Article
Urology & Nephrology
Jule Pinter, Brendan Smyth, Stefano Stuard, Meg Jardine, Christoph Wanner, Patrick Rossignol, David C. Wheeler, Mark R. Marshall, Bernard Canaud, Bernd Genser
Summary: Excess mortality in hemodialysis patients is associated with abnormal fluid status and plasma sodium concentrations. The choice of dialysate sodium affects sodium removal and tonicity adjustment. Lower dialysate sodium may increase sodium removal but comes with certain risks, while higher dialysate sodium can preserve blood volume and hemodynamic stability.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pediatrics
Olga Caporale, Silvia Consolo, Francesca S. Grassi, Maria R. Grassi, Giuseppe Puccio, Giovanni Montini, Fabio Paglialonga
Summary: This study compares the effects of low and standard dialysate sodium concentrations on interdialytic weight gain and blood pressure in children and young adults on hemodialysis. The results show that a lower dialysate sodium concentration is associated with a significant reduction in interdialytic weight gain. Further long-term studies are needed to investigate the effect of lowering dialysate sodium concentration on blood pressure.
PEDIATRIC NEPHROLOGY
(2023)
Article
Engineering, Biomedical
Thierry Petitclerc
Summary: The study developed a model for solute mass-transfer across the dialyzer membrane in online hemodiafiltration and adapted the Diacontrol algorithm based on a single-pool kinetic model. Results showed that using conductivity measurements instead of sodium measurements allows for better control of tonicity, which is a more physiological parameter. Additionally, the differences between the model used by Diacontrol and the models used by other software were highlighted.
Article
Urology & Nephrology
Francisco Maduell, Jose J. Broseta, Diana Rodriguez-Espinosa, Joaquim Casals, Victor Escudero, Miquel Gomez, Lida M. Rodas, Marta Arias-Guillen, Manel Vera, Nestor Fontsere
Summary: A new automated dialysate Na control biosensor was implemented in this study to optimize dialysis treatment and reduce discomfort symptoms by reducing the diffusive load of Na. The module showed significant differences in serum Na values and changes in pre- to postdialysis plasma Na levels.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Wojciech Zylka, Krystyna Tecza, Krzysztof Szemela, Piotr Prach, Marta Zylka, Dorota Jakubczyk, Maciej Bladzinski, Agnieszka Gala-Bladzinska, Pawel Jakubczyk
Summary: The aim of this study was to propose a method for predicting changes in uric acid concentrations in chronically hemodialyzed patients using optical measurement of specific wavelengths in the dialysate. Blood samples were taken every 30 minutes from the arterial line to measure uric acid levels, while optical measurements were made on dialysate from the dialyzer. Uric acid concentration can be accurately measured using both direct blood measurement or dialyzer outflow, and the method can assess the adequacy of hemodialysis.
SCIENTIFIC REPORTS
(2023)
Review
Transplantation
Jack Kit-Chung Ng, Brendan Smyth, Mark R. Marshall, Amy Kang, Jule Pinter, Abhinav Bassi, Rathika Krishnasamy, Patrick Rossignol, Michael Rocco, Zuo Li, Vivekanand Jha, Carmel M. Hawley, Peter G. Kerr, Gian Luca Di Tanna, Mark Woodward, Meg Jardine
Summary: Evidence suggests that prescribed and measured dialysate sodium (DNa) are generally similar, but with large differences. Further consideration of the precision of delivered DNa is needed to inform rational prescribing.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Transplantation
Magdalene M. Assimon, Patrick H. Pun, Sana M. Al-Khatib, M. Alan Brookhart, Bradley N. Gaynes, Wolfgang C. Winkelmayer, Jennifer E. Flythe
Summary: The study suggests that the use of high QT-prolonging potential SSRIs is associated with an increased risk of sudden cardiac death in hemodialysis patients with higher serum-to-dialysate potassium gradients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Food Science & Technology
Cunshan Zhou, Tong Zhao, Li Chen, Abu ElGasim A. Yagoub, Huilin Chen, Xiaojie Yu
Summary: This study investigates the effect of dialysate type on the properties of nanocomplexes. The results show that Ca2+ dialysis improves the encapsulation efficiency and thermal stability of the nanoparticles, enhancing the loading characteristics of zein nanoparticles.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Simon Krenn, Michael Schmiedecker, Daniel Schneditz, Sebastian Hoedlmoser, Christopher C. Mayer, Siegfried Wassertheurer, Haris Omic, Eva Schernhammer, Peter Wabel, Manfred Hecking
Summary: This study utilizes the changes in relative blood volume monitored by ultrasound to calculate the absolute blood volume in hemodialysis patients. The study assesses the clinical feasibility, standardizes the data read-out, determines optimal time-points for ABV calculation, and evaluates ABV variation.
FRONTIERS IN MEDICINE
(2022)
Article
Transplantation
Finnian R. Mc Causland, Katherine Scovner Ravi, Katherine A. Curtis, Zoe A. Kibbelaar, Samuel A. P. Short, Anika T. Singh, Simon Correa, Sushrut S. Waikar
Summary: This study found no significant difference in systolic blood pressure decline or risk of intra-dialytic hypotension between hospitalized hemodialysis patients receiving higher or lower dialysate sodium concentrations. Adjusted analyses suggested a lower risk of intra-dialytic hypotension with higher dialysate sodium concentration, warranting further larger, multi-center studies to confirm these findings.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Ali M. Shendi, Andrew Davenport
Summary: There is a systematic bias in the delivery of DNa with measured DNa being greater than programmed by hemodialysis (HD) machines. The magnitude of bias varies between different machines and DNa concentrations, which may help explain the conflicting results in studies on DNa.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Austin Hu, Sai Liu, Maria E. Montez-Rath, Pascale Khairallah, Jingbo Niu, Mintu P. Turakhia, Tara I. Chang, Wolfgang C. Winkelmayer
Summary: This study aimed to investigate the association between serum potassium concentration and dialysate potassium concentration with atrial fibrillation (AF) incidence. The results showed that lower serum potassium concentration was associated with an increased risk of AF, while higher serum potassium concentration was not. Dialysis with a dialysate potassium concentration of 3 mEq/l compared to 2 mEq/l was independently associated with a lower incidence of AF. A rating of 7 out of 10.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Hematology
Nagaraja Rao Sridhar, Ziqiang Chen, Guan Yu, Judy Lambert, Mary Muscarella, Madan Nanjundegowda, Mandip Panesar
Summary: Based on the findings of this study, adjusting the dialysate bicarbonate concentration based on pre-HD serum bicarbonate is unnecessary, while higher bicarbonate and lower dialysate sodium are associated with post-HD alkalemia.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Article
Urology & Nephrology
Asmaa Elemshaty, Nagy Sayed-Ahmed, Abeer Mesbah, Mohammed Kamal Nassar
Summary: This study aimed to determine the impact of individualized dialysate cooling on nutritional and inflammatory parameters in chronic hemodialysis patients. The results showed that after 6 months of dialysate cooling, episodes of intradialytic hypotension significantly decreased, but there was no significant improvement in the nutritional and inflammatory markers. Therefore, further studies are needed to evaluate the effects of dialysate cooling on inflammation and nutrition in chronic hemodialysis patients.
Article
Engineering, Biomedical
Aurele Buzancais, Vincent Brunot, Romaric Larcher, Jean-Jacques Tudesq, Laura Platon, Noemie Besnard, Matthieu Amalric, Delphine Daubin, Philippe Corne, Valerie Moulaire, Boris Jung, Bernard Canaud, Jean-Paul Cristol, Kada Klouche
Summary: A higher sodium dialysate concentration is recommended during renal replacement therapy (RRT) of acute kidney injury (AKI) to improve intradialytic hemodynamic tolerance, but it may lead to sodium loading to the patient.
Article
Cardiac & Cardiovascular Systems
Jason H. Greenberg, Michael Parsons, Michael Zappitelli, Yaqi Jia, Heather R. Thiessen-Philbrook, Prasad Devarajan, Allen D. Everett, Chirag R. Parikh
Summary: This study investigated the association between three plasma biomarkers and AKI before and after surgery, finding that postoperative plasma galectin-3 and ST2 levels were related to AKI in children aged 2 years and older, indicating that these two markers can help improve risk assessment for AKI in pediatric patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Surgery
Caroline Liu, Sami Alasfar, Peter P. Reese, Sumit Mohan, Mona D. Doshi, Isaac E. Hall, Heather Thiessen Philbrook, Yaqi Jia, Darren Stewart, Chirag R. Parikh
Summary: Kidney procurement and discard rates from deceased donors with AKI have increased from 2010 to 2020, especially for stage 3 AKI donors. Despite the increase in procurement of stage 3 AKI kidneys, high discard rates suggest room for improvement in utilization.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Simke W. Waijer, Taha Sen, Clare Arnott, Bruce Neal, Jos G. W. Kosterink, Kenneth W. Mahaffey, Chirag R. Parikh, Dick de Zeeuw, Vlado Perkovic, Brendon L. Neuen, Steven G. Coca, Michael K. Hansen, Ron T. Gansevoort, Hiddo J. L. Heerspink
Summary: This study evaluated the value of TNF receptor-1 and TNF receptor-2 as prognostic biomarkers for CKD progression in patients with normoalbuminuria, finding that both were associated with kidney outcomes while KIM-1 was not.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Carolina Lopez-Silva, Aditya Surapaneni, Josef Coresh, Jochen Reiser, Chirag R. Parikh, Wassim Obeid, Morgan E. Grams, Teresa K. Chen
Summary: This study evaluated the use of SOM Ascan technology for quantification of immune activation biomarkers and cystatin C in CKD. The results showed high correlations between SOM Ascan measurements and immunoassays. Certain biomarkers were associated with increased risks of kidney failure and all-cause mortality.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Transplantation
Daniel Lazzareschi, Ravindra L. Mehta, Laura M. Dember, Juliane Bernholz, Alparslan Turan, Amit Sharma, Sachin Kheterpal, Chirag R. Parikh, Omar Ali, Ivonne H. Schulman, Abigail Ryan, Jean Feng, Noah Simon, Romain Pirracchio, Patrick Rossignol, Matthieu Legrand
Summary: Acute kidney injury is a growing epidemic that is associated with increased risk of death, chronic kidney disease, and cardiovascular events. Clinical trials in this field are challenging due to the heterogeneity of the disease. Identifying subphenotypes of acute kidney injury can help elucidate its diverse etiologies and enhance prevention and treatment strategies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Ian E. McCoy, Jesse Y. Hsu, Joseph Bonventre, Chirag R. Parikh, Alan S. Go, Kathleen D. Liu, Ana C. Ricardo, Anand Srivastava, Debbie L. Cohen, Jiang He, Jing Chen, Panduranga S. Rao, Chi-Yuan Hsu
Summary: Hospitalized acute kidney injury (AKI) is associated with long-term changes in kidney injury markers TNFR1, TNFR2, and KIM-1.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Kalie L. Tommerdahl, Emily A. Hu, Elizabeth Selvin, Lyn M. Steffen, Josef Coresh, Morgan E. Grams, Petter Bjornstad, Casey M. Rebholz, Chirag R. Parikh
Summary: In the ARIC study, higher coffee intake was associated with a lower risk of incident AKI, indicating that coffee may have cardiorenal protective effects. Further evaluation of the physiological mechanisms underlying these effects is needed.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Surgery
Kathleen Yu, Syed A. Husain, Kristen King, Jacob S. Stevens, Chirag R. Parikh, Sumit Mohan
Summary: Acute kidney injury (AKI) severity is a strong risk factor for kidney nonprocurement in deceased organ donors. Efforts to address the organ shortage should focus on encouraging the procurement and utilization of kidneys from deceased donors with severe AKI, given the large prevalence of donor AKI and successful transplant outcomes with these kidneys.
CLINICAL TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Caroline Liu, Neha Debnath, Gohar Mosoyan, Kinsuk Chauhan, George Vasquez-Rios, Celine Soudant, Steve Menez, Chirag R. Parikh, Steven G. Coca
Summary: Sensitive and specific biomarkers are needed to better understand the risk of incident and progressive CKD. A systematic review and meta-analysis were conducted to assess the prognostic value of preclinical plasma and urine biomarkers for CKD outcomes. The most frequently studied biomarkers (TNFR1, FGF23, TNFR2, KIM-1, suPAR, KIM-1, NGAL) showed significant associations with CKD outcomes. These findings suggest these biomarkers should be assessed in clinical practice.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Qandeel H. Soomro, Sonia T. Anand, Steven D. Weisbord, Martin P. Gallagher, Ryan E. Ferguson, Paul M. Palevsky, Deepak L. Bhatt, Chirag R. Parikh, James S. Kaufman
Summary: Contrast-associated AKI is associated with periprocedure fluid administration. The study found that smaller volume of fluid administration may increase the risk of adverse outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Transplantation
Rakesh Malhotra, Ronit Katz, Paul L. Kimmel, Ramachandran S. Vasan, Jeffrey S. Schelling, Jason H. Greenberg, Chirag R. Parikh, Joseph Bonventre, Tala Al-Rousan, Mark J. Sarnak, Orlando M. Gutierrez, Michael G. Shlipak, Joachim H. Ix
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Pavan K. Bhatraju, David K. Prince, Sherry Mansour, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Amit X. Garg, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Steve G. Coca, Chirag R. Parikh, Mark M. Wurfel, Jonathan Himmelfarb
Summary: This study identifies AKI subphenotypes that are molecularly distinct and have different risks of long-term outcomes, independent of the current criteria for risk stratifying AKI.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Steven Menez, Steven G. Coca, Dennis G. Moledina, Yumeng Wen, Lili Chan, Heather Thiessen-Philbrook, Wassim Obeid, Brian T. Garibaldi, Evren U. Azeloglu, Ugochukwu Ugwuowo, C. John Sperati, Lois J. Arend, Avi Z. Rosenberg, Madhurima Kaushal, Sanjay Jain, F. Perry Wilson, Chirag R. Parikh
Summary: The study found that sTNFR1 and sTNFR2 are independently associated with MAKE in patients hospitalized with COVID-19, and both can serve as predictors for adverse kidney outcomes.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Letter
Urology & Nephrology
Dipal M. Patel, Sumeska Thavarajah, Jack Bitzel, Thomas Grader-Beck, Derek M. Fine, Morgan E. Grams, Chirag R. Parikh, Deidra C. Crews
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Kuan Jiang, Jason H. Greenberg, Alison Abraham, Yunwen Xu, Jeffrey R. Schelling, Harold I. Feldman, Sarah J. Schrauben, Sushrut S. Waikar, Michael G. Shlipak, Nicholas Wettersten, Steven G. Coca, Ramachandran S. Vasan, Orlando M. Gutierrez, Joachim H. Ix, Bradley A. Warady, Paul L. Kimmel, Joseph V. Bonventre, Chirag R. Parikh, Mark M. Mitsnefes, Michelle R. Denburg, Susan Furth
Summary: The prevalence of left ventricular hypertrophy (LVH) in children with chronic kidney disease (CKD) is associated with increased levels of kidney injury molecule-1 (KIM-1), monocyte chemoattractant protein-1 (MCP-1), and decreased levels of urine alpha-1 microglobulin (alpha-1m).
