Phosphoinositide turnover in Toll-like receptor signaling and trafficking

Phosphatidylinositol 4-Phosphate 5-Kinase α Facilitates Toll-like Receptor 4-mediated Microglial Inflammation through Regulation of the Toll/Interleukin-1 Receptor Domain-containing Adaptor Protein (TIRAP) Location

(2013) Tu Thi Ngoc Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR2 Ligands Induce NF-κB Activation from Endosomal Compartments of Human Monocytes

(2013) Karim J. Brandt et al.   PLoS One

PTEN regulates TLR5-induced intestinal inflammation by controlling Mal/TIRAP recruitment

(2012) Yoon Jeong Choi et al.   FASEB JOURNAL

Phosphoinositide Binding by the Toll Adaptor dMyD88 Controls Antibacterial Responses in Drosophila

(2012) Lorri R. Marek et al.   IMMUNITY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Phospholipase Cγ-2 and Intracellular Calcium Are Required for Lipopolysaccharide-induced Toll-like Receptor 4 (TLR4) Endocytosis and Interferon Regulatory Factor 3 (IRF3) Activation

(2011) Chih-Yuan Chiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

One lipid, multiple functions: how various pools of PI(4,5)P2 are created in the plasma membrane

(2010) Katarzyna Kwiatkowska   CELLULAR AND MOLECULAR LIFE SCIENCES

Phosphatidylinositol 4-phosphate 5-kinase α is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses

(2010) Sang Yoon Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Regulation of PIP5K activity by Arf6 and its physiological significance

(2010) Yuji Funakoshi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Enhanced phosphatidylinositol 4-phosphate 5-kinase α expression and PI(4,5)P2 production in LPS-stimulated microglia

(2010) Sang Yoon Lee et al.   NEUROCHEMISTRY INTERNATIONAL

Phosphoinositide phosphatases in cell biology and disease

(2010) Yang Liu et al.   PROGRESS IN LIPID RESEARCH

AIP1 Functions as Arf6-GAP to Negatively Regulate TLR4 Signaling

(2009) Ting Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TIR Domain Variant of MyD88 Adapter-like (Mal)/TIRAP Results in Loss of MyD88 Binding and Reduced TLR2/TLR4 Signaling

(2009) Kamalpreet Nagpal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential and unique roles of PIP5K-γ and -α in Fcγ receptor-mediated phagocytosis

(2009) Yuntao S. Mao et al.   JOURNAL OF CELL BIOLOGY

PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions

(2009) I. van den Bout et al.   JOURNAL OF CELL SCIENCE

Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease

(2009) Heather J. McCrea et al.   PHYSIOLOGY

Mammalian phosphoinositide kinases and phosphatases

(2009) Takehiko Sasaki et al.   PROGRESS IN LIPID RESEARCH

Toll-like receptors in neurodegeneration

(2008) Eitan Okun et al.   BRAIN RESEARCH REVIEWS

Membrane traffic in the secretory pathway

(2008) M. Vicinanza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Location, location, location: identifying the neighborhoods of LPS signaling

(2008) Colin Watts   NATURE IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Glial toll-like receptor signaling in central nervous system infection and autoimmunity

(2007) Pamela A. Carpentier et al.   BRAIN BEHAVIOR AND IMMUNITY