they could be considered as alternatives to liver biopsy.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Michael Pavlides, Ferenc E. Mozes, Salma Akhtar, Kristy Wonders, Jeremy Cobbold, Elizabeth M. Tunnicliffe, Michael Allison, Edmund M. Godfrey, Guruprasad P. Aithal, Susan Francis, Manuel Romero-Gomez, Javier Castell, Isabel Fernandez-Lizaranzu, Rocio Aller, Rebeca Siguenza Gonzalez, Salvador Agustin, Juan M. Pericas, Jerome Boursier, Christophe Aube, Vlad Ratziu, Mathilde Wagner, Salvatore Petta, Michela Antonucci, Elisabetta Bugianesi, Riccardo Faletti, Luca Miele, Andreas Geier, Jorn M. Schattenberg, Emrich Tilman, Mattias Eksted, Peter Lundberg, Annalisa Berzigotti, Adrian T. Huber, George Papatheodoridis, Hannele Yki-Jarvinen, Kimmo Porthan, Moritz Jorg Schneider, Paul Hockings, Elizabeth Shumbayawonda, Rajarshi Banerjee, Kay Pepin, Mike Kalutkiewicz, Richard L. Ehman, Harvey O. Coxson, Carla LITMUS Consortium Investigators, Miljen Martic, Carla Yunis, Theresa Tuthill, Patrick M. Bossuyt, Quentin M. Anstee, Stefan Neubauer, Stephen Harrison
Summary: Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent liver disease with no approved pharmacotherapy for progressive cases. The invasive nature and observer-dependent variability of liver biopsy hinder its use for identifying those at risk of progressive NAFLD. This study aims to evaluate non-invasive imaging biomarkers against liver histology to address this unmet need and potentially influence clinical practice for the benefit of NAFLD patients.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Medicine, General & Internal
Luca Miele, Marianxhela Dajko, Maria Chiara D. Savino, Nicola Capocchiano, Valentino Calvez, Antonio Liguori, Carlotta Masciocchi, Lorenzo Vetrone, Irene Mignini, Tommaso Schepis, Giuseppe Marrone, Marco Biolato, Alfredo Cesario, Stefano Patarnello, Andrea Damiani, Antonio Grieco, Vincenzo Valentini, Antonio Gasbarrini, Gemelli COVID Grp
Summary: This study aimed to develop and validate predictive mortality models using data from hospitalized COVID-19 patients. Increased FIB-4 index values were found to be associated with poor clinical outcomes. The study utilized artificial intelligence and big data processing to retrieve data and developed a multivariable logistic regression model. Among 4936 patients, 15.4% died.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Nadia Aspromonte, Isabella Fumarulo, Lucrezia Petrucci, Bianca Biferali, Antonio Liguori, Antonio Gasbarrini, Massimo Massetti, Luca Miele
Summary: This article examines the mutual relationship between the heart and liver in heart failure patients and analyzes the underlying pathophysiology of hepatic congestion. Furthermore, it discusses the potential role of biomarkers and non-invasive tests in managing this complex disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Alessandro Vitale, Giuseppe Cabibbo, Massimo Iavarone, Luca Vigano, DavidJ Pinato, Francesca Romana Ponziani, Quirino Lai, Andrea Casadei-Gardini, Ciro Celsa, Giovanni Galati, Martina Gambato, Laura Crocetti, Matteo Renzulli, Edoardo G. Giannini, Fabio Farinati, Franco Trevisani, Umberto Cillo
Summary: Advancements in hepatocellular carcinoma treatment have made patient management more complex, with a shift towards personalized treatment approaches that consider factors beyond staging. A new framework for treatment allocation is proposed based on a multiparametric therapeutic hierarchy, ordering therapies based on survival benefit and conversely based on conversion abilities or adjuvant abilities.
Review
Oncology
Giuseppe Marrone, Maria Sandrina Leone, Marco Biolato, Antonio Liguori, Giuseppe Bianco, Gabriele Spoletini, Antonio Gasbarrini, Luca Miele, Maurizio Pompili
Summary: Hepatocellular carcinoma (HCC) is increasingly being treated with liver transplantation (LT). Successful treatment depends on selecting appropriate candidates and implementing various therapies before and after transplantation. The risk of recurrence and suitable treatment options vary among patients and transplant centers. The use of immunosuppressive therapy and potential drug interactions further complicate patient management. This paper reviews the current literature on post-transplant HCC recurrence, addressing evidence and controversies.