Structural insights into the transcription-independent apoptotic pathway of p53

Structural basis for the conserved binding mechanism of MDM2-inhibiting peptides and anti-apoptotic Bcl-2 family proteins

(2014) Min-Sung Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Conserved Mechanism for Binding of p53 DNA-Binding Domain and Anti-Apoptotic Bcl-2 Family Proteins

(2014) Dong-Hwa Lee et al.   MOLECULES AND CELLS

Targeting of p53 peptide analogues to anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy

(2013) Jae-Sun Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual-site Interactions of p53 Protein Transactivation Domain with Anti-apoptotic Bcl-2 Family Proteins Reveal a Highly Convergent Mechanism of Divergent p53 Pathways

(2013) Ji-Hyang Ha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural insights into the dual-targeting mechanism of Nutlin-3

(2012) Jae-Sun Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FGF-2 inhibits TNF-α mediated apoptosis through up-regulation of Bcl2-A1 and Bcl-xL in ATDC5 cells

(2012) Hey-Ryun Kim et al.   BMB Reports

MicroRNA let-7c inhibits Bcl-xl expression and regulates ox-LDL-induced endothelial apoptosis

(2012) Bing Qin et al.   BMB Reports

Interaction of a putative BH3 domain of clusterin with anti-apoptotic Bcl-2 family proteins as revealed by NMR spectroscopy

(2011) Dong-Hwa Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BH3 activation blocks Hdmx suppression of apoptosis and cooperates with Nutlin to induce cell death

(2011) Mark Wade et al.   CELL CYCLE

The transcription-independent mitochondrial p53 program is a major contributor to Nutlin-induced apoptosis in tumor cells

(2011) Angelina V. Vaseva et al.   CELL CYCLE

Molecular Mimicry-Based Repositioning of Nutlin-3 to Anti-Apoptotic Bcl-2 Family Proteins

(2011) Ji-Hyang Ha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular Basis of Bcl-XL-p53 Interaction: Insights from Molecular Dynamics Simulations

(2011) Nagakumar Bharatham et al.   PLoS One

Molecular Interaction between a Bcl_2 Homolog from Kaposi Sarcoma Virus and p53

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma

(2010) Manujendra N. Saha et al.   CANCER BIOLOGY & THERAPY

Profiling small molecule inhibitors against helix–receptor interactions: the Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

(2010) Jason R. Porter et al.   CHEMICAL COMMUNICATIONS

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

(2009) Erinna F. Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The MDM2-Binding Region in the Transactivation Domain of p53 Also Acts as a Bcl-XL-Binding Motif

(2009) Huibin Xu et al.   BIOCHEMISTRY

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain

(2009) Franz Hagn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY