Article
Cell Biology
Chang-Lun Huang, David Achudhan, Po- Liu, Yen-You Lin, Shan-Chi Liu, Jeng-Hung Guo, Chun-Lin Liu, Chih-Ying Wu, Shih-Wei Wang, Chih-Hsin Tang
Summary: This study found that the expression levels of visfatin and VEGF-C are significantly higher in esophageal cancer tissue compared to normal tissue, and their high expression is associated with advanced stage esophageal squamous cell carcinoma (ESCC). Experimental results demonstrate that visfatin can upregulate the expression of VEGF-C and stimulate lymphangiogenesis in lymphatic endothelial cells by activating the MEK1/2-ERK and NF-KB signaling pathways. Therefore, visfatin and VEGF-C may be promising therapeutic targets for inhibiting lymphangiogenesis in esophageal cancer.
Article
Biochemistry & Molecular Biology
Chih-Yang Lin, Shih-Wei Wang, Jeng-Hung Guo, Huai-Ching Tai, Wen-Chun Sun, Cheng-Ta Lai, Chen-Yu Yang, Shih-Chia Liu, Yi-Chin Fong, Chih-Hsin Tang
Summary: WISP-3 can promote the production of VEGF-C in chondrosarcoma cells, stimulating lymphatic endothelial cell tube formation and promoting lymphangiogenesis by modulating the ERK, JNK, and p38 signaling pathways. This suggests that the WISP-3/VEGF-C axis may be a valuable target for treating lymphangiogenesis in human chondrosarcoma.
Article
Peripheral Vascular Disease
Ajit Muley, Minji Kim Uh, Glicella Salazar-De Simone, Bhairavi Swaminathan, Jennifer M. James, Aino Murtomaki, Seock Won Youn, Joseph D. McCarron, Chris Kitajewski, Maria Gnarra Buethe, Gloria Riitano, Yoh-suke Mukouyama, Jan Kitajewski, Carrie J. Shawber
Summary: Research in mice has revealed distinct roles for Notch4 signaling versus canonical Notch signaling in embryonic dermal lymphangiogenesis. Notch4 activation suppresses LEC migration more effectively than Notch1, while canonical Notch signaling affects LEC proliferation. These findings highlight the different functions of Notch4 signaling and canonical Notch signaling in coordinating lymphatic development.
Review
Biochemistry & Molecular Biology
Filippo Reno, Maurizio Sabbatini
Summary: The lymphatic system plays a crucial role in maintaining fluid balance and tissue homeostasis by draining lymph and facilitating immune response. Blood and lymph vessels are important for tissue regeneration and healing. Disorders of the lymphatic system can lead to chronic and disabling conditions. Impaired lymphangiogenesis can cause delayed wound healing, such as in diabetes.
Article
Biotechnology & Applied Microbiology
Mahsa Khademi, Zeinab Babaei, Seyedeh Sara Ghorbanhosseini, Amirnader Emami Razavi, Mahmoud Aghaei
Summary: miR-1236 plays an important role in the lymphangiogenesis of ovarian cancer, and its expression is associated with clinical features and prognosis. The expression of miR-1236 is significantly decreased in ovarian tumors and correlated with advanced stage, lymph node metastasis, distant metastasis, and patient survival. In addition, lymphatic vessel density and the expression of VEGFR3, VEGF-C, and LYVE-1 are increased in ovarian tumors compared to control tissues. miR-1236 expression is inversely associated with lymphatic vessel density and the expression of VEGFR3, LYVE-1, and PROX1. miR-1236 expression has the potential to be used as a diagnostic and prognostic biomarker for ovarian cancer.
JOURNAL OF GENE MEDICINE
(2023)
Review
Biotechnology & Applied Microbiology
Selvaraj Vimalraj, Krishnasamy Naidu Gopal Hariprabu, Mostafizur Rahaman, Periyasami Govindasami, Karthikeyan Perumal, Saravanan Sekaran, Dhanraj Ganapathy
Summary: The cancer-promoting ligand VEGF-C activates VEGFR-3, which is expressed by tumor cells and lymphatic endothelial cells. This signaling pathway promotes metastasis by enhancing lymphangiogenesis and angiogenesis. It plays a role in various types of tumors and further research is needed to fully understand its function.
Article
Engineering, Environmental
Jingquan Lin, Hangxiang Sun, Hongjie Jiang, Rui Xue, Bing Qin, Jianan Lu, Zhoule Zhu, Chengwei Cai, Jiawei Han, Jianmin Zhang, Xiaohua Yu, Junming Zhu
Summary: Persistent neuroinflammation following traumatic brain injury (TBI) is a major challenge in the clinic. However, the role of meningeal lymphatics dysfunction related to neuroinflammation has been overlooked. Researchers found that meningeal lymphatics showed hyperplasia but decreased lymphatic drainage in moderate open-skull TBI. To address this issue, they designed a neuroinflammation-resolving hydrogel that enhances lymphatic drainage and provides neurovascular protection. This delivery system, which releases VEGF-C 156S and bone mesenchymal stem cells derived extracellular vehicles (EVs), promotes meningeal lymphangiogenesis, reduces microglia activation, and improves motor function.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Oncology
Sen Liu, Xu Chen, Tianxin Lin
Summary: The article summarizes the molecular mechanisms of lymphatic metastasis in bladder cancer, including lymphangiogenesis, noncoding RNAs, and microenvironment-associated molecules. Newly discovered radiomics and genomics approaches have improved the preoperative diagnostic accuracy of lymph node metastasis, potentially leading to promising therapeutic strategies.
Article
Gastroenterology & Hepatology
Shao-Jung Hsu, Chihao Zhang, Jain Jeong, Seong-il Lee, Matthew McConnell, Teruo Utsumi, Yasuko Iwakiri
Summary: This study demonstrated that enhancing meningeal lymphatic drainage can reduce neuroinflammation and ameliorate hepatic encephalopathy, suggesting a new therapeutic strategy for the treatment of HE.
Article
Cell Biology
Po- Liu, Ya-Jing Jiang, An-Chen Chang, Chang-Lun Huang, Yi-Chin Fong, Jeng-Hung Guo, Chun-Lin Liu, Shih-Wei Wang, Ju-Fang Liu, Sunny Li-Yu Chang, Chih-Hsin Tang
Summary: Lung cancer is common and metastatic lung cancer has a low survival rate. Lymphangiogenesis plays a crucial role in the development and metastasis of lung cancer. The adipokine angiopoietin-like protein 2 (ANGPTL2) is involved in tumor progression and metastasis, but its role in lung cancer is unknown. Analysis of data from multiple sources revealed a correlation between high levels of ANGPTL2 expression and disease progression and lymph node metastasis in lung cancer. ANGPTL2 promotes lymphatic endothelial cell tube formation and migration through integrin alpha 5 beta 1, p38, and nuclear factor (NF)-KB signaling. In vivo studies showed that overexpression of ANGPTL2 enhances tumor growth and lymphangiogenesis. Therefore, ANGPTL2 is a potential therapeutic target for treating lung cancer.
Review
Biochemistry & Molecular Biology
Aditya Jain, Phillip S. Ang, Matthew J. Matrongolo, Max A. Tischfield
Summary: Meningeal lymphatic vessels play a crucial role in maintaining CNS homeostasis and have been extensively studied in humans, non-human primates, and rodents. Recent studies have explored their growth, development, and changes in injury, disease, or aging, leading to the development of potential therapeutic approaches. Further research is needed to fully understand and harness the therapeutic potential of meningeal lymphatics.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Medicine, Research & Experimental
Wenjing Xu, Natalie R. Harris, Kathleen M. Caron
Summary: The lymphatic system is receiving increasing attention for its role in diseases and drug delivery. Despite identified crucial lymphatic genes with therapeutic potential, effective targeted therapeutics for human lymphatic pathologies are lacking. Promising therapeutic targets for modulating lymphangiogenesis or lymphatic function are being explored for future clinical applications.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Cell Biology
Lorenz M. Brunner, Yuliang He, Nikola Cousin, Jeannette Scholl, Livia K. Albin, Bianca Schmucki, Sandrin Supersaxo, Gaetana Restivo, Juerg Hafner, Dario Neri, Sabine Werner, Michael Detmar
Summary: Chronic wounds pose a significant challenge for therapy, with impaired lymphatic vessel function. The role of lymphangiogenesis in wound healing has been unclear. This study found that chronic human wounds had a lack of lymphatic vessels. In mouse models, the absence of lymphatic vessels led to a proinflammatory wound environment and delayed wound closure, highlighting the importance of the VEGF-C/VEGFR3 signaling axis in wound lymphangiogenesis. Treatment with the F8-VEGF-C fusion protein promoted wound healing and induced lymphangiogenesis, while reducing tissue inflammation and improving the wound microenvironment.
Article
Oncology
Qiu-Yue Lin, Yun-Long Zhang, Jie Bai, Jin-Qiu Liu, Hui-Hua Li
Summary: The study demonstrated that upregulation of cardiac lymphangiogenesis and reduced protein expression of VEGF-C and VEGFR-3 in failing hearts can lead to adverse effects such as cardiac edema, hypertrophy, fibrosis, apoptosis, inflammation, and dysfunction. Activation of the VEGF-C-VEGFR-3 axis may have a protective effect during the transition from cardiac hypertrophy to heart failure and targeted stimulation of cardiac lymphangiogenesis could be a potential therapeutic approach for hypertrophic heart diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, Research & Experimental
Heidi A. Creed, Joseph M. Rutkowski
Summary: Acute kidney injury is a common pathology that can progress to renal failure and increase the risk of future chronic kidney disease. The extent of inflammation and the role of lymphatics in the inflammatory response may play a crucial role in determining the progression from acute kidney injury to chronic kidney disease.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Kuai-Lu Lin, Ou-Chen Wang, Xiao-Hua Zhang, Xuan-Xuan Dai, Xiao-Qu Hu, Jin-Miao Qu
ANNALS OF SURGICAL ONCOLOGY
(2010)
Article
Oncology
Xiu-Feng Zhang, Ying Zhang, Xiao-Hua Zhang, Su-Mei Zhou, Guan-Gen Yang, Ou-Chen Wang, Gui-Long Guo, Gao-Yi Yang, Xiao-Qu Hu
Article
Oncology
Ru-Tian Hao, Xiao-Hua Zhang, Yi-Fei Pan, Hai-Guang Liu, You-Qun Xiang, Li Wan, Xiu-Ling Wu
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2010)
Article
Oncology
Guan-Li Huang, Xiao-Hua Zhang, Gui-Long Guo, Ka-Te Huang, Kai-Yan Yang, Xian Shen, Jie You, Xiao-Qu Hu
Article
Genetics & Heredity
Qing-Xuan Wang, En-Dong Chen, Ye-Feng Cai, Yi-Li Zhou, Si-Yang Dong, Xiao-Hua Zhang, Ou-Chen Wang, Quan Li
Article
Endocrinology & Metabolism
Danrong Ye, Yang Jiang, Yihan Sun, Yuefeng Li, Yefeng Cai, Qingxuan Wang, Ouchen Wang, Endong Chen, Xiaohua Zhang
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2019)
Article
Cell Biology
Yaoyao Guan, Adheesh Bhandari, Xiaohua Zhang, Ouchen Wang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Article
Oncology
Xubin Dong, Shihui Lv, Dianna Gu, Xiaohua Zhang, Zhiqiang Ye
Summary: The study revealed that LAGE3 plays a role in promoting the progression of breast cancer, and it may serve as a potential diagnostic and prognostic biomarker, as well as a treatment target for breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Xubin Dong, Jingjing Song, Jing Hu, Cheng Zheng, Xiaohua Zhang, Haiguang Liu
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Oncology
Yi-Xiang Jin, Xiao-fen Zhou, Ying-ying Chen, Wen-xu Jin, Ying-hao Wang, Dan-rong Ye, Yi-han Sun, Yue-feng Li, Qian-xuan Wang, Xiao-Hua Zhang, Ou-Chen Wang, En-Dong Chen