Discovery of co-occurring driver pathways in cancer

Using passenger mutations to estimate the timing of driver mutations and identify mutator alterations

(2013) Ahrim Youn et al.   BMC BIOINFORMATICS

Exome profiling of primary, metastatic and recurrent ovarian carcinomas in a BRCA1-positive patient

(2013) Jian Zhang et al.   BMC CANCER

MYC, FBXW7 and TP53 copy number variation and expression in Gastric Cancer

(2013) Danielle Queiroz Calcagno et al.   BMC GASTROENTEROLOGY

Network analysis of genomic alteration profiles reveals co-altered functional modules and driver genes for glioblastoma

(2013) Yunyan Gu et al.   Molecular BioSystems

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis

(2013) Eric P Rahrmann et al.   NATURE GENETICS

Simultaneous Identification of Multiple Driver Pathways in Cancer

(2013) Mark D. M. Leiserson et al.   PLoS Computational Biology

Loss of CDKN2B Promotes p53-Dependent Smooth Muscle Cell Apoptosis and Aneurysm Formation

(2012) Nicholas J. Leeper et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Efficient methods for identifying mutated driver pathways in cancer

(2012) Junfei Zhao et al.   BIOINFORMATICS

Loss of PPP2R2A Inhibits Homologous Recombination DNA Repair and Predicts Tumor Sensitivity to PARP Inhibition

(2012) P. Kalev et al.   CANCER RESEARCH

Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature

(2012) Hilla Solomon et al.   JOURNAL OF CELL SCIENCE

Identification of Molecular Pathway Aberrations in Uterine Serous Carcinoma by Genome-wide Analyses

(2012) Elisabetta Kuhn et al.   JNCI-Journal of the National Cancer Institute

Discovery of multi-dimensional modules by integrative analysis of cancer genomic data

(2012) Shihua Zhang et al.   NUCLEIC ACIDS RESEARCH

The role of Wt1 in regulating mesenchyme in cancer, development, and tissue homeostasis

(2012) You-Ying Chau et al.   TRENDS IN GENETICS

Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma

(2012) D Kesanakurti et al.   Cell Death & Disease

Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors

(2011) Christopher A Miller et al.   BMC Medical Genomics

Cell cycle and aging, morphogenesis, and response to stimuli genes are individualized biomarkers of glioblastoma progression and survival

(2011) Nicola VL Serão et al.   BMC Medical Genomics

Cooperativity within and among Pten, p53, and Rb Pathways Induces High-Grade Astrocytoma in Adult Brain

(2011) Lionel M.L. Chow et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

De novo discovery of mutated driver pathways in cancer

(2011) F. Vandin et al.   GENOME RESEARCH

Mutual exclusivity analysis identifies oncogenic network modules

(2011) G. Ciriello et al.   GENOME RESEARCH

Analysis of pathway mutation profiles highlights collaboration between cancer-associated superpathways

(2011) Yunyan Gu et al.   HUMAN MUTATION

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring V600EBRAF

(2011) F Xing et al.   ONCOGENE

Detecting Cancer Gene Networks Characterized by Recurrent Genomic Alterations in a Population

(2011) Sol Efroni et al.   PLoS One

Patient-oriented gene set analysis for cancer mutation data

(2011) Simina M Boca et al.   GENOME BIOLOGY

Prognostic Implication of EGFR, KRAS, and TP53 Gene Mutations in a Large Cohort of Japanese Patients with Surgically Treated Lung Adenocarcinoma

(2010) Takayuki Kosaka et al.   Journal of Thoracic Oncology

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Identification of Networks of Co-Occurring, Tumor-Related DNA Copy Number Changes Using a Genome-Wide Scoring Approach

(2010) Christiaan Klijn et al.   PLoS Computational Biology

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1

(2009) M. K.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Combinatorial patterns of somatic gene mutations in cancer

(2008) Chen-Hsiang Yeang et al.   FASEB JOURNAL

Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: Implications in cancer therapy

(2008) Ana Ramírez de Molina et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE