Article
Cell Biology
Hyeyoon Eo, Rudy J. Valentine
Summary: The study found that the PKR inhibitor IMX can alleviate TN-induced ER stress and suppression of the insulin signaling pathway, potentially through reducing PKR phosphorylation and modulating the expression of ER stress markers.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shweta Sharma, Faiyaz Ahmad, Anchal Singh, Sushma Rathaur
Summary: GRP94, a member of HSP90 family, is influenced by ER stress in the bovine filarial parasite Setaria cervi, and its expression is regulated by transcription factors ATF-6 and XBP-1S. Following Tunicamycin treatment, the expression of GRP94 is associated with the propagation of survival pathway.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Ophthalmology
Longdan Kang, Shin-ichi Ikeda, Yajing Yang, Heonuk Jeong, Junhan Chen, Yan Zhang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Summary: Recent studies have shown a strong correlation between ER stress and myopia, with eyedrops containing the ER stress inducer Tm inducing myopic changes in mice. The study aimed to create a new myopia model using Tm eyedrops and explore the mechanism of ER stress-mediated myopia development. Tm eyedrops were found to induce myopic changes, decrease scleral collagen expression, and upregulate the expression of matrix metalloproteinase-2, leading to collagen degradation in the sclera.
Article
Cell Biology
Yiping Kong, Yiwen Zhang, Yongjie Cai, Di Li, Baicheng Yi, Qiong Xu
Summary: This study demonstrates that METTL3 knockdown enhances Grp78 expression through YTHDF2-mediated RNA degradation, inducing ER stress and promoting osteoblast apoptosis while inhibiting cell proliferation and differentiation under LPS-induced inflammatory condition.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Berrin Tugrul, Erdal Balcan, Zubeyde Oztel, Fatih Collu, Beyhan Gurcu
Summary: In this study, the effects of doxorubicin and tunicamycin alone or in combination on the subcellular regulation of p53 through MDM, Cul9, and PrP were investigated. The results showed that doxorubicin increased p53, MDM2, and CUL9 levels in a dose-dependent manner, while tunicamycin had varying effects on p53 and MDM2 expression. Combination treatment resulted in increased p53 expression and decreased MDM2 and CUL9 expressions, making the cells more susceptible to apoptosis. PrP may play a role in determining cell fate under ER stress conditions. Further studies are needed to explore the molecular networks involved.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Merve Yemenici, Burcu Kartal Sural, Semian Karaer Uzuner, Bedia Palabiyik
Summary: This study investigates the involvement of Sec71 and Ubp2 in the tunicamycin-induced ER stress response. The results show that Ubp2 plays an important role in the ubiquitin-proteasome system in ER stress, while Sec71 may be associated with ER homeostasis.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Microbiology
Feng Yang, Hui Lu, Hao Wu, Ting Fang, Judith Berman, Yuan-ying Jiang
Summary: This study demonstrates that Candida parapsilosis can adapt to stress by acquiring different aneuploid karyotypes, which enable the fungus to tolerate specific stresses and even cross-adapt to different stresses. The findings highlight the genome plasticity and adaptive mechanisms of C. parapsilosis, contributing to our understanding of how fungi develop resistance to multiple drugs.
MICROBIOLOGY SPECTRUM
(2021)
Article
Biology
Anupam Bhoi, Francesca Palladino, Paola Fabrizio
Summary: Auxins are plant growth regulators that influence various aspects of plant development. The development of an AID system allows rapid, conditional protein degradation, which has been successfully implemented in Caenorhabditis elegans. Indole-3-acetic acid functions through the IRE-1/XBP-1 branch of the UPR to promote resistance to ER stress, indicating caution is needed when using the AID system to study related processes.
Article
Nutrition & Dietetics
Sindiyan Alshaikh Mubarak, Abeer Al Otaibi, Ali Al Qarni, Ahmed Bakillah, Jahangir Iqbal
Summary: Saturated FFAs, such as palmitate, circulating in the body can cause ER stress and insulin resistance. In this study, it was found that palmitate treatment reduced insulin-mediated glucose uptake and ERK phosphorylation in Huh-7 cells, while AKT phosphorylation remained unchanged. Supplementation of oleate alleviated palmitate-induced ER stress but did not affect insulin-mediated glucose uptake or ERK phosphorylation.
Article
Plant Sciences
Ming-Shi Ren, Hui-Hui Xie, Yu Ding, Zi-Han Li, Bo Liu
Summary: This study aimed to determine whether the serum containing EXD promotes the proliferation and differentiation of osteoblasts through the regulation of BK channel.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Carolina Moura Costa Catta-Preta, Allan Cezar de Azevedo-Martins, Wanderley de Souza, Maria Cristina Machado Motta
Summary: This study investigated the effects of the antibiotic tunicamycin on the association between Angomonas deanei and its symbiotic bacterium. The cells treated with tunicamycin showed decreased proliferation, enlargement of the ER and Golgi cisternae, and increased distance between the symbiont and the ER. Changes in protein composition, particularly the increased expression of the Hsp90 chaperone, were observed in the host protozoan. These findings highlight the importance of the ER in the adaptation and maintenance of symbiotic associations between prokaryotes and eukaryotes.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Toxicology
F. Olivares-Silva, J. Espitia-Corredor, A. Letelier, R. Vivar, P. Parra-Flores, I. Olmedo, J. Montenegro, V. Pardo-Jimenez, G. Diaz-Araya
Summary: In this study, we found that TGF-beta 1 partially protects CF apoptosis induced by sI/R or Tn, through a mechanism involving ER stress. Additionally, TGF-beta 1 pretreatment completely prevented the increase of CHOP induced by sI/R or Tn. However, TGF-beta 1 treatment did not prevent the decrease in alpha-SMA expression induced by sI/R or the decrease in collagen secretion induced by Tn.
TOXICOLOGY IN VITRO
(2021)
Article
Cell Biology
Jingmin Che, Huanhuan Lv, Jiancheng Yang, Bin Zhao, Sibo Zhou, Tongyao Yu, Peng Shang
Summary: In this study, iron overload induced apoptosis in osteoblasts through activating ER stress, resulting in mitochondrial dysfunction. Pretreatment with NAC or TUDC attenuated cell apoptosis and restored protein expression related to iron metabolism.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Eveline M. Anto, C. R. Sruthi, Lekshmy Krishnan, K. G. Raghu, Jayamurthy Purushothaman
Summary: Endoplasmic reticulum (ER) stress and associated oxidative stress play a role in skeletal muscle diseases. Targeting ER stress can lead to better treatment strategies. Tangeretin, a citrus flavonoid, has a protective effect against ER stress in rat skeletal muscle cells.
CELL STRESS & CHAPERONES
(2023)
Article
Chemistry, Medicinal
Seung-Hong Lee, Mihyang Kim, Mi Hwa Park
Summary: The study demonstrated that DPHC from Ishige okamurae has protective effects against oxidative damage in osteoblastic cells induced by H2O2 through the BMP2/Runx2 signaling pathway, improving cellular functions and promoting osteoblast differentiation. DPHC also reduced the expression levels of bone resorption-promoting factors and inhibited the generation of reactive oxygen species induced by oxidative stress.
