Article
Biochemistry & Molecular Biology
Pawel Pecak, Marta Switalska, Elwira Chrobak, Grzegorz Boryczka, Ewa Bebenek
Summary: Betulin, a natural triterpene, has promising antiproliferative activity. In this study, 38 betulin acid ester derivatives modified at the C-28 position were tested for antitumor activities. Some of the derivatives showed strong antiproliferative activity with IC50 values between 2 and 5 μM. Mechanistic studies revealed that some derivatives induced apoptosis by activating caspase-3/7 activity. A strong structure-activity correlation and pharmacokinetic properties were also proposed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Eric J. Gapud, Maria Isabel Trejo-Zambrano, Eduardo Gomez-Banuelos, Eleni Tiniakou, Brendan Antiochos, David J. Granville, Felipe Andrade, Livia Casciola-Rosen, Antony Rosen
Summary: This study unveils a range of novel signaling activities of Granzyme B that do not require perforin, occur intracellularly, and are not associated with cell death, which could have mechanistic implications for human diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Asal Moradi, Mohammadreza Abdihaji, Sara Barari Kouchaksaraie, Tabarek Abdulrazaq Alkinani, Aida Mahmoudi, Arash Davoudi, William Dashtmiani, Somayeh Mikaeili Ghezeljeh, Shahrzad Aghajani, Reza Ghasemian, Somayeh Maghsoomi Taramsari, Amitis Majlesi, Zahra Mahdavi Niyaki, Ali Salehzadeh
Summary: The study aimed to fabricate Bi2O3/Gln-TSC nanoparticles and investigate their anticancer mechanism. The results showed that Bi2O3/Gln-TSC had significant cytotoxicity against prostate cancer cells and induced apoptosis.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Rosa Manca, Monia Delia, Marianna Abate, Silvia Zappavigna, Sergio Papa, Chester Glomski, Alessandra Pica
Summary: Apoptosis, programmed cell death, plays a central role in haematopoiesis. This study investigates the expression and subcellular distribution of Bcl-2, Bcl-X-L, and Bax proteins in nucleated erythrocytes and the effect of X-ray irradiation on these cells. The results demonstrate the role of these proteins in the maturation of erythrocytes.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Matthias Kist, Domagoj Vucic
Summary: In recent years, research has identified various forms of cell death, each relying on different proteins for activation. Many pathways share components and signaling principles, working together rather than independently. Several cell death regulators are linked to human diseases and may be potential therapeutic targets.
Article
Medicine, General & Internal
Aleksandra Mielczarek-Palacz, Sylwia Jasinska, Anna Strzelec
Summary: Ovarian cancer is a major issue in gynecological oncology, and research on diagnostic markers like caspase-3, -8, and -9 is ongoing. This study found significantly decreased levels of these caspases in ovarian cancer patients compared to healthy controls, suggesting a link to immune system disturbances and potential for future diagnostic use, pending further research.
Review
Biology
Sanna Huda, Bethany Chau, Chuanqi Chen, Herman Somal, Neiloy Chowdhury, Nicola Cirillo
Summary: The study indicates that caspase activation plays a significant role in the pathogenesis of pemphigus vulgaris, but most in vivo studies assessing caspase inhibition in PV models have a high risk of bias. Further research is needed to confirm the efficacy of caspase inhibitors in preventing PV-induced blistering in vivo.
Article
Fisheries
Lei Gao, Qingsong Li, Ziyang Zhang, Pingan Ge, Jiejie Sun, Xue Qiao, Lingling Wang, Linsheng Song
Summary: In this study, the expanded repertoire of Caspases was revealed in the Pacific oyster, and a specific subgroup, CgCaspase-Cg, was found to be expanded through positive selection. The expression of CgCaspase-Cg-5 was upregulated in response to bacterial and viral stimulations or environmental stresses, and it regulated the expression of apoptosis-related genes to induce haemocyte apoptosis in the early stage of immune response.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Environmental Sciences
Haiying Wei, Wanjun Yuan, Huan Yu, Hong Geng
Summary: PM2.5 can induce apoptosis in alveolar macrophages, causing cytotoxic effects, increasing levels of reactive oxygen species and intracellular calcium ions, and leading to lung injury diseases through a mitochondrial-mediated pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Inorganic & Nuclear
Fatemeh Mehraban, Fariba Heidari Esfahani, Zahra Mosayebi Dorcheh, Erfaneh Heidari Esfahani, Mansoureh Azadeh, Ali Salehzadeh
Summary: This study evaluated the cytotoxic effect of GaFe2O4@Ag nanocomposite biosynthesized by Spirulina platensis on breast cancer cell line and investigated its influence on apoptosis pathways. The results showed that the nanocomposite exhibited high cytotoxicity against breast cancer cells and induced apoptosis through activation of apoptosis pathways.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Veterinary Sciences
Wonchul Jung, Inkyu Yoo, Jisoo Han, Minjeong Kim, Soohyung Lee, Yugeong Cheon, Minsun Hong, Bo-Young Jeon, Hakhyun Ka
Summary: Research has shown that caspases are dynamically expressed in the endometrium throughout the estrous cycle and at the maternal-conceptus interface during pregnancy in pigs. The expression of CASP3, CASP6, and CASP7 changes in a stage-specific manner in the endometrium during different reproductive stages. Additionally, the expression of caspases in endometrial cells is influenced by steroid hormones and cytokines, suggesting that caspase action may play an important role in regulating endometrial and placental function in pigs during the implantation period.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Environmental Sciences
Shanshan Hou, Xiayu Zhang, Xiaofan Ning, Hao Wu, Xinyue Li, Kai Ma, Huifang Hao, Chunping Lv, Chunrui Li, Zhongjun Du, Haiying Du, Minghua Jin
Summary: This study explores the role of ROS-mediated PARP/AIF apoptosis signaling pathway in MeHg-induced cell death. The results suggest that increased levels of ROS and calcium ion, as well as the activation of caspase cascades and PARP, are involved in MeHg-induced apoptosis. The inhibition of ROS production can reduce the apoptosis rate. The PARP/AIF apoptotic pathway is independent of the caspase pathway and regulates it.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Immunology
Thomas A. Premeaux, Stephen T. Yeung, Zaheer Bukhari, Scott Bowler, Oral Alpan, Raavi Gupta, Lishomwa C. Ndhlovu
Summary: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a significant global health emergency that can lead to multi-organ failure and death. Understanding the immunological processes is crucial for effective therapeutic interventions for high-risk patients. This review highlights the importance of caspase family members in SARS-CoV-2 infection and disease, suggesting that the function of multiple caspases is linked to the severity of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Fanbi Meng, Shuang Chen, Chunliang Liu, Muhammad Shoaib Khan, Yan Yan, Jun Wan, Yue Xia, Chenglin Sun, Mengnan Yang, Renping Hu, Kesheng Dai
Summary: PKC plays a critical role in regulating megakaryocyte development and platelet production in thrombocytopenia. The inhibition of PKC activation delays and reduces radiation-induced megakaryocyte apoptosis, leading to improved platelet count recovery. This study provides a potential therapeutic target for treating thrombocytopenia.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Xia Chen, Fang Liu, Yuanyuan Ren, Luyang Zhang, Yang Wan, Wenyu Yang, Xiaojuan Chen, Li Zhang, Yao Zou, Yumei Chen, Xiaofan Zhu, Ye Guo
Summary: Unrelated umbilical cord blood transplantation (UCBT) is an effective alternative treatment for pediatric patients with bone marrow failure. The use of the TBI/BU + FLU + CY conditioning regimen ensures a high engraftment rate for UCBT and overcomes the challenge of graft failure. Secondary salvage use of cord blood transplantation may still be useful for patients who have failed after other transplantation.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Chithra D. Palani, Xingguo Zhu, Manickam Alagar, Otis C. Attucks, Betty S. Pace
Summary: This study evaluated the ability of a novel Bach1 inhibitor, HPP-D, to induce HbF in KU812 cells and primary sickle erythroid progenitors. The results showed that HPP-D increased HbF levels and decreased Bach1 protein levels in both cell types. Furthermore, it enhanced NRF2 binding to the gamma-globin promoter antioxidant response elements, leading to an open chromatin configuration and increased gamma-globin transcription.
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Letter
Hematology
Marcos Borato Viana, Erica Louback Oliveira, Andre Rolim Belisario
BLOOD CELLS MOLECULES AND DISEASES
(2024)
Article
Hematology
Ke Zhang, Longying Ye, Yanhui Jin, Yuan Chen, Shuting Jiang, Haixiao Xie, Lihong Yang, Mingshan Wang
Summary: This study investigated two pedigrees with FV deficiency and identified three mutations that may have deleterious effects on the function and structure of FV.
BLOOD CELLS MOLECULES AND DISEASES
(2024)