4.6 Correction

Disease candidate gene identification and prioritization using protein interaction networks (vol 10, pg 73, 2009)

Journal

BMC BIOINFORMATICS
Volume 10, Issue -, Pages -

Publisher

BMC
DOI: 10.1186/1471-2105-10-406

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Immunology

Characterization of HCV NS3 Protease Variants in HCV/ HIV-Coinfected Patients by Ultra-Deep Sequence Analysis: Relationship with Hepatic Fibrosis

Enass A. Abdel-hameed, Susan D. Rouster, Xiang Zhang, Jing Chen, Mario Medvedovic, Zachary D. Goodman, Kenneth E. Sherman

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES (2017)

Article Genetics & Heredity

Novel phenotype-disease matching tool for rare genetic diseases

Jing Chen, Huan Xu, Anil Jegga, Kejian Zhang, Pete S. White, Ge Zhang

GENETICS IN MEDICINE (2019)

Article Multidisciplinary Sciences

Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy

Jacqueline Alexander, April M. Teague, Jing Chen, Christopher E. Aston, Yuet-Kin Leung, Steven Chernausek, Rebecca A. Simmons, Sara E. Pinney

PLOS ONE (2018)

Article Cell Biology

An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination

Jiangtong Peng, Yutian Li, Xiaohong Wang, Shan Deng, Jenna Holland, Emily Yates, Jing Chen, Haitao Gu, Kobina Essandoh, Xingjiang Mu, Boyu Wang, Robert K. Mcnamara, Tianqing Peng, Anil G. Jegga, Tiemin Liu, Takahisa Nakamura, Kai Huang, Diego Perez-Tilve, Guo-Chang Fan

CELL REPORTS (2018)

Article Multidisciplinary Sciences

In utero gene expression in the Slc39α8(neo/neo) knockdown mouse

Jing Chen, Marina Galvez-Peralta, Xiang Zhang, Jingyuan Deng, Zijuan Liu, Daniel W. Nebert

SCIENTIFIC REPORTS (2018)

Article Cardiac & Cardiovascular Systems

The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

Lisa E. Dorn, Lior Lasman, Jing Chen, Xianyao Xu, Thomas J. Hund, Mario Medvedovic, Jacob H. Hanna, Jop H. van Berlo, Federica Accornero

CIRCULATION (2019)

Article Biochemistry & Molecular Biology

Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage

Shan Deng, Kobina Essandoh, Xiaohong Wang, Yutian Li, Wei Huang, Jing Chen, Jiangtong Peng, Ding-Sheng Jiang, Xingjiang Mu, Chenran Wang, Tianqing Peng, Jun-Lin Guan, Yigang Wang, Anil Jegga, Kai Huang, Guo-Chang Fan

REDOX BIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Sectm1a deficiency aggravates inflammation-triggered cardiac dysfunction through disruption of LXRα signalling in macrophages

Yutian Li, Shan Deng, Xiaohong Wang, Wei Huang, Jing Chen, Nathan Robbins, Xingjiang Mu, Kobina Essandoh, Tianqing Peng, Anil G. Jegga, Jack Rubinstein, David E. Adams, Yigang Wang, Jiangtong Peng, Guo-Chang Fan

Summary: This study utilizing a global Sectm1a-knockout mouse model revealed that Sectm1a deficiency leads to increased accumulation of inflammatory macrophages in the heart, worsening cardiac injury in response to inflammatory stimuli. By modulating LXR alpha signaling in macrophages, Sectm1a was identified as a novel regulator of inflammation-induced cardiac dysfunction, suggesting its potential as a therapeutic target for resolving inflammation and associated cardiac dysfunction.

CARDIOVASCULAR RESEARCH (2021)

Article Medicine, General & Internal

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs

Jing Chen, Jonas Bacelis, Pol Sole-Navais, Amit Srivastava, Julius Juodakis, Amy Rouse, Mikko Hallman, Kari Teramo, Mads Melbye, Bjarke Feenstra, Rachel M. Freathy, George Davey Smith, Deborah A. Lawlor, Jeffrey C. Murray, Scott M. Williams, Bo Jacobsson, Louis J. Muglia, Ge Zhang

PLOS MEDICINE (2020)

Article Biotechnology & Applied Microbiology

Sectm1a Facilitates Protection against Inflammation-Induced Organ Damage through Promoting TRM Self-Renewal

Xingjiang Mu, Hongkuan Fan, Peng Wang, Yutian Li, Karen Domenico, Qianqian Li, Xiaohong Wang, Kobina Essandoh, Jing Chen, Tianqing Peng, Guo-Chang Fan

Summary: Tissue-resident macrophages (TRMs) are crucial for maintaining tissue homeostasis and organ function, with Sectm1a identified as a novel regulator of TRM self-renewal. Sectm1a contributes to stabilizing TRM populations and improving host immune response to acute inflammation, suggesting its potential as a new therapeutic agent for treating inflammatory diseases.

MOLECULAR THERAPY (2021)

Article Immunology

Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in Macrophages

Qianqian Li, Yutian Li, Wei Huang, Xiaohong Wang, Zhenling Liu, Jing Chen, Yanbo Fan, Tianqing Peng, Sakthivel Sadayappan, Yigang Wang, Guo-Chang Fan

Summary: Metabolic disorders lead to increased secretion of inflammatory cytokines/chemokines in the heart, potentially contributing to cardiomyopathy. Studies have found that Lcn10 is significantly downregulated in cardiac tissue of diabetic patients, and may promote inflammation by affecting macrophage polarization.

FRONTIERS IN IMMUNOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Prevalence of Genetic Diagnoses in a Cohort With Valvar Pulmonary Stenosis

K. Nicole Weaver, Jing Chen, Amy Shikany, Pete S. White, Carlos E. Prada, Bruce D. Gelb, James F. Cnota

Summary: This study analyzed genomic data from a large cohort of patients with valvar pulmonary stenosis (vPS) to determine the prevalence of genetic diagnosis. The results showed a high proportion of individuals with extracardiac and neurodevelopmental phenotypes in vPS patients, and a high rate of genetic diagnosis. Therefore, clinicians should have a high suspicion for genetic diagnosis in individuals with vPS and consider sequencing of relevant genes.

CIRCULATION-GENOMIC AND PRECISION MEDICINE (2022)

Article Genetics & Heredity

Using deep learning and electronic health records to detect Noonan syndrome in pediatric patients

Zeyu Yang, Amy Shikany, Yizhao Ni, Ge Zhang, K. Nicole Weaver, Jing Chen

Summary: This study investigated the utility of using electronic health records (EHRs) to identify patients at high risk of Noonan syndrome (NS) and developed a deep learning model to analyze EHR data. The results showed that the text-based deep learning method performed better than previous methods and could potentially be used as a tool to identify patients with features of rare diseases.

GENETICS IN MEDICINE (2022)

Article Genetics & Heredity

Genetic effects on the timing of parturition and links to fetal birth weight

Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey M. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Maegi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson

Summary: The study conducted a meta-analysis and identified genetic variants associated with gestational duration and preterm delivery. It revealed the importance of maternal alleles in influencing gestational duration and the complex relationship between gestational duration and birth weight. The study also identified antagonistic pleiotropy, where maternal alleles that increase gestational duration have negative effects on birth weight.

NATURE GENETICS (2023)

Correction Genetics & Heredity

Genetic effects on the timing of parturition and links to fetal birth weight (vol 55, pg 559, 2023)

Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe Jr, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey S. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Magi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johansson, Ge Zhang, Bo Jacobsson

NATURE GENETICS (2023)

No Data Available