Article
Health Care Sciences & Services
Denis Chemla, Davide Agnoletti, Mathieu Jozwiak, Yi Zhang, Athanase D. Protogerou, Sandrine Millasseau, Jacques Blacher
Summary: In this non-invasive study, the estimation of central systolic blood pressure (cSBP) using the DCBP formula was compared with the estimation using radial tonometry. The results showed a linear relationship between cSBP estimated by DCBP and cSBP estimated by radial tonometry, and the DCBP method exhibited good sensitivity and specificity in discriminating high blood pressure threshold.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
Weiwei Zeng, Brian Tomlinson
Summary: This prospective study aimed to examine the effects of bisoprolol, a highly P1-selective agent, on central aortic systolic pressure (CASP). The study found that bisoprolol effectively reduced CASP and this reduction was proportional to the decrease in brachial systolic blood pressure (Br-SBP). Additionally, the reduction in CASP after the first dose could predict more favorable CASP responses to long-term therapy.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Peripheral Vascular Disease
Thomas Weber, Athanase D. Protogerou, Mohsen Agharazii, Antonis Argyris, Sola Aoun Bahous, Jose R. Banegas, Ronald K. Binder, Jacques Blacher, Andrea Araujo Brandao, Juan J. Cruz, Kathrin Danninger, Cristina Giannatasio, Auxiliadora Graciani, Bernhard Hametner, Piotr Jankowski, Yan Li, Alessandro Maloberti, Christopher C. Mayer, Barry J. McDonnell, Carmel M. McEniery, Marco Antonio Mota Gomes, Annelise Machado Gomes, Maria Lorenza Muiesan, Janos Nemcsik, Anna Paini, Enrique Rodilla, Aletta E. Schutte, Petros P. Sfikakis, Dimitrios Terentes-Printzios, Alexandre Vallee, Charalambos Vlachopoulos, Lisa Ware, Ian Wilkinson, Robert Zweiker, James E. Sharman, Siegfried Wassertheurer
Summary: Central systolic blood pressure (cSBP) is more closely associated with hypertension-mediated organ damage and prognosis than brachial systolic blood pressure. This study investigated the 24-hour profiles of brachial and central SBP in untreated adults, providing reference values and analyzing daytime-nighttime variability. The findings have potential implications for refining hypertension diagnosis and management.
Article
Peripheral Vascular Disease
Simon Helleputte, Bart Spronck, James E. E. Sharman, Luc Van Bortel, Patrick Segers, Patrick Calders, Bruno Lapauw, Tine De Backer
Summary: The central blood pressure values estimated by radial artery tonometry in T1DM patients depend significantly on the method used for calibration of the radial waveforms. Using brachial MAP/DBP calibration resulted in higher central blood pressure compared to using brachial SBP/DBP calibration, indicating the importance of calibration approach for accurate estimation of central blood pressure using noninvasive methods.
JOURNAL OF HYPERTENSION
(2023)
Article
Physiology
Daniel Bia, Yanina Zocalo, Ramiro Sanchez, Gustavo Lev, Oscar Mendiz, Franco Pessana, Agustin Ramirez, Edmundo Cabrera-Fischer
Summary: This study evaluated the agreement between invasively and non-invasively obtained aoSBP and aoPP values using different recording techniques, sites, waveform analysis algorithms, and calibration schemes. Overall, non-invasive methods yielded lower aoSBP and aoPP levels compared to invasive methods. CCA recordings provided values closest to invasive recordings, followed by BA recordings. The 033HR and 0412 calibration schemes showed the lowest mean error, while the 033 method had the highest error. Most non-invasive methods overestimated and underestimated aoSBP at low and high invasive aoSBP values, respectively. The higher the invasively measured aoPP, the greater the underestimation by non-invasive methods. Therefore, the recording method and site, the mathematical method/model used to quantify aoSBP and aoPP, and the calibration method for waveforms are essential for accurate estimation of aoBP. This study highlights the importance of methodological transparency and consensus for non-invasive aoBP assessment.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Yi-Bang Cheng, Lutgarde Thijs, Lucas S. Aparicio, Qi-Fang Huang, Fang-Fei Wei, Yu-Ling Yu, Jessica Barochiner, Chang-Sheng Sheng, Wen-Yi Yang, Teemu J. Niiranen, Jose Boggia, Zhen-Yu Zhang, Katarzyna Stolarz-Skrzypek, Natasza Gilis-Malinowska, Valerie Tikhonoff, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Jan Filipovsky, Kalina Kawecka-Jaszcz, Ji-Guang Wang, Yan Li, Jan A. Staessen
Summary: This study investigated the relationship between cardiovascular risk and central and brachial systolic pressure and proposed thresholds to differentiate hypertension from normal blood pressure. Regardless of brachial blood pressure status, central hypertension was associated with increased cardiovascular and cerebrovascular risk, highlighting the importance of controlling central hypertension.
Article
Cardiac & Cardiovascular Systems
Nelson Wang, Katie Harris, Pavel Hamet, Stephen Harrap, Giuseppe Mancia, Neil Poulter, Bryan Williams, Sophia Zoungas, Mark Woodward, John Chalmers, Anthony Rodgers
Summary: The study found that cumulative systolic blood pressure load was associated with an increased risk of cardiovascular events and death in patients with type 2 diabetes, and provided better prediction compared to traditional blood pressure measures.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Audrey Adji, Michael F. O'Rourke
Summary: This study explains the changes in arterial pulse waveform in humans from birth to old age as a result of body growth and degeneration and dilation of the aorta. These changes are linked to brachial pressure values and provide insight into optimal pulse wave pattern for cardiac interaction.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Angela Tagetti, Claudia A. Piona, Denise Marcon, Alice Giontella, Lorella Branz, Stefano Bortolotti, Anita Morandi, Claudio Maffeis, Cristiano Fava
Summary: This study found that a high proportion of early vascular damage, especially increased cIMT, is present in children and adolescents with type 1 diabetes. cSBP seems to be a common determinant, and there should be a special focus on hemodynamic risk factors beyond metabolic ones in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Isabella Tan, Edward Barin, Mark Butlin, Alberto P. Avolio
Summary: The relationship between heart rate and central aortic pressure is important in the assessment and treatment of isolated systolic hypertension in the young (ISHY). An increase in heart rate leads to increased amplification of the pressure pulse, but elevated heart rate is not always seen in ISHY. This review summarizes the physiological aspects of this relationship, how it changes with age, and the implications for the assessment and treatment of ISHY.
Article
Cardiac & Cardiovascular Systems
Denis Chemla, Sandrine Millasseau, Olfa Hamzaoui, Jean-Louis Teboul, Xavier Monnet, Frederic Michard, Mathieu Jozwiak
Summary: The study found that cSBP could be reliably estimated using only MBP and DBP, provided that blood pressure measurement errors are minimized. This method may have implications for assessing cardiovascular risk associated with cSBP on large BP databases, warranting further research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Kevin E. Boczar, Munir Boodhwani, Luc Beauchesne, Carole Dennie, Kwan Leung Chan, George A. Wells, Thais Coutinho
Summary: The study shows that measures of aortic stiffness and pulsatile hemodynamics are independently associated with future thoracic aortic aneurysm growth, providing novel insights into disease activity. These findings highlight the role of central hemodynamic assessment in tailoring new risk assessment and therapeutic strategies for patients with thoracic aortic aneurysm.
Article
Peripheral Vascular Disease
Florence Lamarche, Mohsen Agharazii, Francois Madore, Remi Goupil
Summary: This study found that central blood pressure measured with a type I device was statistically but likely not clinically superior to brachial blood pressure in a general population without prior cardiovascular disease. The optimal central systolic blood pressure threshold associated with increased risk of major adverse cardiovascular events was identified as 112 mm Hg.
Article
Multidisciplinary Sciences
Sun Ryoung Choi, Young-Ki Lee, Hayne Cho Park, Do Hyoung Kim, Ajin Cho, Min-Kyung Kang, Seonghoon Choi
Summary: Cardiovascular disease is the leading cause of death in patients with end-stage kidney disease, and left ventricular diastolic dysfunction is common in these patients. The relationship between central blood pressure and LV diastolic dysfunction in dialysis patients is unclear. LV diastolic dysfunction can independently predict cardiovascular mortality in dialysis patients.
Review
Cardiac & Cardiovascular Systems
Sara L. Hungerford, Audrey I. Adji, Navin K. Kapur
Summary: The central aortic pressure waveform is simple in form but complex in physiological interpretation. There is increasing interest in the contour of the pressure wave in elderly patients with aortic valve stenosis. Methods to measure the central aortic pressure waveform and transcatheter aortic valve implantation technologies have enhanced our understanding of waveform alterations in elderly patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Transplantation
Jennifer B. Green, Amy K. Mottl, George Bakris, Hiddo J. L. Heerspink, Johannes F. E. Mann, Janet B. McGill, Masaomi Nangaku, Peter Rossing, Charlie Scott, Alain Gay, Rajiv Agarwal
Summary: This study aims to investigate the efficacy of dual therapy with finerenone and an SGLT2i in reducing chronic kidney disease and type 2 diabetes. The results will provide important insights for improving treatment methods for kidney disease and cardiovascular risks.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Peter Rossing, Rajiv Agarwal, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Luis M. Ruilope, Vivian Fonseca, Guillermo E. Umpierrez, Maria Luiza Caramori, Amer Joseph, Marc Lambelet, Robert Lawatscheck, George L. Bakris
Summary: This study investigated the effect of GLP-1RA use on the outcomes of patients with CKD and T2D treated with finerenone. The results showed that the use of GLP-1RA did not affect the cardiorenal benefits of finerenone.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jens Christian Laursen, Ida Kirstine Bull Rasmussen, Emilie Hein Zobel, Philip Hasbak, Lene Holmvang, Christian Stevns Hansen, Bernt Johan von Scholten, Marie Frimodt-Moller, Peter Rossing, Tine Willum Hansen, Andreas Kjaer, Rasmus Sejersten Ripa
Summary: Cardiac angiogenesis assessed by Ga-68-RGD PET was similar in type 2 diabetes and non-diabetic controls, and was not associated with kidney function or other risk factors.
Article
Medicine, General & Internal
Sankar D. Navaneethan, Sophia Zoungas, M. Luiza Caramori, Juliana C. N. Chan, Hiddo J. L. Heerspink, Clint Hurst, Adrian Liew, Erin D. Michos, Wasiu A. Olowu, Tami Sadusky, Nikhil Tandon, Katherine R. Tuttle, Christoph Wanner, Katy G. Wilkens, Jonathan C. Craig, David J. Tunnicliffe, Marcello Tonelli, Michael Cheung, Amy Earley, Peter Rossing, Ian H. de Boer, Kamlesh Khunti
Summary: The KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease is an update of the 2020 guideline. The guideline was updated based on reviewing new evidence and using the GRADE approach to assess evidence and develop consensus practice points. The recommendations were updated in the areas of comprehensive care and glucose-lowering therapies, while recommendations in the areas of glycemic monitoring, lifestyle interventions, and management approaches remained unchanged.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Meir Schechter, Niels Jongs, Glenn M. Chertow, Ofri Mosenzon, John J. McMurray, Ricardo Correa-Rotter, Peter Rossing, Anna Maria Langkilde, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: This study aimed to determine the effects of dapagliflozin on hospitalizations in patients with chronic kidney disease (CKD). The results showed that dapagliflozin reduced the risk of hospitalization for any cause in patients with CKD, regardless of whether they had type 2 diabetes or not.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Viktor Rotbain Curovic, Niels Jongs, Marjolein Y. A. M. Kroonen, Emilie H. Zobel, Tine W. Hansen, Taha Sen, Gozewijn D. Laverman, Adriaan Kooy, Frederik Persson, Peter Rossing, Hiddo J. L. Heerspink
Summary: This randomized crossover trial found significant variation in participants' responses to different drug classes in terms of urinary albumin to creatinine ratio (UACR) reduction. The results suggest that systematic rotation through different drug classes can overcome resistance to RAS inhibitors.
Review
Peripheral Vascular Disease
Kei Asayama, Katarzyna Stolarz-Skrzypek, Wen-Yi Yang, Tine W. Hansen, Jana Brguljan-Hitij, Augustine N. Odili, Yan Li, Jan A. Staessen
Summary: The International Databases on Ambulatory (IDACO) and Home (IDHOCO) Blood Pressure in Relation to Cardiovascular Outcome conducted a meta-analysis which found that 24-hour and nighttime blood pressure levels are the best predictors of adverse health outcomes. They also established corresponding thresholds for home and ambulatory blood pressure. The study emphasized the importance of out-of-office blood pressure monitoring in tackling the hypertension pandemic.
HYPERTENSION RESEARCH
(2023)
Article
Transplantation
Peter Rossing, Florian M. M. Baeres, George Bakris, Heidrun Bosch-Traberg, Mette Gislum, Stephen C. L. Gough, Thomas Idorn, Jack Lawson, Kenneth W. Mahaffey, Johannes F. E. Mann, Henriette Mersebach, Vlado Perkovic, Katherine Tuttle, Richard Pratley, FLOW Steering Comm, FLOW Trial Investigators
Summary: This study aims to investigate the effects of semaglutide on kidney outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). The participants were found to be mostly at high risk for CKD progression. The study is expected to be completed in late 2024.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Christina Gjerlev W. Poulsen, Daniel G. K. Rasmussen, Federica Genovese, Tine Hansen, Signe Holm K. Nielsen, Henrik Reinhard, Bernt Johan von Scholten, Peter Jacobsen, Hans-Henrik Parving, Morten Asser Karsdal, Peter Rossing, Marie Frimodt-Moller
Summary: This study investigated whether C3M, a degradation product of collagen type III, is a risk marker for the progression of chronic kidney disease (CKD) in individuals with type 2 diabetes and microalbuminuria. The results showed that higher levels of sC3M were associated with CKD progression in these patients.
Article
Genetics & Heredity
Claire Hill, Seamus M. Duffy, Laura Kettyle, Liane McGlynn, Niina M. Sandholm, Rany Salem, Alex J. Thompson, Elizabeth Swan, Jill Kilner, Peter G. Rossing, Paul Shiels, Maria Lajer, Per-Henrik Groop, Alexander Peter Maxwell, Amy Jayne McKnight, GENIE Consortium
Summary: Diabetic kidney disease (DKD) is a major global health problem characterized by accelerated aging. This study explored features affecting telomere biology and methylation dysregulation in DKD using multi-omics approaches, which may provide useful biomarkers or therapeutic targets.
Article
Endocrinology & Metabolism
Hiddo J. L. Heerspink, Andreas L. Birkenfeld, David Z. I. Cherney, Helen M. Colhoun, Linong Ji, Chantal Mathieu, Per-Henrik Groop, Richard E. Pratley, Sylvia E. Rosas, Peter Rossing, Jay S. Skyler, Katherine R. Tuttle, Robert Lawatscheck, Charlie Scott, Robert Edfors, Markus F. Scheerer, Peter Kolkhof, Janet B. McGill
Summary: This study aims to evaluate the efficacy and safety of Finerenone in type 1 diabetes and chronic kidney disease (CKD). Finerenone could potentially become the first registered treatment for CKD associated with type 1 diabetes in almost 30 years.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Zeinab Schafer, Andreas Mathisen, Trine Rolighed Thomsen, Peter Rossing, Klaus Kirketerp-Moller
Summary: This study conducted a cohort analysis on 309,116 patients with type 2 diabetes and found that GLP-1 agonist treatment significantly reduces the risk of lower extremity amputations, particularly among middle-income patients.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Review
Endocrinology & Metabolism
Vikas S. Sridhar, Christine P. Limonte, Per-Henrik Groop, Hiddo J. L. Heerspink, Richard E. Pratley, Peter Rossing, Jay S. Skyler, David Z. I. Cherney
Summary: The current management of CKD in type 1 diabetes focuses on blood sugar control, inhibiting the renin-angiotensin system and optimizing risk factors. However, individuals with type 1 diabetes and CKD still face elevated risks for kidney and cardiovascular events. Novel therapies used in type 2 diabetes, such as sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide 1 receptor agonists, have shown potential kidney and heart protection. Applying these therapies to individuals with type 1 diabetes for the prevention of CKD is of great importance.
Article
Urology & Nephrology
Robert A. Fletcher, Niels Jongs, Glenn M. Chertow, John J. V. Mcmurray, Clare Arnott, Meg J. Jardine, Kenneth W. Mahaffey, Vlado Perkovic, Patrick Rockenschaub, Peter Rossing, Ricardo Correa-Rotter, Robert D. Toto, Muthiah Vaduganathan, David C. Wheeler, Hiddo J. L. Heerspink, Brendon L. Neuen
Summary: This study analyzed the effect of SGLT2 inhibitors on the discontinuation of RAS blockade and found that patients receiving SGLT2 inhibitors had a lower risk of discontinuing RAS blockade. This effect was particularly pronounced in patients with a high baseline urinary albumin-to-creatinine ratio.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hashmat Sayed Zohori Bahrami, Peter Godsk Jorgensen, Jens Dahlgaard Hove, Ulrik Dixen, Tor Biering-Sorensen, Peter Rossing, Magnus T. Jensen
Summary: Cardiovascular disease is the leading cause of death in type 1 and type 2 diabetes patients. The myocardial performance index (MPI), which reflects left ventricular function, has not been evaluated for its prognostic value in diabetes populations. This study evaluated two prospective cohort studies and found that MPI is associated with major adverse cardiovascular events and heart failure, particularly in type 1 diabetes patients, and improves prediction in this group.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)