Review
Cell Biology
Y. Grace Chen, Sun Hur
Summary: DSRNA, whether of viral origin or endogenous, can lead to immune disorders or be utilized for immunotherapy. Organisms have mechanisms to recognize and respond to dsRNA to minimize potential infections, with infected and dysregulated cells both triggering immune responses.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Claudia Capdevila, Maria Trifas, Jonathan Miller, Troy Anderson, Peter A. Sims, Kelley S. Yan
Summary: Understanding the development and hierarchical organization of tissues is crucial for comprehending how they are affected in injury and disease, and how they can be manipulated therapeutically for restoration of homeostasis. Single-cell RNA sequencing technologies play a key role in elucidating the lineage relationships of intestinal epithelial cells, refining our understanding of tissue development and highlighting their strengths and limitations. These technologies have been applied to study the dynamics of intestinal epithelial cells in both homeostatic and injury-induced regeneration models.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fan Chen, Jinpeng Liu, Robert M. Flight, Kassandra J. Naughton, Alexsandr Lukyanchuk, Abigail R. Edgin, Xiulong Song, Haikuo Zhang, Kwok-Kin Wong, Hunter N. B. Moseley, Chi Wang, Christine F. Brainson
Summary: This study presents a method for using third-generation TKIs to treat EGFR-driven lung cancer, and describes how tumors with distinct epigenetic states can be obtained through different cell types. It was found that tumors of different origins retain their epigenetic differences and have distinct drug vulnerabilities.
Review
Gastroenterology & Hepatology
Agnes Holczbauer, Kirk J. Wangensteen, Soona Shin
Summary: Hepatocellular carcinoma (HCC), originating from the liver, is a major primary cancer and a leading cause of cancer-related death worldwide. The cellular origin of HCC is still controversial, with conflicting views on whether it begins in hepatocytes, biliary cells, or facultative stem cells. Most HCCs develop in the setting of chronic liver injury caused by various factors. Understanding the cellular origin of HCC is crucial for prevention and treatment.
Article
Computer Science, Information Systems
Ke Feng, Martin Haenggi
Summary: This work focuses on the signal-to-interference-plus-noise ratio (SINR) meta distribution in cellular networks, particularly the Poisson model. It shows that the base station density and noise power mainly affect the SINR distribution through the network signal-to-noise ratio (NSNR). For Poisson cellular networks, the SINR MD can be expressed based on a constraint involving the target SINR and target reliability.
IEEE WIRELESS COMMUNICATIONS LETTERS
(2021)
Review
Oncology
Susan Swee-Shan Hue, Siok-Bian Ng, Shi Wang, Soo-Yong Tan
Summary: The intestinal immune system is made up of innate lymphoid cells and various T-cell subsets, which play important roles in immune responses and can also be involved in the development of lymphoma. Understanding the different cell types and their functions in the gastrointestinal tract is crucial for studying and treating related diseases.
Article
Nanoscience & Nanotechnology
Huan Zhang, Natalie S. Goh, Jeffrey W. Wang, Rebecca L. Pinals, Eduardo Gonzalez-Grandio, Gozde S. Demirer, Salwan Butrus, Sirine C. Fakra, Antonio Del Rio Flores, Rui Zhai, Bin Zhao, So-Jung Park, Markita P. Landry
Summary: The study shows the efficient delivery of siRNA and gene silencing in plant leaves by gold nanospheres and nanorods, with 10 nm spherical AuNPs demonstrating the best performance. The research highlights the importance of nanoparticle size in transport within plant tissues and efficient biomolecule delivery.
NATURE NANOTECHNOLOGY
(2022)
Article
Developmental Biology
Jorge B. Aquino, Romina Sierra, Laura A. Montaldo
Summary: The origin and renewal of vascular endothelial cells primarily depend on local resident cells and endothelial progenitor cells. Research shows that some cells can generate endothelial-like cells, with mesenchymal stromal progenitors being a source. Different subpopulations of bone marrow stromal cells exhibit unexpected heterogeneity.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Computer Science, Information Systems
Junhui Zhao, Lihua Yang, Minghua Xia, Mehul Motani
Summary: This article provides a comprehensive analysis of the performance of three CoMP strategies in mmWave cellular networks, showing different advantages and disadvantages in various network densities. The suggestion of selecting the optimal CoMP scheme based on distance and radius of line-of-sight region is proposed.
IEEE INTERNET OF THINGS JOURNAL
(2021)
Article
History & Philosophy Of Science
Guenther Eder
Summary: This article aims to contribute to a better understanding of Frege's views on semantics and metatheory by examining his take on several themes in nineteenth century geometry. By focusing on three key issues, the article explores Frege's perspective on these matters, ultimately concluding with a discussion of what his views entail for the debate about his stance towards semantics and metatheory more generally.
Article
Engineering, Industrial
Zhenglin Liang, Yan-Fu Li
Summary: Nowadays, the disruption of telecommunication networks can have a significant negative impact on various industries, such as smart manufacturing, remote surgery, and harbor logistic. The development of 5G mobile networks highlights the importance of reliability. Evaluating the reliability of large-scale telecommunication networks is a challenging task due to their spatiotemporal characteristics. This paper introduces a novel approach that combines concepts from computational geometry and reliability engineering to address this challenge. By using a Voronoi-based Graphic network (VGN) model with coverage dependence, the resilience and reliability of telecommunication networks in a large region can be holistically assessed.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2023)
Article
Medicine, Research & Experimental
Ethan Z. Malkin, Steven De Michino, Meghan Lambie, Rita Gill, Zhen Zhao, Ariana Rostami, Andrea Arruda, Mark D. Minden, Scott V. Bratman
Summary: Cancer cells release cfDNA, which is predominantly associated with nucleosomal particles and not EVs. Additionally, a subset of mitochondrial cfDNA is membrane protected and derived from non-tumor cells. These findings have important implications for understanding the topology of cfDNA in cancer.
Article
Biology
Charles Ross Lindsey, Frank Rosenzweig, Matthew D. Herron
Summary: The volvocine algae, including Chlamydomonas reinhardtii and Volvox carteri, are important models for studying evolution of multicellularity and cellular differentiation. Research shows that multicellularity evolved independently at least twice in this group, and cellular differentiation arose independently at least four times, affirming their significance as a model system.
Review
Cell Biology
Paul Manoukian, Maarten Bijlsma, Hanneke van Laarhoven
Summary: Pancreatic tumors are characterized by abundant and highly desmoplastic stroma, with cancer-associated fibroblasts (CAFs) playing a crucial role in tumor development and architecture. However, the heterogeneity in CAF populations and the exact sources and functions of different CAF phenotypes remain to be fully understood. Understanding the roles of different subsets of CAFs within the stroma and the cellular dynamics that contribute to heterogeneity may be essential for developing novel therapies to improve clinical outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Guobin Liao, Jun Tang, Jianying Bai
Summary: Esophageal squamous cell carcinoma (ESCC) is a highly malignant cancer with poor prognosis, and its development is based on the classical view of cancer development from stem cell origin and multistep progression. Recent advancements in large-scale and single-cell sequencing technologies, along with transgenic lineage tracing in mouse models, have provided a more detailed understanding of the heterogeneity and early clonal evolution of esophageal stem cells and ESCC. This review discusses the potential relationship between esophageal basal-layer stem cells and cells of ESCC origin, as well as the role of NOTCH1 mutants in the early clonal evolution of ESCCs.
