Article
Peripheral Vascular Disease
Beata Korosi, Helga Gyongyosi, Dora Batta, Andrea Laszlo, Illes Kovacs, Andras Tisler, Orsolya Cseprekal, Zsofia Nemcsik-Bencze, Xenia Gonda, Zoltan Rihmer, Janos Nemcsik
Summary: White-coat and resistant hypertensive patients exhibit specific affective temperament patterns, and evaluating these patterns can provide insight into the psychopathological background of these conditions.
HYPERTENSION RESEARCH
(2021)
Review
Immunology
Shao-Fei Liu, Netra Nambiar Veetil, Qiuhua Li, Mariya M. M. Kucherenko, Christoph Knosalla, Wolfgang M. M. Kuebler
Summary: Pulmonary hypertension is a progressive disease caused by inflammation, which leads to pulmonary arterial stiffness and vascular remodeling, driving the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bernardo Rodriguez-Iturbe, Richard J. Johnson, Laura Gabriela Sanchez-Lozada, Hector Pons
Summary: Heat shock protein 70 (HSP70) plays a role in both inflammation and immune reactivity, depending on the context. It is associated with hypertension, which is an important risk factor for cardiovascular disease mortality. The HSP70 response can either drive inflammatory immune reactivity or protect against hypertension through immunomodulatory responses.
Article
Cardiac & Cardiovascular Systems
Hiroki Nakano, Kazuki Shiina, Takamichi Takahashi, Masatsune Fujii, Yoichi Iwasaki, Chisa Matsumoto, Akira Yamashina, Taishiro Chikamori, Hirofumi Tomiyama
Summary: In this 16-year study, bidirectional relationships were found between arterial stiffness and hypertension, but not between arterial stiffness and diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Peripheral Vascular Disease
Qianhui Ling, Qirui Song, Jingjing Bai, Shouling Wu, Weili Zhang, Mulei Chen, Jun Cai
Summary: This study examined the temporal relationship between arterial stiffness and systolic blood pressure (SBP), and found that arterial stiffening precedes SBP, particularly in the intensive treatment group, and leads to difficulty in achieving the target SBP.
Article
Peripheral Vascular Disease
Michal Schafer, Lorna P. Browne, Uyen Truong, Petter Bjornstad, Shoshana Tell, Janet Snell-Bergeon, Amy Baumgartner, Kendall S. Hunter, Jane E. B. Reusch, Alex J. Barker, Kristen J. Nadeau, Irene E. Schauer
Summary: In this study, researchers tested whether BCQR could improve vascular health in youth with T1D. The results showed that compared to placebo, BCQR could lower blood pressure and improve aortic stiffness and pressure hemodynamics. Therefore, BCQR may help improve arterial stiffness in youth with T1D and longer-term studies are needed to confirm these findings.
Article
Peripheral Vascular Disease
Xue Tian, Yingting Zuo, Shuohua Chen, Yijun Zhang, Xiaoli Zhang, Qin Xu, Shouling Wu, Anxin Wang
Summary: This study investigated the association between different blood pressure and arterial stiffness status with diabetes. The results showed that both hypertension and arterial stiffness were associated with diabetes. Additionally, arterial stiffness had a better predictive ability for diabetes than hypertension.
Article
Peripheral Vascular Disease
Anna Rogowska, Lukasz Obrycki, Zbigniew Kulaga, Claudia Kowalewska, Mieczyslaw Litwin
Summary: The study found that hypertensive children show signs of microcirculation remodeling and decreased neural layer of the retina, associated with hypertensive macrocirculation remodeling characterized by increased carotid intima-media thickness and elevated central systolic blood pressure.
Article
Medicine, General & Internal
Qirui Song, Qianhui Ling, Jingjing Bai, Hongwei Zhang, Peili Bu, Fang Chen, Shouling Wu, Weili Zhang, Mulei Chen, Jun Cai
Summary: This study found no significant difference in the effects of intensive versus standard systolic blood pressure treatments among older patients with arterial stiffness. The beneficial effects of intensive treatment were similar in patients with and without arterial stiffness, regardless of baseline conditions.
Article
Medicine, General & Internal
Anna Vegh, Adrienn Barczi, Orsolya Cseprekal, Eva Kis, Kata Kelen, Szilard Torok, Attila J. Szabo, Gyorgy S. Reusz
Summary: Pediatric renal transplant recipients have a high prevalence of hypertension, with controlled hypertension potentially impacting the evolution of GFR. It is suggested to enhance the control of hypertension to maintain renal transplant function.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Michal Schafer, D. Dunbar Ivy, Kathleen Nguyen, Katie Boncella, Benjamin S. Frank, Gareth J. Morgan, Kathleen Miller-Reed, Uyen Truong, Kelley Colvin, Michael E. Yeager
Summary: The disturbed balance between matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) is recognized as a pathophysiological component of pulmonary arterial hypertension (PAH). This study found that levels of MMPs and TIMPs in children with PAH were associated with standard cardiac MRI hemodynamic indices and markers of pulmonary arterial stiffness, suggesting their potential as prognostic indicators in PAH.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Pierre Boutouyrie, Phil Chowienczyk, Jay D. Humphrey, Gary F. Mitchell
Summary: Arterial stiffness is a key marker of risk in hypertension, and can be measured at material or structural levels. Studies have shown that structural stiffness predicts outcomes, with elastic arteries being most sensitive to blood pressure and age. Stiffness is considered an index of vascular aging and affects brain, kidneys, and heart function. Reduction of stiffness through antihypertensive treatments and preventive drugs may have additional benefits beyond lowering blood pressure. Newer anti-inflammatory drugs also have effects on stiffness independent of blood pressure.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Aimilia Eirini Papathanasiou, Fotios Spyropoulos, Zoe Michael, Kyoung E. Joung, Despina D. Briana, Ariadne Malamitsi-Puchner, Christos S. Mantzoros, Helen Christou
Summary: The study found significantly elevated levels of fatty acid binding protein 4, fibroblast growth factor-21, and adiponectin in the circulation of pulmonary hypertension patients, with increased mRNA levels of these metabolic regulators and PPAR γ gene in patient lung tissue. Experimental rodent models of PH and human patients demonstrated increased gene expression related to glucose uptake, glycolysis, tricarboxylic acid cycle, and fatty acid oxidation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jun Fan, Shirley Wang, Kai Chen, Zhongjie Sun
Summary: This study found that aging and arterial stiffness can be caused by Klotho deficiency leading to immune dysfunction and decreased arterial elasticity. AAV-SKL can alleviate arterial stiffness in aging mice by restoring B-cell populations and serum IgG levels.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Peripheral Vascular Disease
Akio Ishida, Hirona Taira, Tomoko Shinzato, Yusuke Ohya
Summary: Obesity and arterial stiffness are important risk factors for disease development. However, the relationship between obesity and arterial stiffness remains unclear. This study aimed to examine the relationship of visceral fat area (VFA) and anthropometric obesity indices with arterial stiffness. The results showed that VFA and most anthropometric indices were positively associated with age in both men and women. Furthermore, visceral fat area and most anthropometric obesity indices were positively associated with metabolic syndrome components, including hypertension, dyslipidemia, and hyperglycemia.
HYPERTENSION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Erifili Venieri, Constantina Aggeli, Aris Anastasakis, Helen Sambatakou, Christodoulos Stefanadis, Dimitrios Tousoulis
Summary: This study assessed the mitral valve in HCM patients and found that patients with and without obstruction share some common anatomic features, but those with obstruction have unique characteristics that may contribute to LVOT obstruction.
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Letter
Medicine, General & Internal
Ioannis Doundoulakis, Dimitris Tsiachris, Konstantinos A. Gatzoulis, Christodoulos Stefanadis, Konstantinos Tsioufis
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Ioannis Andrikou, Kyriakos Dimitriadis, Dimitris Konstantinidis, Ioannis Leontsinis, Eirini Andrikou, Panagiotis Iliakis, Ioannis Liatakis, Eleni Manta, Nikos Karaminas, Panagiotis Tsioufis, Nikolaos Magkas, Georgios Georgiopoulos, Christina Chrysohoou, Costas Thomopoulos, Dimitrios Tousoulis, Costas Tsioufis
Summary: In treated hypertensive patients, the presence of left ventricular hypertrophy and arterial stiffness indicate cardiovascular risk, with left ventricular hypertrophy being a better predictor of coronary artery disease. Age over 65, male gender, chronic kidney disease, diabetes, and left ventricular hypertrophy were identified as independent predictors of CAD.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Christos Fragoulis, Kyriakos Dimitriadis, Eirini Siafi, Panagiotis Iliakis, Alexandros Kasiakogias, Theodoros Kalos, Ioannis Leontsinis, Ioannis Andrikou, Dimitrios Konstantinidis, Petros Nihoyannopoulos, Georgios Tsivgoulis, Costas Thomopoulos, Dimitrios Tousoulis, Maria L. Muiesan, Konstantinos P. Tsioufis
Summary: This study provides epidemiological data on the prevalence, clinical characteristics, and management of hypertensive urgencies and emergencies in an emergency department. Stress, increased salt intake, and medication non-adherence were identified as main triggers. Patients with urgencies commonly presented with dizziness and headache, while those with emergencies often showed symptoms of dyspnea and chest pain.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Environmental Sciences
Kyriakos Dimitriadis, Krzysztof Narkiewicz, Ioannis Leontsinis, Dimitris Konstantinidis, Costas Mihas, Ioannis Andrikou, Costas Thomopoulos, Dimitrios Tousoulis, Konstantinos Tsioufis
Summary: This study compared the acute effects of tobacco cigarette, electronic cigarette, and sham smoking on sympathetic nerve activity and blood pressure, finding that electronic cigarette smoking led to a decrease in muscle sympathetic nerve activity and an increase in mean arterial pressure similar to traditional cigarette smoking in healthy habitual smokers.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Peripheral Vascular Disease
Lida Koskina, Ioannis Andrikou, Costas Thomopoulos, Konstantinos Tsioufis
Summary: Cancer is a leading cause of death and hypertension is a common comorbidity in cancer patients. Preexisting hypertension is an independent risk factor for increased blood pressure during anticancer therapy. Recognizing and managing hypertension as a modifiable risk factor prior to cancer therapy initiation is crucial to prevent premature chemotherapy cessation. Studying onco-hypertension will help establish specific guidelines for managing hypertension in cancer patients.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Peripheral Vascular Disease
Shane A. Phillips, Kendra Osborn, Chueh-Lung Hwang, Ahmad Sabbahi, Mariann R. Piano
Summary: Oxidative stress is implicated in the development of many ethanol-induced pathologies, contributing to endothelial dysfunction and cardiovascular diseases such as hypertension. Ethanol consumption may alter vascular cell function and microvascular function, increasing the risk for hypertension. Data from human investigations have shown an association between alcohol consumption, changes in blood pressure, and hypertension risk.
CURRENT HYPERTENSION REVIEWS
(2021)